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公开(公告)号:US20170157104A1
公开(公告)日:2017-06-08
申请号:US15431069
申请日:2017-02-13
申请人: AbbVie Inc.
发明人: Mary E. Bellizzi , David A. Betebenner , Jean-Christophe C. Califano , William A. Carroll , Daniel D. Caspi , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Yi Gao , Charles W. Hutchins , Douglas K. Hutchinson , Tammie K. Jinkerson , Warren M. Kati , Ryan G. Keddy , Allan C. Krueger , Wenke Li , Dachun Liu , Clarence J. Maring , Mark A. Matulenko , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , John K. Pratt , John T. Randolph , Todd W. Rockway , Kathy Sarris , Michael D. Tufano , Seble H. Wagaw , Rolf Wagner , Kevin R. Woller
IPC分类号: A61K31/454 , A61K31/4184 , A61K31/4439 , A61K31/422 , A61K31/438 , A61K31/4178 , A61K31/695 , A61K31/496 , A61K31/506 , A61K31/4418 , A61K31/5377 , A61K31/4355 , A61K45/06 , A61K31/4545
CPC分类号: A61K31/454 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D491/113 , C07F7/02 , Y02P20/582
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号:US09428514B2
公开(公告)日:2016-08-30
申请号:US14564352
申请日:2014-12-09
申请人: AbbVie Inc.
发明人: Andrew Bogdan , Warren M. Kati , Keith F. McDaniel , Chang H. Park , George S. Sheppard , Le Wang
IPC分类号: A01N43/54 , C07D487/04 , C07D211/86 , C07D405/04 , C07D401/04 , C07D417/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D213/69
CPC分类号: A61K31/506 , A61K31/4412 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , C07D211/86 , C07D213/69 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04
摘要: The present invention provides for compounds of formula (I) wherein Y1, Y2, R1, R2, R3, A1, A2, A3, and A4, have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
摘要翻译: 本发明提供式(I)化合物,其中Y1,Y2,R1,R2,R3,A1,A2,A3和A4具有说明书中定义的任何值及其药学上可接受的盐,其是有用的 作为治疗疾病和病症的药剂,包括炎性疾病,癌症和艾滋病。 还提供了由一种或多种式(I)化合物组成的药物组合物。
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公开(公告)号:US20150158873A1
公开(公告)日:2015-06-11
申请号:US14564352
申请日:2014-12-09
申请人: AbbVie Inc.
发明人: Andrew Bogdan , Warren M. Kati , Keith F. McDaniel , Chang H. Park , George S. Sheppard , Le Wang
IPC分类号: C07D487/04 , C07D417/04 , C07D401/04 , C07D211/86 , C07D405/04
CPC分类号: A61K31/506 , A61K31/4412 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , C07D211/86 , C07D213/69 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04
摘要: The present invention provides for compounds of formula (I) wherein Y1, Y2, R1, R2, R3, A1, A2, A3, and A4, have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
摘要翻译: 本发明提供式(I)化合物,其中Y1,Y2,R1,R2,R3,A1,A2,A3和A4具有说明书中定义的任何值及其药学上可接受的盐,其是有用的 作为治疗疾病和病症的药剂,包括炎性疾病,癌症和艾滋病。 还提供了由一种或多种式(I)化合物组成的药物组合物。
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公开(公告)号:US20190008866A1
公开(公告)日:2019-01-10
申请号:US16117203
申请日:2018-08-30
申请人: AbbVie Inc.
发明人: Andrew Bogdan , Warren M. Kati , Keith F. McDaniel , Chang H. Park , George S. Sheppard , Le Wang
IPC分类号: A61K31/506 , C07D487/04 , A61K31/4412 , A61K31/4433 , A61K31/4439 , A61K31/4709 , A61K31/497 , C07D211/86 , C07D213/69 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/04 , A61K31/444 , C07D417/12
摘要: The present invention provides for compounds of formula (I) wherein Y1, Y2, R1, R2, R3, A1, A2, A3, and A4, have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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公开(公告)号:US20180296566A1
公开(公告)日:2018-10-18
申请号:US16012379
申请日:2018-06-19
申请人: AbbVie Inc.
发明人: Le Wang , John K. Pratt , Keith F. McDaniel , Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James H. Holms , Warren M. Kati , Dachun Liu , Robert A. Mantei , William J. McClellan , George S. Sheppard , Carol K. Wada
IPC分类号: A61K31/541 , A61K45/06 , C07D487/04 , C07D471/04 , A61K31/5025 , A61K31/437 , A61K31/5377
摘要: The present invention provides for compounds of formula (I) wherein A1, A2, A3, A4, X1, X2, Y1, L1, G1, Rx, and Ry have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
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公开(公告)号:US10085985B2
公开(公告)日:2018-10-02
申请号:US15216855
申请日:2016-07-22
申请人: AbbVie Inc.
发明人: Andrew Bogdan , Warren M. Kati , Keith F. McDaniel , Chang H. Park , George S. Sheppard , Le Wang
IPC分类号: A61K31/506 , C07D487/04 , C07D211/86 , C07D405/04 , C07D401/04 , C07D417/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D213/69 , A61K31/4412 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497
摘要: The present invention provides for compounds of formula (I) wherein Y1, Y2, R1, R2, R3, A1, A2, A3, and A4, have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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公开(公告)号:US20170157105A1
公开(公告)日:2017-06-08
申请号:US15434789
申请日:2017-02-16
申请人: AbbVie Inc.
发明人: Mary E. Bellizzi , David A. Betebenner , Jean-Christophe C. Califano , William A. Carroll , Daniel D. Caspi , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Yi Gao , Charles W. Hutchins , Douglas K. Hutchinson , Tammie K. Jinkerson , Warren M. Kati , Ryan G. Keddy , Allan C. Krueger , Wenke Li , Dachun Liu , Clarence J. Maring , Mark A. Matulenko , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , John K. Pratt , John T. Randolph , Todd W. Rockway , Kathy Sarris , Michael D. Tufano , Seble H. Wagaw , Rolf Wagner , Kevin R. Woller
IPC分类号: A61K31/695
CPC分类号: A61K31/454 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D491/113 , C07F7/02 , Y02P20/582
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号:US20160368905A1
公开(公告)日:2016-12-22
申请号:US15141556
申请日:2016-04-28
申请人: AbbVie Inc.
发明人: David A. Betebenner , John K. Pratt , David A. DeGoey , Pamela L. Donner , Charles A. Flentge , Douglas K. Hutchinson , Warren M. Kati , Allan C. Krueger , Kenton L. Longenecker , Clarence J. Maring , John T. Randolph , Todd W. Rockway , Michael D. Tufano , Rolf Wagner , Dachun Liu
IPC分类号: C07D409/10 , A61K31/513 , C07D213/64 , A61K31/4418 , C07C311/08 , A61K31/18 , C07D233/72 , A61K31/4166 , A61K31/27 , C07D263/24 , A61K31/421 , C07D239/10 , C07D207/27 , A61K31/402 , C07D405/10 , C07D403/10 , A61K45/06 , A61K31/425 , C07D275/02 , C07D239/54
CPC分类号: C07D409/10 , A61K31/18 , A61K31/27 , A61K31/402 , A61K31/4166 , A61K31/421 , A61K31/425 , A61K31/4418 , A61K31/503 , A61K31/513 , A61K45/06 , C07C311/08 , C07D207/27 , C07D213/64 , C07D233/32 , C07D233/72 , C07D239/10 , C07D239/54 , C07D263/22 , C07D263/24 , C07D275/02 , C07D403/10 , C07D405/10 , Y02P20/55
摘要: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
摘要翻译: 本发明涉及:(a)特别是抑制HCV的化合物及其盐; (b)可用于制备这些化合物和盐的中间体; (c)包含这些化合物和盐的组合物; (d)制备这种中间体,化合物,盐和组合物的方法; (e)使用这些化合物,盐和组合物的方法; 和(f)包含这些化合物,盐和组合物的试剂盒。
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公开(公告)号:US20160331749A1
公开(公告)日:2016-11-17
申请号:US15216855
申请日:2016-07-22
申请人: AbbVie Inc.
发明人: Andrew Bogdan , Warren M. Kati , Keith F. McDaniel , Chang H. Park , George S. Sheppard , Le Wang
IPC分类号: A61K31/506 , A61K31/4433 , A61K31/497 , A61K31/444 , A61K31/4709 , A61K31/4412 , A61K31/4439
CPC分类号: A61K31/506 , A61K31/4412 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , C07D211/86 , C07D213/69 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04
摘要: The present invention provides for compounds of formula (I) wherein Y1, Y2, R1, R2, R3, A1, A2, A3, and A4, have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
摘要翻译: 其中Y1,Y2,R1,R2,R3,A1,A2,A3和A4具有说明书中定义的任何值及其药学上可接受的盐,其可用作治疗疾病和病症的试剂,包括 炎性疾病,癌症和艾滋病。 还提供了由一种或多种式(I)化合物组成的药物组合物。
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公开(公告)号:US09249138B2
公开(公告)日:2016-02-02
申请号:US14017901
申请日:2013-09-04
申请人: ABBVIE INC.
发明人: David A. Degoey , Pamela L. Donner , Warren M. Kati , Charles W. Hutchins , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Preethi Krishnan , Neeta C. Mistry , Tami J. Pilot-Matias , Sachin V. Patel , Xiaoyan Li , Todd N. Soltwedel , Lissa T. Nelson
IPC分类号: C07D239/48 , C07D471/04
CPC分类号: C07D471/04 , C07D239/48
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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