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公开(公告)号：US11363990B2
公开(公告)日：2022-06-21
申请号：US15826224
申请日：2017-11-29
Inventor： Nongjian Tao , Dangdang Shao
Abstract: A system and method for monitoring one or more physiological parameters of a subject under free-living conditions is provided. The system includes a camera configured to capture and record a video sequence including at least one image frame of at least one region of interest (ROI) of the subject's body. A computer in signal communication with the camera to receive signals transmitted by the camera representative of the video sequence includes a processor configured to process the signals associated with the video sequence recorded by the camera and a display configured to display data associated with the signals.
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公开(公告)号：US20220178834A1
公开(公告)日：2022-06-09
申请号：US17681128
申请日：2022-02-25
Inventor： Nongjian Tao , Di Wang , Chenwen Lin
Abstract: A micro-colorimetric sensor for sensing target chemicals using edge tracking includes a substrate. A plurality of parallel linear channels of porous media is entrenched into the substrate and each linear channel includes a sensing material adapted to sense one of several specific target chemicals in air. The plurality of parallel linear channels is separated by barrier material from the adjacent parallel linear channel where the barrier material blocks diffusion of chemicals from one linear channel to another. A plate is affixed over the substrate top to cover the plurality of parallel linear channels. An air sample is diffused along the micro-colorimetric sensor and color images are captured. An intensity profile is derived from the plurality of color images to determine a maximum and a minimum intensity value along the sensor. A plurality of positions along the sensor is tracked to determine an edge position.
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公开(公告)号：US11293875B2
公开(公告)日：2022-04-05
申请号：US16142463
申请日：2018-09-26
Inventor： Nongjian Tao , Di Wang , Chenwen Lin
Abstract: A micro-colorimetric sensor for sensing target chemicals that converts time sequence information into a spatial distribution of color. By tracking the spatial color distribution, chemical exposure over time is thus detected, which overcomes the limitation of traditional colorimetric sensors. A porous media is coated on a top surface of the substrate. Multiple sensing chemicals are fused in parallel linear channels into the porous media coating. A plate is affixed over the substrate top surface to cover the plurality of parallel linear channels. An air sample is diffused along the porous media to get a clear pattern of spatial color distribution and color images are captured. Optical parameters like gradient of spatial color distribution, intensity, and absorbance, etc., can be tracked to calculate analytes concentrations.
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公开(公告)号：US11229372B2
公开(公告)日：2022-01-25
申请号：US16335480
申请日：2017-09-21
Inventor： Nongjian Tao , Yuting Yang
IPC: A61B5/02 , A61B5/024 , G06T7/20 , G06T5/50 , G06T7/00 , G06T7/33 , A61B5/00 , G06T5/40 , A61B5/08 , H04N9/73
Abstract: Provided herein are systems and methods for computer monitoring of remote photoplethysmography (rPPG) from camera images based on chromaticity in a converted color space, which reduces motion-induced artifacts in camera images for improved rPPG computer monitoring of physiological parameters. In particular, a rPPG system for monitoring at least one physiological parameter from image data is disclosed herein. A processor subsystem electronically receives a first image data set representative of a series of consecutive images of at least a portion of a living body. The processor subsystem converts the first image data set from a first color space to a second color space to generate a second image data set including first channel data comprising a luminance component and second channel data comprising a chromatic component. The processor subsystem processes the second channel data to monitor the at least one physiological parameter of the living body.
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25.发明授权公开(公告)号：US10209232B2
公开(公告)日：2019-02-19
申请号：US15104668
申请日：2014-12-17
Inventor： Erica Forzani , Nongjian Tao , Di Zhao , Francis Tsow
Abstract: A CO2 detection chamber includes a gas inlet and a gas outlet. A CO2 sensor is housed in the CO2 detection chamber, where the sensor includes a reversible and selective pH-sensitive nanocomposite sensor element for CO2 detection, and a hydrophobic surface. A flowmeter, a thermistor and a humidity sensor operate to read flow and compensate for humidity conditions. A light source is coupled to receive signals from the CO2 sensor and respond to color changes in the sensor by transducing the color change into a light intensity change. A photodiode receives signals from the light source and responds to light intensity changes by transducing the light intensity changes into electronic signals representing varying degrees of light intensity. Data representing CO2 measurements is transmitted for display to a mobile device.
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Patent Agency Ranking
26.发明申请SPECIFIC, REVERSIBLE, AND WIDE-DYNAMIC RANGE SENSOR FOR REAL TIME DETECTION OF CARBON DIOXIDE 审中-公开二氧化碳实时检测的特殊，可逆和宽动态范围传感器公开(公告)号：US20160313290A1
公开(公告)日：2016-10-27
申请号：US15104668
申请日：2014-12-17
Inventor： Erica Forzani , Nongjian Tao , Di Zhao , Francis Tsow
IPC: G01N33/00 , G01N21/84 , G01N33/497 , A61B5/08 , A61B5/00
CPC classification number: G01N33/004 , A61B5/0022 , A61B5/0059 , A61B5/082 , A61B2560/0242 , A61B2560/0252 , G01N21/8483 , G01N33/497
Abstract: A CO2 detection chamber includes a gas inlet and a gas outlet. A CO2 sensor is housed in the CO2 detection chamber, where the sensor includes a reversible and selective pH-sensitive nanocomposite sensor element for CO2 detection, and a hydrophobic surface. A flowmeter, a thermistor and a humidity sensor operate to read flow and compensate for humidity conditions. A light source is coupled to receive signals from the CO2 sensor and respond to color changes in the sensor by transducing the color change into a light intensity change. A photodiode receives signals from the light source and responds to light intensity changes by transducing the light intensity changes into electronic signals representing varying degrees of light intensity. Data representing CO2 measurements is transmitted for display to a mobile device.
Abstract translation: CO 2检测室包括气体入口和气体出口。 CO 2传感器被容纳在CO 2检测室中，其中传感器包括用于CO 2检测的可逆和选择性pH敏感的纳米复合传感器元件和疏水表面。 流量计，热敏电阻和湿度传感器用于读取流量并补偿湿度条件。 耦合光源以从CO 2传感器接收信号，并通过将颜色变化转换为光强度变化来响应传感器中的颜色变化。 光电二极管从光源接收信号并通过将光强度变化转换成表示不同程度的光强度的电子信号来响应光强度变化。 发送表示二氧化碳测量的数据被发送以便显示到移动设备。
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公开(公告)号：US12146836B2
公开(公告)日：2024-11-19
申请号：US17681128
申请日：2022-02-25
Inventor： Nongjian Tao , Di Wang , Chenwen Lin
Abstract: A micro-colorimetric sensor for sensing target chemicals using edge tracking includes a substrate. A plurality of parallel linear channels of porous media is entrenched into the substrate and each linear channel includes a sensing material adapted to sense one of several specific target chemicals in air. The plurality of parallel linear channels is separated by barrier material from the adjacent parallel linear channel where the barrier material blocks diffusion of chemicals from one linear channel to another. A plate is affixed over the substrate top to cover the plurality of parallel linear channels. An air sample is diffused along the micro-colorimetric sensor and color images are captured. An intensity profile is derived from the plurality of color images to determine a maximum and a minimum intensity value along the sensor. A plurality of positions along the sensor is tracked to determine an edge position.
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公开(公告)号：US11543345B2
公开(公告)日：2023-01-03
申请号：US16857660
申请日：2020-04-24
Inventor： Nongjian Tao , Di Wang
IPC: H01L27/146 , G01N21/77 , G01N21/25 , G01N1/31
Abstract: A colorimetric sensor array includes a CMOS image sensor having a surface including pixels and a multiplicity of colorimetric sensing elements. Each sensing element has a sensing material disposed directly on one or more of the pixels. The colorimetric sensing elements are distributed randomly on the surface of the CMOS image sensor. Fabricating the colorimetric sensor array includes spraying a sensing fluid in the form of droplets directly on a surface of a CMOS image sensor and removing the solvent from the droplets to yield a multiplicity of sensing elements on the surface of the CMOS image sensor. Each droplet covers one or more pixels of the CMOS image sensor with the sensing fluid. The sensing fluid includes a solvent and a sensing material. The droplets are distributed randomly on the surface of the CMOS image sensor.
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29.发明授权公开(公告)号：US11480541B2
公开(公告)日：2022-10-25
申请号：US16584120
申请日：2019-09-26
Inventor： Nongjian Tao , Guanzhong Ma
IPC: G01N27/327 , G01N21/47 , G06T7/00 , C03C17/36 , G01N33/487 , G01N33/68 , G01N33/543 , G01N15/14 , G01N21/17
Abstract: A method for optical imaging of single protein molecules including tethering single protein molecules via a flexible polymer linker to a glass slide having a surface coated with an indium tin oxide (ITO) so that the single protein molecules are tethered to the coated surface. The single protein molecules are driven into oscillation by applying an alternating electric field to the coated surface and the glass slide is located in the field of view of an objective lens. Incident light is directed onto the coated surface from an angle to generate an evanescent field and produce scattered light. The scattered light is collected and imaged by a CMOS imager to record a sequence of images of the scattered light. A Fast Fourier Transform (FFT) filter is applied to each pixel of the recorded image sequence to produce an oscillation amplitude image from which size, charge, and mobility of the plurality of single protein molecules can be determined.
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30.发明授权公开(公告)号：US11198897B2
公开(公告)日：2021-12-14
申请号：US17072742
申请日：2020-10-16
Inventor： Nongjian Tao , Karan Syal
IPC: G06K9/00 , C12Q1/18 , G01N15/14 , G01N33/543 , G01N15/00
Abstract: A method for rapid antibiotic susceptibility testing by tracking sub-micron scale motion of single bacterial cells including obtaining a biological sample from a subject including live bacteria. Different doses of antibiotic are added to a multi-well glass slide and adding portions of the biological sample to the wells. Bacterial cells are tethered onto the surface. The tethered bacterial cells are imaged and tracked. Bacterial sub-micron motion of tethered cells is measured at the different doses. A processor performs statistical analysis on a population of cells for each antibiotic dose to generate an antibiotic dose curve proportional to the motion changes, where the antibiotic dose curve plots data including a decrease in movement over time indicating a proportional effectiveness of an antibiotic applied to a well.
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