公开(公告)号：US6110446A

公开(公告)日：2000-08-29

申请号：US166025

申请日：1998-10-05

Applicant: Michael Prencipe ,  Vincent O. Drago ,  Mike Wong ,  Barry D. Self ,  Malcolm Williams ,  John Afflitto

Inventor： Michael Prencipe ,  Vincent O. Drago ,  Mike Wong ,  Barry D. Self ,  Malcolm Williams ,  John Afflitto

IPC: A61K8/22 ,  A61K8/24 ,  A61K8/73 ,  A61K8/81 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/20

CPC classification number: A61Q11/00 ,  A61K8/22 ,  A61K8/24 ,  A61K8/73 ,  A61K8/8147 ,  A61K2800/88

Abstract: A dual component antiplaque and whitening dentifrice composition in which the first component is a paste composition containing an antibacterial agent such as Triclosan and the second component contains a peroxide compound such as hydrogen peroxide in a vehicle thickened with a combination of an inorganic thickeners and an organic thickener other than an alkylene oxide polymer wherein the antiplaque and whitening efficacy of the components is unimpaired when the components are physically separated prior to use and thereafter are mixed upon application to dental tissue.

Abstract translation: 双组分抗菌和增白牙粉组合物，其中第一组分是含有抗菌剂如三氯生的糊组合物，第二组分在无机增稠剂和有机物的组合物中加入过氧化氢等过氧化物化合物 除了环氧烷聚合物之外的增稠剂，其中当组分在使用之前物理分离时，组分的抗牙斑和增白功效不受损害，然后在施用于牙齿组织时混合。

公开(公告)号：US5639445A

公开(公告)日：1997-06-17

申请号：US177900

申请日：1994-01-06

Applicant: John Curtis ,  Salim Nathoo ,  Michael Prencipe

Inventor： John Curtis ,  Salim Nathoo ,  Michael Prencipe

IPC: A61C19/06 ,  A61K6/00 ,  A61K6/093 ,  A61K8/22 ,  A61K8/42 ,  A61K8/81 ,  A61K8/891 ,  A61Q11/00 ,  A61K6/08 ,  A61K31/74 ,  A61K33/40

CPC classification number: A61Q11/00 ,  A61C19/063 ,  A61C19/066 ,  A61K8/22 ,  A61K8/42 ,  A61K8/8176 ,  A61K8/891

Abstract: A dental composition is produced from a dilatant silicone polymer composition by dispersing a bioactive component in the polymer composition. The dental composition is shaped and pressed against the teeth and gum surfaces and allowed to remain in place for a period of time sufficient to release the active component to the tooth and gums. The dilatant rheological properties enable the dental composition to be pushed under the gingival flap to remove food particles and treat tooth and gum surfaces below the gum line. The composition is sufficiently plastic to be easily removed from the teeth without pieces breaking and adhering to tooth surfaces.

Abstract translation: 通过将生物活性成分分散在聚合物组合物中，由膨胀性硅氧烷聚合物组合物制备牙科用组合物。 牙科组合物成形并压靠牙齿和牙龈表面，并使其保持在适当位置足以将活性成分释放到牙齿和牙龈的时间。 膨胀的流变学特性使牙科组合物能够在牙龈瓣下推动以除去食物颗粒并处理牙龈线下面的牙齿和牙龈表面。 该组合物具有足够的塑性，以便容易地从牙齿上除去，而没有破碎并附着在牙齿表面上。

公开(公告)号：US5310563A

公开(公告)日：1994-05-10

申请号：US782700

申请日：1991-10-25

Applicant: John Curtis ,  Salim Nahoo ,  Michael Prencipe

Inventor： John Curtis ,  Salim Nahoo ,  Michael Prencipe

IPC: A61C19/06 ,  A61K6/00 ,  A61K6/093 ,  A61K8/22 ,  A61K8/42 ,  A61K8/81 ,  A61K8/891 ,  A61Q11/00 ,  A61K6/08 ,  A61K31/74 ,  A61K33/40

CPC classification number: A61Q11/00 ,  A61C19/063 ,  A61C19/066 ,  A61K8/22 ,  A61K8/42 ,  A61K8/8176 ,  A61K8/891

Abstract: A dental composition is produced from a dilatant silicone polymer composition by dispersing a bioactive component in the polymer composition. The dental composition is shaped and pressed against the teeth and gum surfaces and allowed to remain in place for a period of time sufficient to release the active component to the tooth and gums. The dilatant rheological properties enable the dental composition to be pushed under the gingival flap to remove food particles and treat tooth and gum surfaces below the gum line. The composition is sufficiently plastic to be easily removed from the teeth without pieces breaking and adhering to tooth surfaces.

Abstract translation: 通过将生物活性成分分散在聚合物组合物中，由膨胀性硅氧烷聚合物组合物制备牙科用组合物。 牙科组合物成形并压靠牙齿和牙龈表面，并使其保持在适当位置足以将活性成分释放到牙齿和牙龈的时间。 膨胀的流变学特性使牙科组合物能够在牙龈瓣下推动以除去食物颗粒并处理牙龈线下面的牙齿和牙龈表面。 该组合物具有足够的塑性，以便容易地从牙齿上除去，而没有破碎并附着在牙齿表面上。

公开(公告)号：US5300283A

公开(公告)日：1994-04-05

申请号：US51319

申请日：1992-10-22

Applicant: Michael Prencipe ,  Gary A. Durga

Inventor： Michael Prencipe ,  Gary A. Durga

IPC: A61K8/00 ,  A61K8/21 ,  A61K8/24 ,  A61K8/25 ,  A61K8/29 ,  A61K8/34 ,  A61K8/36 ,  A61K8/40 ,  A61K8/60 ,  A61K8/72 ,  A61K8/73 ,  A61K8/81 ,  A61K8/85 ,  A61K8/97 ,  A61Q5/06 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/10 ,  A61K7/16 ,  A61K7/18

CPC classification number: A61Q11/00 ,  A61K8/8164

Abstract: A toothpaste or dental gel composition containing an amount of a synthetic linearly viscoelastic cross-linked polymeric thickening agent, especially a cross-linked methyl vinyl ether/maleic anhydride copolymer, effective to render the composition linearly viscoelastic, and a method of promoting oral hygiene by applying an effective amount of the composition to dental surface.

Abstract translation: 含有一定量的合成线性粘弹性交联聚合物增稠剂，特别是交联的甲基乙烯基醚/马来酸酐共聚物的牙膏或牙科凝胶组合物，有效使组合物线性粘弹性，以及通过以下方法促进口腔卫生： 将有效量的组合物施用于牙齿表面。

公开(公告)号：US5000944A

公开(公告)日：1991-03-19

申请号：US364406

申请日：1989-06-09

Applicant: Michael Prencipe ,  Shamsul K. Bakar

Inventor： Michael Prencipe ,  Shamsul K. Bakar

IPC: A61K8/24 ,  A61K8/27 ,  A61Q11/00

CPC classification number: A61Q11/00 ,  A61K8/24 ,  A61K8/27

Abstract: A zinc-containing antitartar oral product substantially free of astringency, containing as the essential agent, a zinc/polyphosphate complex having at least about a 50% water solubility, formed by the reaction or interaction of a zinc compound with a potassium or sodium polyphosphate by dissolving a zinc salt in a polyphosphate solution such as pyrophosphate, tripolyphosphate, hexametaphosphate and combinations thereof.

Abstract translation: 通过锌化合物与多磷酸钾或多磷酸钠的反应或相互作用而形成的含有至少约50％水溶性的锌/多磷酸盐络合物的基本上不含涩味的含锌抗口服制品 将锌盐溶解在聚磷酸盐溶液如焦磷酸盐，三聚磷酸盐，六偏磷酸盐及其组合中。

公开(公告)号：US09775788B2

公开(公告)日：2017-10-03

申请号：US14356687

申请日：2011-11-15

Applicant: Elva Chen ,  Sharon Kennedy ,  Yelloji-Rao Mirajkar ,  Suzanne Jogun ,  Michael Prencipe

Inventor： Elva Chen ,  Sharon Kennedy ,  Yelloji-Rao Mirajkar ,  Suzanne Jogun ,  Michael Prencipe

IPC: A61Q11/00 ,  A61K8/21 ,  A61K8/73 ,  A61K8/04 ,  A61K8/34 ,  A61K8/46 ,  A61K8/49

CPC classification number: A61K8/042 ,  A61K8/345 ,  A61K8/466 ,  A61K8/498 ,  A61K8/73 ,  A61K8/731 ,  A61K2800/45 ,  A61Q11/00

Abstract: The invention provides an orally acceptable plaque indicator gel comprising a dye in sufficient concentration to visibly stain plaque upon application, optionally for use in combination with an orally acceptable plaque removal gel comprising an antiplaque agent in sufficient concentration to remove plaque and or kill bacteria upon application, in each case the gel having a specific viscosity permitting efficient application using a pen dispenser, as well as reduced dye or antiplaque agent concentration, together with methods of using the same.

公开(公告)号：US09486396B2

公开(公告)日：2016-11-08

申请号：US13996036

申请日：2010-12-21

Applicant: Venda Porter Maloney ,  Vyoma Patel ,  Steven Wade Fisher ,  Andre Michelle Morgan ,  Michael Prencipe ,  Stanislav Jaracz

Inventor： Venda Porter Maloney ,  Vyoma Patel ,  Steven Wade Fisher ,  Andre Michelle Morgan ,  Michael Prencipe ,  Stanislav Jaracz

IPC: A61K8/58 ,  A61K8/27 ,  A61Q11/00 ,  A61K8/36 ,  A61K8/362 ,  A61K8/365 ,  A61K8/44

CPC classification number: A61K8/58 ,  A61K8/24 ,  A61K8/27 ,  A61K8/36 ,  A61K8/361 ,  A61K8/362 ,  A61K8/365 ,  A61K8/44 ,  A61Q11/00

Abstract: Described herein are compositions comprising combinations of metal salts, and methods of preparing and using the same.

Abstract translation: 本文描述的是包含金属盐的组合的组合物，以及制备和使用它们的方法。

公开(公告)号：US20160193124A1

公开(公告)日：2016-07-07

申请号：US15068418

申请日：2016-03-11

Applicant: Venda PORTER ,  Andre MORGAN ,  Michael PRENCIPE ,  Sarita MELLO

Inventor： Venda PORTER ,  Andre MORGAN ,  Michael PRENCIPE ,  Sarita MELLO

IPC: A61K8/27 ,  A61K8/86 ,  A61Q11/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/73 ,  A61K8/21

Abstract: Disclosed are oral care compositions, for example dentifrice compositions, comprising an orally acceptable vehicle, metal oxide particles having an average particle size of no greater than a dentin tubule and a polymeric adherent material for adhering the metal oxide particles in the dentin tubule. The metal oxide particles have a median particle size of 5 microns or less, and may comprise zinc oxide.

公开(公告)号：US09308399B2

公开(公告)日：2016-04-12

申请号：US13582115

申请日：2010-03-11

Applicant: Lynette Zaidel ,  Suman Chopra ,  Michael Prencipe ,  Prakasarao Mandadi

Inventor： Lynette Zaidel ,  Suman Chopra ,  Michael Prencipe ,  Prakasarao Mandadi

IPC: A61Q11/00 ,  A61K8/22 ,  A61K8/25 ,  A61K6/00 ,  A61K33/40 ,  A61Q11/02 ,  A61K8/31 ,  A61K8/49 ,  A61K8/81 ,  A61K8/891

CPC classification number: A61Q11/00 ,  A61K8/22 ,  A61K8/31 ,  A61K8/4913 ,  A61K8/8111 ,  A61K8/8176 ,  A61K8/891

Abstract: A tooth whitening composition for whitening a surface of a tooth, the composition comprising a mixture of a whitening agent comprising an aqueous peroxide, a hydrophobic polymer carrier for adhering the tooth whitening composition to a tooth surface and at least one adhesion enhancing agent.

Abstract translation: 一种用于使牙齿表面美白的牙齿美白组合物，所述组合物包含含有过氧化氢的增白剂，用于将牙齿增白组合物粘附到牙齿表面的疏水聚合物载体和至少一种粘合增强剂的混合物。

公开(公告)号：US09125860B2

公开(公告)日：2015-09-08

申请号：US13812266

申请日：2010-07-29

Applicant: Yelloji-Rao K. Mirajkar ,  Guofeng Xu ,  Ying Yang ,  Thomas Boyd ,  Michael Prencipe

Inventor： Yelloji-Rao K. Mirajkar ,  Guofeng Xu ,  Ying Yang ,  Thomas Boyd ,  Michael Prencipe

IPC: A61K36/575 ,  A61Q11/00 ,  A61K8/97 ,  A61K8/27 ,  A61K31/05

CPC classification number: A61K31/05 ,  A61K8/27 ,  A61K8/97 ,  A61K36/575 ,  A61K2300/00 ,  A61Q11/00

Abstract: An oral care composition for treating or preventing calculus comprising an anticalculus agent and an antibacterial agent comprising a biphenol compound obtainable from Magnolia officinalis, wherein the composition is free of phosphate-containing anticalculus agents.

Abstract translation: 一种用于治疗或预防结石的口腔护理组合物，其包含抗结石剂和抗菌剂，其包含可从木兰木兰获得的联苯酚化合物，其中所述组合物不含含磷酸盐的抗牙垢剂。