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27 条记录 (耗时 0.032 秒)

    Shielding apparatus for microwave thawing
    21.
    发明授权
    Shielding apparatus for microwave thawing 失效
    微波解冻屏蔽装置

    公开(公告)号：US4503307A

    公开(公告)日：1985-03-05

    申请号：US505584

    申请日：1983-06-20

    申请人： Nancy L. Campbell ,  John G. Pinto ,  John A. Drewe ,  Patrick D. Hayes ,  Nelson Robert A.

    发明人： Nancy L. Campbell ,  John G. Pinto ,  John A. Drewe ,  Patrick D. Hayes ,  Nelson Robert A.

    IPC分类号： A61M5/44 ,  H05B6/64 ,  H05B6/80 ,  A61M1/03

    CPC分类号： H05B6/64 ,  A61M5/445 ,  A61M2205/3686

    摘要： A shielding apparatus is provided for containing frozen bags of fluid and re particularly for containing frozen bags of blood components during microwave thaw. The apparatus includes a metal box for receiving a blood bag, the box having a bottom and sides. A metallic lid is provided, and a hinging device pivotally mounts the lid to the box for enclosing the blood bag therein. The lid and optionally the bottom of the box may be provided with an aperture for allowing microwaves to enter the box. Radiation absorbing strips are mounted along the edges of the apertures for absorbing E field reflections toward the blood bag. The apertures allow microwave energy to be concentrated in the more voluminous part of the blood bag while the edges of bag as well as any tubing are shielded by the metallic box. This apparatus prevents boiling of the blood in the lower volume areas of the bag.

    摘要翻译： 提供一种屏蔽装置，用于容纳冻结的流体袋，并且更具体地用于在微波解冻期间包含冷冻袋的血液成分。 该装置包括用于接收血袋的金属盒，该盒具有底部和侧面。 设有金属盖，铰链装置将盖子可枢转地安装在盒子上，以将血袋封闭在其中。 盖子和可选的盒子的底部可以设置有允许微波进入盒子的孔。 沿着孔的边缘安装辐射吸收条，用于吸收朝向血袋的E场反射。 孔口允许微波能量集中在血袋的较大部分中，而袋子的边缘以及任何管道被金属盒屏蔽。 该装置防止袋的下部体积区域内的血液沸腾。

    Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
    24.
    发明授权
    Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效
    取代的4H-色烯和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途

    公开(公告)号：US07507762B2

    公开(公告)日：2009-03-24

    申请号：US11072499

    申请日：2005-03-07

    申请人： John A. Drewe ,  Sui Xiong Cai ,  Yan Wang

    发明人： John A. Drewe ,  Sui Xiong Cai ,  Yan Wang

    IPC分类号： A61K31/352 ,  A61K31/36

    CPC分类号： C07D311/58 ,  C07D311/92 ,  C07D405/04 ,  C07D407/04 ,  C07D409/04 ,  C07D491/04

    摘要： The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, Z and R5 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

    摘要翻译： 本发明涉及由通式I表示的取代的4H-色烯及其类似物：其中A，B，X，Y，Z和R5如本文所定义。 本发明还涉及发现具有式I的化合物是胱天蛋白酶的活化剂和凋亡诱导剂。 因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于诱导异常细胞发生不受控制的生长和扩散的各种临床病症中的细胞死亡。

    Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for caspases and other enzymes and the use thereof
    26.
    发明授权
    Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for caspases and other enzymes and the use thereof 失效
    荧光或荧光报告分子及其在半胱氨酸蛋白酶和其他酶的全细胞荧光筛选测定中的应用及其用途

    公开(公告)号：US06759207B2

    公开(公告)日：2004-07-06

    申请号：US09947387

    申请日：2001-09-07

    申请人： Eckard Weber ,  Sui Xiong Cai ,  John F. W. Keana ,  John A. Drewe ,  Han-Zhong Zhang

    发明人： Eckard Weber ,  Sui Xiong Cai ,  John F. W. Keana ,  John A. Drewe ,  Han-Zhong Zhang

    IPC分类号： G01N33573

    CPC分类号： G01N15/1456 ,  C12Q1/68 ,  G01N33/533 ,  G01N2015/1006 ,  G01N2015/1488 ,  Y10S436/80

    摘要： The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of caspases and other enzymes involved in apoptosis in whole cells, cell lines and tissue samples derived from any living organism or organ. The reporter molecules and assay processes can be used in drug screening procedures to identify compounds which act as inhibitors or inducers of the caspase cascade in whole cells or tissues. The reagents and assays described herein are also useful for determining the chemosensitivity of human cancer cells to treatment with chemotherapeutic drugs. The present invention also relates to novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of type 2 methionine aminopeptidase, dipeptidyl peptidase IV, calpain, aminopeptidase, HIV protease, adenovirus protease, HSV-1 protease, HCMV protease and HCV protease.

    摘要翻译： 本发明涉及新的荧光染料，新的荧光和荧光报道分子和新的酶测定方法，其可用于检测来自任何活生物体的全细胞，细胞系和组织样品中参与细胞凋亡的半胱天冬酶和其它酶的活性 或器官。 报告分子和测定方法可以用于药物筛选程序中，以鉴定在整个细胞或组织中作为半胱天冬酶级联的抑制剂或诱导剂的化合物。 本文所述的试剂和测定法也可用于确定人类癌细胞对用化学治疗药物治疗的化学敏感性。 本发明还涉及可用于检测2型甲硫氨酸氨基肽酶，二肽基肽酶IV，钙蛋白酶，氨基肽酶，HIV蛋白酶，腺病毒蛋白酶，HSV-1蛋白酶的活性的新型荧光和荧光报告分子和新的酶测定方法， HCMV蛋白酶和HCV蛋白酶。