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公开(公告)号：US20180292397A1
公开(公告)日：2018-10-11
申请号：US16002305
申请日：2018-06-07
发明人： Michael NGUYEN , Robert PARKHILL
IPC分类号： G01N33/543 , G01N35/02 , B01L9/00 , G01N33/53
摘要： A system and method provide for high through put determination of agglutination states. The system includes a rotating table and multiple plate tilting stations. The system also includes one or more optical paths positioned to image entire plate arrays in tilted and/or untilted configurations. The system preferably includes image analysis software to analyze an image of an array of test wells and determine an agglutination state of each well based on the image analysis.
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22.发明申请公开(公告)号：US20180125961A1
公开(公告)日：2018-05-10
申请号：US15534443
申请日：2015-12-08
申请人： SANOFI PASTEUR
IPC分类号： A61K39/095 , C12N9/52
CPC分类号： A61K39/095 , C07K2319/40 , C12N9/52 , C12Y304/21072
摘要： The present invention relates to novel polypeptides derived from Neisseria meningitidis proteins, in particular auto-transporters of the trypsin-like serine protease subclass, such as IgA1P, App and AusI, and their use in immunogenic compositions i.a., vaccine compositions for the prevention and/or treatment of meningococcal infections. In particular, it provides fragments of IgA1P, App and AusI and polypeptides comprising or consisting of these fragments and fusions thereof, which may be used in immunogenic compositions, for example vaccine compositions.
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公开(公告)号：US20180119111A1
公开(公告)日：2018-05-03
申请号：US15572890
申请日：2016-05-12
发明人： Simon Delagrave , CharChang Lai
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/16651 , A61K2300/00 , A61K39/12 , A61K39/245 , A61K2039/5254 , A61K35/76 , A61K2039/525 , C12N15/86 , C12N2710/16643 , C12N2710/16034 , C12N2710/16611 , C12N15/869 , C12N2710/16652 , C12N2710/16661 , C07K14/005 , C07K14/035
摘要： Methods and compositions for increasing the production of recombinant proteins by introducing ICP0 to cells capable of producing a recombinant protein are encompassed. In one method, the recombinant protein is a protein that is required for the replication of a replication defective virus, wherein the recombinant protein is provided to the replication defective virus in trans.
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公开(公告)号：US09938055B2
公开(公告)日：2018-04-10
申请号：US14720515
申请日：2015-05-22
申请人： Sanofi Pasteur
发明人： Isabelle Chacornac , Nabila Ikhelef-Gribi , Frederic Ronzon , Julien Tirefort , Sandrine Lentsch Graf
IPC分类号： B65D51/00 , A61K39/00 , A61K39/05 , A61K39/08 , A61K39/02 , A61K39/29 , B65B3/00 , B65B7/28 , C12N7/00
CPC分类号： B65D51/005 , A61K39/00 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/292 , A61K2039/55505 , B65B3/003 , B65B7/2821 , B65D51/002 , C12N7/00 , C12N2730/10134 , Y02A50/466
摘要： The invention relates to a method for loading and storing a vaccine composition, containing the antigen adsorbed on the aluminum adjuvant which (a) comprises (i) loading the composition into a container; and (ii) closing the container with a device in particular acting as a stopper, the surface of the device getting into contact with the composition being coated with a fluoropolymer such as Teflon™ and/or (b) loading the composition into a container wherein the inner surface of which is coated with polymerized silicone. The use of fluoropolymer or polymerized silicone optimizes the adsorbed antigen stability upon storage. In a particular embodiment, the antigen is the hepatitis B surface antigen and the aluminum adjuvant is aluminum oxy hydroxide.
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公开(公告)号：US09920989B2
公开(公告)日：2018-03-20
申请号：US14348877
申请日：2012-10-04
申请人： Sanofi Pasteur SA
IPC分类号： F26B5/06
摘要： A process line (300) for the production of freeze-dried particles under closed conditions comprising at least a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles and a bulk freeze-dryer (304) for freeze drying the particles, the freeze-dryer (304) comprising a rotary drum for receiving the particles. Further, a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304). For the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for operation preserving sterility of the product to be freeze-dried and/or containment.
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公开(公告)号：US09878028B2
公开(公告)日：2018-01-30
申请号：US15046902
申请日：2016-02-18
申请人： SANOFI PASTEUR SA
发明人： Pierre Chouvenc , Alain Francon
IPC分类号： A61K9/14 , A61K39/08 , A61K39/385 , A61K39/00 , A61K9/19 , A61K39/145 , C12N7/00 , A61K39/102 , A61K39/05 , A61K39/12 , A61K39/02 , A61K9/16 , C07K14/285 , A61K38/48 , A61K47/26
CPC分类号： A61K39/08 , A61K9/1617 , A61K9/1623 , A61K9/1694 , A61K9/19 , A61K38/4893 , A61K39/0208 , A61K39/05 , A61K39/102 , A61K39/12 , A61K39/145 , A61K47/26 , A61K2039/555 , A61K2039/55505 , A61K2039/6037 , A61K2039/70 , C07K14/285 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16334 , Y02A50/466 , Y02A50/469
摘要： The present invention relates to a process for stabilizing an adjuvant containing vaccine composition, an adjuvanted vaccine composition in dry form and in particular a process for stabilizing an influenza vaccine composition, particularly an adjuvanted influenza vaccine composition in dry form.
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公开(公告)号：US09687541B2
公开(公告)日：2017-06-27
申请号：US15083428
申请日：2016-03-29
CPC分类号： A61K39/08 , A61K9/0019 , A61K9/19 , A61K39/00 , A61K47/08 , A61K47/12 , A61K47/26 , A61K2039/55505
摘要： This invention relates to compositions including Clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention include one or more excipients that increase stability and/or decrease aggregation of the toxins.
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公开(公告)号：US20170102385A1
公开(公告)日：2017-04-13
申请号：US15382827
申请日：2016-12-19
IPC分类号： G01N33/569
CPC分类号： G01N33/56944 , G01N33/53 , G01N33/569 , G01N2333/3156
摘要： Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.
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公开(公告)号：US09556464B2
公开(公告)日：2017-01-31
申请号：US14411241
申请日：2013-07-02
申请人： Sanofi Pasteur
IPC分类号： C12N1/20 , C12P19/04 , A61K39/102 , A61K39/00
CPC分类号： C12P19/04 , A61K39/102 , A61K2039/55 , A61K2039/6037 , C12N1/20 , Y02A50/466
摘要： The invention concerns a method for producing, on an industrial scale, capsular polysaccharide of Haemophilus influenzae type b (PRP) intended for vaccine purposes, according to which a strain of Haemophilus influenzae type b (Hib) is cultured in a culture medium, the culture supernatant is harvested and treated in order to extract the capsular polysaccharide therefrom, said culture medium comprising at least: —one source of carbon, —protoporphyrin, —salts, —amino acids, —NAD or NADH, —vitamins, —means for regulating the pH, characterised in that said culture medium is chemically defined.
摘要翻译： 本发明涉及一种在工业规模上生产用于疫苗目的的流感嗜血杆菌B型（PRP）的荚膜多糖的方法，根据该方法将b型流感嗜血杆菌（Hib）菌株培养在培养基中，培养 收获上清液并进行处理以从其中提取荚膜多糖，所述培养基包含至少：一个碳源， - 原卟啉，盐，氨基酸，-NAD或NADH，维生素， - 用于调节 pH，其特征在于所述培养基是化学定义的。
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30.发明申请公开(公告)号：US20160317640A1
公开(公告)日：2016-11-03
申请号：US15083428
申请日：2016-03-29
CPC分类号： A61K39/08 , A61K9/0019 , A61K9/19 , A61K39/00 , A61K47/08 , A61K47/12 , A61K47/26 , A61K2039/55505
摘要： This invention relates to compositions including Clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention include one or more excipients that increase stability and/or decrease aggregation of the toxins.
摘要翻译： 本发明涉及包含艰难梭菌毒素和/或毒素的组合物和相应的方法。 本发明的组合物包括增加毒素的稳定性和/或降低毒素聚集的一种或多种赋形剂。
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