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公开(公告)号:US20200316372A1
公开(公告)日:2020-10-08
申请号:US15733276
申请日:2018-12-11
Applicant: Galvani Bioelectronics Limited , UCL Business PLC
Inventor: Rizwan BASHIRULLAH , Gerald Edwin HUNSBERGER , Matteo DONEGA , Daniel CHEW , David Holder , Kirill ARISTOVICH
Abstract: A nerve interface device including at least one cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the at least one cuff portion, each ring of electrodes including a plurality of electrodes. Each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The plurality of pairs of electrodes includes at least a first pair of electrodes, the first pair of electrodes mounted on the at least one cuff portion. The at least one cuff portion includes an asymmetric configuration about a central axis perpendicular to the longitudinal cuff axis.
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公开(公告)号:US20190388696A1
公开(公告)日:2019-12-26
申请号:US16446681
申请日:2019-06-20
Applicant: Greatbatch Ltd. , Galvani Bioelectronics Limited
Inventor: Ignacio A. Armesto , Luis Daniel Villamil , Refet Firat Yazicioglu , Kristina Schlegel , Kent Leyde
IPC: A61N1/375
Abstract: A device that is implantable in body tissue of a human or animal. The device is comprised of a header comprising at least one terminal adapted for removable connection to a lead and an open ended case closed by a plate to form a housing. The housing is comprised of a surrounding edge wall joined to a first side wall and a second side wall opposed to the first side wall. At least a first suture port extends through the edge wall and the second side wall but not the first side wall at an upper edge region of the housing. A second suture port may extend through the surrounding edge wall and the second side wall but not the first side wall in a similar manner. A third suture port may extend through the header. The three suture ports may define a triangular attachment configuration.
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公开(公告)号:US20190262613A1
公开(公告)日:2019-08-29
申请号:US16348924
申请日:2017-11-10
Inventor: Hans Jakob Kristoffer FAMM , Harumi HOTTA , Arun SRIDHAR
Abstract: Modulation of neural activity in the superior laryngeal nerve (SLN) or cervical sympathetic trunk (CST) is effective in treating diseases and conditions mediated by thyroid and parathyroid hormones, in particular diseases associated with calcitonin secretion (e.g. osteoporosis) or diseases associated with thyroxine secretion (e.g. hypothyroid syndrome).
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公开(公告)号:US20180117319A1
公开(公告)日:2018-05-03
申请号:US15568964
申请日:2016-04-22
Applicant: GALVANI BIOELECTRONICS LIMITED , ACADEMISCH MEDISCH CENTRUM
Inventor: Daniel John CHEW , Wouter Jacob DE JONGE , Hans Jakob Kristoffer FAMM , Sonal PATEL , Olaf WELTING
CPC classification number: A61N1/3606 , A61N1/0551 , A61N1/0556 , A61N1/36007 , A61N1/3605 , A61N1/36135
Abstract: The invention provides devices, apparatuses, systems and methods for treating and ameliorating inflammation of the gut. In particular, the invention provides devices, apparatuses and methods in which a neuromodulatory signal is delivered a splenic nerve and/or superior mesenteric plexus (SMP). The signal is able to treat inflammatory disorders, e.g., colitis, for example in Inflammatory Bowel Disease.
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公开(公告)号:US20180043155A1
公开(公告)日:2018-02-15
申请号:US15551592
申请日:2016-02-19
Applicant: GALVANI BIOELECTRONICS LIMITED , HUNTINGTON MEDICAL RESEARCH INSTITUTES , UNIVERSITY OF CHILI
Inventor: Hans Jakob Kristoffer FAMM , Hernan E. LARA , Victor Eugene PIKOV , Arun SRIDHAR
CPC classification number: A61N1/3606 , A61F7/12 , A61F2007/126 , A61N1/0551 , A61N1/20 , A61N1/36007 , A61N1/36135 , A61N5/0622 , A61N7/00 , A61N2005/063 , A61N2007/0026
Abstract: The present invention relates to medical devices and, more particularly, to medical devices that deliver neuromodulating therapy.
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公开(公告)号:US12280253B2
公开(公告)日:2025-04-22
申请号:US17248735
申请日:2021-02-05
Applicant: Galvani Bioelectronics Limited
Inventor: Faisal Zaidi , Sabastien Ouchouche , Paul Matteucci
Abstract: An extravascular or intravascular neural interface is disclosed comprising three C-ring portions, with at least two including an electrode, an electrode pair or an electrode array. The portions are formed of a flexible material that is configured to enable the portions to self-size to fit around or against a surface of a target vessel when the neural interface is released at a position along the target vessel. A spinal portion configured to house electrical conductors for the electrodes is connected to one or more portions. The portions may be spaced sufficient apart to permit radial expansion and contraction of a target vessel around or within which the neural interface is placed, to reduce never compression, open trench low-pressure unrestricted blood-flow, and to enhance fluid exchange with the target vessel. The portions may be arranged in a low helix angle forming at least two full turns.
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27.
公开(公告)号:US20240299737A1
公开(公告)日:2024-09-12
申请号:US18573365
申请日:2022-06-23
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor: Rizwan BASHIRULLAH , Gerald Edwin HUNSBERGER
IPC: A61N1/05
CPC classification number: A61N1/0558
Abstract: Stents for intravascular neural stimulation are disclosed herein that at least partially contact a vessel wall. The stent comprises a scaffold extending in a longitudinal direction and having an outer perimeter that at least partially contacts the wall. A pulse generator can generate electrical signals for delivery to a nerve for intravascular neural stimulation. The scaffold has mounted thereon a first set of one or more electrodes electrically coupled to the pulse generator. The stent further comprises a second set of one or more electrodes electrically coupled to the pulse generator. The second set of electrodes is unconnected to the scaffold, i.e. not directly mounted on the scaffold. Methods of implanting a stent into a vessel using a deployment catheter are disclosed herein. The stent to be implanted comprises a pulse generator, a scaffold, and a distal set of one or more electrodes electrically coupled to the pulse generator. The distal set of electrodes is unconnected to the scaffold, i.e. not directly mounted on the scaffold. The method comprises positioning a distal end of the deployment catheter at the intravascular location, advancing the stent within the deployment catheter, further advancing the stent to expose the one or more electrodes of the distal set of one or more electrodes outside of, preferably beyond the deployment catheter, providing an electrical stimulation via the exposed electrodes, and withdrawing the stent within the deployment catheter.
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公开(公告)号:USD1009265S1
公开(公告)日:2023-12-26
申请号:US29788570
申请日:2021-06-24
Applicant: GALVANI BIOELECTRONICS LIMITED
Designer: Peng Cong , Benjamin Yaffe , Morten Hansen
Abstract: FIG. 1 is a perspective view of suture tabs showing the claimed design;
FIG. 2 is a top view thereof;
FIG. 3 is a bottom view thereof;
FIG. 4 is an enlarged right side view thereof;
FIG. 5 is an enlarged left side view thereof;
FIG. 6 is a front view thereof;
FIG. 7 is a rear view thereof;
FIG. 8 is a perspective view of suture tabs showing the claimed design;
FIG. 9 is a top view thereof;
FIG. 10 is a bottom view thereof;
FIG. 11 is an enlarged right side view thereof;
FIG. 12 is an enlarged left side view thereof;
FIG. 13 is a front view thereof;
FIG. 14 is a rear view thereof;
FIG. 15 is a perspective view of suture tabs showing the claimed design;
FIG. 16 is a top view thereof;
FIG. 17 is a bottom view thereof;
FIG. 18 is an enlarged right side view thereof;
FIG. 19 is an enlarged left side view thereof;
FIG. 20 is a front view thereof; and,
FIG. 21 is a rear view thereof.
The dashed broken lines in the Figures show portions of the pair of suture tabs that form no part of the claimed design.-
公开(公告)号:US20230271010A1
公开(公告)日:2023-08-31
申请号:US18140387
申请日:2023-04-27
Applicant: Galvani Bioelectronics Limited
Inventor: Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
CPC classification number: A61N1/3606 , A61N1/0556 , A61N1/36139 , A61N1/36178 , A61N1/36135 , A61N1/3614 , A61N1/36171 , A61N2001/083
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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公开(公告)号:US11672972B2
公开(公告)日:2023-06-13
申请号:US15733276
申请日:2018-12-11
Applicant: Galvani Bioelectronics Limited , UCL Business PLC
Inventor: Rizwan Bashirullah , Gerald Edwin Hunsberger , Matteo Donega , Daniel Chew , David Holder , Kirill Aristovich
CPC classification number: A61N1/0556 , A61N1/36053 , A61N1/36182
Abstract: A nerve interface device including at least one cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the at least one cuff portion, each ring of electrodes including a plurality of electrodes. Each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The plurality of pairs of electrodes includes at least a first pair of electrodes, the first pair of electrodes mounted on the at least one cuff portion. The at least one cuff portion includes an asymmetric configuration about a central axis perpendicular to the longitudinal cuff axis.
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