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公开(公告)号：US10799696B2
公开(公告)日：2020-10-13
申请号：US15904036
申请日：2018-02-23
Applicant: Oculeve, Inc.
Inventor： James Donald Loudin , Amitava Gupta , John Wardle , Christopher William Stivers , Anand Doraiswamy , Marie Dvorak Christ , F. Richard Christ
IPC: A61N1/05 , H01B1/12 , A61N1/04 , C08F220/54 , C08F230/08 , C08F220/20 , A61N1/36
Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.
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公开(公告)号：US10799695B2
公开(公告)日：2020-10-13
申请号：US15851505
申请日：2017-12-21
Applicant: Oculeve, Inc.
Inventor： Douglas Michael Ackermann , James Donald Loudin , John Wardle , Janusz Kuzma
IPC: A61N1/36 , A61N1/05 , A61H1/00 , A61F7/12 , A61H9/00 , A61H21/00 , A61H23/02 , A61N1/378 , H02J7/00 , A61N1/04 , A61N7/00 , A61M31/00
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
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公开(公告)号：US10155108B2
公开(公告)日：2018-12-18
申请号：US14256916
申请日：2014-04-18
Applicant: Oculeve, Inc.
Inventor： Douglas Michael Ackermann , James Donald Loudin
IPC: A61N1/18 , A61N1/05 , A61N1/36 , A61H1/00 , A61F7/12 , A61N1/378 , A61H9/00 , A61H21/00 , A61H23/02 , H02J7/00 , A61N1/04 , A61M31/00 , A61N7/00
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
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公开(公告)号：US10112048B2
公开(公告)日：2018-10-30
申请号：US15676910
申请日：2017-08-14
Applicant: Oculeve, Inc.
Inventor： Manfred Franke , James Donald Loudin , John Wardle , Mark Jeffrey Holdbrook
Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.
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Patent Agency Ranking
公开(公告)号：US20180154137A1
公开(公告)日：2018-06-07
申请号：US15851505
申请日：2017-12-21
Applicant: Oculeve, Inc.
Inventor： Douglas Michael ACKERMANN , James Donald LOUDIN , John WARDLE , Janusz KUZMA
IPC: A61N1/05 , A61H1/00 , A61N1/36 , A61H21/00 , A61H23/02 , A61N7/00 , A61F7/12 , H02J7/00 , A61N1/04 , A61N1/378 , A61H9/00 , A61M31/00
Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
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公开(公告)号：US20180153394A1
公开(公告)日：2018-06-07
申请号：US15827683
申请日：2017-11-30
Applicant: Oculeve, Inc.
Inventor： Manfred FRANKE , Chao LIU , Abirami MURALIDHARAN , James Donald LOUDIN , Douglas Michael ACKERMANN , Michael G. ROGERS
CPC classification number: A61B3/101 , A61B3/0025 , A61B3/0033 , A61B5/6802 , A61B5/742 , A61K9/0048 , G06F19/3418 , G16H15/00 , G16H20/00 , G16H50/20
Abstract: Generally, a machine may include a processor and a memory connected to the processor, where the memory stores instructions executed by the processor to determine first and second properties related to dry eye symptoms of a patient. The properties may be used to form a dry eye forecast. A treatment recommendation may be selected based at least in part upon the dry eye forecast. The treatment recommendation may be supplied to a device.
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公开(公告)号：US20170252563A1
公开(公告)日：2017-09-07
申请号：US15598063
申请日：2017-05-17
Applicant: Oculeve, Inc.
Inventor： Manfred FRANKE , James Donald LOUDIN
IPC: A61N1/02
Abstract: Described herein are electrical stimulation patterns and methods of use thereof for treating dry eye disease, tired eye, or other forms of ocular discomfort. The methods generally include applying patterned stimulation to an anatomical structure located in an ocular region or a nasal region to increase tear production.
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公开(公告)号：US20170239459A1
公开(公告)日：2017-08-24
申请号：US15438577
申请日：2017-02-21
Applicant: Oculeve, Inc.
Inventor： James Donald LOUDIN , Daniel N. HAMILTON , Manfred FRANKE , Douglas Michael ACKERMANN
CPC classification number: A61N1/0546 , A61N1/0456 , A61N1/36014 , A61N1/36034
Abstract: Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.
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公开(公告)号：US20160121118A1
公开(公告)日：2016-05-05
申请号：US14920860
申请日：2015-10-22
Applicant: Oculeve, Inc.
Inventor： Manfred FRANKE , James Donald LOUDIN , John WARDLE , Mark Jeffrey HOLDBROOK
CPC classification number: A61N1/36046 , A61N1/0526 , A61N1/0546 , A61N1/3606 , A61N1/36146 , A61N1/37205 , A61N1/37247 , A61N1/3756 , A61N1/3758
Abstract: Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described.
Abstract translation: 本文描述了用于治疗干眼症，疲劳的眼睛或其它形式的眼部不适的装置和方法，例如由隐形眼镜。 方法通常包括将空间和/或时间图案化的刺激应用于位于眼睛或鼻部区域中的一个或多个解剖结构。 电刺激可以引起激活泪腺的反射，或者可以直接激活支配泪腺的泪腺或神经以产生泪液。 所述装置可以是可植入的或手持式的，并且可以被配置为递送所描述的空间和/或时间图案化的刺激图案。
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