公开(公告)号：US06251125B1

公开(公告)日：2001-06-26

申请号：US09053115

申请日：1998-04-01

Applicant: Bruce H. KenKnight ,  William Hsu ,  Yayun Lin ,  Janice Jones

Inventor： Bruce H. KenKnight ,  William Hsu ,  Yayun Lin ,  Janice Jones

IPC: A61N139

CPC classification number: A61N1/3962

Abstract: A method and system for ventricular defibrillation by coordinating the delivery of defibrillation shocks with sensed ventricular fibrillation complexes in a way which improves the probability of success of the defibrillation shock. Ventricular electrical activity is monitored in two ventricular locations during ventricular fibrillation to detect coarse ventricular fibrillation complexes and contractions of the ventricular cardiac tissue. The defibrillation shock is delivered in coordination with the occurrence of coarse ventricular fibrillation complexes and the contractions of ventricular cardiac tissue, and specifically to occur on the up-slope portion thereof, for optimal probability of success.

Abstract translation: 通过以提高除颤休克成功概率的方式协调将感染的心室颤动复合物递送除颤电击的心室除颤的方法和系统。 在心室纤维性颤动期间，在两个心室位置监测心室电活动，以检测心室心脏组织的粗略心室颤动复合物和收缩。 伴随发生粗心室颤动复合物和心室心脏组织的收缩，特别是在其上坡部分发生除颤休克，以获得最佳的成功概率。

公开(公告)号：US06212434B1

公开(公告)日：2001-04-03

申请号：US09120824

申请日：1998-07-22

Applicant: Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W. Goebel ,  Douglas A. Heitkamp ,  Randall M. Peterfeso

Inventor： Avram Scheiner ,  William Hsu ,  David M. Flynn ,  Qingsheng Zhu ,  John E. Heil ,  Ronald W. Heil, Jr. ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  Jay A. Warren ,  Gerrard M. Carlson ,  Carol Werlein ,  Aaron W. Janke ,  Mary Lee Cole ,  Jeffrey T. Bartig ,  Gary W. Goebel ,  Douglas A. Heitkamp ,  Randall M. Peterfeso

IPC: A61N105

CPC classification number: A61N1/0573 ,  A61N1/0563

Abstract: A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

公开(公告)号：US09119547B2

公开(公告)日：2015-09-01

申请号：US12686122

申请日：2010-01-12

Applicant: Shelley Cazares ,  Jaeho Kim ,  Yayun Lin ,  Carlos Alberto Ricci

Inventor： Shelley Cazares ,  Jaeho Kim ,  Yayun Lin ,  Carlos Alberto Ricci

IPC: A61B5/0464 ,  A61B5/0452 ,  A61B5/00

CPC classification number: A61B5/0464 ,  A61B5/04525 ,  A61B5/7264

Abstract: Cardiac systems and methods provide for discriminating between supraventricular tachyarrhythmia and ventricular tachyarrhythmia based on a determination that the patient's supraventricular rhythm exhibits rate dependency. One approach involves determining if a patient's supraventricular rhythm exhibits rate dependent morphology. If the patient's supraventricular rhythm is determined to exhibit rate dependent morphology, an implantable device classifies a detected tachyarrhythmia episode based on one or more templates selected from a plurality of rate-indexed templates stored in the device. Determining if the supraventricular rhythm exhibits rate dependent morphology may also include determining one or more rates at which the rate dependent morphology occurs.

Abstract translation: 心脏系统和方法基于确定患者的室上节律表现出速率依赖性，确定了室上性快速性心律失常与室性快速性心律失常之间的区别。 一种方法涉及确定患者的室上节律是否表现出速率依赖性形态。 如果确定患者的室上节律表现出与速率相关的形态，则可植入装置基于从存储在装置中的多个速率索引模板中选择的一个或多个模板来分类检测到的快速性心律失常发作。 确定室性心律显示出速率依赖性形态还可以包括确定发生速率依赖形态的一个或多个速率。

公开(公告)号：US08583228B2

公开(公告)日：2013-11-12

申请号：US13048582

申请日：2011-03-15

Applicant: Dan Li ,  Yayun Lin

Inventor： Dan Li ,  Yayun Lin

IPC: A61N1/00

CPC classification number: A61N1/3622 ,  A61B5/04525 ,  A61B5/0464 ,  A61N1/36585 ,  A61N1/3962

Abstract: Methods and systems for selecting tachyarrhythmia therapy based on the morphological organization level of the arrhythmia are described. Morphological organization levels of arrhythmias are associated with cardiac therapies. The morphological organization levels are related to cardiac signal morphologies of the arrhythmias. An arrhythmia episode is detected and the morphological organization level of the arrhythmia episode is determined. A cardiac therapy associated with the morphological organization level of the arrhythmia episode is delivered to treat the arrhythmia. For example, the morphological organization levels may be associated with the cardiac therapies based on one or more of retrospective database analysis, patient therapy tolerance, and physician input. The associations may be static or may be dynamically adjusted based on therapy efficacy.

Abstract translation: 描述了基于心律失常形态组织水平选择快速性心律失常治疗的方法和系统。 心律失常的形态学组织水平与心脏治疗有关。 形态组织水平与心律失常的心脏信号形态有关。 检测到心律失常发作，确定心律失常发作的形态组织水平。 与心律失常发作的形态组织水平相关的心脏治疗被递送以治疗心律失常。 例如，形态组织水平可以基于回顾性数据库分析，患者治疗耐受性和医师输入中的一种或多种与心脏疗法相关联。 协会可以是静态的，或者可以基于治疗功效来动态调整。

公开(公告)号：US08483808B2

公开(公告)日：2013-07-09

申请号：US12879147

申请日：2010-09-10

Applicant: Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

Inventor： Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

IPC: A61N5/0472 ,  A61B5/0452

CPC classification number: A61B5/04525 ,  G06K9/00536

Abstract: A system and method for automatically analyzing a cardiac signal, including the step of providing an episode database on a computer storage medium including a plurality of episode data records of one or more patients. Each episode data record includes a cardiac signal from at least one data-generating device. The method also includes the step of selecting one or more of the N beats to be one or more beat templates, for at least a first cardiac signal having N beats. Another step is determining a value K for the cardiac signal using a computer system where K beat templates can represent all the N beats in the cardiac signal.

Abstract translation: 一种用于自动分析心脏信号的系统和方法，包括在包括一个或多个患者的多个发作数据记录的计算机存储介质上提供情节数据库的步骤。 每个剧集数据记录包括来自至少一个数据生成装置的心脏信号。 该方法还包括为至少具有N次拍子的第一个心脏信号选择N个节拍中的一个或多个作为一个或多个节拍模板的步骤。 另一步是使用计算机系统确定心脏信号的值K，其中K搏动模板可以表示心脏信号中的所有N个搏动。

公开(公告)号：US08078272B2

公开(公告)日：2011-12-13

申请号：US11625432

申请日：2007-01-22

Applicant: Yayun Lin

Inventor： Yayun Lin

IPC: A61B5/0402

CPC classification number: A61B5/7221 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/7264 ,  A61N1/3704 ,  A61N1/3718

Abstract: Detecting or validating signals such as cardiac beats can be performed in the presence of myopotential or other noise. An amplitude peak, which can be a candidate for a detected beat, can be used in a normalized or other weighted average, along with a preceding and subsequent sample. The weighted average is compared to a noise threshold. Based on the result, the amplitude peak is either deemed an actual beat (e.g., depolarization or repolarization), or noise. The described systems, devices, and methods can improve the accuracy of detecting an actual beat in the presence of noise, during normal sinus rhythm or during an arrhythmia such as ventricular fibrillation. This, in turn, improves the accuracy with which therapy is delivered or withheld by an implantable device.

Abstract translation: 检测或验证心脏搏动等信号可以在有电位或其他噪声的情况下进行。 可以作为检测到的拍子的候选者的振幅峰值可以与归一化或其他加权平均值一起使用，以及前一个和后续的采样。 将加权平均值与噪声阈值进行比较。 基于该结果，振幅峰值被认为是实际的搏动（例如去极化或复极化）或噪声。 所描述的系统，装置和方法可以提高在正常窦性心律期间或在诸如心室颤动的心律失常期间在噪声存在下检测实际搏动的准确性。 这反过来又提高了可植入装置输送或保留治疗的准确性。

公开(公告)号：US07653431B2

公开(公告)日：2010-01-26

申请号：US11312280

申请日：2005-12-20

Applicant: Shelley Cazares ,  Jaeho Kim ,  Yayun Lin ,  Carlos Ricci

Inventor： Shelley Cazares ,  Jaeho Kim ,  Yayun Lin ,  Carlos Ricci

IPC: A61B5/04

CPC classification number: A61B5/0464 ,  A61B5/04525 ,  A61B5/7264

Abstract: Cardiac systems and methods provide for discriminating between supraventricular tachyarrhythmia and ventricular tachyarrhythmia based on a determination that the patient's supraventricular rhythm exhibits rate dependency. One approach involves determining if a patient's supraventricular rhythm exhibits rate dependent morphology. If the patient's supraventricular rhythm is determined to exhibit rate dependent morphology, an implantable device classifies a detected tachyarrhythmia episode based on one or more templates selected from a plurality of rate-indexed templates stored in the device. Determining if the supraventricular rhythm exhibits rate dependent morphology may also include determining one or more rates at which the rate dependent morphology occurs.

Abstract translation: 心脏系统和方法基于确定患者的室上节律表现出速率依赖性，确定了室上性快速性心律失常与室性快速性心律失常之间的区别。 一种方法涉及确定患者的室上节律是否表现出速率依赖性形态。 如果确定患者的室上节律表现出与速率相关的形态，则可植入装置基于从存储在装置中的多个速率索引模板中选择的一个或多个模板来分类检测到的快速性心律失常发作。 确定室性心律显示出速率依赖性形态还可以包括确定发生速率依赖形态的一个或多个速率。

公开(公告)号：US20070239218A1

公开(公告)日：2007-10-11

申请号：US11277773

申请日：2006-03-29

Applicant: Gerrard Carlson ,  Yayun Lin

Inventor： Gerrard Carlson ,  Yayun Lin

IPC: A61N1/365

CPC classification number: A61N1/3962 ,  A61B5/02028 ,  A61B5/024 ,  A61B5/02405 ,  A61B7/04 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36578 ,  A61N1/37247 ,  A61N1/37282

Abstract: A system comprising an implantable medical device (IMD). The IMD includes an implantable sensor operable to produce an electrical signal representative of mechanical activity of a heart of a subject and a controller circuit coupled to the sensor. The IMD also includes a heart sound sensor interface circuit to produce a heart sound signal, a tachyarrhythmia detector, and a controller circuit. The controller circuit includes a hemodynamic stability assessment module configured to determine that at least one episode of ventricular tachyarrhythmia is detected in a subject and obtain a measurement of hemodynamic stability of the ventricular tachyarrhythmia from the heart sound signal.

Abstract translation: 一种包括可植入医疗装置（IMD）的系统。 IMD包括可植入传感器，其可操作以产生代表受试者心脏的机械活动的电信号和耦合到传感器的控制器电路。 IMD还包括产生心脏声音信号的心脏声音传感器接口电路，快速心律失常检测器和控制器电路。 控制器电路包括血液动力学稳定性评估模块，其被配置为确定在受试者中检测到至少一次心室快速性心律失常发作，并且从心脏声音信号获得心室快速性心律失常的血液动力学稳定性的测量。

公开(公告)号：US07215993B2

公开(公告)日：2007-05-08

申请号：US10213364

申请日：2002-08-06

Applicant: Yayun Lin

Inventor： Yayun Lin

IPC: A61B5/0456

CPC classification number: A61B5/7221 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/7264 ,  A61N1/3704 ,  A61N1/3718

Abstract: This document describes systems, devices, and methods for detecting or validating cardiac beats, such as in the presence of myopotential or other noise. In one example, an amplitude peak, which is a candidate for a detected cardiac beat, is used in a weighted average, along with a preceding and subsequent sample. The weighted average is compared to a noise threshold. Based on the result of comparison, the amplitude peak is either deemed an actual cardiac beat, or otherwise is deemed noise. The described systems, devices, and methods improve the accuracy of detecting an actual cardiac beat in the presence of noise, during normal sinus rhythm or during an arrhythmia such as ventricular fibrillation. This, in turn, improves the accuracy with which therapy is delivered or withheld by an implantable cardiac rhythm management device. In one example, such as where the system includes a cardiac signal detector with automatic gain control (AGC) circuitry, the weighted average is normalized.

Abstract translation: 本文件描述了用于检测或验证心脏搏动的系统，设备和方法，例如在存在神经或其他噪声的情况下。 在一个示例中，作为检测到的心跳的候选者的振幅峰值与加权平均值一起使用，以及之前和随后的样本。 将加权平均值与噪声阈值进行比较。 基于比较结果，振幅峰值被认为是实际心跳，或者被认为是噪声。 所描述的系统，装置和方法提高了在正常窦性心律期间或在诸如心室颤动的心律失常期间在噪声存在下检测实际心搏的准确性。 这反过来又提高了植入式心律管理装置的治疗的输送或保留的准确性。 在一个示例中，例如系统包括具有自动增益控制（AGC）电路的心脏信号检测器的地方，加权平均值被归一化。

公开(公告)号：US20070049974A1

公开(公告)日：2007-03-01

申请号：US11209976

申请日：2005-08-23

Applicant: Dan Li ,  Yayun Lin

Inventor： Dan Li ,  Yayun Lin

IPC: A61N1/00

CPC classification number: A61N1/3622 ,  A61B5/04525 ,  A61B5/0464 ,  A61N1/36585 ,  A61N1/3962

Abstract: Methods and systems for selecting tachyarrhythmia therapy based on the morphological organization level of the arrhythmia are described. Morphological organization levels of arrhythmias are associated with cardiac therapies. The morphological organization levels are related to cardiac signal morphologies of the arrhythmias. An arrhythmia episode is detected and the morphological organization level of the arrhythmia episode is determined. A cardiac therapy associated with the morphological organization level of the arrhythmia episode is delivered to treat the arrhythmia. For example, the morphological organization levels may be associated with the cardiac therapies based on one or more of retrospective database analysis patient therapy tolerance, and physician input. The associations may be static or may be dynamically adjusted based on therapy efficacy.

Abstract translation: 描述了基于心律失常形态组织水平选择快速性心律失常治疗的方法和系统。 心律失常的形态学组织水平与心脏治疗有关。 形态组织水平与心律失常的心脏信号形态有关。 检测到心律失常发作，确定心律失常发作的形态组织水平。 与心律失常发作的形态组织水平相关的心脏治疗被递送以治疗心律失常。 例如，形态组织水平可以基于回顾性数据库分析患者治疗耐受性和医师输入中的一种或多种与心脏治疗相关联。 协会可以是静态的，或者可以基于治疗功效来动态调整。