公开(公告)号：US5752977A

公开(公告)日：1998-05-19

申请号：US842581

申请日：1997-04-15

申请人： John J. Grevious ,  Robert A. Neumann ,  Koen J. Weijand

发明人： John J. Grevious ,  Robert A. Neumann ,  Koen J. Weijand

IPC分类号： A61N1/372 ,  A61N1/37

CPC分类号： A61N1/3727

摘要： A method and apparatus for transmitting information-encoded, telemetry signals percutaneously between an implanted medical device and an external device as telemetry RF pulses which are modulated in pulse position and/or in pulse width within a telemetry frame comprising at least a telemetry frame boundary RF pulse and a telemetry frame data RF pulse. Data to be transmitted in a given telemetry frame is encoded into a PPM code for positioning at least certain telemetry RF pulses at pulse positions of the telemetry frame and a PWM code for establishing the pulse widths of at least certain telemetry RF pulses of the telemetry frame. The telemetry frame is formatted from the PPM code, and the telemetry RF pulses are generated at the formatted pulse positions within the telemetry frame. The pulse widths of the telemetry RF pulses are controlled in accordance with the PWM code for the certain telemetry RF pulses. The PWM and PPM combinations of RF pulses of a telemetry frame can convey the data type, the telemetry frame frequency, number of pulse positions of the telemetry frame, data type and data content, including the identification of the implanted medical device. The selective PWM of certain or all RF pulses of the telemetry frame allows its data content to be increased or the telemetry frame size to be shortened or telemetry frame energy reduced by reducing the number of RF pulses of the telemetry frame or the range of possible pulse positions in the telemetry frame. The PWM may be reduced or disabled in noisy conditions.

摘要翻译： 一种用于在植入的医疗装置和外部装置之间经皮传输信息编码的遥测信号的方法和装置，作为在遥测框架内以脉冲位置和/或脉冲宽度调制的遥测RF脉冲，其包括至少一个遥测帧边界RF 脉冲和遥测帧数据RF脉冲。 要在给定遥测帧中传输的数据被编码为PPM码，用于在遥测帧的脉冲位置处至少定位一些遥测RF脉冲，以及用于建立遥测帧的至少某些遥测RF脉冲的脉冲宽度的PWM码 。 遥测帧由PPM码格式化，遥测RF脉冲在遥测帧内的格式化脉冲位置产生。 遥测RF脉冲的脉冲宽度根据某些遥测RF脉冲的PWM码进行控制。 遥测帧的RF脉冲的PWM和PPM组合可以传送数据类型，遥测帧频率，遥测帧的脉冲位置数，数据类型和数据内容，包括植入的医疗设备的识别。 遥测帧的某些或所有RF脉冲的选择性PWM允许通过减少遥测帧的RF脉冲的数量或可能的脉冲的范围来增加其数据内容或缩短遥测帧大小或缩短遥测帧的能量， 位置在遥测框架。 在噪声条件下，PWM可能会被减少或禁用。

公开(公告)号：US07209790B2

公开(公告)日：2007-04-24

申请号：US10722891

申请日：2003-11-26

申请人： David L. Thompson ,  Koen J. Weijand ,  Daniel R. Greeninger

发明人： David L. Thompson ,  Koen J. Weijand ,  Daniel R. Greeninger

IPC分类号： A61N1/08

CPC分类号： A61N1/37252 ,  H04B1/385 ,  H04B1/401 ,  Y10S128/903

摘要： The invention is directed to a programmer for communication with different medical devices that utilize different telemetry communication techniques. The programmer receives telemetry signals from a given medical device, and selects an appropriate communication mode, which can be pre-programmed into the programmer as one of a plurality of possible communication modes. The programmer can configure itself for communication with a given medical device based on the telemetry signal it receives. Specifically the programmer is implemented as a software based, power efficient receiver/transmitter based upon an inexpensive, simple motor-controller DSP.

摘要翻译： 本发明涉及一种用于与使用不同遥测通信技术的不同医疗设备进行通信的编程器。 编程器从给定的医疗设备接收遥测信号，并且选择适当的通信模式，其可以作为多种可能的通信模式之一被预先编程到编程器中。 编程人员可以根据其接收的遥测信号，将其自身配置为与给定医疗设备进行通信。 具体地说，程序员被实现为基于基于软件的功率效率接收器/发射机，其基于廉价的简单的电动机控制器DSP。

公开(公告)号：US07070577B1

公开(公告)日：2006-07-04

申请号：US09519563

申请日：2000-03-06

申请人： Markus Haller ,  Koen J. Weijand

发明人： Markus Haller ,  Koen J. Weijand

IPC分类号： A61M37/00

CPC分类号： A61M5/14276 ,  A61M5/16831 ,  A61M31/002 ,  A61M39/22 ,  A61M2005/14513 ,  A61M2205/0244 ,  A61M2205/0294 ,  A61M2205/3523 ,  A61M2205/8212 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0048 ,  F16K2099/0088 ,  H02N2/067

摘要： An implantable beneficial agent infusion device featuring a unique energy recovery circuit and a deflectable energy storing member such as a piezo-electric membrane is disclosed. The circuit and deflectable energy storing member cooperate to permit electrical energy employed to activate the member to be at least partially recovered. In a preferred embodiment, the deflectable energy storing member is connected to a seal which is opened to permit the delivery or infusion of a pre-determined amount of a beneficial agent to a patient when the member is deflected or actuated through the application of a sufficiently high voltage thereacross. Charge stored on or in the deflectable energy storing member as a result of the voltage being applied thereacross is recovered by a novel circuit when the deflectable energy storing membrane is permitted to return to its non-actuated state or position.

摘要翻译： 公开了一种具有独特的能量回收电路和诸如压电膜的可偏转能量存储构件的植入式有益剂输注装置。 电路和可偏转能量存储构件协作以允许用于激活构件的电能被至少部分恢复。 在优选实施例中，可偏转能量存储构件连接到打开的密封件，以允许当通过足够的应用来使构件偏转或致动时向患者输送或输注预定量的有益剂 高电压。 当可偏转能量储存膜被允许返回到其非致动状态或位置时，作为施加在其上的电压的结果，存储在可偏转能量存储构件上或其中的电荷通过新颖的电路回收。

公开(公告)号：US06859385B2

公开(公告)日：2005-02-22

申请号：US10341133

申请日：2003-01-13

申请人： Magnus Karl-Olof Karlsson ,  Koen J. Weijand ,  Tony Hans Ohlsson

发明人： Magnus Karl-Olof Karlsson ,  Koen J. Weijand ,  Tony Hans Ohlsson

IPC分类号： G11C11/412 ,  G11C11/413 ,  G11C11/00

CPC分类号： G11C11/412 ,  G11C11/413

摘要： An SRAM has a bit cell for storing a data bit in voltage mode at a data node, and a single bit line for respectively writing to and reading from said data node a data bit in reference current controlled mode. The SRAM has ultra low power consumption and can be used in word based SRAMs.

摘要翻译： SRAM具有用于在数据节点处以电压模式存储数据位的位单元和用于分别以参考电流控制模式分别写入和读取数据位的数据位的单位线。 SRAM具有超低功耗，可用于基于字的SRAM。

公开(公告)号：US06261280B1

公开(公告)日：2001-07-17

申请号：US09551193

申请日：2000-04-17

申请人： Richard P. M. Houben ,  Alexis C. M. Renirie ,  Koen J. Weijand

发明人： Richard P. M. Houben ,  Alexis C. M. Renirie ,  Koen J. Weijand

IPC分类号： A61M3100

CPC分类号： A61N1/36007

摘要： There is provided an implantable system and method for monitoring pancreatic beta cell electrical activity in a patient in order to obtain a measure of a patient's insulin demand and blood glucose level. A stimulus generator is controlled to deliver stimulus pulses so as to synchronize pancreatic beta cell depolarization, thereby producing an enhanced electrical signal which is sensed and processed. In a specific embodiment, the signal is processed to determine the start and end of beta cell depolarization, from which the depolarization duration is obtained. In order to reduce cardiac interference, each stimulus pulse is timed to be offset from the QRS signal which can interfere with the pancreas sensing. Additionally, the beta cell signals are processed by a correction circuit, e.g., an adaptive filter, to remove QRS artifacts, as well as artifacts from other sources, such as respiration. The thus obtained insulin demand signal is used either to control delivery of insulin from an implanted insulin pump, or to control ongoing pancreatic stimulation of a form to enhance insulin production.

摘要翻译： 提供了一种用于监测患者胰腺β细胞电活动的可植入系统和方法，以便获得患者的胰岛素需求量和血糖水平的量度。 控制刺激发生器以递送刺激脉冲，以使胰腺β细胞去极化同步，从而产生被感测和处理的增强的电信号。 在具体实施方案中，处理信号以确定β细胞去极化的开始和结束，从中获得去极化持续时间。 为了减少心脏干扰，每个刺激脉冲被定时偏离可能干扰胰腺感测的QRS信号。 此外，β细胞信号由校正电路（例如，自适应滤波器）处理，以去除QRS伪影，以及来自其他来源（例如呼吸）的伪影。 由此获得的胰岛素需求信号用于控制从植入的胰岛素泵输送胰岛素，或用于控制正在进行的胰腺刺激形式以增强胰岛素产生。

公开(公告)号：US6125300A

公开(公告)日：2000-09-26

申请号：US152072

申请日：1998-09-11

申请人： Koen J. Weijand ,  Robert Leinders

发明人： Koen J. Weijand ,  Robert Leinders

IPC分类号： A61N1/36 ,  A61N1/368 ,  A61N1/00

CPC分类号： A61N1/3605 ,  A61N1/368 ,  A61N1/378

摘要： There is provided an implantable device with two or more output stages for delivering concurrent output pulses to two or more sites within a patient's body. Each output circuit has a common architecture, including a switchable generator which has a plurality of storage capacitors and switches for arranging the capacitors either to be charged by the battery, or to discharge a stimulus pulse. A programmable regulator is provided for further regulation of the output voltage; and a multiplexer connects the output to the desired electrodes placed at the patient site. For concurrent dual pulse-dual site stimulation, a pair of active rectifier switches are connected between the negative terminal of each output stage and the battery positive terminal, whereby at the time of concurrent pulse delivery, the output stage having the greatest negative voltage relative to battery plus has its negative terminal connected to the battery plus terminal, while the other output stage is disconnected from the battery so that it floats. This arrangement reduces crosstalk current while ensuring continued positive biasing of the semi-conductor switches in each output stage.

摘要翻译： 提供了一种具有两个或多个输出级的可植入装置，用于将同时的输出脉冲输送到患者体内的两个或多个位置。 每个输出电路具有共同的架构，包括具有多个存储电容器的开关发生器和用于布置要由电池充电的电容器的开关或放电刺激脉冲。 提供可编程调节器，用于进一步调节输出电压; 并且多路复用器将输出连接到放置在患者现场的期望电极。 对于并发双脉冲双站点刺激，一对有源整流开关连接在每个输出级的负极端子和电池正极端子之间，由此在并发脉冲输送时，输出级相对于 电池加上其负极端子连接到电池加端子，而另一个输出级与电池断开，使其浮动。 这样可以降低串扰电流，同时确保在每个输出级中半导体开关的持续正偏置。

公开(公告)号：US6093167A

公开(公告)日：2000-07-25

申请号：US876738

申请日：1997-06-16

申请人： Richard P. M. Houben ,  Alexis C. M. Renirie ,  Koen J. Weijand

发明人： Richard P. M. Houben ,  Alexis C. M. Renirie ,  Koen J. Weijand

IPC分类号： A61B5/00 ,  A61N1/36 ,  A61M31/00

CPC分类号： A61B5/14532 ,  A61B5/425 ,  A61B5/7207 ,  A61N1/36007

摘要： There is provided an implantable system and method for monitoring pancreatic beta cell electrical activity in a patient in order to obtain a measure of a patient's insulin demand and blood glucose level. A stimulus generator is controlled to deliver stimulus pulses so as to synchronize pancreatic beta cell depolarization, thereby producing an enhanced electrical signal which is sensed and processed. In a specific embodiment, the signal is processed to determine the start and end of beta cell depolarization, from which the depolarization duration is obtained. In order to reduce cardiac interference, each stimulus pulse is timed to be offset from the QRS signal which can interfere with the pancreas sensing. Additionally, the beta cell signals are processed by a correction circuit, e.g., an adaptive filter, to remove QRS artifacts, as well as artifacts from other sources, such as respiration. The thus obtained insulin demand signal is used either to control delivery of insulin from an implanted insulin pump, or to control ongoing pancreatic stimulation of a form to enhance insulin production.

公开(公告)号：US5836983A

公开(公告)日：1998-11-17

申请号：US879214

申请日：1997-06-19

申请人： Koen J. Weijand ,  Robert Leinders

发明人： Koen J. Weijand ,  Robert Leinders

IPC分类号： A61N1/362 ,  A61N1/37 ,  H03K5/02

CPC分类号： A61N1/3706 ,  H03K5/02 ,  H03K5/023

摘要： An output circuit is provided for delivering output pulses in either a constant voltage or constant current mode. The output circuit has a simple architecture built around a pair of area-ratioed transistors which operate in a linear range carrying a ratio of currents corresponding to the area ratio. The circuit is mode controlled by a switch network which connects to a constant current source, which constant current source controls the pulse amplitude, either current or voltage. As used in a pacemaker embodiment, the circuit is controllable to control the mode and/or amplitude of the pulse following a cyclical decision to deliver a pulse, and with an amplitude derived from pacemaker data and controllable during delivery of the pulse. The circuit has high speed control which enables amplitude modulation of the pulse, for transmitting encoded data to an external device adapted to receive the data.

摘要翻译： 提供输出电路用于以恒定电压或恒定电流模式传送输出脉冲。 输出电路具有围绕一对面积比的晶体管构建的简单架构，其在线性范围内工作，该线性范围具有对应于面积比的电流比。 电路由连接恒流源的开关网络进行模式控制，恒流源控制脉冲幅度，电流或电压。 如在起搏器实施例中所使用的，电路是可控制的，以在循环决定传递脉冲之后，并且具有从起搏器数据导出的振幅并且在脉冲传递期间可控制的脉冲的模式和/或幅度。 该电路具有高速度控制，其使能脉冲的幅度调制，用于将编码的数据发送到适于接收数据的外部设备。

公开(公告)号：US5824029A

公开(公告)日：1998-10-20

申请号：US233901

申请日：1994-04-28

申请人： Koen J. Weijand ,  John D. Wahlstrand

发明人： Koen J. Weijand ,  John D. Wahlstrand

IPC分类号： A61B5/05 ,  A61B5/053 ,  A61B5/08 ,  A61N1/05 ,  A61N1/08 ,  A61N1/365

CPC分类号： A61N1/36521 ,  A61B5/0535 ,  A61B5/0538 ,  A61N1/056 ,  A61N1/08 ,  A61B5/0809 ,  A61B5/7217

摘要： A method and apparatus for deriving impedance signals with an implanted pulse generator and lead system. In particular the present invention provides a medical system which delivers electrical stimulation pulses to a first area and senses impedance in a second area, in particular the medical system features a multi electrode lead connectable to a pulse generator through a standardized connector assembly. The lead has two internal conductors and three electrodes. Two of the electrodes are coupled by means of a capacitor integral with the lead.

摘要翻译： 一种用植入脉冲发生器和引导系统导出阻抗信号的方法和装置。 特别地，本发明提供了一种医疗系统，其将电刺激脉冲传送到第一区域并且感测第二区域中的阻抗，特别地，医疗系统具有通过标准化连接器组件连接到脉冲发生器的多电极引线。 引线有两个内部导体和三个电极。 两个电极通过与引线一体的电容器耦合。

公开(公告)号：US5697952A

公开(公告)日：1997-12-16

申请号：US516415

申请日：1995-08-17

申请人： David Francischelli ,  John Hammargren ,  Johann J. Neisz ,  David K. Peterson ,  Koen J. Weijand

发明人： David Francischelli ,  John Hammargren ,  Johann J. Neisz ,  David K. Peterson ,  Koen J. Weijand

IPC分类号： A61N1/365 ,  A61N1/36 ,  A61N1/362 ,  A61N1/39

CPC分类号： A61N1/3621 ,  A61N1/36042 ,  A61N1/3962

摘要： A cardiac assist device having muscle augmentation after a confirmed arrhythmia. In particular the present invention operates, in a first embodiment, to sense a cardiac event, next it determines whether the cardiac event is a cardiac arrhythmia, if the event is not a cardiac arrhythmia the devices delivers stimulation to a skeletal muscle grafted about a heart, but if the event is a cardiac arrhythmia the device inhibits delivery of skeletal muscle stimulation and once the arrhythmia is confirmed, then delivers therapeutic stimulation to the heart. In a second embodiment the present invention operates to re-initiate skeletal muscle stimulation once the arrhythmia is confirmed but prior to the delivery of the therapeutic stimulation to the heart.

摘要翻译： 心脏辅助装置在经确认的心律失常后具有肌肉增强。 特别地，本发明在第一实施例中操作以感测心脏事件，接下来，它确定心脏事件是否是心律失常，如果事件不是心脏心律失常，则装置向围绕心脏移植的骨骼肌递送刺激 但是如果事件是心律失常，则该装置抑制骨骼肌刺激的传递，并且一旦心律失常得到确认，则向心脏递送治疗刺激。 在第二个实施方案中，本发明一旦确认了心律失常，但是在将治疗刺激递送到心脏之前，就重新启动骨骼肌肉刺激。