公开(公告)号：US20210069496A1

公开(公告)日：2021-03-11

申请号：US17018888

申请日：2020-09-11

Applicant: Oculeve, Inc.

Inventor： James Donald Loudin ,  Amitava Gupta ,  John L. Wardle ,  Christopher William Stivers ,  Anand Doraiswamy ,  Marie Dvorak Christ ,  F. Richard Christ

IPC: A61N1/05 ,  H01B1/12 ,  A61N1/04 ,  C08F220/54 ,  C08F230/08 ,  C08F220/20

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

公开(公告)号：US09440065B2

公开(公告)日：2016-09-13

申请号：US14313937

申请日：2014-06-24

Applicant: Oculeve, Inc.

Inventor： Douglas Michael Ackermann ,  James Donald Loudin ,  John Wardle ,  Jarren Armond Baldwin ,  Daniel N. Hamilton ,  Janusz Kuzma ,  Christopher William Stivers ,  Manfred Franke

IPC: A61N1/05 ,  A61N1/36 ,  A61H1/00 ,  A61F7/12 ,  A61N1/378 ,  A61H9/00 ,  A61H21/00 ,  A61H23/02 ,  H02J7/00 ,  A61M31/00 ,  A61N7/00

CPC classification number: A61N1/0546 ,  A61F7/12 ,  A61H1/00 ,  A61H9/0071 ,  A61H21/00 ,  A61H23/02 ,  A61H23/0218 ,  A61H23/0245 ,  A61H23/0263 ,  A61H2201/0153 ,  A61H2201/0173 ,  A61H2201/0207 ,  A61H2201/0214 ,  A61H2201/025 ,  A61H2201/10 ,  A61H2201/165 ,  A61H2201/5002 ,  A61H2201/5005 ,  A61H2201/5015 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5043 ,  A61H2205/023 ,  A61H2205/024 ,  A61M31/00 ,  A61N1/0456 ,  A61N1/36014 ,  A61N1/36046 ,  A61N1/36071 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/3615 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/3787 ,  A61N7/00 ,  A61N2007/0043 ,  H02J7/0044

Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

公开(公告)号：US10799696B2

公开(公告)日：2020-10-13

申请号：US15904036

申请日：2018-02-23

Applicant: Oculeve, Inc.

Inventor： James Donald Loudin ,  Amitava Gupta ,  John Wardle ,  Christopher William Stivers ,  Anand Doraiswamy ,  Marie Dvorak Christ ,  F. Richard Christ

IPC: A61N1/05 ,  H01B1/12 ,  A61N1/04 ,  C08F220/54 ,  C08F230/08 ,  C08F220/20 ,  A61N1/36

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

公开(公告)号：US08996137B2

公开(公告)日：2015-03-31

申请号：US14256915

申请日：2014-04-18

Applicant: Oculeve, Inc.

Inventor： Douglas Michael Ackermann ,  James Donald Loudin ,  John Wardle ,  Jarren Armond Baldwin ,  Daniel N. Hamilton ,  Janusz Kuzma ,  Christopher William Stivers

IPC: A61N1/20 ,  A61N1/05 ,  A61N1/36 ,  A61H1/00 ,  A61M31/00 ,  A61F7/12

CPC classification number: A61N1/0546 ,  A61F7/12 ,  A61H1/00 ,  A61H9/0071 ,  A61H21/00 ,  A61H23/02 ,  A61H23/0218 ,  A61H23/0245 ,  A61H23/0263 ,  A61H2201/0153 ,  A61H2201/0173 ,  A61H2201/0207 ,  A61H2201/0214 ,  A61H2201/025 ,  A61H2201/10 ,  A61H2201/165 ,  A61H2201/5002 ,  A61H2201/5005 ,  A61H2201/5015 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5043 ,  A61H2205/023 ,  A61H2205/024 ,  A61M31/00 ,  A61N1/0456 ,  A61N1/36014 ,  A61N1/36046 ,  A61N1/36071 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/3615 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/3787 ,  A61N7/00 ,  A61N2007/0043 ,  H02J7/0044

Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

Abstract translation: 这里描述了通过向鼻腔或鼻窦组织提供刺激来治疗一种或多种病症（如干眼症）或改善眼部健康的装置，系统和方法。 通常，设备可以是手持式的或可植入的。 在一些变型中，手持装置可以具有刺激器主体和具有一个或多个鼻插入尖端的刺激器探针。 当装置和系统用于治疗干眼症时，可以刺激鼻或鼻窦组织以增加泪液产生，减少干眼症状和/或改善眼部表面的健康。

公开(公告)号：US10537469B2

公开(公告)日：2020-01-21

申请号：US15649364

申请日：2017-07-13

Applicant: Oculeve, Inc.

Inventor： Janusz Kuzma ,  Douglas Michael Ackermann ,  Christopher William Stivers

IPC: A61F9/007 ,  A61F9/00 ,  A61F2/14 ,  A61F2/16 ,  A61M31/00

Abstract: Systems, devices, and methods for delivering an implant to the orbit. In some instances, the systems may include a delivery device having a tongue member and a handle. The delivery device may further include an ejector configured to deliver an implant from the tongue member. The delivery device may also include a piercing member configured to create an opening in tissue. The systems may further include a piercing member for creating an opening in tissue. In some instances, the piercing member may have a first blade member rotatably connected to a second blade member.

公开(公告)号：US20200038238A1

公开(公告)日：2020-02-06

申请号：US16595841

申请日：2019-10-08

Applicant: Oculeve, Inc.

Inventor： Janusz Kuzma ,  Douglas Michael Ackermann ,  Christopher William Stivers

IPC: A61F9/007 ,  A61F9/00

Abstract: Described here are systems, devices, and methods for delivering an implant to the orbit. In some instances, the systems may comprise a delivery device having a tongue member and a handle. The delivery device may further include an ejector configured to deliver an implant from the tongue member. The delivery device may also include a piercing member configured to create an opening in tissue. The systems may further comprise a piercing member for creating an opening in tissue. In some instances, the piercing member may have a first blade member rotatably connected to a second blade member.

公开(公告)号：US09717627B2

公开(公告)日：2017-08-01

申请号：US14207072

申请日：2014-03-12

Applicant: Oculeve, Inc.

Inventor： Janusz Kuzma ,  Douglas Michael Ackermann ,  Christopher William Stivers

IPC: A61F9/007 ,  A61F9/00 ,  A61F2/14 ,  A61F2/16 ,  A61M31/00

CPC classification number: A61F9/007 ,  A61F2/14 ,  A61F2/141 ,  A61F2/148 ,  A61F2/1662 ,  A61F9/0017 ,  A61M31/007 ,  A61M2210/0612

Abstract: Systems, devices, and methods for delivering an implant to the orbit. In some instances, the systems may include a delivery device having a tongue member and a handle. The delivery device may further include an ejector configured to deliver an implant from the tongue member. The delivery device may also include a piercing member configured to create an opening in tissue. The systems may further include a piercing member for creating an opening in tissue. In some instances, the piercing member may have a first blade member rotatably connected to a second blade member.