公开(公告)号：US07705151B2

公开(公告)日：2010-04-27

申请号：US12399292

申请日：2009-03-06

Applicant: Charles L. Cywin ,  Scott E. Jakes ,  Joachim Heider ,  Mark A. Bobko ,  Renee L. Des Jarlais ,  Mark Player ,  James Rinker ,  Michael Winters ,  Bao-ping Zhao

Inventor： Charles L. Cywin ,  Scott E. Jakes ,  Joachim Heider ,  Mark A. Bobko ,  Renee L. Des Jarlais ,  Mark Player ,  James Rinker ,  Michael Winters ,  Bao-ping Zhao

IPC: C07D471/02 ,  C07D413/00

CPC classification number: C07D471/04

Abstract: Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

Abstract translation: 公开了式（I）的化合物：其中R 3，R 5，R 7和R 8在本文中定义，其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：US07678911B2

公开(公告)日：2010-03-16

申请号：US12014190

申请日：2008-01-15

Applicant: Charles L. Cywin ,  Scott E. Jakes ,  Joachim Heider ,  Mark A. Bobko ,  Renee L. Des Jarlais ,  Mark Player ,  James Rinker ,  Michael Winters ,  Bao-ping Zhao

Inventor： Charles L. Cywin ,  Scott E. Jakes ,  Joachim Heider ,  Mark A. Bobko ,  Renee L. Des Jarlais ,  Mark Player ,  James Rinker ,  Michael Winters ,  Bao-ping Zhao

IPC: C07D471/02 ,  C07D413/00

CPC classification number: C07D471/04

Abstract: Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

Abstract translation: 公开了式（I）的化合物：其中R 3，R 5，R 7和R 8在本文中定义，其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：US07321041B2

公开(公告)日：2008-01-22

申请号：US10413980

申请日：2003-04-15

Applicant: Charles L. Cywin ,  Scott E. Jakes ,  Joachim Heider ,  Mark A. Bobko ,  Renee L. Des Jarlais ,  Mark Player ,  James Rinker ,  Michael Winters ,  Bao-ping Zhao

Inventor： Charles L. Cywin ,  Scott E. Jakes ,  Joachim Heider ,  Mark A. Bobko ,  Renee L. Des Jarlais ,  Mark Player ,  James Rinker ,  Michael Winters ,  Bao-ping Zhao

IPC: C07D471/02

CPC classification number: C07D471/04

Abstract: Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

Abstract translation: 公开了式（I）的化合物：其中R 3，R 5，R 7和R 8是 其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：US20070225282A1

公开(公告)日：2007-09-27

申请号：US11685544

申请日：2007-03-13

Applicant: Mark Player ,  Tianbao Lu ,  Huaping Hu ,  Xizhen Zhu ,  Christopher Teleha ,  Kevin Kreutter

Inventor： Mark Player ,  Tianbao Lu ,  Huaping Hu ,  Xizhen Zhu ,  Christopher Teleha ,  Kevin Kreutter

IPC: A61K31/5377 ,  A61K31/4439 ,  C07D413/14

CPC classification number: C07D213/89 ,  C07D213/74 ,  C07D213/84 ,  C07D401/14 ,  C07D413/14

Abstract: The present invention describes compounds of Formula I: wherein W, X, Y, Z, and Q are defined herein, or a pharmaceutically acceptable salt thereof, for the prophylaxis, or treatment of diseases and conditions related to thrombin activity in a mammal.

Abstract translation: 本发明描述了式I的化合物：其中W，X，Y，Z和Q在本文中定义，或其药学上可接受的盐，用于预防或治疗与哺乳动物中凝血酶活性相关的疾病和病症。

公开(公告)号：US20060241148A1

公开(公告)日：2006-10-26

申请号：US11385056

申请日：2006-03-21

Applicant: Kevin Kreutter ,  Tianbao Lu ,  Yu Lee ,  Christopher Teleha ,  Mark Player ,  Xizhen Zhu

Inventor： Kevin Kreutter ,  Tianbao Lu ,  Yu Lee ,  Christopher Teleha ,  Mark Player ,  Xizhen Zhu

IPC: A61K31/444 ,  C07D213/84 ,  C07D401/02

CPC classification number: C07D213/89 ,  C07D215/60 ,  C07D239/24 ,  C07D241/10

Abstract: The present invention describes compounds of Formula I or a pharmaceutically acceptable salt thereof, for the prophylaxis, or treatment of diseases and conditions related to thrombin activity in a mammal. The present invention also relates to a novel method of N-oxidation of nitrogen containing heteroaryls.

Abstract translation: 本发明描述了式I化合物或其药学上可接受的盐，用于预防或治疗与哺乳动物中凝血酶活性相关的疾病和病症。 本发明还涉及含氮杂芳基的N-氧化的新方法。

公开(公告)号：US07060706B1

公开(公告)日：2006-06-13

申请号：US10089167

申请日：2000-09-13

Applicant: Werner Mederski ,  Ralf Devant ,  Gerhard Barnickel ,  Sabine Bernotat-Danielowski ,  Guido Melzer ,  Bertram Cezanne ,  Daljit Dhanoa ,  Bao-Ping Zhao ,  James Rinker ,  Mark Player ,  Richard Soll

Inventor： Werner Mederski ,  Ralf Devant ,  Gerhard Barnickel ,  Sabine Bernotat-Danielowski ,  Guido Melzer ,  Bertram Cezanne ,  Daljit Dhanoa ,  Bao-Ping Zhao ,  James Rinker ,  Mark Player ,  Richard Soll

IPC: C07D239/91 ,  A61K31/517 ,  A61P9/10

CPC classification number: C07D239/91

Abstract: Quinazolinones of formula (I) in which R, R1, R2, R3, R4, Y, n and m have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein IbIX antagonists

Abstract translation: 式（I）的喹唑啉酮，其中R 1，R 2，R 2，R 3，R 4， Y，n和m具有专利权利要求1中所示的含义，其盐或溶剂合物作为糖蛋白IbIX拮抗剂

公开(公告)号：US07058090B1

公开(公告)日：2006-06-06

申请号：US10023675

申请日：2001-12-18

Applicant: Andrew Mark Player ,  Alan Michael Sorgi ,  George Beshara Bendak

Inventor： Andrew Mark Player ,  Alan Michael Sorgi ,  George Beshara Bendak

IPC: H04J3/04

CPC classification number: H04J3/062 ,  H04J3/1611

Abstract: A system and method are provided for paralleling data streams in a G.709 network of connected integrated circuits. The system comprises a demultiplexer for receiving a first digital wrapper data stream having a first data rate. The demultiplexer demultiplexes the first data stream into a second plurality of digital wrapper data streams having a second data rate, less than the first data rate. A second plurality of processors each accept a corresponding one of the second plurality of data streams and supply a processed data stream at the second data rate. The demultiplexer receives frame alignment signal bytes in the overhead of every first data stream frame and synchronizes frame alignment signal bytes in each of the second plurality of data streams to the frame alignment signal bytes in the first data stream.

Abstract translation: 提供了一种用于在连接的集成电路的G.709网络中并行数据流的系统和方法。 该系统包括用于接收具有第一数据速率的第一数字包装数据流的解复用器。 解复用器将第一数据流解复用为具有小于第一数据速率的第二数据速率的第二多个数字封装数据流。 第二多个处理器各自接受第二多个数据流中的对应的一个，并以第二数据速率提供经处理的数据流。 解复用器在每个第一数据流帧的开销中接收帧对准信号字节，并将第二多个数据流中的每一个中的帧对准信号字节同步到第一数据流中的帧对准信号字节。

公开(公告)号：US20110294780A1

公开(公告)日：2011-12-01

申请号：US13114084

申请日：2011-05-24

Applicant: Gilles Bignan ,  Wing Cheung ,  Micheal Gaul ,  Hui Huang ,  Xun Li ,  Raymond Patch ,  Sharmila Patel ,  Mark Player ,  Guozhang Xu ,  Bao-Ping Zhao ,  Jian Liu

Inventor： Gilles Bignan ,  Wing Cheung ,  Micheal Gaul ,  Hui Huang ,  Xun Li ,  Raymond Patch ,  Sharmila Patel ,  Mark Player ,  Guozhang Xu ,  Bao-Ping Zhao ,  Jian Liu

IPC: A61K31/427 ,  C07D413/14 ,  C07D401/14 ,  C07D453/02 ,  C07D451/04 ,  C07D498/04 ,  C07D455/02 ,  C07D419/14 ,  A61K31/5377 ,  A61K31/454 ,  A61K31/496 ,  A61K31/46 ,  A61K31/439 ,  A61K31/55 ,  A61K31/541 ,  A61K31/551 ,  A61K31/4439 ,  A61K31/5383 ,  A61K31/433 ,  A61K31/4245 ,  A61K31/41 ,  A61P19/08 ,  A61P19/06 ,  A61P19/10 ,  A61P35/04 ,  A61P19/04 ,  A61P35/00 ,  A61P19/02 ,  A61P29/00 ,  A61P11/00 ,  A61P11/08 ,  A61P3/00 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P5/48 ,  C07D417/14

CPC classification number: C07D417/06

Abstract: The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

Abstract translation: 本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期 关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失， 软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性 骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨 骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖症，升高的血糖水平和胰岛素抵抗。

公开(公告)号：US20070060577A1

公开(公告)日：2007-03-15

申请号：US11519611

申请日：2006-09-12

Applicant: Mark Player ,  Hui Huang ,  Daniel Hutta

Inventor： Mark Player ,  Hui Huang ,  Daniel Hutta

IPC: A61K31/541 ,  A61K31/5377 ,  A61K31/519 ,  A61K31/496 ,  A61K31/4745 ,  C07D487/02 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof, wherein: W, A, Y, Z, R101 and R200 are described in the specification.

Abstract translation: 本发明通过提供c-fms激酶的有效抑制剂来解决当前对选择性和有效的蛋白酪氨酸激酶抑制剂的需要。 本发明涉及新的式I化合物或其溶剂合物，水合物，互变异构体或其药学上可接受的盐，其中：W，A，Y，Z，R 101和R 200 在说明书中描述。

公开(公告)号：US07072361B1

公开(公告)日：2006-07-04

申请号：US10094259

申请日：2002-03-08

Applicant: Andrew Mark Player

Inventor： Andrew Mark Player

IPC: H04J3/16 ,  H04J3/22

CPC classification number: H04J3/14 ,  H04J3/1611

Abstract: A system and method are provided for transporting backward information in a digital wrapper format network of connected simplex devices. The system comprises a first simplex processor receiving downstream messages with overhead bytes. The first simplex processor selectively replaces overhead bytes with calculated overhead bytes and supplies the calculated overhead bytes. The system further comprises a buffer receiving the calculated overhead bytes from the first simplex processor and supplying the calculated overhead bytes. A second simplex processor accepts the calculated overhead bytes from the buffer and supplies an upstream message including the calculated overhead bytes. The first simplex processor receives messages in a frame format with an overhead section, drops the overhead section, and selectively reads backward message monitor bytes in the dropped overhead section to determine if upstream communication nodes are receiving transmitted messages.

Abstract translation: 提供了一种用于在连接的单工装置的数字包装格式网络中传送反向信息的系统和方法。 该系统包括接收具有开销字节的下行消息的第一单工处理器。 第一个单工处理器用计算出的开销字节选择性地替换开销字节，并提供计算的开销字节。 该系统还包括缓冲器，其从第一单工处理器接收所计算的开销字节并提供所计算的开销字节。 第二个单工处理器接受来自缓冲区的计算开销字节，并提供包括计算的开销字节的上游消息。 第一单工处理器以帧格式接收具有开销部分的消息，丢弃开销部分，并且选择性地读取丢弃的开销部分中的反向消息监视字节，以确定上游通信节点是否正在接收发送的消息。