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公开(公告)号：US20120121633A1
公开(公告)日：2012-05-17
申请号：US13184530
申请日：2011-07-16
CPC分类号： C07K16/1063 , A61K39/12 , A61K39/21 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/55544 , A61K2039/55561 , A61K2039/55566 , A61K2039/6037 , A61K2039/6081 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C12N2740/16071 , C12N2740/16122 , C12N2740/16134
摘要： Provided are immunogenic compositions based on the highly conserved, core CD4 binding site of the gp120 protein of the human immunodeficiency virus. One embodiment includes an antigenic conjugate of an electophilic derivative of HIV gp120 peptide 416-433, designated E-416-433, covalently linked to an immunogenic carrier protein. The compositions are effective in stimulating the production of HIV neutralizing antibodies in mammals. Provided also are related methods of immunization, methods of antibody production and antibodies obtained using the methods of the invention.
摘要翻译： 提供基于人免疫缺陷病毒的gp120蛋白的高度保守的核心CD4结合位点的免疫原性组合物。 一个实施方案包括与免疫原性载体蛋白共价连接的HIV gp120肽416-433的亲电子衍生物（命名为E-416-433）的抗原缀合物。 该组合物有效刺激哺乳动物中HIV抗体的产生。 还提供了相关免疫方法，抗体产生方法和使用本发明的方法获得的抗体。
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公开(公告)号：US20050142649A1
公开(公告)日：2005-06-30
申请号：US10930548
申请日：2004-08-31
申请人： Sudhir Paul , Yasuhiro Nishiyama
发明人： Sudhir Paul , Yasuhiro Nishiyama
IPC分类号： C07K16/10 , C07K16/32 , C12N9/00 , A61K39/395 , C07K14/47
CPC分类号： C12N9/0002 , A61K2039/505 , C07K16/1063 , C07K16/32 , C07K2319/00
摘要： Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.
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3.发明授权Methods for identifying inducers and inhibitors of proteolytic antibodies, compositions and their uses 有权用于鉴定诱导物和蛋白水解抗体抑制剂的方法，组合物及其用途公开(公告)号：US06855528B2
公开(公告)日：2005-02-15
申请号：US09862849
申请日：2001-05-22
申请人： Sudhir Paul , Gennady Gololobov , Larry J. Smith
发明人： Sudhir Paul , Gennady Gololobov , Larry J. Smith
IPC分类号： A61K39/00 , A61K38/00 , A61K39/395 , A61P5/14 , A61P11/06 , A61P17/00 , A61P19/02 , A61P19/04 , A61P29/00 , A61P35/00 , A61P37/06 , C07K7/04 , C07K16/00 , C07K16/10 , C07K16/32 , C12N9/00 , C12N9/64 , A61K38/04 , A61K38/43
CPC分类号： C07K16/1063 , A61K2039/505 , C07K16/32 , C07K2317/34 , C12N9/0002
摘要： Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens assocated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders.
摘要翻译： 本文公开了共价反应性抗原类似物。 本发明的抗原可用于刺激与特定医学病症有关的预定抗原特异性的催化抗体的产生。 抗原类似物也可用于永久灭活在某些自身免疫性疾病以及某些淋巴组织增生性疾病中产生的内源性产生的催化抗体。
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公开(公告)号：US6156541A
公开(公告)日：2000-12-05
申请号：US000023
申请日：1998-01-21
申请人： Sudhir Paul , Ravishankar Kalaga
发明人： Sudhir Paul , Ravishankar Kalaga
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K39/395 , A61P31/00 , A61P31/18 , C07K16/10 , C12N9/00 , C12P21/08 , C12P21/00
CPC分类号： C12N9/0002 , C07K16/1063 , A61K2039/505 , A61K38/00 , C07K2317/50
摘要： A catalytic antibody and components thereof which cleave HIV gp120 are disclosed. Methods of isolating, cloning and purifying such antibodies or antibody components from patients are also described. The compositions described may provide utility in the treatment of HIV infection.
摘要翻译： PCT No.PCT / US96 / 12025 Sec。 371日期1998年1月21日 102（e）1998年1月21日PCT PCT 1996年7月19日PCT公布。 出版物WO97 / 03696 日期：1997年2月6日公开了一种切割HIV gp120的催化抗体及其成分。 还描述了从患者分离，克隆和纯化此类抗体或抗体组分的方法。 所描述的组合物可用于治疗HIV感染。
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公开(公告)号：US5229272A
公开(公告)日：1993-07-20
申请号：US498225
申请日：1990-03-23
IPC分类号： A61K39/395 , C07K1/113 , C07K1/22 , C07K14/00 , C07K14/52 , C07K14/54 , C07K14/55 , C07K14/575 , C07K14/705 , C07K16/00 , C07K16/06 , C07K16/26 , C07K16/44 , C07K19/00 , C12N9/00 , C12N9/48 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91
CPC分类号： C07K14/57563 , C07K14/55 , C07K16/06 , C07K16/26 , C07K16/44 , C12N9/0002 , C12N9/48 , C07K2319/00 , C07K2319/75
摘要： Catalytic antibody components, methods for producing catalytic antibody components, methods for using catalytic antibody components, in particular, single chain and smaller components are disclosed. Catalytic antibody components able to promote the cleavage or formation of an amide, peptide, ester or glycosidic bond, and which are prepared from monoclonal catalytic antibodies, catalytic autoantibodies or by site-directed mutagenesis are disclosed. Methods of using catalytic antibody components alone or in combination with other antibody components or other biological moieties are disclosed.
摘要翻译： 公开了催化抗体组分，用于制备催化抗体组分的方法，使用催化抗体组分的方法，特别是单链和较小组分。 公开了能够促进切割或形成酰胺，肽，酯或糖苷键的催化抗体组分，其由单克隆催化抗体，催化自身抗体或通过定点诱变制备。 公开了单独使用催化抗体组分或与其它抗体组分或其它生物学部分组合的方法。
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公开(公告)号：US20090297534A1
公开(公告)日：2009-12-03
申请号：US11988761
申请日：2006-07-13
申请人： Sudhir Paul , Yasuhiro Nishiyama , Carl V. Hanson , Marc Weksler
发明人： Sudhir Paul , Yasuhiro Nishiyama , Carl V. Hanson , Marc Weksler
IPC分类号： A61K39/395
CPC分类号： C12N9/0002 , C07K16/1063 , C07K16/18 , C07K2317/34
摘要： The present invention describes the composition of class and subclass selected pooled human immunoglobulins with catalytic activity, methods of preparation thereof, and therapeutic utility thereof.
摘要翻译： 本发明描述了具有催化活性的选择的合并的人免疫球蛋白的类别和亚类的组成，其制备方法及其治疗用途。
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公开(公告)号：US20070105218A1
公开(公告)日：2007-05-10
申请号：US10581295
申请日：2004-03-29
申请人： Sudhir Paul
发明人： Sudhir Paul
CPC分类号： C07K14/005 , C07K16/1045 , C07K16/1063 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , C12N2740/10022 , C12N2740/16222
摘要： Disclosed are monoclonal antibodies and antibody fragments which recognize antigens encoded by HERV DNA sequences, and methods for production, including recombinant antibody fragments derived from lymphoid cells of lupus patients that make antibodies which neutralize HIV.
摘要翻译： 公开了识别由HERV DNA序列编码的抗原的单克隆抗体和抗体片段，以及生产方法，包括衍生自中和HIV抗体的狼疮患者的淋巴样细胞的重组抗体片段。
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8.发明授权Monoclonal antibody and antibody components elicited to a polypeptide antigen ground state 失效单克隆抗体和抗体成分引起多肽抗原基础状态
公开(公告)号：US5318897A
公开(公告)日：1994-06-07
申请号：US789344
申请日：1991-11-08
申请人： Sudhir Paul
发明人： Sudhir Paul
IPC分类号： C12N15/09 , C07K14/55 , C07K14/575 , C07K16/06 , C07K16/26 , C07K16/44 , C12N9/00 , C12N9/48 , C12P21/06 , C12P21/08 , C07K15/28
CPC分类号： C07K14/55 , C07K14/57563 , C07K16/06 , C07K16/26 , C07K16/44 , C12N9/0002 , C12N9/48 , C07K2319/75
摘要： What is disclosed is a catalytic monoclonal antibody able to cleave a polypeptide and in particular, a catalytic monoclonal antibody elicited by a ground state antigen is disclosed. Antigens include, among others, the polypeptide, a derivative of the polypeptide, a fragment of the polypeptide or any of these bound to a carrier molecule. Methods of making and using the catalytic monoclonal antibody are also disclosed.
摘要翻译： 公开的是能够切割多肽的催化单克隆抗体，特别是公开了由基态抗原引发的催化单克隆抗体。 抗原尤其包括多肽，多肽的衍生物，多肽的片段或结合至载体分子的任何一种。 还公开了制备和使用催化单克隆抗体的方法。
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公开(公告)号：US5236836A
公开(公告)日：1993-08-17
申请号：US343081
申请日：1989-04-25
申请人： Sudhir Paul
发明人： Sudhir Paul
IPC分类号： A61K39/395 , A61P31/04 , A61P35/00 , C07K1/12 , C07K1/22 , C07K14/00 , C07K14/575 , C07K14/62 , C07K14/655 , C07K16/00 , C07K16/06 , C07K16/26 , C12N9/00 , C12N9/48 , C12N9/64 , C12P21/06 , C12P21/08 , G01N33/53 , G01N33/557 , G01N33/577
CPC分类号： C07K14/57563 , C07K16/06 , C07K16/26 , C12N9/0002 , C12N9/48 , C07K2317/34
摘要： Autoantibodies which enhance the rate of a chemical reaction of a substrate, processes for their preparation, their use and compositions thereof are disclosed. In particular, an autoantibody capable of catalyzing the hydrolysis of the peptide bond between amino acid residues 16 and 17 in the neurotransmitter vasoactive intestinal peptide (VIP) is disclosed.
摘要翻译： 公开了增加底物的化学反应速率的自身抗体，其制备方法，用途及其组合物。 特别地，公开了能够催化神经递质血管活性肠肽（VIP）中的氨基酸残基16和17之间的肽键的水解的自身抗体。
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公开(公告)号：US5194585A
公开(公告)日：1993-03-16
申请号：US486594
申请日：1990-02-28
IPC分类号： A61K35/16 , A61K38/00 , A61K39/395 , A61P3/08 , A61P11/00 , A61P11/06 , A61P13/02 , A61P15/00 , A61P37/00 , A61P37/06 , C07K1/22 , C07K7/06 , C07K14/435 , C07K14/575 , C07K16/00 , C07K16/06 , C07K16/18 , C07K16/26 , C12N9/00 , C12N9/48 , C12N9/99 , C12P21/08 , G01N33/53 , G01N33/564
CPC分类号： C07K16/06 , C07K14/57563 , C07K16/18 , C07K16/26 , C12N9/0002 , C12N9/48 , A61K38/00 , C07K2317/34 , Y10S424/81 , Y10S530/868
摘要： Specific, selective inhibitors of catalytic antibodies both synthetic and naturally occurring, their use and compositions thereof are disclosed. In particular, an inhibitor preventing the hydrolysis of the peptide bond between amino acid residues 16 and 17 in the neurotransmitter vasoactive intestinal peptide (VIP) by an anti-VIP catalytic autoantibody is disclosed.
摘要翻译： 公开了特定的合成和天然存在的催化抗体的选择性抑制剂，其用途和组合物。 具体地，公开了通过抗VIP催化剂自身抗体阻止神经递质血管活性肠肽（VIP）中的氨基酸残基16和17之间的肽键水解的抑制剂。
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