公开(公告)号：US5763564A

公开(公告)日：1998-06-09

申请号：US627790

申请日：1996-03-29

Applicant: Patrick Richard Gruber ,  Jeffrey John Kolstad ,  Eric Stanley Hall ,  Robin Sue Eichen Conn ,  Christopher M. Ryan

Inventor： Patrick Richard Gruber ,  Jeffrey John Kolstad ,  Eric Stanley Hall ,  Robin Sue Eichen Conn ,  Christopher M. Ryan

IPC: C08K3/16 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/88 ,  C08G63/90 ,  C08J5/18 ,  C08K3/22 ,  C08K3/26 ,  C08K3/30 ,  C08K3/34 ,  C08K5/10 ,  C08K5/13 ,  C08K5/1515 ,  C08K5/1575 ,  C08K5/29 ,  C08K5/51 ,  C08K5/524 ,  C08K5/54 ,  C08L67/00 ,  C08L67/04 ,  C08L101/00 ,  C08L101/16 ,  C09D167/04 ,  D01F6/62 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62

CPC classification number: C08J5/18 ,  A61L15/26 ,  A61L31/06 ,  C08G63/08 ,  C08G63/90 ,  C08L67/04 ,  C09D167/04 ,  D01F6/625 ,  D04H1/42 ,  D21H19/28 ,  D21H19/62 ,  C08G2230/00 ,  C08J2367/04 ,  C08L101/00 ,  Y10T428/31504 ,  Y10T428/31786 ,  Y10T428/3179 ,  Y10T428/31808 ,  Y10T428/31819 ,  Y10T428/31993

Abstract: A lactide polymer composition combining compositional and purity limitations and catalyst optimization or addition of stabilizing agents resulting in a melt-stable polymer is disclosed. The melt-stable lactide polymer comprises a plurality of polylactide polymer chains, residual lactide in concentration of less than 2 percent and water in concentration of less than 1000 parts-per-million. A stabilizing agent in an amount sufficient to reduce depolymerization of the lactide polymer during melt-processing or alternatively, control of catalyst level at a molar ratio of monomer to catalyst greater than 3000:1 is also included in the melt-stable composition. A process for manufacture of a melt-stable lactide polymer composition includes polymerizing a lactide mixture and adding stabilizing agents sufficient to reduce depolymerization of the polylactide during melt-processing, followed by devolatilizing the polylactide to remove monomer and water.