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34 条记录 (耗时 0.03 秒)

    Method and apparatus for adaptive control of neurostimulation using cardiac restitution
    22.
    发明授权
    Method and apparatus for adaptive control of neurostimulation using cardiac restitution 有权
    使用心脏恢复法进行神经刺激的自适应控制的方法和装置

    公开(公告)号：US09126045B2

    公开(公告)日：2015-09-08

    申请号：US13586503

    申请日：2012-08-15

    申请人： Shibaji Shome ,  Stephen Ruble ,  Jason J. Hamann ,  Stephen J. Hahn ,  Arjun D. Sharma

    发明人： Shibaji Shome ,  Stephen Ruble ,  Jason J. Hamann ,  Stephen J. Hahn ,  Arjun D. Sharma

    IPC分类号： A61N1/365 ,  A61N1/36

    CPC分类号： A61N1/36114 ,  A61N1/36139

    摘要： A neurostimulation system measures a cardiac parameter at various cardiac intervals and analyzes its restitution, including computing a restitution slope being a rate of change of the restitution parameter with respect to change in the cardiac interval. In various embodiments, the system uses the restitution slope to provide for adaptive control of neurostimulation. In various embodiments, one or more cardiac parameters such as action potential duration (APD), conduction velocity (CV), QT interval (QT), and/or T-wave morphology (TM) parameter are measured and analyzed for restitution of each parameter, which is then used to control the delivery of the neurostimulation.

    摘要翻译： 神经刺激系统以各种心脏间隔测量心脏参数并分析其恢复，包括计算相对于心脏间隔变化的恢复参数的变化率的恢复斜率。 在各种实施例中，系统使用恢复斜率来提供神经刺激的自适应控制。 在各种实施例中，测量并分析一个或多个心脏参数，例如动作电位持续时间（APD），传导速度（CV），QT间期（QT）和/或T波形态（TM）参数，以分析每个参数的恢复 ，然后用于控制神经刺激的递送。

    Management of fusion beat detection during capture threshold determination
    23.
    发明授权
    Management of fusion beat detection during capture threshold determination 有权
    捕获阈值确定期间融合搏动检测的管理

    公开(公告)号：US09020596B2

    公开(公告)日：2015-04-28

    申请号：US13546820

    申请日：2012-07-11

    申请人： Shibaji Shome ,  Yanting Dong ,  Aaron R. McCabe

    发明人： Shibaji Shome ,  Yanting Dong ,  Aaron R. McCabe

    IPC分类号： A61N1/37

    CPC分类号： A61N1/3712

    摘要： An improved technique is described for dealing with the detection of fusion beats when capture verification is performed by a cardiac pacing device such as during a capture threshold determination procedure. Schemes for classifying heart beats may misclassify beats as fusion beats due to feature/morphology changes in the test electrogram waveform that may occur even when capture is achieved.

    摘要翻译： 描述了一种改进的技术，用于处理在心脏起搏装置执行捕获验证时，例如在捕获阈值确定过程期间的融合节拍的检测。 分类心脏跳动的方案可能由于测试电描记图波形中的特征/形态变化而将节拍错误分类为融合节拍，即使实现捕获也可能发生。

    AUTOTHRESHOLD WITH SENSING FROM PACING CATHODE
    24.
    发明申请
    AUTOTHRESHOLD WITH SENSING FROM PACING CATHODE 有权
    自动检测从PACING CATHODE

    公开(公告)号：US20130138174A1

    公开(公告)日：2013-05-30

    申请号：US13684814

    申请日：2012-11-26

    申请人： David W. Yost ,  Deepa Mahajan ,  Clayton S. Foster ,  Aaron R. McCabe ,  Shibaji Shome ,  Amy Jean Brisben

    发明人： David W. Yost ,  Deepa Mahajan ,  Clayton S. Foster ,  Aaron R. McCabe ,  Shibaji Shome ,  Amy Jean Brisben

    IPC分类号： A61N1/37

    CPC分类号： A61N1/3712

    摘要： Cardiac electrostimulation energy is delivered to a heart chamber of a subject according to a normal pacing mode using a set of implantable pacing electrodes. When a threshold test for the heart chamber is initiated and a sensing electrode independent from the set of pacing electrodes is unavailable for the heart chamber, cardiac electrostimulation energy is delivered to the subject according to a threshold test mode. The threshold test mode includes sensing a cardiac activity signal from a subject using a set of sensing electrodes that includes an electrode common to the set of pacing electrodes, and changing the electrostimulation energy and sensing a resulting cardiac activity signal using the set of sensing electrodes to determine the optimum electrostimulation energy for capture of the heart chamber.

    摘要翻译： 心脏电刺激能量使用一组可植入起搏电极根据正常起搏模式递送到受试者的心室。 当启动心脏室的阈值测试并且独立于该组起搏电极的感测电极不能用于心脏室时，根据阈值测试模式将心脏电刺激能量递送给受试者。 阈值测试模式包括使用包括一组起搏电极的电极的一组感测电极来感测来自对象的心脏活动信号，并且使用该组感测电极改变电刺激能量并感测所得到的心脏活动信号， 确定用于捕获心室的最佳电刺激能量。

    Systems and Methods for Ranking and Selection of Pacing Vectors
    26.
    发明申请
    Systems and Methods for Ranking and Selection of Pacing Vectors 有权
    用于起搏向量排序和选择的系统和方法

    公开(公告)号：US20110004264A1

    公开(公告)日：2011-01-06

    申请号：US12822487

    申请日：2010-06-24

    申请人： Krzysztof Z. Siejko ,  Shibaji Shome ,  Jiang Ding

    发明人： Krzysztof Z. Siejko ,  Shibaji Shome ,  Jiang Ding

    IPC分类号： A61N1/08

    CPC分类号： A61N1/3704 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/36514 ,  A61N1/36542 ,  A61N1/36585 ,  A61N1/368 ,  A61N1/3686 ,  A61N1/371

    摘要： Approaches to rank potential left ventricular (LV) pacing vectors are described. Early elimination tests are performed to determine the viability of LV cathode electrodes. Some LV cathodes are eliminated from further testing based on the early elimination tests. LV cathodes identified as viable cathodes are tested further. Viable LV cathode electrodes are tested for hemodynamic efficacy. Cardiac capture and phrenic nerve activation thresholds are then measured for potential LV pacing vectors comprising a viable LV cathode electrode and an anode electrode. The potential LV pacing vectors are ranked based on one or more of the hemodynamic efficacy of the LV cathodes, the cardiac capture thresholds, and the phrenic nerve activation thresholds.

    摘要翻译： 描述了评估潜在的左心室（LV）起搏向量的方法。 执行早期消除测试以确定LV阴极的可行性。 基于早期消除测试，一些LV阴极被进一步测试消除。 确定为阴极的LV阴极被进一步测试。 测试可行的LV阴极电极的血液动力学效能。 然后测量包含可行的LV阴极电极和阳极电极的潜在LV起搏向量的心脏捕获和膈神经激活阈值。 潜在的LV起搏向量基于LV阴极的血液动力学功效，心脏捕获阈值和膈神经激活阈值中的一种或多种进行排名。

    Systems and methods for ranking and selection of pacing vectors
    28.
    发明授权
    Systems and methods for ranking and selection of pacing vectors 有权
    起搏向量的排序和选择的系统和方法

    公开(公告)号：US08886313B2

    公开(公告)日：2014-11-11

    申请号：US12822487

    申请日：2010-06-24

    申请人： Krzysztof Z. Siejko ,  Shibaji Shome ,  Jiang Ding

    发明人： Krzysztof Z. Siejko ,  Shibaji Shome ,  Jiang Ding

    IPC分类号： A61N1/05 ,  A61N1/365 ,  A61N1/36 ,  A61N1/368 ,  A61N1/37

    CPC分类号： A61N1/3704 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/36514 ,  A61N1/36542 ,  A61N1/36585 ,  A61N1/368 ,  A61N1/3686 ,  A61N1/371

    摘要： Approaches to rank potential left ventricular (LV) pacing vectors are described. Early elimination tests are performed to determine the viability of LV cathode electrodes. Some LV cathodes are eliminated from further testing based on the early elimination tests. LV cathodes identified as viable cathodes are tested further. Viable LV cathode electrodes are tested for hemodynamic efficacy. Cardiac capture and phrenic nerve activation thresholds are then measured for potential LV pacing vectors comprising a viable LV cathode electrode and an anode electrode. The potential LV pacing vectors are ranked based on one or more of the hemodynamic efficacy of the LV cathodes, the cardiac capture thresholds, and the phrenic nerve activation thresholds.

    摘要翻译： 描述了评估潜在的左心室（LV）起搏向量的方法。 执行早期消除测试以确定LV阴极的可行性。 基于早期消除测试，一些LV阴极被进一步测试消除。 确定为阴极的LV阴极被进一步测试。 测试可行的LV阴极电极的血液动力学效能。 然后测量包含可行的LV阴极电极和阳极电极的潜在LV起搏向量的心脏捕获和膈神经激活阈值。 潜在的LV起搏向量基于LV阴极的血液动力学功效，心脏捕获阈值和膈神经激活阈值中的一种或多种进行排名。

    Anodal stimulation detection and avoidance
    30.
    发明授权
    Anodal stimulation detection and avoidance 有权
    阳极刺激检测和避免

    公开(公告)号：US08401639B2

    公开(公告)日：2013-03-19

    申请号：US12724729

    申请日：2010-03-16

    申请人： Aaron R. McCabe ,  Shibaji Shome ,  Yanting Dong ,  Amy Jean Brisben

    发明人： Aaron R. McCabe ,  Shibaji Shome ,  Yanting Dong ,  Amy Jean Brisben

    IPC分类号： A61N1/39

    CPC分类号： A61N1/3627 ,  A61N1/3712

    摘要： Cardiac resynchronization therapy is delivered to a heart using an extended bipolar electrode configuration in accordance with programmed pacing parameters including a non-zero intraventricular delay. The extended bipolar electrode configuration comprises a left ventricular electrode defining a cathode of the extended bipolar electrode configuration and a right ventricular electrode defining an anode of the extended bipolar electrode configuration. A pace pulse is delivered to the left ventricular electrode and anodal stimulation of the right ventricle is detected based on the sensed response to the pace pulse.

    摘要翻译： 使用扩展双极电极配置将心脏再同步治疗按照已编程的起搏参数（包括非零心室延迟）递送至心脏。 扩展双极电极配置包括限定扩展双极电极配置的阴极的左心室电极和限定延伸双极电极配置的阳极的右心室电极。 步速脉冲输送到左心室电极，并且基于感测到的对步速脉冲的响应来检测右心室的阳极刺激。