公开(公告)号：US20200205655A1

公开(公告)日：2020-07-02

申请号：US16633548

申请日：2018-07-23

Applicant: Tohoku University ,  Kowa Company, Ltd.

Inventor： Toru Nakazawa ,  Satoshi Shimada ,  Takuya Hara

IPC: A61B3/024 ,  A61B3/00 ,  A61B3/06

Abstract: A perimeter 2 capable of acquiring, as a threshold SV, a value corresponding to a response result of a subject 22 to an optotype presented with various brightness, for measurement points set across an entire measurement field of view of the ocular fundus, displaying the threshold SV as a threshold inspection result SHR and storing the same in a memory 13, comprises: a portion 15 for obtaining a pattern deviation PDV of the threshold SV relating to each measurement point RG, from the threshold inspection result SHR; a portion for 15 for obtaining a P value representing the obtained pattern deviation PDV for each measurement point RG as a probability variable, and generating a probability map image MAP4 indicating the measurement points RG separately for each P value; a portion 16 for selecting, from an abnormal measurement point group RG of points in the probability map image MAP4 in which at least a prescribed number of measurement points having a P value at most equal to 5% are continuous, and, of those, for which at least a prescribed number of points have a P value at most equal to 1%, measurement points to be used as subsequent measurement points, until ten points have been reached; and a memory 13 for storing the selected subsequent measurement points, wherein the selection of the subsequent measurement points is controlled in such a way that the measurement points RG are selected from the abnormal measurement point group in order of those having a good pattern deviation PDV.

公开(公告)号：US10573007B2

公开(公告)日：2020-02-25

申请号：US15752946

申请日：2016-08-09

Applicant: KOWA COMPANY, LTD. ,  Casio Computer Co., Ltd.

Inventor： Toshiaki Nakagawa ,  Takao Shinohara ,  Yasushi Maeno ,  Akira Hamada

IPC: G06T7/13 ,  G06T1/00 ,  A61B3/10 ,  G06T7/143 ,  G06T7/00

Abstract: Edges of layers are detected from an input image to create a boundary line candidate image that represents the detected edges. A luminance value of the input image is differentiated to create a luminance value-differentiated image that represents luminance gradient of the layers. An evaluation score image is created which is obtained by weighting calculation at an optimum ratio between a boundary line position probability image and the luminance value-differentiated image. The boundary line position probability image is obtained from the boundary line candidate image and an existence probability image that represents existence of a boundary line to be extracted. A route having the highest total evaluation score is extracted as the boundary line. According to such an image processing apparatus and image processing method, boundary lines of layers can be extracted with a high degree of accuracy from a captured image of a target object composed of a plurality of layers.

公开(公告)号：US10335306B2

公开(公告)日：2019-07-02

申请号：US14298346

申请日：2014-06-06

Applicant: Kowa Company, Ltd. ,  Advancing Inc. ,  DMChain Cooperative

Inventor： Hidetaka Okada ,  Hitoshi Ojima ,  Hidenori Kaseno

IPC: A61F5/02 ,  A61F5/03 ,  A61F5/00

Abstract: A supporter includes a body section having a back-contact section, a first auxiliary band section of which one end is fixed to the top end of a left side of the back-contact section and the other end is fixed to the bottom end of a right side of the back-contact section, a second auxiliary band section forming a pair with the first auxiliary band section, a first ring arranged to slide between the one end and the other end of the first auxiliary band section, a second ring forming a pair with the first ring, a first adjustment band section of which one end is fixed to loops on a right end side of the body section and the other end can be fastened to loops on the right end side of the body section, and a second adjustment band section forming a pair with the first adjustment band section.

公开(公告)号：US10219692B2

公开(公告)日：2019-03-05

申请号：US15322151

申请日：2015-06-30

Applicant: KOWA COMPANY, LTD.

Inventor： Naoki Kobayashi

IPC: A61B3/10 ,  A61B3/00 ,  G01B9/02

Abstract: The tomographic image capturing device of the present invention is configured to: split light from a light source (11) into measurement light and reference light; cause the measurement light and the reference light to be incident to an object (E) and a reference object (49), respectively; and capture tomographic images of the object (E) on the basis of interference light generated by superposition of the measurement light reflected from the object (E) and the reference light reflected from the reference object (49). The tomographic image capturing device has a first image capturing mode and a second image capturing mode. The first and second image capturing modes are each a mode in which the measurement light is two-dimensionally scanned to be incident to the object (E) and the tomographic images of the object (E) are captured. The two-dimensional scans in the second image capturing mode require a shorter time than that required for the two-dimensional scans in the first image capturing mode. The capturing of the tomographic images in the first image capturing mode is performed after performing adjustment of an image capturing condition necessary for capturing the tomographic images in the first image capturing mode. The adjustment is based on the tomographic images captured in the second image capturing mode.

公开(公告)号：US20180240240A1

公开(公告)日：2018-08-23

申请号：US15752967

申请日：2016-08-09

Applicant: KOWA COMPANY, LTD. ,  Casio Computer Co., Ltd.

Inventor： Toshiaki NAKAGAWA ,  Takao SHINOHARA ,  Yasushi MAENO ,  Akira HAMADA

IPC: G06T7/13 ,  G06T7/00 ,  A61B3/10

CPC classification number: G06T7/13 ,  A61B3/10 ,  A61B3/102 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041

Abstract: The image processing apparatus includes a boundary line extraction means that extracts a boundary line of a layer from an input image obtained by capturing an image of a target object composed of a plurality of layers. The boundary line extraction means is configured to first extract boundary lines at upper and lower ends of the target object, limit a search range using the extracted boundary lines at the upper and lower ends to extract another boundary line, limit the search range using an extraction result of the other boundary line to extract still another boundary line, and then sequentially repeat similar processes to extract subsequent boundary lines. In another aspect, the image processing apparatus includes a boundary line extraction means that extracts a boundary line of a layer from an input image obtained by capturing an image of a target object composed of a plurality of layers and a search range setting means that utilizes an already extracted boundary line extracted by the boundary line extraction means to dynamically set a search range for another boundary line. According to such an image processing apparatus and image processing method, boundary lines of layers can be extracted with a high degree of accuracy from a captured image of a target object composed of a plurality of layers.

公开(公告)号：US10034885B2

公开(公告)日：2018-07-31

申请号：US15511736

申请日：2015-09-24

Applicant: KOWA COMPANY, LTD.

Inventor： Hiroyuki Takahashi ,  Kiyoshi Toya ,  Akifumi Tsuchiura

IPC: A61K31/551 ,  C07D401/12 ,  A61K9/00

CPC classification number: A61K31/551 ,  A61K9/0048 ,  A61K31/496 ,  A61P27/02

Abstract: The present invention provides a novel corneal thickness modulating agent. The present invention pertains to a corneal thickness modulating agent containing 1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine or a salt thereof or a solvate thereof.

公开(公告)号：US09989351B2

公开(公告)日：2018-06-05

申请号：US15329725

申请日：2015-07-29

Applicant: KOWA COMPANY, LTD.

Inventor： Naoki Kobayashi ,  Toshiaki Nakagawa

IPC: A61B3/14 ,  G01B9/02 ,  A61B3/10 ,  A61B3/13 ,  A61B3/15 ,  G01B11/02

CPC classification number: G01B9/02091 ,  A61B3/0058 ,  A61B3/102 ,  A61B3/13 ,  A61B3/15 ,  G01B9/02027 ,  G01B9/0203 ,  G01B9/02068 ,  G01B9/02077 ,  G01B11/02 ,  G01N21/17

Abstract: The tomographic image capturing device of the present invention comprises a display means (18) configured to: split light from a light source (11) into measurement light and reference light and cause the measurement light and the reference light to be incident to an object (E) and a reference object (49), respectively; capture tomographic images of the object (E) on the basis of interference light generated by superposition of the measurement light reflected from the object (E) and the reference light reflected from the reference object (49); and display tomographic pictures of the object generated on the basis of the captured tomographic images. The tomographic image capturing device has a first image capturing mode and a second image capturing mode. The first image capturing mode is a mode in which the measurement light is two-dimensionally scanned by raster scan to be incident to the object (E) and the tomographic images of the object (E) are captured. The second image capturing mode is a mode in which the measurement light is two-dimensionally scanned by raster scan to be incident to the object (E) and the tomographic images of the object (E) are captured. The raster scan in the second image capturing mode is thinned from the raster scan in the first image capturing mode. The display means (18) is configured to be switchable between a first display mode and a second display mode. The first display mode is a mode in which a plurality of tomographic pictures including a region of interest of the object (E) is selected from among the tomographic pictures generated on the basis of the tomographic images captured in the second image capturing mode and only the selected plurality of tomographic pictures is displayed. The second display mode is a mode in which all of the tomographic pictures generated on the basis of the tomographic images captured in the second image capturing mode are in turn displayed. The capturing of the tomographic images in the first image capturing mode is performed after separately performing a first adjustment operation and a second adjustment operation for adjustment of an image capturing condition necessary for capturing the tomographic images in the first image capturing mode. The first adjustment operation is based on the tomographic pictures displayed in the first display mode. The second adjustment operation is based on the tomographic pictures displayed in the second display mode.

公开(公告)号：USD816218S1

公开(公告)日：2018-04-24

申请号：US29525243

申请日：2015-04-28

Applicant: KOWA COMPANY, LTD.

Designer： Naoki Kambe ,  Nozomu Toriba

公开(公告)号：US20180098842A1

公开(公告)日：2018-04-12

申请号：US15567053

申请日：2016-01-20

Applicant: KOWA COMPANY, LTD.

Inventor： Genyo Midorikawa

IPC: A61F2/16

Abstract: An intraocular lens insertion apparatus includes an apparatus body configured to include a housing member for housing an intraocular lens and an insertion tube member for ejecting the intraocular lens into an eyeball of a patient, a plunger configured to move in the apparatus body, and a hook member formed on the apparatus body for a user of the intraocular lens insertion apparatus to hook a finger when the user moves the plunger. The plunger is moved to a side of the insertion tube member, the intraocular lens housed in the housing member is pushed by a distal end of the plunger, and the intraocular lens is ejected from the insertion tube member, and a connecting member configured to connect an operability enhancing member for enhancing an operability of the plunger when the plunger is moved with the apparatus body is provided for the apparatus body.

公开(公告)号：USD809149S1

公开(公告)日：2018-01-30

申请号：US35501089

申请日：2015-12-16

Applicant: KOWA COMPANY, LTD. ,  ADVANCING INC. ,  DMCHAIN COOPERATIVE

Designer： Kenta Tsuzuranuki ,  Hitoshi Ojima ,  Hidenori Kaseno