公开(公告)号：US20190010491A1

公开(公告)日：2019-01-10

申请号：US15732957

申请日：2018-01-16

Applicant: Rosetta Genomics Ltd.

Inventor： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

IPC: C12N15/113 ,  C12Q1/6886

Abstract: Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods ad compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

公开(公告)号：US09845470B2

公开(公告)日：2017-12-19

申请号：US15334422

申请日：2016-10-26

Applicant: Regulus Therapeutics Inc. ,  Rosetta Genomics Ltd.

Inventor： C. Frank Bennett ,  Ayelet Chajut ,  Christine Esau ,  Eric Marcusson ,  Noga Yerushalmi

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/7088 ,  A61K31/513 ,  A61K31/7068 ,  A61K31/704 ,  A61K31/407 ,  A61K31/44 ,  A61K31/7048 ,  A61K31/555 ,  A61K31/4745

CPC classification number: C12N15/113 ,  A61K31/407 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61K31/7088 ,  A61K31/7105 ,  A61K45/06 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.

公开(公告)号：US20170240894A1

公开(公告)日：2017-08-24

申请号：US15586783

申请日：2017-05-04

Applicant: Rosetta Genomics Ltd.

Inventor： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2330/10 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  Y02A90/26

Abstract: Described herein are polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

公开(公告)号：US20170226510A1

公开(公告)日：2017-08-10

申请号：US15731118

申请日：2017-04-21

Applicant: Rosetta Genomics Ltd.

Inventor： Itzhak Bentwich ,  Amir Avniel ,  Yael Karov ,  Ranit Aharonov

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2330/10 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  Y02A90/26

Abstract: Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

公开(公告)号：US09708667B2

公开(公告)日：2017-07-18

申请号：US15237364

申请日：2016-08-15

Applicant: ROSETTA GENOMICS, LTD.

Inventor： Gila Lithwick Yanai ,  Eti Meiri ,  Yael Spector ,  Hila Benjamin ,  Nir Dromi

IPC: C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  G06F19/18 ,  G06F19/20

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/178 ,  G06F19/18 ,  G06F19/20

Abstract: The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.

公开(公告)号：US20170137811A1

公开(公告)日：2017-05-18

申请号：US15334422

申请日：2016-10-26

Applicant: Regulus Therapeutics Inc. ,  Rosetta Genomics Ltd.

Inventor： C. Frank Bennett ,  Ayelet Chajut ,  Christine Esau ,  Eric Marcusson ,  Noga Yerushalmi

IPC: C12N15/113 ,  A61K31/513 ,  A61K31/7068 ,  A61K31/4745 ,  A61K31/407 ,  A61K31/44 ,  A61K31/7048 ,  A61K31/555 ,  A61K31/7088 ,  A61K31/704

CPC classification number: C12N15/113 ,  A61K31/407 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61K31/7088 ,  A61K31/7105 ,  A61K45/06 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.

公开(公告)号：US20140179757A1

公开(公告)日：2014-06-26

申请号：US13986802

申请日：2013-06-06

Applicant: ROSETTA GENOMICS, LTD.

Inventor： Issac Bentwich ,  Amir Avniel ,  Ranit Aharonov ,  Yael Karov ,  Yonat Shemer-Avni ,  Asaf Levy

IPC: C12N15/113

CPC classification number: C12N15/1133 ,  A61K48/00 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/1132 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2330/10 ,  C12N2330/31 ,  C12N2710/16022 ,  C12N2760/16122 ,  C12N2760/18522

Abstract: Provided herein are isolated viral and human nucleic acids associated with viral infection and various nucleic acid molecules relating thereto or derived therefrom. The nucleic acids may be useful for the prevention, treatment and diagnosis of viral infections.

Abstract translation: 本文提供了与病毒感染相关的分离的病毒和人核酸以及与其相关或由其衍生的各种核酸分子。 核酸可用于预防，治疗和诊断病毒感染。

公开(公告)号：US20220267863A1

公开(公告)日：2022-08-25

申请号：US17740067

申请日：2022-05-09

Applicant: ROSETTA GENOMICS LTD.

Inventor： Ofer Nativ ,  Yaron Goren

IPC: C12Q1/6886

Abstract: Described herein are compositions and methods for the prediction of bladder cancer risk of invasiveness. The compositions are microRNA molecules associated with the prognosis of bladder cancer, as well as various nucleic acid molecules relating thereto or derived therefrom.

公开(公告)号：US20190032142A1

公开(公告)日：2019-01-31

申请号：US15909145

申请日：2018-03-01

Applicant: Rosetta Genomics Ltd.

Inventor： Ranit Aharonov ,  Nitzan Rosenfeld ,  Shai Rosenwald ,  Nir Dromi

IPC: C12Q1/6886

Abstract: The present invention provides a process for classification of cancers and tissues of origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA tree-based expression framework allows optimization of treatment, and determination of specific therapy.

公开(公告)号：US20180127835A1

公开(公告)日：2018-05-10

申请号：US15853258

申请日：2017-12-22

Applicant: Rosetta Genomics Ltd.

Inventor： Ranit Aharonov ,  Nitzan Rosenfeld ,  Shai Rosenwald

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The present invention provides a process for classification of cancers and tissues of origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA tree-based expression framework allows optimization of treatment, and determination of specific therapy.