公开(公告)号：US07601742B2

公开(公告)日：2009-10-13

申请号：US12107637

申请日：2008-04-22

Applicant: Baogen Wu ,  Yun He ,  Truc Ngoc Nguyen ,  Kelli L. Kuhen ,  David Archer Ellis ,  Tao Jiang ,  Xiaohui He ,  Kunyong Yang ,  Badry Bursulaya

Inventor： Baogen Wu ,  Yun He ,  Truc Ngoc Nguyen ,  Kelli L. Kuhen ,  David Archer Ellis ,  Tao Jiang ,  Xiaohui He ,  Kunyong Yang ,  Badry Bursulaya

IPC: A61K31/443 ,  A61K31/402 ,  C07D401/04 ,  C07D207/08

CPC classification number: C07D207/26 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.

公开(公告)号：US20080287516A1

公开(公告)日：2008-11-20

申请号：US11814480

申请日：2006-01-30

Applicant: Baogen Wu ,  Truc Ngoc Nguyen ,  David Archer Ellis ,  Xiaohui He ,  Beth Marie Anaclerio ,  Kunyong Yang ,  Ha-soon Choi ,  Zhicheng Wang ,  Thomas H. Marsilje ,  Yun He

Inventor： Baogen Wu ,  Truc Ngoc Nguyen ,  David Archer Ellis ,  Xiaohui He ,  Beth Marie Anaclerio ,  Kunyong Yang ,  Ha-soon Choi ,  Zhicheng Wang ,  Thomas H. Marsilje ,  Yun He

IPC: A61K31/416 ,  C07D207/12 ,  C07D231/56 ,  A61P31/18 ,  A61K31/4015

CPC classification number: C07D207/27 ,  C07D403/04

Abstract: The present invention relates to phenyl-substituted pyrrolidones and compounds related to phenyl-substituted pyrrolidones. One use of these compounds is for the inhibition of viruses, e.g., HIV. The invention further relates to methods of malting these compounds, methods of identifying the efficacy of these compounds, and methods of using these compounds to inhibit or prevent HIV infection and related disease states such as AIDS.

Abstract translation: 本发明涉及苯基取代的吡咯烷酮和与苯基取代的吡咯烷酮有关的化合物。 这些化合物的一个用途是用于抑制病毒，例如HIV。 本发明还涉及这些化合物的发酵方法，鉴定这些化合物的功效的方法，以及使用这些化合物抑制或预防HIV感染和相关疾病状态如AIDS的方法。

公开(公告)号：US08362050B2

公开(公告)日：2013-01-29

申请号：US12999887

申请日：2009-06-23

Applicant: Xiaohui He ,  Xuefeng Zhu ,  Kunyong Yang ,  Robert Epple ,  Hong Liu

Inventor： Xiaohui He ,  Xuefeng Zhu ,  Kunyong Yang ,  Robert Epple ,  Hong Liu

IPC: A61K31/426 ,  C07D277/18

CPC classification number: C07D249/06 ,  C07D271/06 ,  C07D277/38

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by G protein-coupled receptors, in particular G protein-coupled receptor 120.

Abstract translation: 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与G蛋白偶联受体，特别是G蛋白偶联受体120相关或介导的疾病或病症的方法。

公开(公告)号：US20120225869A1

公开(公告)日：2012-09-06

申请号：US13415565

申请日：2012-03-08

Applicant: Hong Liu ,  Xiaohui He ,  Ha-Soon Choi ,  Kunyong Yang ,  David H. Woodmansee ,  Zhicheng Wang ,  David Archer Ellis ,  Boagen Wu ,  Yun He ,  Truc Ngoc Nguyen

Inventor： Hong Liu ,  Xiaohui He ,  Ha-Soon Choi ,  Kunyong Yang ,  David H. Woodmansee ,  Zhicheng Wang ,  David Archer Ellis ,  Boagen Wu ,  Yun He ,  Truc Ngoc Nguyen

IPC: A61K31/519 ,  C07D473/30 ,  A61P3/04 ,  A61K31/4985 ,  A61K31/5377 ,  C07D487/04 ,  A61K31/522

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D473/30 ,  C07D498/04

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

Abstract translation: 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与大麻素受体1（CB1）的活性相关的疾病或病症的方法。

公开(公告)号：US20110172278A1

公开(公告)日：2011-07-14

申请号：US12999887

申请日：2009-06-23

Applicant: Xiaohui He ,  Xuefeng Zhu ,  Kunyong Yang ,  Robert Epple ,  Hong Liu

Inventor： Xiaohui He ,  Xuefeng Zhu ,  Kunyong Yang ,  Robert Epple ,  Hong Liu

IPC: A61K31/4192 ,  C07D277/42 ,  C07D271/06 ,  C07D249/06 ,  A61K31/426 ,  A61K31/4245 ,  C12N5/071 ,  A61P3/10 ,  A61P3/04 ,  A61P3/00 ,  A61P3/06 ,  A61P19/02 ,  A61P17/06 ,  A61P7/06

CPC classification number: C07D249/06 ,  C07D271/06 ,  C07D277/38

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by G protein-coupled receptors, in particular G protein-coupled receptor 120.

Abstract translation: 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与G蛋白偶联受体，特别是G蛋白偶联受体120相关或介导的疾病或病症的方法。

公开(公告)号：US20110053897A1

公开(公告)日：2011-03-03

申请号：US12843771

申请日：2010-07-26

Applicant: Jianwei CHE ,  Bei Chen ,  Qiang Ding ,  Xueshi Hao ,  Xiaohui He ,  Songchun Jiang ,  Qihui Jin ,  Yunho Jin ,  Hong Liu ,  Yahua Liu ,  Barun Okram ,  Tetsuo Uno ,  Xu Wu ,  Kunyong Yang ,  Xuefeng Zhu

Inventor： Jianwei CHE ,  Bei Chen ,  Qiang Ding ,  Xueshi Hao ,  Xiaohui He ,  Songchun Jiang ,  Qihui Jin ,  Yunho Jin ,  Hong Liu ,  Yahua Liu ,  Barun Okram ,  Tetsuo Uno ,  Xu Wu ,  Kunyong Yang ,  Xuefeng Zhu

IPC: A61K31/635 ,  C07D471/04 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/444 ,  A61P11/06 ,  A61P19/02 ,  A61P35/00 ,  A61P7/06 ,  A61P25/00

CPC classification number: C07D471/04 ,  A61K31/4375

Abstract: Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.

Abstract translation: 本文提供了区域新颖的化合物类，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的Syk激酶活性相关的疾病或病症的方法。

公开(公告)号：US20070259852A1

公开(公告)日：2007-11-08

申请号：US11769679

申请日：2007-06-27

Applicant: Valentina Molteni ,  Xiaohui He ,  Yun He ,  Andreas Kreusch ,  Juliet Nabakka ,  Kunyong Yang

Inventor： Valentina Molteni ,  Xiaohui He ,  Yun He ,  Andreas Kreusch ,  Juliet Nabakka ,  Kunyong Yang

IPC: A61K31/47 ,  A61K31/54 ,  A61K31/55 ,  C07D215/02 ,  C07D279/10 ,  C07D417/00 ,  C07D487/00

CPC classification number: C07D279/16 ,  C07D215/227 ,  C07D417/06 ,  C07D417/12

Abstract: This invention is directed to novel bicyclic compounds, to the uses of these compounds in various medicinal applications, including treating disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections, and to pharmaceutical compositions comprising these compounds.

Abstract translation: 本发明涉及新颖的双环化合物，涉及这些化合物在各种药物应用中的用途，包括治疗适合于通过肽基变性酶抑制剂治疗的疾病，例如治疗细菌感染，以及包含这些化合物的药物组合物。

公开(公告)号：US20070225306A1

公开(公告)日：2007-09-27

申请号：US10589099

申请日：2005-02-14

Applicant: Ha-Soon Choi ,  Zhicheng Wang ,  Nathanael Gay ,  Xiang-Ju Gu ,  Xiaohui He ,  Yun He ,  Toa Jiang ,  Yi Liu ,  Windy Richmond ,  Taebo Sim ,  Kunyong Yang

Inventor： Ha-Soon Choi ,  Zhicheng Wang ,  Nathanael Gay ,  Xiang-Ju Gu ,  Xiaohui He ,  Yun He ,  Toa Jiang ,  Yi Liu ,  Windy Richmond ,  Taebo Sim ,  Kunyong Yang

IPC: A61K31/519 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the FAK, Abl, BCR-Abl, PDGF-R, c-Kit, NPM-ALK, Flt-3, JAK2 and c-Met kinases.

Abstract translation: 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及FAK异常活化的疾病或病症，Abl，BCR -AbI，PDGF-R，c-Kit，NPM-ALK，Flt-3，JAK2和c-Met激酶。

公开(公告)号：US07253164B2

公开(公告)日：2007-08-07

申请号：US10903349

申请日：2004-07-30

Applicant: Valentina Molteni ,  Xiaohui He ,  Yun He ,  Andreas Kreusch ,  Juliet Nabakka ,  Kunyong Yang

Inventor： Valentina Molteni ,  Xiaohui He ,  Yun He ,  Andreas Kreusch ,  Juliet Nabakka ,  Kunyong Yang

IPC: C07D417/12 ,  C07D279/16 ,  A61K31/5415

CPC classification number: C07D279/16 ,  C07D215/227 ,  C07D417/06 ,  C07D417/12

Abstract: This invention is directed to novel bicyclic compounds, to the uses of these compounds in various medicinal applications, including treating disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections, and to pharmaceutical compositions comprising these compounds.

Abstract translation: 本发明涉及新颖的双环化合物，涉及这些化合物在各种药物应用中的用途，包括治疗适合于通过肽基变性酶抑制剂治疗的疾病，例如治疗细菌感染，以及包含这些化合物的药物组合物。