公开(公告)号：US09969797B2

公开(公告)日：2018-05-15

申请号：US12589440

申请日：2009-10-23

Applicant: Sudhir Paul ,  Stephanie Planque ,  Yasuhiro Nishiyama ,  Eric L. Brown ,  Keri C. Smith ,  Hiroaki Taguchi

Inventor： Sudhir Paul ,  Stephanie Planque ,  Yasuhiro Nishiyama ,  Eric L. Brown ,  Keri C. Smith ,  Hiroaki Taguchi

IPC: C07K16/18 ,  C07K16/10 ,  C07K16/12 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K16/1063 ,  C07K16/109 ,  C07K16/1271 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  G01N33/6854

Abstract: Disclosed are antibodies (immunoglobulins) and fragments thereof that hydrolyze or bind polypeptide antigens belonging to Staphyloccus aureus, hepatitis C virus, human immunodeficiency virus and Alzheimer's disease. Also disclosed are novel methods to improve the antigen reactivity of the immunoglobulins and to treat a pathophysiological condition using the immunoglobulins as therapeutics.

公开(公告)号：US08246957B2

公开(公告)日：2012-08-21

申请号：US10581295

申请日：2004-03-29

Applicant: Sudhir Paul

Inventor： Sudhir Paul

IPC: C12P21/08 ,  C07K16/00 ,  A61K39/21 ,  A61K39/42

CPC classification number: C07K14/005 ,  C07K16/1045 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  C12N2740/10022 ,  C12N2740/16222

Abstract: Disclosed are monoclonal antibodies and antibody fragments which recognize antigens encoded by HERV DNA sequences, and methods for production, including recombinant antibody fragments derived from lymphoid cells of lupus patients that make antibodies which neutralize HIV.

Abstract translation: 公开了识别由HERV DNA序列编码的抗原的单克隆抗体和抗体片段，以及生产方法，包括衍生自中和HIV抗体的狼疮患者的淋巴样细胞的重组抗体片段。

公开(公告)号：US20100183614A1

公开(公告)日：2010-07-22

申请号：US12589440

申请日：2009-10-23

Applicant: Sudhir Paul ,  Stephanie Planque ,  Yasuhiro Nishiyama ,  Eric L. Brown ,  Keri C. Smith ,  Hiroaki Taguchi

Inventor： Sudhir Paul ,  Stephanie Planque ,  Yasuhiro Nishiyama ,  Eric L. Brown ,  Keri C. Smith ,  Hiroaki Taguchi

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/10 ,  C07K16/12 ,  A61P31/18 ,  A61P31/14 ,  A61P31/04 ,  A61P25/28 ,  C40B30/04

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K16/1063 ,  C07K16/109 ,  C07K16/1271 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  G01N33/6854

Abstract: Disclosed are antibodies (immunoglobulins) and fragments thereof that hydrolyze or bind polypeptide antigens belonging to Staphyloccus aureus, hepatitis C virus, human immunodeficiency virus and Alzheimer's disease. Also disclosed are novel methods to improve the antigen reactivity of the immunoglobulins and to treat a pathophysiological condition using the immunoglobulins as therapeutics.

Abstract translation: 公开了水解或结合属于金黄色葡萄球菌，丙型肝炎病毒，人类免疫缺陷病毒和阿尔茨海默氏病的多肽抗原的抗体（免疫球蛋白）及其片段。 还公开了改善免疫球蛋白的抗原反应性并使用免疫球蛋白作为治疗剂治疗病理生理状况的新方法。

公开(公告)号：US20090117115A1

公开(公告)日：2009-05-07

申请号：US11983592

申请日：2007-11-09

Applicant: Sudhir Paul ,  Yasuhiro Nishiyama ,  Stephanie Planque

Inventor： Sudhir Paul ,  Yasuhiro Nishiyama ,  Stephanie Planque

IPC: A61K39/395 ,  C07K14/00 ,  G01N33/53 ,  A61P31/18

CPC classification number: C07K16/1063 ,  A61K2039/505 ,  C07K2317/34

Abstract: Provided herein are dual epitope polypeptides and electrophilic analogs thereof having a superantigenic epitope and at least one other epitope effective to induce the production of antibodies with binary specificity for the epitopes on a polypeptide antigen. Also, provided are electrophilic analogs of polyclonal B cell stimulants or lipids, polysaccharides and lipopolysaccharides or nucleotides. In addition, provided herein are methods for increasing production of binary epitope specific antibodies recognizing B cell polypeptide antigens, for stimulating production of antibodies using one or more of the polypeptides or electrophilic analogs and for isolating binary epitope specific antibodies or fragments thereof. Further provided are the antibodies so produced and methods of treating HIV using the same.

Abstract translation: 本文提供了双表位多肽及其亲电子类似物，其具有超抗原表位和至少一个其他表位，其有效地诱导针对多肽抗原上的表位具有二元特异性的抗体的产生。 此外，提供多克隆B细胞兴奋剂或脂质的亲电子类似物，多糖和脂多糖或核苷酸。 此外，本文提供的是用于增加识别B细胞多肽抗原的二元表位特异性抗体的产生的方法，用于刺激使用一种或多种多肽或亲电子类似物产生抗体并分离二聚表位特异性抗体或其片段。 还提供了如此制备的抗体以及使用其制备HIV的方法。

公开(公告)号：US06855804B2

公开(公告)日：2005-02-15

申请号：US10114716

申请日：2002-04-01

Applicant: Sudhir Paul ,  Yasuhiro Nishiyama

Inventor： Sudhir Paul ,  Yasuhiro Nishiyama

IPC: C07K16/10 ,  C07K16/32 ,  C12N9/00 ,  C07K14/00

CPC classification number: C12N9/0002 ,  A61K2039/505 ,  C07K16/1063 ,  C07K16/32 ,  C07K2319/00

Abstract: Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.

Abstract translation: 公开了用于生产，选择和抑制催化抗体的改进方法。

公开(公告)号：US06235714B1

公开(公告)日：2001-05-22

申请号：US09046373

申请日：1998-03-23

Applicant: Sudhir Paul ,  Gennady Gololobov ,  Larry J. Smith

Inventor： Sudhir Paul ,  Gennady Gololobov ,  Larry J. Smith

IPC: A61K3800

CPC classification number: C07K16/1063 ,  A61K2039/505 ,  C07K16/32 ,  C07K2317/34 ,  C12N9/0002

Abstract: Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens associated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders.

Abstract translation: 本文公开了共价反应性抗原类似物。 本发明的抗原可用于刺激对与特定医学病症相关的预定抗原特异性的催化抗体的产生。 抗原类似物也可用于永久灭活在某些自身免疫性疾病以及某些淋巴组织增生性疾病中产生的内源性产生的催化抗体。

公开(公告)号：US6048717A

公开(公告)日：2000-04-11

申请号：US478285

申请日：1995-06-07

Applicant: Sudhir Paul ,  Michael J. Powell ,  Richard J. Massey

Inventor： Sudhir Paul ,  Michael J. Powell ,  Richard J. Massey

IPC: A61K38/00 ,  C07K14/575 ,  C07K16/06 ,  C07K16/18 ,  C07K16/26 ,  C12N9/00 ,  C12N9/48

CPC classification number: C07K16/06 ,  C07K14/57563 ,  C07K16/18 ,  C07K16/26 ,  C12N9/0002 ,  C12N9/48 ,  A61K38/00 ,  C07K2317/34

Abstract: Specific, selective inhibitors of catalytic antibodies both synthetic and naturally occurring, their use and compositions thereof are disclosed. In particular, an inhibitor preventing the hydrolysis of the peptide bond between amino acid residues 16 and 17 in the neurotransmitter vasoactive intestinal peptide (VIP) by an anti-VIP catalytic autoantibody is disclosed.

Abstract translation: 公开了特定的合成和天然存在的催化抗体的选择性抑制剂，其用途和组合物。 具体地，公开了通过抗VIP催化剂自身抗体阻止神经递质血管活性肠肽（VIP）中的氨基酸残基16和17之间的肽键水解的抑制剂。

公开(公告)号：US5658753A

公开(公告)日：1997-08-19

申请号：US402158

申请日：1995-03-09

Applicant: Sudhir Paul ,  Michael J. Powell ,  Richard J. Massey ,  John H. Kenten

Inventor： Sudhir Paul ,  Michael J. Powell ,  Richard J. Massey ,  John H. Kenten

IPC: C12N9/00 ,  C12P21/06

CPC classification number: C12N9/0002

Abstract: Catalytic antibody components, methods for producing catalytic antibody components, methods for using catalytic antibody components, in particular, single chain and smaller components are disclosed. Catalytic antibody components able to promote the cleavage or formation of an amide, peptide, ester or glycosidic bond, and which are prepared from monoclonal catalytic antibodies, catalytic autoantibodies or by site-directed mutagenesis are disclosed. Methods of using catalytic antibody components alone or in combination with other antibody components or other biological moieties are disclosed.

Abstract translation: 公开了催化抗体组分，用于制备催化抗体组分的方法，使用催化抗体组分的方法，特别是单链和较小组分。 公开了能够促进切割或形成酰胺，肽，酯或糖苷键的催化抗体组分，其由单克隆催化抗体，催化自身抗体或通过定点诱变制备。 公开了单独使用催化抗体组分或与其它抗体组分或其它生物学部分组合的方法。