公开(公告)号：US20060058604A1

公开(公告)日：2006-03-16

申请号：US10926380

申请日：2004-08-25

Applicant: Gopal Avinash ,  Allison Weiner ,  Peter Anderson

Inventor： Gopal Avinash ,  Allison Weiner ,  Peter Anderson

IPC: A61B5/05

CPC classification number: A61B5/06 ,  A61B5/062 ,  A61B5/065 ,  A61B5/066 ,  A61B5/067 ,  A61B5/4528 ,  A61B34/20 ,  A61B90/36 ,  A61B90/37 ,  A61B2034/2048 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/064 ,  A61B2090/0818 ,  A61B2090/366 ,  A61B2090/3925 ,  A61B2090/3937 ,  A61B2090/3954 ,  A61B2090/3995

Abstract: A system and method for hybrid tracking in surgical navigation is disclosed. A plurality of tracking technologies is used in a medical procedure where a reconciler determines an active tracking technology. The reconciler determines the active tracking technology during the medical procedure. A switch may then activate one or more tracking technologies. The determination of which technology or technologies are to be activated may be based, for example, on metrics measured by each of the technologies, such as an accuracy measurement. In addition, a display may present representations based on at least data obtained by one or more of the tracking technologies. The switch may employ weighted switching to gradually switch the display of a first representation corresponding to a first tracking technology to the display of a second representation corresponding to a second tracking technology, where the first technology is deactivated and the second technology is activated.

Abstract translation: 公开了一种用于手术导航中的混合跟踪的系统和方法。 在医疗过程中使用多种跟踪技术，其中协调者确定主动跟踪技术。 调解者在医疗过程中确定主动跟踪技术。 然后，交换机可以激活一个或多个跟踪技术。 要激活哪些技术或技术的确定可以基于例如由每种技术测量的度量，例如精度测量。 此外，显示器可以至少基于由一个或多个跟踪技术获得的数据来呈现表示。 开关可以采用加权切换来逐渐地将对应于第一跟踪技术的第一表示的显示切换到对应于第二跟踪技术的第二表示的显示，其中第一技术被停用并且第二技术被激活。

公开(公告)号：US20060008174A1

公开(公告)日：2006-01-12

申请号：US10710391

申请日：2004-07-07

Applicant: Gopal Avinash ,  Nicholas Marinelli ,  Kadri Jabri

Inventor： Gopal Avinash ,  Nicholas Marinelli ,  Kadri Jabri

IPC: G06K9/40

CPC classification number: G06T5/002 ,  G06T5/20 ,  G06T2207/10116 ,  G06T2207/20012 ,  G06T2207/30004

Abstract: A method of adaptively reducing noise within an x-ray image includes receiving raw data (R) representing a detected x-ray signal from an object. A counts-based modulation mask (Mcb) is generated in response to the raw data (R). In one embodiment, a structure dependent noise filtered image (Iblended) is generated in response to the raw data. A noise-reduced image (IF) is generated in response to the counts-based modulation mask (Mcb) and the structure dependent noise filtered image (Iblended). In another embodiment, a structure gradient mask (Mcs) is generated in response to the raw data (R). The noise-reduced image (IF) is generated in response to the counts-based modulation mask (Mcb) and the structure gradient mask (Mcs).

Abstract translation: 自适应地降低X射线图像内的噪声的方法包括从对象接收表示检测到的x射线信号的原始数据（R）。 基于原始数据（R）生成基于计数的调制掩码（M SUB cb）。 在一个实施例中，响应原始数据生成结构依赖噪声滤波图像（I＆lt;＆lt;＆lt;＆lt;＆lt;＆gt;）。 响应于基于计数的调制掩码（M SUB）和结构依赖的噪声滤波图像（I SUB），产生噪声降低的图像（I SUB） 混合）。 在另一实施例中，响应原始数据（R）产生结构梯度掩模（M SUB）。 响应于基于计数的调制掩模（M SUB）和结构梯度掩模（M SUB），产生噪声降低的图像（I SUB） / SUB>）。

公开(公告)号：US20050031176A1

公开(公告)日：2005-02-10

申请号：US10604673

申请日：2003-08-08

Applicant: Sarah Hertel ,  Gopal Avinash

Inventor： Sarah Hertel ,  Gopal Avinash

IPC: G06K9/00 ,  G06K9/32 ,  G06T7/00

CPC classification number: G06T7/38 ,  G06T7/33

Abstract: The present invention is directed to a method and apparatus for fusing or combining functional image data and anatomical image data. The invention, which may be carried out through user interaction or automatically, enables composite and clinically valuable images to be generated that display functional and anatomical data acquired with different imaging systems. By identifying fiducial markers on a functional data image and correlating the fiducial markers with anatomical markers or indicia on the anatomical data image, the respective images may be aligned with one another before a composite image is generated.

Abstract translation: 本发明涉及一种用于融合或组合功能图像数据和解剖图像数据的方法和装置。 可以通过用户交互或自动进行的本发明使得能够生成显示使用不同成像系统获取的功能和解剖学数据的复合和临床有价值的图像。 通过在功能性数据图像上识别基准标记并将基准标记与解剖学标记或标记相关联在解剖数据图像上，在生成合成图像之前，各个图像可以彼此对准。

公开(公告)号：US20050002550A1

公开(公告)日：2005-01-06

申请号：US10613591

申请日：2003-07-03

Applicant: Kadri Jabri ,  Gopal Avinash ,  Stephen Metz ,  John Sabol ,  Jeffrey Eberhard ,  Bernard Claus ,  John Kaufhold

Inventor： Kadri Jabri ,  Gopal Avinash ,  Stephen Metz ,  John Sabol ,  Jeffrey Eberhard ,  Bernard Claus ,  John Kaufhold

IPC: G06K9/00 ,  G06T5/00 ,  G06T11/00

CPC classification number: G06T11/008 ,  G06T5/00 ,  G06T11/005 ,  G06T2207/10112 ,  G06T2207/30004 ,  G06T2211/436

Abstract: A method of creating and displaying images resulting from digital tomosynthesis performed on a subject using a flat panel detector is disclosed. The method includes the step of acquiring a series of x-ray images of the subject, where each x-ray image is acquired at different angles relative to the subject. The method also includes the steps of applying a first set of corrective measures to the series of images, reconstructing the series of images into a series of slices through the subject, and applying a second set of corrective measures to the slices. The method further includes the step of displaying the images or slices according to at least one of a plurality of display options.

Abstract translation: 公开了一种创建和显示使用平板检测器对受试者进行数字断层合成所产生和显示的图像的方法。 该方法包括获取被摄物体的一系列X射线图像的步骤，其中以相对于被摄体的不同角度获取每个X射线图像。 该方法还包括以下步骤：将第一组校正措施应用于一系列图像，将该系列图像重建成通过对象的一系列切片，以及将第二组校正措施应用于切片。 该方法还包括根据多个显示选项中的至少一个显示图像或切片的步骤。

公开(公告)号：US09008394B2

公开(公告)日：2015-04-14

申请号：US12324498

申请日：2008-11-26

Applicant: Zhongmin Steve Lin ,  Gopal Avinash ,  Saad Sirohey ,  Ananth Mohan ,  Satoshi Minoshima

Inventor： Zhongmin Steve Lin ,  Gopal Avinash ,  Saad Sirohey ,  Ananth Mohan ,  Satoshi Minoshima

IPC: A61B5/055 ,  A61B5/107

CPC classification number: A61B5/1075 ,  A61B5/055 ,  G06T7/62 ,  G06T2207/10088 ,  G06T2207/30016

Abstract: Methods and apparatus for determining brain cortical thickness are provided. One method includes determining an intensity profile at each of a plurality of cortical surface points of an imaged brain using brain tissue image data and calculating a cortical thickness based on a parametrically determined transition point of each intensity profile.

Abstract translation: 提供了确定脑皮质厚度的方法和装置。 一种方法包括使用脑组织图像数据确定成像脑的多个皮质表面点中的每一个处的强度分布，并且基于每个强度分布的参数确定的转变点来计算皮质厚度。

公开(公告)号：US08754888B2

公开(公告)日：2014-06-17

申请号：US13108882

申请日：2011-05-16

Applicant: Patrick Virtue ,  Gopal Avinash ,  Adam Budde

Inventor： Patrick Virtue ,  Gopal Avinash ,  Adam Budde

IPC: G06T15/08

CPC classification number: G06T7/174 ,  G06T2207/30004

Abstract: A method is provided for segmenting three-dimensional (3D) image volumes. The method includes obtaining a 3D volume data set corresponding to an imaged volume, rendering at least a portion of the 3D volume data set based on 3D rendering settings, and creating a two-dimensional (2D) segmentation of the rendered 3D volume data set. The method further includes segmenting the 3D volume data set using the 2D segmentation and the 3D rendering settings to define a 3D region of interest within the 3D volume data set.

Abstract translation: 提供了一种用于分割三维（3D）图像体积的方法。 该方法包括获得对应于成像的体积的3D体数据集，基于3D渲染设置渲染3D体数据集的至少一部分，以及创建渲染的3D体数据集的二维（2D）分割。 该方法还包括使用2D分割和3D渲染设置来分割3D体数据集，以定义3D体数据集内的感兴趣的3D区域。

公开(公告)号：US20130050207A1

公开(公告)日：2013-02-28

申请号：US13217053

申请日：2011-08-24

Applicant: Zhongmin LIN ,  Gopal AVINASH ,  Patrick Michael VIRTUE

Inventor： Zhongmin LIN ,  Gopal AVINASH ,  Patrick Michael VIRTUE

IPC: G06T17/00

CPC classification number: G06T19/20 ,  G06T7/12 ,  G06T7/149 ,  G06T17/20 ,  G06T2207/10088 ,  G06T2207/20101 ,  G06T2207/20124 ,  G06T2207/30016 ,  G06T2219/028 ,  G06T2219/2016

Abstract: A method for navigating a three-dimensional (3D) image includes accessing a 3D image dataset, generating a 3D mesh corresponding to a 3D segmentation result using the 3D image dataset, displaying a 3D surface rendering of the 3D image intensities on the 3D mesh, and navigating the 3D image based on a manual input received from a user indicated on the rendered 3D image.

Abstract translation: 用于导航三维（3D）图像的方法包括访问3D图像数据集，使用3D图像数据集生成对应于3D分割结果的3D网格，在3D网格上显示3D图像强度的3D表面渲染， 以及基于从渲染的3D图像上指示的用户接收到的手动输入来导航3D图像。

公开(公告)号：US20120293514A1

公开(公告)日：2012-11-22

申请号：US13108882

申请日：2011-05-16

Applicant: Patrick Virtue ,  Gopal Avinash ,  Adam Budde

Inventor： Patrick Virtue ,  Gopal Avinash ,  Adam Budde

IPC: G06T15/08

CPC classification number: G06T7/174 ,  G06T2207/30004

Abstract: A method is provided for segmenting three-dimensional (3D) image volumes. The method includes obtaining a 3D volume data set corresponding to an imaged volume, rendering at least a portion of the 3D volume data set based on 3D rendering settings, and creating a two-dimensional (2D) segmentation of the rendered 3D volume data set. The method further includes segmenting the 3D volume data set using the 2D segmentation and the 3D rendering settings to define a 3D region of interest within the 3D volume data set.

Abstract translation: 提供了一种用于分割三维（3D）图像体积的方法。 该方法包括获得对应于成像的体积的3D体数据集，基于3D渲染设置渲染3D体数据集的至少一部分，以及创建渲染的3D体数据集的二维（2D）分割。 该方法还包括使用2D分割和3D渲染设置来分割3D体数据集，以定义3D体数据集内的感兴趣的3D区域。

公开(公告)号：US20120078840A1

公开(公告)日：2012-03-29

申请号：US13096063

申请日：2011-04-28

Applicant: Gopal Avinash ,  Ananth Mohan ,  Zhongmin Lin ,  Rick Wascher

Inventor： Gopal Avinash ,  Ananth Mohan ,  Zhongmin Lin ,  Rick Wascher

IPC: G06N5/02

CPC classification number: G16H50/70

Abstract: Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process, and safety testing. An example method includes providing a first set of data corresponding to a drug of interest; providing a reference set of drug interaction data, comparing the first set of data to the reference set using a holistic analysis, and reporting the results of the comparison. An example of the holistic analysis and viewing apparatus for drug safety comprises a standardizer to at least one of standardize and normalize drug interaction data related to drug safety; a deviation analyzer to compare the drug interaction data to data corresponding to a drug under review using a holistic analysis, and a reporter for reporting the output of the deviation analyzer.

Abstract translation: 某些实例提供了整体观察的系统和方法，以便在药物开发过程和安全性测试中提供比较分析和决策支持。 示例性方法包括提供与感兴趣的药物相对应的第一组数据; 提供一组药物相互作用数据，使用整体分析将第一组数据与参考集进行比较，并报告比较结果。 用于药物安全的整体分析和观察装置的一个例子包括标准化器，至少标准化和规范与药物安全有关的药物相互作用数据; 偏差分析仪，用于使用整体分析将药物相互作用数据与正在审查的药物相对应的数据进行比较，以及用于报告偏差分析仪的输出的报告人。

公开(公告)号：US20120078521A1

公开(公告)日：2012-03-29

申请号：US13096046

申请日：2011-04-28

Applicant: Gopal Avinash ,  Ananth Mohan ,  Zhongmin Lin ,  Rick Wascher

Inventor： Gopal Avinash ,  Ananth Mohan ,  Zhongmin Lin ,  Rick Wascher

IPC: G06F19/00

CPC classification number: G01N33/15 ,  G06F19/3456 ,  G16C20/50 ,  G16C20/70 ,  G16C20/80 ,  G16H50/70

Abstract: Certain examples provide systems and methods for holistic viewing to provide comparative analysis and decision support in a drug development process. An example method includes a computer-implemented method for assessing drug efficacy, comprising: accessing a first data set related to the performance of a target drug for a given indication; accessing a second data set related to a control for the indication; comparing the data for the target drug and the data for the control on at least one of a plurality of different metrics using a holistic analysis, wherein the at least one metric corresponds to an outcome associated with the indication and generating a corresponding report. An example apparatus/system includes a holistic analysis and viewing system to support the assessment of drug efficacy, said system comprising: a standardizer to at least one of standardize and normalize data related to drug development; a deviation analyzer to analyze said data based on at least one of a plurality of different efficacy metrics, wherein a quantified variation between a first data set of results corresponding to an identified target drug and a second data set of results corresponding to a control, wherein said first data set of results is provided for comparison with the second data set of results and the deviation therebetween is compared to the at least one efficacy metric.

Abstract translation: 某些例子提供了整体观察的系统和方法，以在药物开发过程中提供比较分析和决策支持。 示例性方法包括用于评估药物功效的计算机实现的方法，包括：访问与给定指示的目标药物的性能相关的第一数据集; 访问与所述指示的控制相关的第二数据集; 使用整体分析来比较目标药物的数据和用于多个不同度量中的至少一个的用于控制的数据，其中所述至少一个度量对应于与所述指示相关联的结果并生成相应的报告。 示例性装置/系统包括支持药物功效评估的整体分析和观察系统，所述系统包括：标准化器，其至少一个标准化和归一化与药物开发有关的数据; 偏差分析器，用于基于多个不同功效度量中的至少一个来分析所述数据，其中对应于所识别的目标药物的第一结果数据集与对照于对照的结果的第二数据集之间的量化变化，其中 提供所述第一数据结果数据集用于与第二数据结果集进行比较，并且将它们之间的偏差与至少一个功效度量进行比较。