公开(公告)号：US10039754B2

公开(公告)日：2018-08-07

申请号：US15431069

申请日：2017-02-13

申请人： AbbVie Inc.

发明人： Mary E. Bellizzi ,  David A. Betebenner ,  Jean-Christophe C. Califano ,  William A. Carroll ,  Daniel D. Caspi ,  David A. DeGoey ,  Pamela L. Donner ,  Charles A. Flentge ,  Yi Gao ,  Charles W. Hutchins ,  Douglas K. Hutchinson ,  Tammie K. Jinkerson ,  Warren M. Kati ,  Ryan G. Keddy ,  Allan C. Krueger ,  Wenke Li ,  Dachun Liu ,  Clarence J. Maring ,  Mark A. Matulenko ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  John K. Pratt ,  John T. Randolph ,  Todd W. Rockway ,  Kathy Sarris ,  Michael D. Tufano ,  Seble H. Wagaw ,  Rolf Wagner ,  Kevin R. Woller

IPC分类号： A61K38/00 ,  A61K31/454 ,  A61K45/06 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/422 ,  A61K31/438 ,  A61K31/4545 ,  A61K31/695 ,  A61K31/496 ,  A61K31/506 ,  A61K31/4418 ,  A61K31/5377 ,  A61K31/4355 ,  A61K31/4178

CPC分类号： A61K31/454 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D491/113 ,  C07F7/02 ,  Y02P20/582

摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US20180162850A1

公开(公告)日：2018-06-14

申请号：US15735418

申请日：2016-06-23

申请人： Takeda Pharmaceutical Company Limited

发明人： Takahiro SUGIMOTO ,  Shinkichi SUZUKI ,  Hiroki SAKAMOTO ,  Masami YAMADA ,  Minoru NAKAMURA ,  Makoto KAMATA ,  Kenichiro SHIMOKAWA ,  Masaki OGINO ,  Eiji KIMURA ,  Masataka MURAKAMI ,  Jinichi YONEMORI ,  Takuto KOJIMA

IPC分类号： C07D413/14 ,  C07D413/10 ,  C07D265/22 ,  C07D417/10 ,  C07F7/08 ,  C07D491/107 ,  A61P25/28

CPC分类号： C07D265/22 ,  A61P25/28 ,  C07B2200/07 ,  C07D413/04 ,  C07D413/06 ,  C07D413/10 ,  C07D413/14 ,  C07D417/06 ,  C07D417/10 ,  C07D471/04 ,  C07D491/107 ,  C07F7/02 ,  C07F7/0814

摘要： The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, which may be useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof: wherein each symbol is as defined in the attached DESCRIPTION.

公开(公告)号：US09938368B2

公开(公告)日：2018-04-10

申请号：US14383038

申请日：2013-03-07

申请人： The Regents of the University of California

发明人： Aaron M. Kushner ,  Zhibin Guan ,  Gregory Williams ,  Yulin Chen

IPC分类号： C07F7/02 ,  C08F293/00 ,  C08K3/36 ,  C08G83/00 ,  C08L51/10 ,  C08L101/02 ,  C08F292/00

CPC分类号： C08F293/00 ,  C07F7/02 ,  C08F292/00 ,  C08F293/005 ,  C08F2438/01 ,  C08G83/008 ,  C08K3/36 ,  C08L51/10 ,  C08L101/02 ,  C08F212/14 ,  C08F2220/365

摘要： A method for a polymeric or nanocomposite material. The method includes assembling a multiphase hard-soft structure, where the structure includes a hard micro- or nano-phase, and a soft micro- or nano-phase that includes a polymeric scaffold. In the method, the polymeric scaffold includes dynamically interacting motifs and has a glass transition temperature (Tg) lower than the intended operating temperature of the material.

公开(公告)号：US09759855B2

公开(公告)日：2017-09-12

申请号：US14769285

申请日：2013-02-25

申请人： Empire Technology Development LLC

发明人： Hidekazu Hayama

IPC分类号： F21V8/00 ,  C07F15/00 ,  C07F7/02 ,  C09K11/02 ,  C09K11/06 ,  G02F1/1335

CPC分类号： G02B6/0065 ,  C07F7/02 ,  C07F15/0033 ,  C09K11/02 ,  C09K11/025 ,  C09K11/06 ,  C09K2211/1088 ,  G02B6/0035 ,  G02B6/0041 ,  G02B6/0055 ,  G02F2001/133614

摘要： Hybrid nanoparticles and transparent light guides using the hybrid nanoparticles are disclosed. In some examples, a hybrid nanoparticle may include an organic blue-light emitting material, and an inorganic material bonded to the organic blue-light emitting material.

公开(公告)号：US20160349268A1

公开(公告)日：2016-12-01

申请号：US15114097

申请日：2015-01-28

申请人： CAPROTEC BIOANALYTICS GMBH

发明人： Hubert KOSTER ,  Mathias DREGER ,  Simon MICHAELIS ,  Thomas LENZ ,  Jelena MILIC ,  Michael SEFKOW

IPC分类号： G01N33/68 ,  C07F7/02 ,  C07H19/16 ,  G01N33/552

CPC分类号： G01N33/6848 ,  C07F7/02 ,  C07H19/16 ,  G01N33/552 ,  G01N33/6845 ,  G01N2500/04

摘要： The invention relates to a process for isolating and/or characterising biomolecules and/or biomolecule fragments, in particular proteins and/or protein fragments, comprising the steps: provision of an immobilized compound IC through the interaction of a capture compound CC and the target compound T and a carrier compound CCB, carrying out a division step, in which a cleavable function F is cleaved, and a division compound DC is produced, and isolation and/or characterisation of said division compound DC. The invention relates further to a carrier compound CCB, a capture compound CC, a precursor compound PC and a division compound DC.

摘要翻译： 本发明涉及用于分离和/或表征生物分子和/或生物分子片段，特别是蛋白质和/或蛋白质片段的方法，包括以下步骤：通过捕获化合物CC和目标化合物的相互作用提供固定的化合物IC T和载体化合物CCB，进行分裂步骤，其中切割功能F被切割，并产生分裂化合物DC，以及分离化合物DC的分离和/或表征。 本发明还涉及载体化合物CCB，捕获化合物CC，前体化合物PC和分割化合物DC。

公开(公告)号：US08937150B2

公开(公告)日：2015-01-20

申请号：US13100827

申请日：2011-05-04

申请人： David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Yi Gao ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  Michael D. Tufano ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi ,  William A. Carroll

发明人： David A. DeGoey ,  Warren M. Kati ,  Charles W. Hutchins ,  Pamela L. Donner ,  Allan C. Krueger ,  John T. Randolph ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  Mark A. Matulenko ,  Ryan G. Keddy ,  Tammie K. Jinkerson ,  Yi Gao ,  Dachun Liu ,  John K. Pratt ,  Todd W. Rockway ,  Clarence J. Maring ,  Douglas K. Hutchinson ,  Charles A. Flentge ,  Rolf Wagner ,  Michael D. Tufano ,  David A. Betebenner ,  Kathy Sarris ,  Kevin R. Woller ,  Seble H. Wagaw ,  Jean C. Califano ,  Wenke Li ,  Daniel D. Caspi ,  Mary E. Bellizzi ,  William A. Carroll

IPC分类号： A61K31/66 ,  C07K16/00 ,  C07D401/14 ,  C07D491/113 ,  C07D413/14 ,  C07D403/14 ,  C07D417/14 ,  C07D405/14 ,  C07D453/00

CPC分类号： A61K31/454 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D491/113 ,  C07F7/02 ,  Y02P20/582

摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：US20140107365A1

公开(公告)日：2014-04-17

申请号：US14051853

申请日：2013-10-11

申请人： Southern Methodist University

发明人： David Y. Son ,  Abby R. Jennings

IPC分类号： C07F7/18

CPC分类号： C07F7/1804 ,  C07F7/02 ,  C07F7/188

摘要： The present invention provides multi-thiol mercaptoalkoxysilane compositions and methods of making multi-thiol mercaptoalkoxysilane compositions having the formula: wherein the R3 group, and the R4 group are independently an alkoxy, a halogen, an alkyl, an aryl, a heteroaryl, a heterocycle or derivatives thereof and n is an integer between 1 and 30.

摘要翻译： 本发明提供多硫醇巯基烷氧基硅烷组合物和制备具有下式的多硫醇巯基烷氧基硅烷组合物的方法：其中R3基团和R4基团独立地为烷氧基，卤素，烷基，芳基，杂芳基，杂环 或其衍生物，n为1〜30的整数。

公开(公告)号：US4013574A

公开(公告)日：1977-03-22

申请号：US571709

申请日：1975-04-22

申请人： John W. Leikhim ,  Edward J. Maguire, Jr. ,  David C. Heckert ,  David M. Watt, Jr.

发明人： John W. Leikhim ,  Edward J. Maguire, Jr. ,  David C. Heckert ,  David M. Watt, Jr.

IPC分类号： C07F7/02 ,  C11D3/16 ,  C11D17/00 ,  C11D1/00

CPC分类号： C11D17/0039 ,  C07F7/02 ,  C11D3/162

摘要： A prill comprising an organosilane and a water-soluble or water-dispersible, normally solid, nonionic material. The organosilane is stabilized within the prill and can be included in moisture-containing, highly alkaline or electrolyte-containing compositions, e.g. detergent compositions.

摘要翻译： 包含有机硅烷和水溶性或水分散性，通常为固体的非离子材料的颗粒。 有机硅烷稳定在颗粒内，并且可以包含在含水的，高碱性的或含电解质的组合物中。 洗涤剂组合物。

公开(公告)号：US3567750A

公开(公告)日：1971-03-02

申请号：US3567750D

申请日：1968-12-23

申请人： VENTRON CORP

发明人： WADE ROBERT C

IPC分类号： C01B35/00 ,  C03C25/38 ,  C07F5/02 ,  C07F5/04 ,  C07F5/06 ,  C07F7/00 ,  C07F7/02 ,  C07F9/00 ,  C07F11/00 ,  C07F15/02 ,  C08F10/00 ,  D06M11/17 ,  D06M11/20 ,  D06M11/22 ,  D06M11/24 ,  D06M11/28 ,  D06M13/503

CPC分类号： D06M13/503 ,  C01B35/00 ,  C03C25/38 ,  C07F5/022 ,  C07F5/04 ,  C07F5/069 ,  C07F7/006 ,  C07F7/02 ,  C07F7/025 ,  C07F9/005 ,  C07F11/005 ,  C07F15/025 ,  C08F10/00 ,  D06M11/17 ,  D06M11/20 ,  D06M11/22 ,  D06M11/24 ,  D06M11/28 ,  C08F4/58 ,  C08F4/6265 ,  C08F4/603

摘要： THE INVENTION RELATES TO PRODUCTS OF UNKNOWN CHEMICAL STRUCTURE PREPARED BY REACTING A BORATE ESTER SUCH AS TRIMETHYL BORATE, TRIETHYL BORATE, TRIPROPYL BORATE, TRIBUTYL BORATE, TRIHEXYL BORATE, TRIHEXYLENE GLYCOL BIBORATE, TRIM,P-CRESYL BORATE, AND TRIMETHOXYLBOROXXINE WITH A CHLORIDE OF A METAL SELECTED FROM THE GROUP CONSISTING OF TI(IV), ZR(IV), HF(IV), SN(IV), AL(III), FE(III), GA(III), IN(III), MO(V), NB(V), TA(V), AND W(VI) IN A MOLAR RATIO OF AT LEAST 0.33 MOLE OF THE SELECTED BORATE ESTER FOR EACH MOLE OF THE CHLORIDE OF THE SELECTED METAL IN A SUBSTANTIALLY ANYDROUS DILUENT, SUCH AS AN EXCESS OF THE SELECTED BORATE ESTER, METHYLENE CHLORIDE, CHLOROFORM, AND CARBON TETRACHLORIDE, AT A TEMPERATURE BETWEEN ROOM TEMPERATURE AND ABOUT 200*C. UNTIL THE REACTION MIXTURE CEASES TO GIVE OFF ORGANIC CHLORIDE THEREBY FORMING ALIQUOR COMPRISING THE DILUENT AND A COMPOUND OF COMPLEX CHEMICAL STRUCTURE COMPRISING THE SELECTED METAL, BORON, CARBON, HYDROGEN, CHLORINE, AND OXYGEN. THEN THERE IS ADDED TO SAID LIQUOR A SILICON-CONTAINING COMPOUND CONFORMING TO THE FORMULA CLNSIR4-N WHERE N IS AN INTERGER FROM 1 TO 4 AND R IS AN ALKYL OR ARYL RADICAL IN A MOLAR QUANTITY NOT GREATER THAN THAT OF THE CHLORIDE OF THE SELECTED METAL TO REACT WITH SAID COMPLEX COMPOUND AT A TEMPERATURE BETWEEN ROOM TEMPERATURE AND ABOUT 200*C. THEREBY FORMING A SECOND COMPOUND OF COMPLEX CHEMICAL STRUCTURE. THE SECOND COMPOUND OF COMPLEX CHEMICAL STRUCTURE MAY BE ISOLATED BY REMOVING VOLATILE MATERIAL FROM THE REACTION MIXTURE BY EVAPORATION. SILICON TETRACHLORIDE, DIMETHYL-DICHLOROSILANE, DIPHENYLDICHLOROSILANE AND TRIMETHYLCHLOROSILANE ARE ILLUSTRATIVE OF COMPOUNDS CONFORMING TO THE FORMULA CLNSIR4-N.

公开(公告)号：US3519664A

公开(公告)日：1970-07-07

申请号：US3519664D

申请日：1968-11-18

申请人： VENTRON CORP

发明人： WADE ROBERT C

IPC分类号： C01B35/00 ,  C03C25/38 ,  C07F5/02 ,  C07F5/04 ,  C07F5/06 ,  C07F7/00 ,  C07F7/02 ,  C07F9/00 ,  C07F11/00 ,  C07F15/02 ,  C08F10/00 ,  D06M11/17 ,  D06M11/20 ,  D06M11/22 ,  D06M11/24 ,  D06M11/28 ,  D06M13/503 ,  C07F7/28

CPC分类号： D06M13/503 ,  C01B35/00 ,  C03C25/38 ,  C07F5/022 ,  C07F5/04 ,  C07F5/069 ,  C07F7/006 ,  C07F7/02 ,  C07F7/025 ,  C07F9/005 ,  C07F11/005 ,  C07F15/025 ,  C08F10/00 ,  D06M11/17 ,  D06M11/20 ,  D06M11/22 ,  D06M11/24 ,  D06M11/28 ,  C08F4/58 ,  C08F4/603 ,  C08F4/6265