公开(公告)号：US20130034869A1

公开(公告)日：2013-02-07

申请号：US13576804

申请日：2011-02-03

申请人： George M. Whitesides ,  Katherine A. Mirica ,  Andres W. Martinez ,  Chao-Min Cheng ,  Scott T. Phillips ,  Monica Mascarenas ,  Xinyu Liu ,  Xiujun Li

发明人： George M. Whitesides ,  Katherine A. Mirica ,  Andres W. Martinez ,  Chao-Min Cheng ,  Scott T. Phillips ,  Monica Mascarenas ,  Xinyu Liu ,  Xiujun Li

IPC分类号： C12M1/34 ,  G01N21/78 ,  G01N33/53

CPC分类号： B01L3/502738 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0681 ,  B01L2300/0887 ,  B01L2300/126 ,  B01L2300/161 ,  B01L2400/065

摘要： The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.

摘要翻译： 本公开提供了用于执行多重测定的低成本便携式三维装置。 这些装置包括设置在平行平面中的至少两个基本上平坦的层，其中层之一可以相对于彼此平行于平面移动，以允许在两层之间串联建立流体流动连通。

公开(公告)号：US20110009983A1

公开(公告)日：2011-01-13

申请号：US12922211

申请日：2009-03-13

申请人： Yu Sun ,  Xinyu Liu

发明人： Yu Sun ,  Xinyu Liu

IPC分类号： G02B21/26 ,  G05D3/12

CPC分类号： G05B19/232 ,  G02B21/26 ,  G05B19/291 ,  G05B19/351 ,  G05B2219/41346 ,  G05B2219/49368

摘要： The present invention relates to a compact motorized rotational stage for microscopy applications and control methods for automated sample orientation/rotation. The rotational stage includes a motor, a rotational motion transmission mechanism, and a rotating sample holder for accommodating a holding device such as glass slides/Petri dishes of different sizes. Mouse embryos are used as an example to explain the control methods. A pattern recognition utility was developed for identifying mouse embryo structures. The transformation between the holding device rotational coordinate frame and the translational positioning stage coordinate frame is calibrated during image-based visual servo control. The polar body of an embryo is oriented through purely image-based visual servo control or through coordinate transformation and closed-loop position control.

摘要翻译： 本发明涉及用于显微镜应用的紧凑型电动旋转台和用于自动取样/旋转的控制方法。 旋转台包括电动机，旋转运动传递机构和用于容纳诸如不同尺寸的玻璃板/培养皿的保持装置的旋转样品保持器。 以小鼠胚胎为例来说明对照方法。 开发了识别小鼠胚胎结构的模式识别实用程序。 在基于图像的视觉伺服控制期间校准保持装置旋转坐标系和平移定位台坐标系之间的变换。 胚胎的极体通过纯粹的基于图像的视觉伺服控制或通过坐标变换和闭环位置控制来定向。

公开(公告)号：US20190270763A9

公开(公告)日：2019-09-05

申请号：US15192680

申请日：2016-06-24

申请人： Xinyu Liu

发明人： Xinyu Liu

IPC分类号： C07H1/00 ,  C07H15/203

摘要： A catalytic glycosylation method comprising: installing thioether to an anomeric carbon of a carbohydrate; and catalytically activating the thioether with a non-oxophilic Lewis acid. The thioether may comprise an anomerically stable thioether leaving group. The catalytic glycosylation method may further comprise: utilizing an acid-sensitive ester protecting group as permanent protecting group or using a reactivity-based one-pot glycosylation that employs a single-component catalyst to accelerate an oligosaccharide assembly process. A protecting group to mask hydroxyl functionalities in the production of oligosaccharides, natural products or any molecule having a hydroxyl group comprising an acid-labile ester protecting group.

公开(公告)号：US20170022237A1

公开(公告)日：2017-01-26

申请号：US15192680

申请日：2016-06-24

申请人： Xinyu Liu

发明人： Xinyu Liu

IPC分类号： C07H1/00 ,  C07H15/203

CPC分类号： C07H1/00 ,  C07C59/66 ,  C07C65/24 ,  C07C69/88 ,  C07C69/94 ,  C07H15/203 ,  Y02P20/55

摘要： A catalytic glycosylation method comprising: installing thioether to an anomeric carbon of a carbohydrate; and catalytically activating the thioether with a non-oxophilic Lewis acid. The thioether may comprise an anomerically stable thioether leaving group. The catalytic glycosylation method may further comprise: utilizing an acid-sensitive ester protecting group as permanent protecting group or using a reactivity-based one-pot glycosylation that employs a single-component catalyst to accelerate an oligosaccharide assembly process. A protecting group to mask hydroxyl functionalities in the production of oligosaccharides, natural products or any molecule having a hydroxyl group comprising an acid-labile ester protecting group.

摘要翻译： 一种催化糖基化方法，包括：将硫醚装入碳水化合物的异头碳中; 并用非极性路易斯酸催化活化硫醚。 硫醚可以包含端基异构稳定的硫醚离去基团。 催化糖基化方法还可以包括：使用酸敏感的酯保护基团作为永久保护基团，或者使用采用单组分催化剂加速寡糖组装过程的基于反应性的一锅糖基化。 在生产低聚糖，天然产物或具有包含酸不稳定酯保护基团的羟基的任何分子中掩蔽羟基官能团的保护基团。

公开(公告)号：US20160186655A1

公开(公告)日：2016-06-30

申请号：US14910664

申请日：2013-09-27

申请人： Xinyu LIU

发明人： Xinyu LIU

IPC分类号： F02B77/04

CPC分类号： F02B77/04

摘要： The present invention discloses an on-line cleaning system and control method for carbon deposit in engine intake valve and combustion chamber comprising a cleaning agent tank, a cleaning agent inlet line and a control circuit, the control circuit comprises a cleaning work procedure, and is provided with a cleaning start-up circuit, the cleaning agent tank is disposed on a frame within the automobile engine hood, one end of the cleaning agent inlet line is connected to the cleaning agent tank, the other end of the cleaning agent inlet line is connected to an engine vacuum pipeline which is a vacuum pipeline in communication with the automobile engine intake valve, a control signal at the automobile engine operating state is connected with the start-up circuit in the control circuit. The on-line cleaning of the carbon deposit in engine intake valve and combustion chamber is achieved without changing the existing automobile basic design, and the control method is simple and practical. A closed-loop automatic control of the cleaning agent inflow amount and the vacuum pressure is achieved; the cleaning process is safe and reliable, and the environmental performance of the engine emission is improved.

摘要翻译： 本发明公开了一种在线清洁系统和发动机进气阀和燃烧室中碳沉积的控制方法，包括清洗剂罐，清洗剂入口管线和控制电路，该控制电路包括清洗工作程序，并且是 设置有清洁启动电路，清洁剂箱设置在汽车发动机罩内的框架上，清洁剂入口管线的一端连接到清洁剂箱，清洁剂入口管线的另一端为 与作为与汽车发动机进气门连通的真空管路的发动机真空管路连接，汽车发动机运转状态下的控制信号与控制电路中的起动电路连接。 实现发动机进气阀和燃烧室中碳沉积物的在线清洗，而不改变现有的汽车基本设计，控制方法简单实用。 实现清洗剂流入量和真空压力的闭环自动控制; 清洁过程安全可靠，提高了发动机排放的环境性能。

公开(公告)号：US20090278420A1

公开(公告)日：2009-11-12

申请号：US12305478

申请日：2007-06-21

申请人： Yu Sun ,  Xinyu Liu

发明人： Yu Sun ,  Xinyu Liu

IPC分类号： H02N1/00

CPC分类号： B25J7/00 ,  B25J9/0015

摘要： A MEMS-based mano manipulator or nanopositioner is provided that can achieve both sub-nanometer resolution and millimeter force output. The nanomanipulator or nanopositioner comprises a linear amplification mechanism that minifies input displacements and amplifies input forces, microactuators that drive the amplification mechanism to generate forward and backward motion, and position sensors that measure the input displacement of the amplification mechanism. The position sensors obtain position feedback enabling precise closed-loop control during nanomanipulation.

摘要翻译： 提供了基于MEMS的马诺机器人或纳米定位器，其可以实现亚纳米分辨率和毫米波力输出。 纳米机械手或纳米定位器包括线性放大机构，其缩小输入位移并放大输入力，驱动放大机构以产生向前和向后运动的微致动器以及测量放大机构的输入位移的位置传感器。 位置传感器获得位置反馈，可在纳米操作期间实现精确的闭环控制。