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公开(公告)号：US20220062888A1
公开(公告)日：2022-03-03
申请号：US17291180
申请日：2019-11-19
发明人： Oh Seok KWON , Kyung Ho KIM , Seon Joo PARK , Seong Eun SEO , Tai Hwan HA
IPC分类号： B01L3/00
摘要： The present invention relates to a light-digital PCR chamber and a light-digital PCR device. The light-digital PCR chamber comprises: a transparent substrate; a metal thin film layer formed on the transparent substrate; a light shielding layer formed on the metal thin film layer; and a microchannel structure formed on the light shielding layer. The light-digital PCR device comprises a laminate comprising a transparent substrate, a metal thin film layer formed on the transparent substrate, and a light shielding layer formed on the metal thin film layer.
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22.发明申请公开(公告)号：US20220016073A1
公开(公告)日：2022-01-20
申请号：US16763630
申请日：2018-11-15
发明人： Won Gon KIM , Baek Soo HAN , Jeong Su BYUN , Van Minh NGUYEN , Ha Young CHOI
IPC分类号： A61K31/36 , A61K31/232 , A23L33/105
摘要： The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising a diterpene, or a pharmaceutically acceptable salt thereof.
Specifically, the diterpene of the present invention can prevent or treat neurodegenerative diseases caused by inhibition of Nurr1 activity by activating Nurr1 and inhibiting the inflammatory response.-
公开(公告)号：US20220000811A1
公开(公告)日：2022-01-06
申请号：US17293595
申请日：2019-11-14
发明人： Myung Jin SON , Kyung-Sook CHUNG , Sung Wuk KIM , Jiae KOOK , Hong Bum LEE , Sanghee YOO , Youjeong KWQN , Seoniu MUN , Jiwon AHN , Jae Sung RYU
IPC分类号： A61K31/155 , A61K8/43 , A61Q7/00 , A61P17/14
摘要： The present invention relates to a composition for hair improvement, and more specifically to a composition for promoting hair growth, or preventing or treating hair loss, comprising a guanine derivative having no toxicity as an active ingredient. The composition has excellent effects of promoting hair growth and regenerating hair follicles, and thus can be effectively used in various fields such as pharmaceutical, food, feed, and cosmetic compositions for promoting hair growth, or preventing, treating, and improving hair loss.
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公开(公告)号：US20210292306A1
公开(公告)日：2021-09-23
申请号：US15999066
申请日：2017-02-13
发明人： Bo Yeon KIM , Nak Kyun SOUNG , Srinivas Rao GANIPISETTI , Jong Seog AHN , Jae-Hyuk JANG , Sung-kyun KO , In Ja RYOO , Hyunjoo CHA , Joon Sung HWANG , Kyung Ho LEE
IPC分类号： C07D405/12 , A61K8/49 , A23L29/00 , A61Q19/00 , A61K31/404 , A61P35/00 , A61K9/00
摘要： The present invention relates to: an indole derivative, which is a novel cell mitosis inhibitor; a stereoisomer thereof or a pharmaceutically acceptable salt thereof; a use thereof as a therapeutic agent; a composition containing the same and a treatment method using the composition; and a preparation method therefor. According to the present invention, the indole derivative, the stereoisomer thereof or the pharmaceutically acceptable salt thereof, inhibits the tubulin polymerization during mitosis so as to induce apoptosis, and has an excellent anti-cancer effect also in cancer cells having multiple drug resistance.
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公开(公告)号：US20210268468A1
公开(公告)日：2021-09-02
申请号：US17259821
申请日：2019-07-12
发明人： Oh Seok KWON , Tai Hwan HA , Kyung Ho KIM , Jin Yeong KIM , Seon Joo PARK , Seong Eun SEO
摘要： The present invention relates to a substrate for nucleic acid amplification, and a method for manufacturing same, the substrate for rapid and accurate PCR analysis comprising: a transparent substrate; a metal layer formed on the transparent substrate; an N-heterocyclic carbene compound having one end annealed to the surface of the metal layer; and a primer immobilized on the other end of the N-heterocyclic carbene compound.
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公开(公告)号：US11051518B2
公开(公告)日：2021-07-06
申请号：US16312035
申请日：2016-06-27
发明人： Choong-Min Ryu , Ga-Hyung Lee
摘要： The present invention provides a strain of Pseudozyma churashimaensis RGJ1, which is isolated from a pepper plant and leads to induced systemic resistance against plant pathogens or plant viruses; a microbial preparation for controlling plant diseases or increasing plant yields, including, as an active ingredient, the strain or a culture thereof; a method for preparing the microbial preparation, including a step of culturing the strain; and a method for controlling plant diseases, including a step of performing dipping treatment, soil drenching treatment or spraying treatment onto aerial foliage for a plant seedling with the strain or the culture thereof.
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公开(公告)号：US20210106645A1
公开(公告)日：2021-04-15
申请号：US17012238
申请日：2020-09-04
发明人： Won Gon KIM , Baek Soo HAN , Jeong Su BYUN , Ha Young CHOI
摘要： The present invention relates to a pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases which include a flower extract of Daphne genkwa or fractions thereof as an active ingredient. The pharmaceutical composition and health functional food for preventing or treating neurodegenerative diseases are, not like extracts from stems and/or roots of Daphne genkwa, free from genotoxicity and have superior prophylactic or treatment effects against neurodegenerative diseases.
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公开(公告)号：US10973884B2
公开(公告)日：2021-04-13
申请号：US15087563
申请日：2016-03-31
发明人： Mi Sun Won , Hyun Seung Ban , Bo Kyung Kim , Soon Woo Nam , Kyeong Lee , Young-Ju Lee , Hong-Sub Lee , Dong Uk Kim , Ki Cheol Park , Joo-Young Im , Kyoung-Jin Oh
IPC分类号： A61K38/44 , C12N9/02 , C12N7/00 , G01N33/574 , A61K48/00
摘要： The present invention relates to a pharmaceutical composition for treating cancer, containing cytochrome b5 reductase 3 (CYB5R3) protein as an active ingredient. Over-expression of CYB5R3 in cancer cells results in significant reduction of hypoxia-inducible factor-1α (HIF-1α) expression, which leads inhibition of cancer cells growth in vitro and in vivo. Thus, the CYB5R3 gene or protein of the present invention can be useful as an active ingredient of a pharmaceutical composition for treating cancer.
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29.发明授权公开(公告)号：US10920248B2
公开(公告)日：2021-02-16
申请号：US16084445
申请日：2017-02-28
发明人： Cha Young Kim , Yu Jeong Jeong , Suk Weon Kim , Mun Chual Rho , Young Bae Ryu , Woo Song Lee , Jae Cheol Jeong
摘要： The present invention relates to a method for mass-production of viniferin using stevioside from cell culture of grape tree tissue. Viniferin is known to be effective for protection of liver, anticancer, antioxidant, and skin whitening, have an effect of inhibiting oxidation of low-density lipoprotein and high-density lipoprotein and inhibiting the proliferation and migration of vascular smooth muscle cells. Therefore, the present invention is very useful for the mass production of viniferin among the useful substances (stilbene compounds) from a callus derived from the anther tissue of the grape plant, which is very important for the related industries.
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30.发明授权公开(公告)号：US10765642B2
公开(公告)日：2020-09-08
申请号：US15758595
申请日：2016-09-09
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
发明人： Ki Sun Kwon , Jeongi Choi , Sung Sup Park , Sun Gun Chung , Eun Soo Kwon , Kwang-Pyo Lee , Seung Min Lee
IPC分类号： A61K31/045 , A61K31/047 , A23L33/10 , A23K50/50 , A23K20/105 , C12N5/077
摘要： The present invention relates to sobrerol or a pharmaceutically acceptable salt thereof, which can promote differentiation of myoblasts to form myotubes, thereby preventing muscle weakness and effectively improving muscle functions. Therefore, the pharmaceutical composition containing the same can be effectively used for preventing or treating muscle weakness related diseases.
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