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公开(公告)号：US20140224018A1
公开(公告)日：2014-08-14
申请号：US13557861
申请日：2012-07-25
Applicant: George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
Inventor： George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
CPC classification number: B81B7/02 , B81C1/0015 , G01G3/13 , G01L1/18 , G01P15/0802 , G01P15/123 , G01P15/18 , G01P2015/0862
Abstract: MEMS devices fabricated using inexpensive substrate materials such as paper or fabric, are provided. Using paper as a substrate, low cost, simple to prepare, lightweight, disposable piezoresistive sensors, including accelerometers are prepared. Signal-processing circuitry can also be patterned on the substrate material.The sensors can be utilized as two-dimensional sensors, or the paper substrate material can be folded to arrange the sensors in a three dimensional conformation. For example, three sensors can be patterned on a paper substrate and folded into a cube such that the three sensors are orthogonally positioned on the faces of a cube, permitting simultaneous measurement of accelerations along three orthogonal directions (x-y-z). These paper-based sensors can be mass produced by incorporating highly developed technologies for automatic paper cutting, folding, and screen-printing.Also provided are methods of modifying paper for use as a substrate material in MEMS devices.
Abstract translation: 提供了使用诸如纸或织物之类的便宜的基底材料制造的MEMS器件。 使用纸作为基材，成本低，制备简单，重量轻，一次性压阻式传感器，包括加速度计。 信号处理电路也可以在衬底材料上图案化。 传感器可以用作二维传感器，或者可以将纸基材料折叠成三维构型。 例如，可以将三个传感器图案化在纸基底上并折叠成立方体，使得三个传感器正交地放置在立方体的表面上，允许沿着三个正交方向（x-y-z）同时测量加速度。 这些纸基传感器可以通过结合高度开发的自动切纸，折叠和丝网印刷技术进行批量生产。 还提供了修改用作MEMS器件中的基底材料的纸的方法。
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公开(公告)号：US08990023B2
公开(公告)日：2015-03-24
申请号：US11678608
申请日：2007-02-25
Applicant: Yu Sun , Wenhui Wang , Xinyu Liu
Inventor： Yu Sun , Wenhui Wang , Xinyu Liu
Abstract: An automated cell injection system and method are described, which can perform automatic, reliable, and high-throughput cell injection of foreign genetic materials, proteins, and other compounds. The system and method overcome the problems inherent in traditional manual injection that is characterized by poor reproducibility, human fatigue, and low throughput. The present invention is particularly suited for zebrafish embryo injection but can be readily extended to other biological injection applications such as mouse embryo, drosophila embryo, and C. elegans injections, capable of facilitating high-throughput genetic research at both academic and industry levels. A novel vacuum based cell-holding device is also provided.
Abstract translation: 描述了自动细胞注射系统和方法，其可以执行外来遗传物质，蛋白质和其他化合物的自动，可靠和高通量的细胞注射。 该系统和方法克服了传统手动注射固有的问题，其特点是重现性差，人体疲劳和生产能力低。 本发明特别适用于斑马鱼胚胎注射，但可以容易地扩展到其他生物注射应用例如小鼠胚胎，果蝇胚和秀丽隐杆线虫注射液，其能够促进学术和工业水平的高通量遗传研究。 还提供了一种新颖的基于真空的电池保持装置。
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公开(公告)号：US08554344B2
公开(公告)日：2013-10-08
申请号：US12922211
申请日：2009-03-13
IPC: G05B19/18
CPC classification number: G05B19/232 , G02B21/26 , G05B19/291 , G05B19/351 , G05B2219/41346 , G05B2219/49368
Abstract: The present invention relates to a compact motorized rotational stage for microscopy applications and control methods for automated sample orientation/rotation. The rotational stage includes a motor, a rotational motion transmission mechanism, and a rotating sample holder for accommodating a holding device such as glass slides/Petri dishes of different sizes. Mouse embryos are used as an example to explain the control methods. A pattern recognition utility was developed for identifying mouse embryo structures. The transformation between the holding device rotational coordinate frame and the translational positioning stage coordinate frame is calibrated during image-based visual servo control. The polar body of an embryo is oriented through purely image-based visual servo control or through coordinate transformation and closed-loop position control.
Abstract translation: 本发明涉及用于显微镜应用的紧凑型电动旋转台和用于自动取样/旋转的控制方法。 旋转台包括电动机，旋转运动传递机构和用于容纳诸如不同尺寸的玻璃板/培养皿的保持装置的旋转样品保持器。 以小鼠胚胎为例来说明对照方法。 开发了识别小鼠胚胎结构的模式识别实用程序。 在基于图像的视觉伺服控制期间校准保持装置旋转坐标系和平移定位台坐标系之间的变换。 胚胎的极体通过纯粹的基于图像的视觉伺服控制或通过坐标变换和闭环位置控制来定向。
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公开(公告)号：US20080077329A1
公开(公告)日：2008-03-27
申请号：US11678608
申请日：2007-02-25
Applicant: Yu Sun , Wenhui Wang , Xinyu Liu
Inventor： Yu Sun , Wenhui Wang , Xinyu Liu
IPC: G01N33/48
Abstract: An automated cell injection system and method are described, which can perform automatic, reliable, and high-throughput cell injection of foreign genetic materials, proteins, and other compounds. The system and method overcome the problems inherent in traditional manual injection that is characterized by poor reproducibility, human fatigue, and low throughput. The present invention is particularly suited for zebrafish embryo injection but can be readily extended to other biological injection applications such as mouse embryo, drosophila embryo, and C. elegans injections, capable of facilitating high-throughput genetic research at both academic and industry levels. A novel vacuum based cell-holding device is also provided.
Abstract translation: 描述了自动细胞注射系统和方法，其可以执行外来遗传物质，蛋白质和其他化合物的自动，可靠和高通量的细胞注射。 该系统和方法克服了传统手动注射固有的问题，其特点是重现性差，人体疲劳和生产能力低。 本发明特别适用于斑马鱼胚胎注射，但可以容易地扩展到其他生物注射应用例如小鼠胚胎，果蝇胚和秀丽隐杆线虫注射液，其能够促进学术和工业水平的高通量遗传研究。 还提供了一种新颖的基于真空的电池保持装置。
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公开(公告)号：US09682856B2
公开(公告)日：2017-06-20
申请号：US13557861
申请日：2012-07-25
Applicant: George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
Inventor： George Whitesides , Xinyu Liu , XiuJun Li , Martin M. Thuo , Michael O'Brien , Yu Sun
CPC classification number: B81B7/02 , B81C1/0015 , G01G3/13 , G01L1/18 , G01P15/0802 , G01P15/123 , G01P15/18 , G01P2015/0862
Abstract: MEMS devices fabricated using inexpensive substrate materials such as paper or fabric, are provided. Using paper as a substrate, low cost, simple to prepare, lightweight, disposable piezoresistive sensors, including accelerometers are prepared. Signal-processing circuitry can also be patterned on the substrate material.The sensors can be utilized as two-dimensional sensors, or the paper substrate material can be folded to arrange the sensors in a three dimensional conformation. For example, three sensors can be patterned on a paper substrate and folded into a cube such that the three sensors are orthogonally positioned on the faces of a cube, permitting simultaneous measurement of accelerations along three orthogonal directions (x-y-z). These paper-based sensors can be mass produced by incorporating highly developed technologies for automatic paper cutting, folding, and screen-printing.Also provided are methods of modifying paper for use as a substrate material in MEMS devices.
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Patent Agency Ranking
公开(公告)号：US20110009983A1
公开(公告)日：2011-01-13
申请号：US12922211
申请日：2009-03-13
CPC classification number: G05B19/232 , G02B21/26 , G05B19/291 , G05B19/351 , G05B2219/41346 , G05B2219/49368
Abstract: The present invention relates to a compact motorized rotational stage for microscopy applications and control methods for automated sample orientation/rotation. The rotational stage includes a motor, a rotational motion transmission mechanism, and a rotating sample holder for accommodating a holding device such as glass slides/Petri dishes of different sizes. Mouse embryos are used as an example to explain the control methods. A pattern recognition utility was developed for identifying mouse embryo structures. The transformation between the holding device rotational coordinate frame and the translational positioning stage coordinate frame is calibrated during image-based visual servo control. The polar body of an embryo is oriented through purely image-based visual servo control or through coordinate transformation and closed-loop position control.
Abstract translation: 本发明涉及用于显微镜应用的紧凑型电动旋转台和用于自动取样/旋转的控制方法。 旋转台包括电动机，旋转运动传递机构和用于容纳诸如不同尺寸的玻璃板/培养皿的保持装置的旋转样品保持器。 以小鼠胚胎为例来说明对照方法。 开发了识别小鼠胚胎结构的模式识别实用程序。 在基于图像的视觉伺服控制期间校准保持装置旋转坐标系和平移定位台坐标系之间的变换。 胚胎的极体通过纯粹的基于图像的视觉伺服控制或通过坐标变换和闭环位置控制来定向。
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公开(公告)号：US20090278420A1
公开(公告)日：2009-11-12
申请号：US12305478
申请日：2007-06-21
IPC: H02N1/00
CPC classification number: B25J7/00 , B25J9/0015
Abstract: A MEMS-based mano manipulator or nanopositioner is provided that can achieve both sub-nanometer resolution and millimeter force output. The nanomanipulator or nanopositioner comprises a linear amplification mechanism that minifies input displacements and amplifies input forces, microactuators that drive the amplification mechanism to generate forward and backward motion, and position sensors that measure the input displacement of the amplification mechanism. The position sensors obtain position feedback enabling precise closed-loop control during nanomanipulation.
Abstract translation: 提供了基于MEMS的马诺机器人或纳米定位器，其可以实现亚纳米分辨率和毫米波力输出。 纳米机械手或纳米定位器包括线性放大机构，其缩小输入位移并放大输入力，驱动放大机构以产生向前和向后运动的微致动器以及测量放大机构的输入位移的位置传感器。 位置传感器获得位置反馈，可在纳米操作期间实现精确的闭环控制。
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公开(公告)号：US20220235204A1
公开(公告)日：2022-07-28
申请号：US17583632
申请日：2022-01-25
IPC: C08L9/00
Abstract: A curable rubber composition including a rubber, a plurality of ground particles, and a reactive surfactant represented by the formula: X—Y—Z where X is a reactive group capable of forming covalent links with the rubber during compounding or vulcanization, Y is a hydrophobic linkage, and Z is a polar group capable of forming self-assemblies via intermolecular interactions, and wherein the reactive surfactant is incompatible with the rubber and a method of making the same.
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公开(公告)号：US11331724B2
公开(公告)日：2022-05-17
申请号：US17280025
申请日：2019-09-25
Applicant: Xiaoming Wang , Yang Zhao , Wenyu Wang , Qing Chang , Zhiqiang Ren , Guofeng Han , Sheng Zhu , Jing Shi , Tao Teng , Yu Sun , Zhiyong Qin , DALIAN UNIVERSITY OF TECHNOLOGY
Inventor： Xiaoming Wang , Yang Zhao , Wenyu Wang , Wei Dong , Yao Meng , Qing Chang , Zhiqiang Ren , Jing Shi , Guofeng Han , Sheng Zhu , Tao Teng , Fumin Xu , Zhaofeng Bai , Yanyang Wang , Yang Han , Guobin Li , Yu Sun , Zhiyong Qin
Abstract: An apparatus efficiently preparing ultrafine spherical metal powder includes a housing, a crucible and a powder collection area arranged in the housing. The turnplate arranged in the powder collection area is an inlaid structure. The part inlaid into the body part acts as an atomization plane of the turnplate. The atomization plane is provided with a concentric circular groove, and the turnplate is provided with an air hole. The apparatus is used for preparing ultrafine spherical metal powder by on-by-one droplets centrifugal atomization method, mainly combining the uniform droplet jet method and the centrifugal atomization method, which breaks through the traditional metal splitting model, makes the molten metal in a fibrous splitting, so as to efficiently prepare ultrafine spherical metal powder with narrow particle size distribution interval, high sphericity, good flowability, excellent spreadability, uniform and controllable size, no satellite droplets and suitable for industrial production.
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公开(公告)号：US09744672B2
公开(公告)日：2017-08-29
申请号：US14355347
申请日：2012-11-16
Applicant: Yu Sun , Michael David Coovert , Ivan Shindev
Inventor： Yu Sun , Michael David Coovert , Ivan Shindev
CPC classification number: B25J11/0005 , B25J9/1674 , G05B2219/40196 , G05B2219/40202 , G05B2219/40414 , G05D1/0246 , G05D1/0274
Abstract: In one embodiment, communicating robot intentions to human beings involves determining movements that a robot will make to complete a task, visually communicating a long-term intention of the robot that provides an indication of the movements the robot will make in completing the task, and visually communicating a short-tem intention of the robot that provides an indication of a movement of the robot will make within the next few seconds in working toward completing the task.
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