Catalytic antibody components
    1.
    发明授权
    Catalytic antibody components 失效
    催化抗体成分

    公开(公告)号:US5658753A

    公开(公告)日:1997-08-19

    申请号:US402158

    申请日:1995-03-09

    IPC分类号: C12N9/00 C12P21/06

    CPC分类号: C12N9/0002

    摘要: Catalytic antibody components, methods for producing catalytic antibody components, methods for using catalytic antibody components, in particular, single chain and smaller components are disclosed. Catalytic antibody components able to promote the cleavage or formation of an amide, peptide, ester or glycosidic bond, and which are prepared from monoclonal catalytic antibodies, catalytic autoantibodies or by site-directed mutagenesis are disclosed. Methods of using catalytic antibody components alone or in combination with other antibody components or other biological moieties are disclosed.

    摘要翻译: 公开了催化抗体组分,用于制备催化抗体组分的方法,使用催化抗体组分的方法,特别是单链和较小组分。 公开了能够促进切割或形成酰胺,肽,酯或糖苷键的催化抗体组分,其由单克隆催化抗体,催化自身抗体或通过定点诱变制备。 公开了单独使用催化抗体组分或与其它抗体组分或其它生物学部分组合的方法。

    Transition state analogs
    8.
    发明授权
    Transition state analogs 失效
    过渡状态类比

    公开(公告)号:US5952462A

    公开(公告)日:1999-09-14

    申请号:US333237

    申请日:1994-11-02

    摘要: Antigens capable of eliciting antibodies which can catalyze chemical reactions, in particular, the cleavage or formation of a peptide linkage, comprising a hapten or a hapten and a suitable carrier molecule are disclosed. Haptens include, among others, silicon and boron containing compounds. Antibodies which are catalytically active for chemical reactions, in particular, the cleavage or formation of a selected peptide linkage or an ester bond, and which are elicited by such antigens are disclosed as well as methods for producing the antibodies and methods for catalyzing the cleavage or formation of a peptide linkage or in ester bond in a molecule.

    摘要翻译: 公开了能够引发抗体的抗原,其可以催化化学反应,特别是包含半抗原或半抗原和合适的载体分子的肽键的切割或形成。 除了其他之外,半抗原包括含有硅和硼的化合物。 公开了对于化学反应具有催化活性的抗体,特别是选择的肽键或酯键的切割或形成,并且由这些抗原引发的抗体以及用于产生抗体的方法和用于催化切割的方法 在分子中形成肽键或酯键。