公开(公告)号：US20210324840A1

公开(公告)日：2021-10-21

申请号：US17322676

申请日：2021-05-17

申请人： Agilent Technologies, Inc.

发明人： Klaus Witt ,  Konstantin Shoykhet

IPC分类号： F04B11/00 ,  F04B13/02

摘要： A solvent supply system for supplying a composite includes a first supply path with a first pump unit, the first supply path being adapted for supplying a first solvent to a mixing unit, the first pump unit operating periodically, and a second supply path with a second pump unit, the second supply path being adapted for supplying a second solvent to the mixing unit, the second pump unit operating periodically. The mixing unit is adapted for mixing the first and the second solvent and for supplying a composite solvent. The solvent supply system further includes a control unit adapted for controlling operation of the first and the second pump unit.

公开(公告)号：US20170219540A1

公开(公告)日：2017-08-03

申请号：US15500706

申请日：2015-05-28

申请人： Agilent Technologies, Inc.

发明人： Herbert Anderer ,  Konstantin Shoykhet ,  Klaus Witt ,  Stephan Buckenmaier

IPC分类号： G01N30/46

摘要： In a method for processing successive fluidic sample portions provided by a sample source, sample reception volumes are filled successively temporarily with at least a respective one of the sample sections, and the sample sections are emptied successively out of the sample reception volumes in such a way, that, while emptying, it is avoided to bring two respective ones of the sample sections, which have not left the sample source directly adjacent to one another, in contact with one another.

公开(公告)号：US20160327528A1

公开(公告)日：2016-11-10

申请号：US15215233

申请日：2016-07-20

申请人： Agilent Technologies, Inc.

发明人： Klaus Witt ,  Herbert Anderer ,  Alwin Ritzmann ,  Dominik Ruf

IPC分类号： G01N30/86 ,  G01N30/34

CPC分类号： G01N30/86 ,  F17D3/00 ,  G01N30/02 ,  G01N30/34 ,  G01N30/8658 ,  G01N30/8662 ,  G01N30/8693 ,  Y10T137/0318 ,  Y10T137/8376

摘要： An apparatus for deriving an operation mode from a first fluidic device to a second fluidic device, wherein the first fluidic device has a first target operation mode representing a desired behavior of the first fluidic device and has a first real operation mode representing the actual behavior of the first fluidic device, wherein the second fluidic device has a second target operation mode representing a desired behavior of the second fluidic device and has a second real operation mode representing the actual behavior of the second fluidic device, the apparatus comprising a first determining unit configured for determining the first real operation mode based on the first target operation mode and based on a preknown parameterization of the first fluidic device, and a second determining unit configured for determining the second target operation mode based on the determined first real operation mode and based on a preknown parameterization of the second fluidic device.

摘要翻译： 一种用于将操作模式从第一流体装置导出到第二流体装置的装置，其中第一流体装置具有表示第一流体装置的期望行为的第一目标操作模式，并且具有表示第一流体装置的实际行为的第一实际操作模式 所述第一流体装置，其中所述第二流体装置具有表示所述第二流体装置的期望行为的第二目标操作模式，并且具有表示所述第二流体装置的实际行为的第二实际操作模式，所述装置包括第一确定单元， 用于基于第一目标操作模式确定第一实际操作模式，并且基于第一流体装置的预先知名参数化;以及第二确定单元，被配置为基于所确定的第一实际操作模式来确定第二目标操作模式，并且基于 第二流体装置的预先参数化。

公开(公告)号：US20160139093A1

公开(公告)日：2016-05-19

申请号：US14898392

申请日：2013-06-14

申请人： Agilent Technologies, Inc.

发明人： Klaus Witt ,  Konstantin Choikhet ,  Manfred Berndt

IPC分类号： G01N30/20

CPC分类号： G01N30/20 ,  G01N30/465 ,  G01N2030/027 ,  G01N2030/202 ,  G01N2030/208

摘要： Disclosed is a sample dispatcher configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a separation system configured for separating compounds of the sample fluids. The separation system comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises a plurality of sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof. The sample dispatcher is configured for selectively coupling one of the plurality of sample reservoirs between the mobile phase drive and the separation unit, and further for coupling at least two of the plurality of sample reservoirs in parallel between the mobile phase drive and the separation unit.

摘要翻译： 公开了一种样品分配器，其被配置用于将一个或多个样品流体的多个部分单独引入配置用于分离样品流体的化合物的分离系统的流动相的流动。 分离系统包括流动相驱动器，其构造成通过分离单元来驱动流动相，该分离单元被配置用于分离流动相中的样品流体的化合物。 样品分配器包括多个样品储存器，每个样品储存器被构造用于接收和临时存储相应的样品流体部分或其至少一部分。 样品分配器被配置为选择性地将移动相位驱动器和分离单元之间的多个样品储存器中的一个耦合，并且还用于将多个样品储存器中的至少两个并联在流动相驱动器和分离单元之间。

公开(公告)号：US10830739B2

公开(公告)日：2020-11-10

申请号：US15500706

申请日：2015-05-28

申请人： Agilent Technologies, Inc.

发明人： Herbert Anderer ,  Konstantin Shoykhet ,  Klaus Witt ,  Stephan Buckenmaier

IPC分类号： G01N30/46 ,  G01N30/82 ,  G01N30/22 ,  G01N30/24 ,  B01D15/18 ,  B01D15/24 ,  G01N30/44 ,  G01N30/20 ,  G01N30/84 ,  G01N30/02

摘要： In a method for processing successive fluidic sample portions provided by a sample source, sample reception volumes are filled successively temporarily with at least a respective one of the sample sections, and the sample sections are emptied successively out of the sample reception volumes in such a way, that, while emptying, it is avoided to bring two respective ones of the sample sections, which have not left the sample source directly adjacent to one another, in contact with one another.

公开(公告)号：US10761071B2

公开(公告)日：2020-09-01

申请号：US15558117

申请日：2016-03-10

申请人： Agilent Technologies, Inc.

发明人： Dwight Robert Stoll ,  Konstantin Shoykhet ,  Klaus Witt ,  Stephan Buckenmaier

IPC分类号： G01N30/34 ,  G01N30/46 ,  G01N30/20

摘要： A control device for controlling at least part of a sample separation apparatus for separating a fluidic sample, the sample separation apparatus including at least two fluid accommodation volumes having different flow through properties and each being configured for temporarily accommodating fluidic sample, wherein the control device is configured for controlling operation of at least part of the sample separation apparatus for at least partially compensating sample separation artifacts resulting from the different flow through properties of the fluid accommodation volumes.

公开(公告)号：US10281058B2

公开(公告)日：2019-05-07

申请号：US14975342

申请日：2015-12-18

申请人： Agilent Technologies, Inc.

发明人： Konstantin Shoykhet ,  Klaus Witt ,  Stephan Buckenmaier ,  Dwight Stoll

IPC分类号： B01D15/14 ,  G01N30/20 ,  G01N30/46 ,  F16K99/00 ,  G01N30/32 ,  B01D15/18 ,  B01D15/10 ,  B01L3/00 ,  G01N27/447 ,  B01D15/40

摘要： A fluid processing device (10) for processing fluid, wherein the fluid processing device (10) comprises a first fluid drive unit (20) configured for driving a first fluid along a first flow path (85), a second fluid drive unit (20′) configured for driving a second fluid along a second flow path (86), and a fluidic switch (90) fluidically coupled to the first flow path (85) and to the second flow path (86) and configured for being switchable for transferring first fluid from the first flow path (85) into the second flow path (86) without interruption of fluid flow along at least one of the first flow path (85) and the second flow path (86).

公开(公告)号：US10012624B2

公开(公告)日：2018-07-03

申请号：US15215233

申请日：2016-07-20

申请人： Agilent Technologies, Inc.

发明人： Klaus Witt ,  Herbert Anderer ,  Alwin Ritzmann ,  Dominik Ruf

IPC分类号： G01N30/02 ,  G01N30/00 ,  F17D3/00 ,  G01N30/86 ,  G01N30/34 ,  G01N33/48 ,  H01J49/44

CPC分类号： G01N30/86 ,  F17D3/00 ,  G01N30/02 ,  G01N30/34 ,  G01N30/8658 ,  G01N30/8662 ,  G01N30/8693 ,  Y10T137/0318 ,  Y10T137/8376

摘要： An apparatus for deriving an operation mode from a first fluidic device to a second fluidic device, wherein the first fluidic device has a first target operation mode representing a desired behavior of the first fluidic device and has a first real operation mode representing the actual behavior of the first fluidic device, wherein the second fluidic device has a second target operation mode representing a desired behavior of the second fluidic device and has a second real operation mode representing the actual behavior of the second fluidic device, the apparatus comprising a first determining unit configured for determining the first real operation mode based on the first target operation mode and based on a preknown parameterization of the first fluidic device, and a second determining unit configured for determining the second target operation mode based on the determined first real operation mode and based on a preknown parameterization of the second fluidic device.

公开(公告)号：US20170131245A1

公开(公告)日：2017-05-11

申请号：US15320185

申请日：2015-06-25

申请人： Agilent Technologies, Inc.

发明人： Dwight Robert Stoll ,  Stephan Buckenmaier ,  Klaus Witt ,  Konstantin Shoykhet

IPC分类号： G01N30/46 ,  G01N30/32 ,  B01D15/18

CPC分类号： G01N30/463 ,  B01D15/1878 ,  G01N30/32 ,  G01N30/465 ,  G01N30/88 ,  G01N2030/322 ,  G01N2030/8881

摘要： A secondary stage sample separation device for separating at least a portion of a fluidic sample includes a fluidic interface configured for forming a fluidic coupling between a primary stage sample separation device and the secondary separation device, so that the fluidic sample separated by the primary stage sample separation device is fluidically suppliable to the secondary stage sample separation device via the fluidic interface for further separation, and a pressure reduction mechanism configured for reducing pressure at the fluidic interface at least in the event of an overpressure or of an excessive pressure increase.

公开(公告)号：US20140183137A1

公开(公告)日：2014-07-03

申请号：US14211286

申请日：2014-03-14

申请人： Agilent Technologies, Inc.

发明人： Klaus Witt

IPC分类号： G01N30/02

CPC分类号： G01N30/02 ,  G01N30/463 ,  G01N30/34

摘要： A control device for a sample separation apparatus, the sample separation apparatus including a first separation unit and a second separation unit downstream of the first separation unit and supplied with the fluidic sample after treatment by the first separation unit. A control device is configured for controlling the first separation unit to execute a primary separation sequence within a time interval for separating the fluidic sample into fractions, and for controlling the second separation unit to execute secondary separation sequences within the time interval for further separating the separated fractions into sub-fractions, wherein the secondary separation sequences form part of a common sample separation method defined by a common specification of the sample separation involving a set of parameters, and adjusting, over a progress of the primary separation sequence, at least one parameter according to which at least one of the plurality of secondary separation sequences is executed.

摘要翻译： 一种用于样品分离装置的控制装置，所述样品分离装置包括在所述第一分离单元下游的第一分离单元和第二分离单元，并且在通过所述第一分离单元处理之后提供所述流体样品。 控制装置被配置为用于控制第一分离单元在用于将流体样品分离成分数的时间间隔内执行主分离序列，并且用于控制第二分离单元在时间间隔内执行二次分离顺序，以进一步分离分离的 其中二次分离序列形成由涉及一组参数的样品分离的共同规范定义的常见样品分离方法的一部分，并且在一级分离序列的进程中调整至少一个参数 根据该方法执行多个次级分离序列中的至少一个。