公开(公告)号：US20070173528A1

公开(公告)日：2007-07-26

申请号：US11645021

申请日：2006-12-21

Applicant: Nurit Perlman ,  Tamar Nidam

Inventor： Nurit Perlman ,  Tamar Nidam

IPC: A61K31/4745 ,  A61K31/47 ,  C07D453/02 ,  C07D217/02

CPC classification number: C07D217/06 ,  C07D453/02

Abstract: Provided are new intermediates of solifenacin and methods for their preparation, as well as methods of preparing solifenacin and solifenacin succinate.

Abstract translation: 提供索非那新的新中间体及其制备方法，以及制备索非那新和索非那新琥珀酸酯的方法。

公开(公告)号：US20060094883A1

公开(公告)日：2006-05-04

申请号：US11250267

申请日：2005-10-13

Applicant: Nurit Perlman ,  Eyal Gilboa

Inventor： Nurit Perlman ,  Eyal Gilboa

IPC: C07D403/02

CPC classification number: C07D235/14 ,  C07D235/18

Abstract: Provided are processes for preparing telmisartan alkyl ester and telmisartan using environmentally friendly organic solvents that are easily removed from the reaction mixture, wherein a telmisartan alkyl ester is isolated and hydrolyzed to form telmisartan or the telmisartan is prepared using a synthesis in a single reaction vessel.

公开(公告)号：US08329696B2

公开(公告)日：2012-12-11

申请号：US12749486

申请日：2010-03-29

Applicant: Gideon Pilarski ,  Nurit Perlman ,  Ariel Mittelman ,  Nada Kosutic Hulita ,  Marina Kalujny ,  Revital Ramaty

Inventor： Gideon Pilarski ,  Nurit Perlman ,  Ariel Mittelman ,  Nada Kosutic Hulita ,  Marina Kalujny ,  Revital Ramaty

IPC: A61K31/495

CPC classification number: C07D487/04

Abstract: Solid state forms of Sitagliptin salts (e.g. Sitagliptin sulfate, Formula I), processes for preparing the solid state forms, and pharmaceutical compositions thereof, are provided. These compounds are of a class of dipeptidyl peptidase IV enzyme inhibitors which are useful, for example, for the manufacture of a medicament for the treatment of type 2 diabetes mellitus.

Abstract translation: 提供西他列汀盐（例如硫酸西替他嗪，式I）的固体形式，制备固体形式的方法及其药物组合物。 这些化合物是一类二肽基肽酶IV酶抑制剂，其可用于例如制备用于治疗2型糖尿病的药物。

公开(公告)号：US08183373B2

公开(公告)日：2012-05-22

申请号：US13077119

申请日：2011-03-31

Applicant: Ariel Mittelman ,  Nada Kosutic Hulita ,  Nurit Perlman ,  Motti Erlich ,  Luna Ben-Sahel Katzav

Inventor： Ariel Mittelman ,  Nada Kosutic Hulita ,  Nurit Perlman ,  Motti Erlich ,  Luna Ben-Sahel Katzav

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Crystalline forms of Sitagliptin salts, processes for preparing crystalline forms of Sitagliptin salts, and pharmaceutical compositions of Sitagliptin salts are provided.

Abstract translation: 提供了西他列汀盐的结晶形式，西他列汀盐的结晶形式的制备方法和西格列汀盐的药物组合物。

公开(公告)号：US20090124814A1

公开(公告)日：2009-05-14

申请号：US12319834

申请日：2009-01-12

Applicant: Nurit Perlman ,  Eyal Gilboa

Inventor： Nurit Perlman ,  Eyal Gilboa

IPC: C07D403/02

CPC classification number: C07D235/14 ,  C07D235/18

Abstract: Provided are processes for preparing telmisartan-alkyl ester and telmisartan using environmentally friendly organic solvents that are easily removed from the reaction mixture, wherein a telmisartan alkyl ester is isolated and hydrolyzed to form telmisartan or the telmisartan is prepared using a synthesis in a single reaction vessel.

Abstract translation: 提供了使用易于从反应混合物中除去的环境友好的有机溶剂来制备替米沙坦 - 烷基酯和替米沙坦的方法，其中分离并水解替米沙坦烷基酯以形成替米沙坦，或者使用单个反应容器中的合成制备替米沙坦 。

公开(公告)号：US20090093631A1

公开(公告)日：2009-04-09

申请号：US12231769

申请日：2008-09-05

Applicant: Ben-Zion Dolitzky ,  Nurit Perlman ,  Marina Kalujny

Inventor： Ben-Zion Dolitzky ,  Nurit Perlman ,  Marina Kalujny

IPC: C07D413/10

CPC classification number: C07D263/24 ,  C07D263/26

Abstract: Provided are methods for the enantiomeric purification of Linezolid hydroxide, comprising providing a solution or a slurry of Linezolid hydroxide and a solvent selected from alcohols and ketones and crystallizing Linezolid hydroxide from the solution or slurry to obtain Linezolid hydroxide with a low content of S isomer.

Abstract translation: 本发明提供了利奈唑烷氢氧化物的对映异构体纯化方法，包括从溶液或浆液中提供选自醇和酮的溶剂或溶剂和选自醇和酮的溶剂和结晶的利奈唑烷，以获得具有低含量的S异构体的生产线型利唑烷。

公开(公告)号：US20080032964A1

公开(公告)日：2008-02-07

申请号：US11786449

申请日：2007-04-10

Applicant: Vinod Kansal ,  Suhail Ahmad ,  Shanmugavel Mariappan ,  Bhupendra Tyagi ,  Nurit Perlman ,  Jacques Le Paih ,  Antonio Zanotti-Gerosa

Inventor： Vinod Kansal ,  Suhail Ahmad ,  Shanmugavel Mariappan ,  Bhupendra Tyagi ,  Nurit Perlman ,  Jacques Le Paih ,  Antonio Zanotti-Gerosa

IPC: A61K31/397 ,  A61P3/06 ,  C07C31/20 ,  C07D205/04 ,  C07D317/26 ,  C07D319/06 ,  C07D321/06 ,  C07D321/12 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06

CPC classification number: C07D413/06 ,  C07D317/30 ,  C07D319/06 ,  C07D321/06 ,  C07D405/06 ,  C07D417/06

Abstract: Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

Abstract translation: 提供了可用于合成羟基 - 烷基取代的氮杂环丁酮的中间体，其制备方法以及合成某些羟基 - 烷基取代的氮杂环丁酮的方法。 还提供了合成1-（4-氟苯基）-3（R） - [3-（4-氟苯基）-3（S） - 羟丙基] -4（S） - （4-羟基苯基）-2 - 氮杂环丁酮或依泽替米贝。

公开(公告)号：US20060293377A1

公开(公告)日：2006-12-28

申请号：US11267520

申请日：2005-11-03

Applicant: Shlomit Wizel ,  Nurit Perlman ,  Sharon Avhar-Maydan ,  Eyal Gilboa

Inventor： Shlomit Wizel ,  Nurit Perlman ,  Sharon Avhar-Maydan ,  Eyal Gilboa

IPC: A61K31/4184 ,  C07D403/02

CPC classification number: C07D235/20

Abstract: Provided is the amorphous form of telmisartan sodium and the preparation thereof. Also provided are the telmisartan sodium polymorph crystal Forms 0 to XIII and XV to XX and preparations thereof. Also provided are pharmaceutical composition of amorphous and polymorphic forms of telmisartan sodium or mixtures thereof, and methods of treatment of a mammal in need thereof.

Abstract translation: 提供替米沙坦钠的无定形形式及其制备方法。 还提供了替米沙坦钠多晶型晶型0至XIII和XV至XX及其制剂。 还提供了替米沙坦钠或其混合物的无定形和多晶型形式的药物组合物，以及治疗有需要的哺乳动物的方法。

公开(公告)号：US20050159615A1

公开(公告)日：2005-07-21

申请号：US11020834

申请日：2004-12-23

Applicant: Revital Lifshitz-Liron ,  Nurit Perlman

Inventor： Revital Lifshitz-Liron ,  Nurit Perlman

IPC: C07C69/66 ,  C07D309/00

CPC classification number: C07D239/42 ,  C07D207/337 ,  C07D209/12 ,  C07D209/18 ,  C07D213/55 ,  C07D215/14

Abstract: Provided is a process for reduction of statin ketoesters and purification of diol esters of the statins through selective crystallization.

Abstract translation: 提供了通过选择性结晶降低他汀类酮酯并且通过选择性结晶纯化他汀类的二醇酯的方法。

公开(公告)号：US20090221595A1

公开(公告)日：2009-09-03

申请号：US12313975

申请日：2008-11-25

Applicant: Nurit Perlman ,  Revital Ramaty ,  Eli Lancry ,  Marina Kalujny

Inventor： Nurit Perlman ,  Revital Ramaty ,  Eli Lancry ,  Marina Kalujny

IPC: A61K31/4985 ,  C07D471/04 ,  A61P3/10

CPC classification number: C07D487/04

Abstract: A Sitagliptin crystalline form characterized by PXRD pattern having any 5 peaks selected from the group consisting of 7.4, 11.5, 16.7, 17.7, 18.9, 24.1, 24.5, 27.0, 28.5 and 28.8±0.2 degrees 2-theta, wherein any combination of peaks selected includes the peak at 7.4±0.2 degrees two theta, processes for preparing said Sitagliptin crystalline form, and pharmaceutical compositions thereof, are provided.

Abstract translation: 西他列汀结晶形式，其特征在于具有选自7.4,11.5,16.7,17.7,18.9,24.1,24.5,27.0,28.5和28.8±0.2度2-θ的任何5个峰的PXRD图，其中所选择的峰的任意组合 包括峰值在7.4±0.2度2θ，制备所述西格列汀结晶形式的方法及其药物组合物。