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公开(公告)号：US11150253B2
公开(公告)日：2021-10-19
申请号：US15498746
申请日：2017-04-27
Inventor： Midori Shima , Keiji Nogami , Tomoko Matsumoto , Sho Shinohara , Nobuo Arai
Abstract: Disclosed is a method for analyzing a blood specimen, including the steps of: coagulating a blood specimen in the presence of an activating agent for fibrinolytic system to acquire a coagulation waveform; and acquiring information about fibrinolytic capacity of the blood specimen based on the acquired coagulation waveform.
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公开(公告)号：US20210282800A1
公开(公告)日：2021-09-16
申请号：US17258429
申请日：2018-07-27
Inventor： Yasuaki NAKANISHI , Shohei OMOKAWA , Hiroo NAKAGAWA
IPC: A61B17/3205
Abstract: To provide a transplant-use tendon harvesting device that can harvest a tendon more easily.
The transplant-use tendon harvesting device 1 includes a mantle portion 5 and a tendon separation element 8. The mantle portion 5 is configured to be inserted into a body from an incision portion 4 and moved along a tendon 3 to be harvested. The tendon separation element 8 is formed of an elastic member and attached to the mantle portion 5 to move along the tendon 3 together with the mantle portion 5 so as to separate an end portion of the tendon 3 on the moving direction side from another tissue. The tendon separation element 8 includes a separation functional portion 6 to cause the tendon 3 to pass inside at a time of moving along the tendon 3 to separate the tendon 3 and linear portions 11 and 12 inserted into the mantle portion 5 to be fixed.-
公开(公告)号：US11078518B2
公开(公告)日：2021-08-03
申请号：US14431425
申请日：2013-09-26
Inventor： Tetsuhiro Soeda , Takehisa Kitazawa , Midori Shima
Abstract: Various methods for evaluating hemostatic effect and various blood coagulation initiation reagents were studied to construct a method for evaluating blood coagulation reaction mediated by a substance having an activity of substituting for coagulation factor VIII (FVIII). As a result, it was discovered that by using a coagulation initiation reagent containing activated coagulation factor XI (FXIa) and phospholipids, the effect of a substance having an activity of substituting for coagulation factor VIII (FVIII) on blood coagulation reaction can be evaluated using the amount of thrombin generated in the blood sample as an indicator.
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公开(公告)号：US20210107994A1
公开(公告)日：2021-04-15
申请号：US16496089
申请日：2018-03-30
Inventor： Midori Shima , Keiji Nogami , Kenichi Ogiwara
IPC: C07K16/36
Abstract: The present inventors examined the procoagulant activity of a multispecific antigen-binding molecule that functionally substitutes for FVIII using blood and plasma derived from FIX disorder patients. The result showed that multispecific antigen-binding molecules that functionally substitute for FVIII can be used not only as methods for preventing and/or treating bleeding in hemophilia A, acquired hemophilia A, von Willebrand disease, and hemophilia C, which are caused by FVIII dysfunction, but also as methods for preventing and/or treating bleeding in FIX disorders, because of their procoagulant activity. Furthermore, the effect of a FIX formulation could be enhanced by using it in combination with a multispecific antigen-binding molecule that functionally substitutes for FVIII, and it was shown that the combined use is promising as a combination therapy that shows stable hemostatic effects.
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公开(公告)号：US20190313921A1
公开(公告)日：2019-10-17
申请号：US16452764
申请日：2019-06-26
Applicant: OMRON HEALTHCARE Co., Ltd. , A SCHOOL CORPORATION KANSAI UNIVERSITY , PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY
Inventor： Miki IMAMURA , Yukiya SAWANOI , Toshihiko OGURA , Hideo UTSUNO , Kimihiko KICHIKAWA , Shigeo ICHIHASHI , Shinichi IWAKOSHI
Abstract: A measurement device includes a pulse wave signal acquisition unit, a pulse wave velocity calculator, a transfer function calculator, a phase diagram classifier, and an aneurysm determinator. The pulse wave signal acquisition unit acquires time-series pulse wave signals of each of an upper arm and an ankle of the subject. The pulse wave velocity calculator obtains a brachial-ankle pulse wave velocity based on the pulse wave signal of the upper arm and the pulse wave signal of the ankle. The transfer function calculator calculates a transfer function from the pulse wave signal of the upper arm and the pulse wave signal of the ankle. The phase diagram classifier classifies the phase diagram of each subject into any one of four groups. The aneurysm determinator determines presence or absence of the abdominal aortic aneurysm by a criterion set according to each group.
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Patent Agency Ranking
公开(公告)号：US20170086803A1
公开(公告)日：2017-03-30
申请号：US15312164
申请日：2014-12-24
Inventor： Yasuaki NAKANISHI , Akinobu HAKODA , Keiko Matsuyoshi
IPC: A61B17/00 , A61B17/3211 , A61B17/3209
CPC classification number: A61B17/00008 , A61B17/32 , A61B17/320036 , A61B17/3209 , A61B17/3211 , A61B2017/320052 , A61B2017/32096 , A61B2017/3407
Abstract: To provide a surgical instrument for performing incision that enables surgery to be performed safely and easily, with minimal invasiveness and a reduced risk of damaging a tissue, such as a tendon, nerve, or blood vessel.The surgical instrument for performing incision includes incision reception means that receives an incision portion of a tendon sheath and an aponeurotic membrane, guide fixture means that fixes the incision reception means outside a body, and incision means that performs incision under guidance of the guide fixture means, the instrument being configured to incise a tendon sheath and an aponeurotic membrane by pressing and moving the incision means against the incision reception means. This surgical instrument for performing incision enables a tendon sheath and an aponeurotic membrane to be incised safely without significantly incising the skin or subcutaneous tissue, and makes it possible to conduct surgery percutaneously at an extremely low level of invasion.
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公开(公告)号：US20160178651A1
公开(公告)日：2016-06-23
申请号：US14969698
申请日：2015-12-15
Inventor： Midori SHIMA , Keiji NOGAMI , Yuka TABUCHI , Hiroshi KURONO
CPC classification number: G01N33/86 , G01N21/49 , G01N21/75 , G01N21/82 , G01N33/4905 , G01N2021/825 , G01N2800/224
Abstract: Disclosed is a blood sample determination method including: emitting light to a measurement specimen prepared by mixing a clotting time measuring reagent and a blood sample suspected to be derived from a subject having lupus anticoagulant or a coagulation factor inhibitor, to obtain optical information about an amount of light from the measurement specimen; obtaining at least one parameter regarding derivative of clot waveform, based on the obtained optical information; and determining, based on a value of the obtained parameter, whether the blood sample is suspected to be a sample derived from a subject having lupus anticoagulant or is suspected to be a sample derived from a subject having a coagulation factor inhibitor.
Abstract translation: 本发明提供一种血液样品测定方法，其特征在于，向通过混合凝血时间测定试剂和怀疑来源于具有狼疮抗凝剂或凝血因子抑制剂的受试者的血液样品而制备的测定试样照射光，得到关于量 来自测量样本的光; 基于获得的光学信息获得关于凝块波形的导数的至少一个参数; 以及基于获得的参数的值来确定是否怀疑血液样品是源自具有狼疮抗凝血剂的受试者的样品，或者怀疑是来自具有凝血因子抑制剂的受试者的样品。
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28.发明公开公开(公告)号：US20230310554A1
公开(公告)日：2023-10-05
申请号：US18023202
申请日：2021-08-27
Applicant: KEIO UNIVERSITY , PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY , KIMIGAFUCHI GAKUEN
Inventor： Kazuaki TAGUCHI , Yuto SUZUKI , Kazuaki MATSUMOTO , Hiromi SAKAI , Masaki OTAGIRI
Abstract: The present invention is intended to provide a medicament for cyanide poisoning, hydrogen sulfide poisoning, and azide poisoning, wherein the medicament does not cause side effects, is excellent in immediate effectiveness, and has a high antidotal effect. Specifically, the present invention relates to a medicament for cyanide poisoning, hydrogen sulfide poisoning, and azide poisoning, wherein the medicament comprises, as an active ingredient(s), one or more selected from the group consisting of a heme protein capable of binding to cyanide ions (CN−), hydrogen sulfide ions (HS−) and azide ions (N3−), a substance containing a heme protein capable of binding to CN−, HS− and N3−, and a heme derivative capable of binding to CN−, HS− and N3−. More specifically, the present invention relates to a medicament or a pharmaceutical composition for the treatment or prophylaxis of cyanide poisoning, hydrogen sulfide poisoning, and azide poisoning.
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公开(公告)号：US20220146537A1
公开(公告)日：2022-05-12
申请号：US17427000
申请日：2020-01-31
Inventor： Toshiki KAWABE , Yukio ODA , Midori SHIMA , Keiji NOGAMI , Kenichi OGIWARA
Abstract: To provide a method for analyzing coagulation characteristics of a blood specimen. To provide a method for analyzing a blood specimen, including: acquiring a waveform related to a coagulation rate or coagulation acceleration of a sample obtained by mixing a subject blood specimen with a reagent for measuring coagulation time; extracting multiple parameters characterizing the waveform related to a coagulation rate or a coagulation acceleration; and determining an activity level or activity abnormality of a coagulation factor in the subject blood specimen on the basis of the multiple parameters.
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公开(公告)号：US10383609B2
公开(公告)日：2019-08-20
申请号：US15312164
申请日：2014-12-24
Inventor： Yasuaki Nakanishi , Akinobu Hakoda , Keiko Matsuyoshi
IPC: A61B17/00 , A61B17/3209 , A61B17/3211 , A61B17/32 , A61B17/34
Abstract: To provide a surgical instrument for performing incision that enables surgery to be performed safely and easily, with minimal invasiveness and a reduced risk of damaging a tissue, such as a tendon, nerve, or blood vessel. This surgical instrument enables a tendon sheath and an aponeurotic membrane to be incised safely without significantly incising the skin or subcutaneous tissue, and makes it possible to conduct surgery percutaneously at an extremely low level of invasion.
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