公开(公告)号：US20110045052A1

公开(公告)日：2011-02-24

申请号：US12809098

申请日：2008-12-19

Applicant: Robert Graham Hill ,  Molly Morag Stevens ,  Matthew O'Donnell

Inventor： Robert Graham Hill ,  Molly Morag Stevens ,  Matthew O'Donnell

IPC: A61K9/14 ,  A61K33/30 ,  A61K33/08 ,  A61K33/42 ,  A61K9/00 ,  A61P43/00 ,  B05D3/02 ,  C23C4/04 ,  C25D13/02

CPC classification number: C03C4/0007 ,  A61C8/0012 ,  A61F2/30767 ,  A61F2310/00928 ,  A61K6/0625 ,  A61L27/306 ,  A61L27/32 ,  C03C3/097 ,  C03C8/08 ,  C03C2204/00

Abstract: The present invention relates to bioactive glass coatings. In particular, the present invention relates to bioactive glass coatings for Ti6Al4V alloys and chrome cobalt alloys, wherein the thermal expansion coefficient of the glass coating is matched to that of the alloy. Such coatings have a particular application in the field of medical prosthetics. The bioactive glass comprises (in mol %) 35-53 SiO2; 2-11 Na20; at least 2% of each of CaO, MgO and K20; 0-15 ZnO; 0-2 B202 and 0-9 P205.

Abstract translation: 本发明涉及生物活性玻璃涂层。 特别地，本发明涉及用于Ti 6 Al 4 V合金和铬钴合金的生物活性玻璃涂层，其中玻璃涂层的热膨胀系数与合金的热膨胀系数相匹配。 这种涂层在医疗假肢领域具有特殊的应用。 生物活性玻璃含有（摩尔％）35-53 SiO2; 2-11 Na20; CaO，MgO和K20中至少有2％ 0-15 ZnO; 0-2 B202和0-9 P205。

公开(公告)号：US20100091613A1

公开(公告)日：2010-04-15

申请号：US12250289

申请日：2008-10-13

Applicant: Russell S. Witte ,  Ragnar Olafsson ,  Sheng-Wen Huang ,  Timothy L. Hall ,  Matthew O'Donnell

Inventor： Russell S. Witte ,  Ragnar Olafsson ,  Sheng-Wen Huang ,  Timothy L. Hall ,  Matthew O'Donnell

IPC: G01H17/00

CPC classification number: G01H11/06

Abstract: An ultrasound system that detects a characteristic of an ultrasound wave. The system includes a circuit member defining a sensing portion operable to be exposed to the ultrasound wave. The system also includes a current generating device that generates a current in the sensing portion of the circuit member. Furthermore, the system includes a voltage sensor that detects a voltage across the sensing portion due to the exposure to the ultrasound wave to thereby detect the characteristic of the ultrasound wave.

Abstract translation: 检测超声波特性的超声波系统。 该系统包括限定可操作以暴露于超声波的感测部分的电路部件。 该系统还包括在电路构件的感测部分中产生电流的电流产生装置。 此外，该系统包括电压传感器，其通过暴露于超声波来检测感测部分两端的电压，从而检测超声波的特性。

公开(公告)号：US07367948B2

公开(公告)日：2008-05-06

申请号：US10643659

申请日：2003-08-19

Applicant: Matthew O'Donnell ,  Jing Yong Ye ,  Theodore B. Norris ,  James R. Baker, Jr. ,  Lajos P. Balogh ,  Susanne M. Milas ,  Stanislav Y. Emelianov ,  Kyle W. Hollman

Inventor： Matthew O'Donnell ,  Jing Yong Ye ,  Theodore B. Norris ,  James R. Baker, Jr. ,  Lajos P. Balogh ,  Susanne M. Milas ,  Stanislav Y. Emelianov ,  Kyle W. Hollman

IPC: A61B8/00 ,  A61B8/12 ,  A61B8/14 ,  A61B6/00 ,  A61H1/00

CPC classification number: B82Y15/00 ,  A61B5/0095 ,  A61B8/481 ,  G01N21/1702 ,  G01N21/718 ,  G01N29/2418 ,  G01N2291/02433 ,  G01N2291/02475 ,  G01N2291/02491 ,  G01N2291/02827

Abstract: An acoustic monitoring method and system in laser-induced optical breakdown (LIOB) provides information which characterize material which is broken down, microbubbles in the material, and/or the microenvironment of the microbubbles. In one embodiment of the invention, femtosecond laser pulses are focused just inside the surface of a volume of aqueous solution which may include dendrimer nanocomposite (DNC) particles. A tightly focused, high frequency, single-element ultrasonic transducer is positioned such that its focus coincides axially and laterally with this laser focus. When optical breakdown occurs, a microbubble forms and a shock or pressure wave is emitted (i.e., acoustic emission). In addition to this acoustic signal, the microbubble may be actively probed with pulse-echo measurements from the same transducer. After the microbubble forms, received pulse-echo signals have an extra pulse, describing the microbubble location and providing a measure of axial microbubble size. Wavefield plots of successive recordings illustrate the generation, growth, and collapse of microbubbles due to optical breakdown. These same plots can also be used to quantify LIOB thresholds.

Abstract translation: 激光诱导光学击穿（LIOB）中的声学监测方法和系统提供表征材料中的材料，材料中的微泡和/或微泡的微环境的信息。 在本发明的一个实施例中，飞秒激光脉冲恰好聚集在一定体积的水溶液的表面内，该溶液可包括树枝状聚合物纳米复合物（DNC）颗粒。 紧密聚焦的高频单元超声波换能器被定位成使得其焦点与该激光焦点轴向和横向重合。 当发生光学击穿时，形成微泡并发射冲击或压力波（即声发射）。 除了这种声学信号之外，微泡可以通过来自相同换能器的脉冲回波测量来主动探测。 在形成微泡后，接收的脉冲回波信号具有额外的脉冲，描述微泡位置并提供轴向微泡尺寸的量度。 连续记录的波场图说明了由于光学破坏引起的微泡的产生，生长和崩溃。 这些相同的图也可以用于量化LIOB阈值。

公开(公告)号：US20080019609A1

公开(公告)日：2008-01-24

申请号：US11781212

申请日：2007-07-20

Applicant: James Hamilton ,  Matthew O'Donnell

Inventor： James Hamilton ,  Matthew O'Donnell

IPC: G06K9/36

CPC classification number: G01S15/8977 ,  G06T7/207 ,  G06T7/32 ,  G06T2207/10132 ,  G06T2207/20016 ,  G06T2207/30004

Abstract: In a first preferred embodiment, the invention includes a method of tracking displacements between ultrasound images by calculating a coarse displacement estimate, and calculating a fine displacement estimate using images and coarse displacement estimate. In a second preferred embodiment, the invention includes a method of calculating a coarse displacement estimate from images by reducing the resolution of the images, correlating the reduced resolution images, and calculating the location of the peak of the correlation function. In a third preferred embodiment, the invention includes a method of calculating a finer displacement estimate from images by using a coarse displacement estimate with correlation processing of the images and calculating the location of the peak value of the correlation function.

Abstract translation: 在第一优选实施例中，本发明包括通过计算粗位移估计来跟踪超声图像之间的位移以及使用图像和粗位移估计来计算精细位移估计的方法。 在第二优选实施例中，本发明包括一种通过降低图像的分辨率，降低分辨率图像的相关性以及计算相关函数的峰值的位置来从图像计算粗略位移估计的方法。 在第三优选实施例中，本发明包括通过使用具有图像的相关处理的粗位移估计和计算相关函数的峰值的位置来从图像计算更精细的位移估计的方法。

公开(公告)号：US06398733B1

公开(公告)日：2002-06-04

申请号：US09556354

申请日：2000-04-24

Applicant: Constantine Simopoulos ,  Kutay F. Ustuner ,  Anming He Cai ,  John Jackson ,  Matthew O'Donnell

Inventor： Constantine Simopoulos ,  Kutay F. Ustuner ,  Anming He Cai ,  John Jackson ,  Matthew O'Donnell

IPC: A61B800

CPC classification number: G01S15/8988 ,  A61B8/14 ,  G01S7/52026 ,  G01S7/52033 ,  G01S7/52034 ,  G01S7/52036

Abstract: A medical ultrasonic imaging system uses an adaptive multi-dimensional back-end mapping stage to eliminate loss of information in the back-end, minimize any back-end quantization noise, reduce or eliminate electronic noise, and map the local average of soft tissue to a target display value throughout the image. The system uses spatial variance to identify regions of the image corresponding substantially to soft tissue and a noise frame acquired with the transmitters turned off to determine the mean system noise level. The system then uses the mean noise level and the identified regions of soft tissue to both locally and adaptively set various back-end mapping stages, including the gain and dynamic range.

Abstract translation: 医疗超声成像系统使用自适应多维后端映射阶段来消除后端信息的丢失，最小化任何后端量化噪声，减少或消除电子噪声，并将软组织的局部平均值映射到 整个图像中的目标显示值。 该系统使用空间方差来识别基本上对应于软组织的图像的区域，并且使用发射器关闭的噪声帧来确定平均系统噪声水平。 然后，系统本地使用平均噪声水平和软组织的识别区域，并自适应地设置各种后端映射阶段，包括增益和动态范围。

公开(公告)号：US5615675A

公开(公告)日：1997-04-01

申请号：US635361

申请日：1996-04-19

Applicant: Matthew O'Donnell ,  James D. Hamilton

Inventor： Matthew O'Donnell ,  James D. Hamilton

IPC: G01N29/00 ,  A61B8/00 ,  G01N29/06 ,  G01N29/24 ,  G01S15/89

CPC classification number: G01N29/069 ,  G01N29/0681 ,  G01N29/2418 ,  G01S15/8965 ,  G01N2291/02475 ,  G01N2291/0421

Abstract: A method and system are provided for 3-D acoustic microscopy using short pulse laser excitation. A 3-D acoustic microscope for use in such a system is also provided. In a first embodiment, wherein optical detection is utilized, a focused excitation beam is scanned by a first acoustooptic scanning device across an absorbing layer of an opto-acoustic transducer (if needed) coupled to an object under investigation to create spherical ultrasonic waves within the object which may be living tissue. The reflected spherical ultrasonic waves are detected through the use of an unfocused probe beam and an optical detector array or a focused probe beam and a single photodetector which receive the probe beam from a reflecting surface of the opto-acoustic transducer. A second acoustooptic scanning device scans the probe beam at a plurality of positions on the reflecting surface of the opto-acoustic transducer. In another embodiment, an ultrasound transducer is utilized to acoustically detect the reflected spherical ultrasonic waves. Signals from the optical detector array, the photodetector, or the ultrasound transducer are subsequently digitized and reconstructed via 3-D synthetic aperture beam-forming equations to generate a 3-D representation of the object. Then the 3-D representation of the image is displayed as an image. The microscope includes the first and second acoustooptic scanning devices and the opto-acoustic transducer housed in a housing to define a needle probe such as a conventional biopsy needle.

Abstract translation: 提供了使用短脉冲激光激发的三维声学显微镜的方法和系统。 还提供了一种用于这种系统的3-D声学显微镜。 在其中使用光学检测的第一实施例中，聚焦的激发光束被第一声光扫描装置扫过耦合到被研究对象的光声换能器的吸收层（如果需要的话），以在其内产生球形超声波 可能是活体组织的物体。 通过使用未聚焦的探针光束和光学检测器阵列或聚焦探针光束以及从光声换能器的反射表面接收探测光束的单个光电检测器来检测反射的球形超声波。 第二声光扫描装置在光声换能器的反射表面上的多个位置扫描探测光束。 在另一个实施例中，使用超声换能器来声学地检测反射的球面超声波。 随后，通过3D合成孔径波束形成方程将来自光学检测器阵列，光电探测器或超声波换能器的信号数字化并重建，以产生物体的3-D表示。 然后，图像的3-D表示显示为图像。 显微镜包括第一和第二声光扫描装置和容纳在壳体中的光声换能器，以限定诸如常规活检针的针探针。

公开(公告)号：US5235982A

公开(公告)日：1993-08-17

申请号：US767460

申请日：1991-09-30

Applicant: Matthew O'Donnell

Inventor： Matthew O'Donnell

IPC: G10K11/34

CPC classification number: G10K11/345

Abstract: A phased array sector scanning (PASS) ultrasonic imaging system produces a fixed focus, steered transmit beam with an array of transducer elements. A receiver forms the echo signals received from an ultrasonic energy reflecting object at the array elements into a receive beam steered in the same direction as the transmit beam and dynamically focused. A midprocessor in the receiver makes corrections to the receive beam samples to offset errors caused by the transmit beam being out of focus at all but its fixed focal range.

Abstract translation: 相控阵扫描（PASS）超声波成像系统产生一个固定焦距的转向发射光束与一组换能器元件。 接收器形成从阵列元件处的超声波能量反射物体接收的回波信号转换成与发射波束相同的方向并被动态聚焦的接收波束。 接收机中的中间处理器对接收波束样本进行校正，以抵消由发射波束所有焦点失真造成的误差，但其固定焦距范围。

公开(公告)号：US5203335A

公开(公告)日：1993-04-20

申请号：US844031

申请日：1992-03-02

Applicant: Sharbel E. Noujaim ,  Steven L. Garverick ,  Matthew O'Donnell

Inventor： Sharbel E. Noujaim ,  Steven L. Garverick ,  Matthew O'Donnell

IPC: A61B8/14 ,  G01N29/06 ,  G01S15/89 ,  G10K11/34

CPC classification number: G10K11/346 ,  G01N29/0645 ,  G01S15/8909 ,  G01S7/52028

Abstract: A beam former in a PASS ultrasonic imaging system includes a set of sigma-delta modulators which operate to separately digitize the received echo signal from each transducer element. The oversampled one-bit digital representations of each echo signal are delayed as required for beam steering and focusing, and are summed together. A decimator filter reduces the sample rate of the digitized receive beam prior to display of the image resulting from the receive beam.

公开(公告)号：US5121364A

公开(公告)日：1992-06-09

申请号：US741874

申请日：1991-08-07

Applicant: Matthew O'Donnell

Inventor： Matthew O'Donnell

IPC: G01S7/52

CPC classification number: G01S7/52046 ,  G01S7/52033 ,  Y10S367/90

Abstract: A phased array sector scanning ultrasonic imaging system produces digitized baseband samples of the received ultrasonic echo signals amplified by a time gain control (TGC) to compensate for dispersion losses in the media in which the ultrasonic signals propagate. A time frequency control filter employs the same TGC control signal to calculate a phase shift correction as well as the coefficients which determine the characteristics of a bandpass filter such that the frequency dependent dispersion losses in the ultrasonic echo signals are compensated.

Abstract translation: 相控阵扫描超声成像系统产生通过时间增益控制（TGC）放大的接收的超声波回波信号的数字化基带样本，以补偿超声信号传播的介质中的色散损失。 时间频率控制滤波器采用相同的TGC控制信号来计算相移校正以及确定带通滤波器的特性的系数，使得超声回波信号中的频率相关色散损耗得到补偿。

公开(公告)号：US4839652A

公开(公告)日：1989-06-13

申请号：US56177

申请日：1987-06-01

Applicant: Matthew O'Donnell ,  William E. Engeler ,  Thomas L. Vogelsong ,  Steven G. Karr ,  Sharbel E. Noujaim

Inventor： Matthew O'Donnell ,  William E. Engeler ,  Thomas L. Vogelsong ,  Steven G. Karr ,  Sharbel E. Noujaim

IPC: G06F3/05 ,  A61B8/00 ,  G01S7/52 ,  G01S7/523 ,  G01S15/89 ,  G10K11/34 ,  H03H17/00 ,  H03H17/06

CPC classification number: H03H17/0664 ,  G01S15/8918 ,  G01S7/52034 ,  G01S7/52046 ,  G10K11/346 ,  H03H2218/04

Abstract: A method for generating an output stream of digital data words, with each data word representing the amplitude of an analog signal at one of a multiplicity F samples each second and with substantially equally spaced time intervals T therebetween, is obtained from a digital baseband demodulation system used for array beam forming. A data stream, formed of interleaved ADC output digital data words acquired from a set of converters, is at a rate of F total samples/second. Subsequent digital demodulation, filtration, and decimation provides digital output signals which need less delay resolution prior to the formation of coherent sum signals, thereby reducing overall channel memory requirements. The output baseband data stream has enhanced dynamic range, thereby reducing the ADC bit density requirements.