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21.发明申请公开(公告)号：US20180052141A1
公开(公告)日：2018-02-22
申请号：US15558117
申请日：2016-03-10
Applicant: Agilent Technologies, Inc.
Inventor： Dwight Robert Stoll , Konstantin Shoykhet , Klaus Witt , Stephan Buckenmaier
Abstract: A control device for controlling at least part of a sample separation apparatus for separating a fluidic sample, the sample separation apparatus including at least two fluid accommodation volumes having different flow through properties and each being configured for temporarily accommodating fluidic sample, wherein the control device is configured for controlling operation of at least part of the sample separation apparatus for at least partially compensating sample separation artifacts resulting from the different flow through properties of the fluid accommodation volumes.
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22.发明申请公开(公告)号：US20170131244A1
公开(公告)日：2017-05-11
申请号：US15320123
申请日：2014-06-25
Applicant: Agilent Technologies, Inc.
Inventor： Klaus Witt , Stephan Buckenmaier , Konstantin Shoykhet
CPC classification number: G01N30/463 , B01D15/1878 , G01N30/32 , G01N30/465 , G01N30/88 , G01N2030/322 , G01N2030/8881
Abstract: A secondary stage sample separation device for separating at least a portion of a fluidic sample includes a fluidic interface configured for forming a detachable fluidic coupling between a primary stage sample separation device and the secondary separation device so that the fluidic sample separated by the primary stage sample separation device is fluidically supplyable to the secondary stage sample separation device via the fluidic interface for further separation, wherein the secondary stage sample separation device is further configured for separating at least a portion of the supplied fluidic sample independent of a flow rate of the fluidic sample supplied from the primary stage sample separation device at the fluidic interface.
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公开(公告)号：US20160231294A1
公开(公告)日：2016-08-11
申请号：US15016989
申请日：2016-02-05
Applicant: Agilent Technologies, Inc.
Inventor： Thorsten Dressler , Manuela Senf , Armin Steinke , Klaus Witt
IPC: G01N30/74
CPC classification number: G01N30/32 , G01N2030/324
Abstract: A liquid chromatography analysis unit configured for executing a predefined liquid chromatography analysis task, wherein the liquid chromatography analysis unit comprises a sample insertion compartment configured for inserting a fluidic sample to be separated, wherein the fluidic sample is to be separated when executing the liquid chromatography analysis task, a solvent accommodation section accommodating a predefined volume of at least one predefined solvent required for executing the liquid chromatography analysis task, and a sample separation unit configured for separating the fluidic sample inserted into the sample insertion compartment upon applying a solvent and sample drive force for driving the solvent and the fluidic sample through the sample separation unit.
Abstract translation: 一种配置用于执行预定液相色谱分析任务的液相色谱分析单元，其中所述液相色谱分析单元包括被配置用于插入要分离的流体样品的样品插入室，其中当执行液相色谱分析时流体样品将被分离 任务，容纳执行液相色谱分析任务所需的预定体积的至少一种预定溶剂的溶剂容纳部分;以及样品分离单元，其构造成在施加溶剂时分离插入样品插入室中的流体样品和样品驱动力 用于驱动溶剂和流体样品通过样品分离单元。
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24.发明申请公开(公告)号：US20160187304A1
公开(公告)日：2016-06-30
申请号：US14586882
申请日：2014-12-30
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Edwin E. Wikfors , Brian A. Bidlingmeyer , Klaus Witt
CPC classification number: G01N1/28 , G01N30/20 , G01N30/36 , G01N2030/202 , G01N2030/207 , G01N2030/342
Abstract: A method and a system for introducing a sample into a mobile phase of a chromatography system is provided. The method includes initially directing the mobile phase directly into a separation unit of the chromatography system, bypassing a sample loop, the mobile phase including a combined solvent, metered from a pressurized first solvent and a second solvent; loading the sample into the sample loop, while the mobile phase continues to be directed directly into the separation unit; pressurizing the sample in the sample loop with the pressurized first solvent, while the mobile phase continues to be directed directly into the separation unit; and switching the sample loop into the mobile phase, thereby introducing the pressurized sample to the separation unit.
Abstract translation: 提供了一种用于将样品引入色谱系统的流动相的方法和系统。 该方法包括首先将流动相直接引入色谱系统的分离单元，绕过样品环，流动相包括从加压的第一溶剂和第二溶剂计量的组合溶剂; 将样品加载到样品回路中，同时流动相继续直接导入分离单元; 在加压的第一溶剂中对样品环中的样品加压，同时流动相继续被直接引导到分离单元中; 并将样品环切换到流动相中，从而将加压的样品引入分离单元。
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公开(公告)号：US20140366739A1
公开(公告)日：2014-12-18
申请号：US14252711
申请日：2014-04-14
Applicant: Agilent Technologies, Inc.
Inventor： Klaus Witt , Konstantin Choikhet , Dwight Stoll
CPC classification number: B01D15/14 , G01N30/20 , G01N30/463 , G01N2030/202 , G01N2030/204 , G01N2030/208
Abstract: A sample dispatcher is disclosed and is configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a liquid separation system. The liquid separation system is configured for separating compounds of the sample fluids and comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises one or more sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof, and a bypass channel.
Abstract translation: 公开了一种样品分配器，并且被配置为将一个或多个样品流体的多个部分单独引入液体分离系统的流动相的流动。 液体分离系统被配置用于分离样品流体的化合物，并且包括流动相驱动器，其构造成用于通过分离单元驱动流动相，该分离单元被配置用于分离流动相中的样品流体的化合物。 样品分配器包括一个或多个样品储存器，每个样品储存器被构造成用于接收和临时存储相应的样品流体部分或其至少一部分，以及旁路通道。
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Patent Agency Ranking
公开(公告)号：US20140251448A1
公开(公告)日：2014-09-11
申请号：US14233966
申请日：2011-07-27
Applicant: AGILENT TECHNOLOGIES, INC.
Inventor： Klaus Witt , Konstantin Choikhet , Hans-Georg Haertl
IPC: F17D3/01
CPC classification number: F17D3/01 , G05D11/133 , Y10T137/2499
Abstract: A fluid supply system (150) adapted for metering two or more fluids in controlled proportions and for supplying a resultant mixture, the fluid supply system (150) comprising a plurality of solvent supply lines (104 to 107), each fluidically connected with a fluid source (100 to 103) providing a respective fluid, a pumping unit (110) comprising a reciprocating element (115) adapted for intaking fluid supplied at an inlet of the pumping unit (110) and for supplying the pressurized fluid at an outlet of the pumping unit (110), wherein the pumping unit (110) is adapted for taking in fluids from selected solvent supply lines (104 to 107) and for supplying a pressurized mixture of the fluids at its outlet, a proportioning valve (108) interposed between the solvent supply lines (104 to 107) and the inlet of the pumping unit (110), the proportioning valve (108) adapted for modulating solvent composition by sequentially coupling selected ones of the solvent supply lines (104 to 107) with the inlet of the pumping unit (110), and a longitudinal mixing unit (152) adapted for mixing longitudinally subsequent sections of the fluids so as to modify their succession in flow direction.
Abstract translation: 一种流体供应系统（150），其适于以受控比例计量两种或多种流体并用于供应所得混合物，所述流体供应系统（150）包括多个溶剂供应管线（104至107），每个流体连接有流体 源（100至103）提供相应的流体;泵送单元（110），包括适于吸入在泵送单元（110）的入口处供应的流体的往复运动元件（115），并用于在加压流体的出口 泵送单元（110），其中所述泵送单元（110）适于从选定的溶剂供应管线（104至107）吸入流体并且用于在其出口处供应流体的加压混合物，位于其间的比例阀（108） 溶剂供应管线（104至107）和泵送单元（110）的入口，比例阀（108）适于通过将选定的溶剂供应管线（104至107）中的选定溶剂供应管线（104至107）与入口 泵送单元（110）的纵向混合单元（152）和适于混合流体纵向后续部分的纵向混合单元（152），以便改变它们在流动方向上的连续性。
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公开(公告)号：US11933769B2
公开(公告)日：2024-03-19
申请号：US17051701
申请日：2019-04-30
Applicant: Agilent Technologies, Inc.
Inventor： Dwight Robert Stoll , Klaus Witt , Konstantin Shoykhet
CPC classification number: G01N30/32 , G01N30/463 , G01N30/466 , G01N30/468
Abstract: A multidimensional sample separation apparatus includes a first separation dimension for separating a fluidic sample, a second separation dimension for further separating the fluidic sample, a switching mechanism, and a control unit. The first separation dimension includes a first fluid drive unit and a first sample separation unit. The second separation dimension includes a second fluid drive unit for driving the separated fluidic sample, and second and third sample separation units each configured for further separating the separated fluidic sample. The switching mechanism is configured for selectively switching an outlet of the first separation dimension in fluid communication with a selected one of the second sample separation unit and/or the third sample separation unit. The control unit is configured for controlling a pressure at inlets of the second sample separation unit and the third sample separation unit to be substantially the same at least at the time of the switching.
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公开(公告)号：US11635065B2
公开(公告)日：2023-04-25
申请号：US17322676
申请日：2021-05-17
Applicant: Agilent Technologies, Inc.
Inventor： Klaus Witt , Konstantin Shoykhet
Abstract: A solvent supply system for supplying a composite includes a first supply path with a first pump unit, the first supply path being adapted for supplying a first solvent to a mixing unit, the first pump unit operating periodically, and a second supply path with a second pump unit, the second supply path being adapted for supplying a second solvent to the mixing unit, the second pump unit operating periodically. The mixing unit is adapted for mixing the first and the second solvent and for supplying a composite solvent. The solvent supply system further includes a control unit adapted for controlling operation of the first and the second pump unit.
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公开(公告)号：US20210223216A1
公开(公告)日：2021-07-22
申请号：US17051701
申请日：2019-04-30
Applicant: Agilent Technologies, Inc.
Inventor： Dwight Robert Stoll , Klaus Witt , Konstantin Shoykhet
Abstract: A multidimensional sample separation apparatus includes a first separation dimension for separating a fluidic sample, a second separation dimension for further separating the fluidic sample, a switching mechanism, and a control unit. The first separation dimension includes a first fluid drive unit and a first sample separation unit. The second separation dimension includes a second fluid drive unit for driving the separated fluidic sample, and second and third sample separation units each configured for further separating the separated fluidic sample. The switching mechanism is configured for selectively switching an outlet of the first separation dimension in fluid communication with a selected one of the second sample separation unit and/or the third sample separation unit. The control unit is configured for controlling a pressure at inlets of the second sample separation unit and the third sample separation unit to be substantially the same at least at the time of the switching.
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公开(公告)号：US10976289B2
公开(公告)日：2021-04-13
申请号：US15691202
申请日：2017-08-30
Applicant: Agilent Technologies, Inc.
Inventor： Klaus Witt , Konstantin Shoykhet , Philip Herzog , Iwan Bouzid
Abstract: To determine a corrected flow rate value of a mobile phase flowing in a liquid chromatography (LC) system, a flow rate of the mobile phase at a selected reference position in the LC system is measured to produce one or more flow rate values. A model of the LC system is applied to the flow rate value(s) to determine the corrected flow rate value(s). The model includes a distribution of capacitive elements and resistive elements arranged according to a topology of the LC system. The capacitive and resistive elements are representative of system and solvent properties affecting flow rate while operating the LC system. The system and solvent properties may be properties affecting the flow rate while operating the LC system under dynamic conditions.
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