公开(公告)号：US20160139093A1

公开(公告)日：2016-05-19

申请号：US14898392

申请日：2013-06-14

Applicant: Agilent Technologies, Inc.

Inventor： Klaus Witt ,  Konstantin Choikhet ,  Manfred Berndt

IPC: G01N30/20

CPC classification number: G01N30/20 ,  G01N30/465 ,  G01N2030/027 ,  G01N2030/202 ,  G01N2030/208

Abstract: Disclosed is a sample dispatcher configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a separation system configured for separating compounds of the sample fluids. The separation system comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises a plurality of sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof. The sample dispatcher is configured for selectively coupling one of the plurality of sample reservoirs between the mobile phase drive and the separation unit, and further for coupling at least two of the plurality of sample reservoirs in parallel between the mobile phase drive and the separation unit.

Abstract translation: 公开了一种样品分配器，其被配置用于将一个或多个样品流体的多个部分单独引入配置用于分离样品流体的化合物的分离系统的流动相的流动。 分离系统包括流动相驱动器，其构造成通过分离单元来驱动流动相，该分离单元被配置用于分离流动相中的样品流体的化合物。 样品分配器包括多个样品储存器，每个样品储存器被构造用于接收和临时存储相应的样品流体部分或其至少一部分。 样品分配器被配置为选择性地将移动相位驱动器和分离单元之间的多个样品储存器中的一个耦合，并且还用于将多个样品储存器中的至少两个并联在流动相驱动器和分离单元之间。

公开(公告)号：US20150122655A1

公开(公告)日：2015-05-07

申请号：US14400312

申请日：2012-05-10

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Konstantin Choikhet ,  Klaus Witt

IPC: B01D15/18 ,  G01N30/72 ,  G01N27/447

CPC classification number: B01D15/18 ,  G01N27/44704 ,  G01N30/32 ,  G01N30/34 ,  G01N30/463 ,  G01N30/465 ,  G01N30/6095 ,  G01N30/72 ,  G01N2030/322 ,  G01N2030/328

Abstract: A sample separation apparatus (200) for separating a fluidic sample, the sample separation apparatus (200) comprising a first separation unit (204) for separating the fluidic sample, a first fluid drive (202) configured for conducting the fluidic sample to be separated through the first separation unit (204), a second separation unit (208), arranged downstream of the first separation unit (204), for further separating the fluidic sample after treatment by the first separation unit (204), a second fluid drive (206) configured for at least partially conducting the fluidic sample, after treatment by the first separation unit (204), through the second separation unit (208), and a fluidic valve (218) having fluidic interfaces (222, 224, 226, 228) fluidically coupled to the first fluid drive (202) and the second fluid drive (206) and being switchable for performing the separation of the fluidic sample, wherein the sample separation apparatus (200) is configured for adjusting a pressure at a predefined position to a predefined value, wherein the predefined position is in a fluidic path between an outlet (270) of the first separation unit (204) and an inlet (272) of the second separation unit (208) or in fluid communication with this fluidic path.

Abstract translation: 一种用于分离流体样品的样品分离装置（200），所述样品分离装置（200）包括用于分离流体样品的第一分离单元（204），被配置用于传导待分离的流体样品的第一流体驱动器（202） 通过第一分离单元（204），布置在第一分离单元（204）下游的第二分离单元（208），用于在第一分离单元（204）处理之后进一步分离流体样品，第二流体驱动器 206）构造成用于在通过第一分离单元（204）经过第二分离单元（208）处理之后至少部分地传导流体样品，以及具有流体界面（222,224,226,228）的流体阀 ）流体耦合到第一流体驱动器（202）和第二流体驱动器（206）并且可切换以执行流体样品的分离，其中样品分离装置（200）构造成用于调节流体样品 预定位置到预定值，其中预定位置处于第一分离单元（204）的出口（270）和第二分离单元（208）的入口（272）之间的流体路径中，或者与该流体连通 流体路径

公开(公告)号：US20140366739A1

公开(公告)日：2014-12-18

申请号：US14252711

申请日：2014-04-14

Applicant: Agilent Technologies, Inc.

Inventor： Klaus Witt ,  Konstantin Choikhet ,  Dwight Stoll

IPC: B01D15/14 ,  G01N30/06

CPC classification number: B01D15/14 ,  G01N30/20 ,  G01N30/463 ,  G01N2030/202 ,  G01N2030/204 ,  G01N2030/208

Abstract: A sample dispatcher is disclosed and is configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a liquid separation system. The liquid separation system is configured for separating compounds of the sample fluids and comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises one or more sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof, and a bypass channel.

Abstract translation: 公开了一种样品分配器，并且被配置为将一个或多个样品流体的多个部分单独引入液体分离系统的流动相的流动。 液体分离系统被配置用于分离样品流体的化合物，并且包括流动相驱动器，其构造成用于通过分离单元驱动流动相，该分离单元被配置用于分离流动相中的样品流体的化合物。 样品分配器包括一个或多个样品储存器，每个样品储存器被构造成用于接收和临时存储相应的样品流体部分或其至少一部分，以及旁路通道。

公开(公告)号：US20140251448A1

公开(公告)日：2014-09-11

申请号：US14233966

申请日：2011-07-27

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Klaus Witt ,  Konstantin Choikhet ,  Hans-Georg Haertl

IPC: F17D3/01

CPC classification number: F17D3/01 ,  G05D11/133 ,  Y10T137/2499

Abstract: A fluid supply system (150) adapted for metering two or more fluids in controlled proportions and for supplying a resultant mixture, the fluid supply system (150) comprising a plurality of solvent supply lines (104 to 107), each fluidically connected with a fluid source (100 to 103) providing a respective fluid, a pumping unit (110) comprising a reciprocating element (115) adapted for intaking fluid supplied at an inlet of the pumping unit (110) and for supplying the pressurized fluid at an outlet of the pumping unit (110), wherein the pumping unit (110) is adapted for taking in fluids from selected solvent supply lines (104 to 107) and for supplying a pressurized mixture of the fluids at its outlet, a proportioning valve (108) interposed between the solvent supply lines (104 to 107) and the inlet of the pumping unit (110), the proportioning valve (108) adapted for modulating solvent composition by sequentially coupling selected ones of the solvent supply lines (104 to 107) with the inlet of the pumping unit (110), and a longitudinal mixing unit (152) adapted for mixing longitudinally subsequent sections of the fluids so as to modify their succession in flow direction.

Abstract translation: 一种流体供应系统（150），其适于以受控比例计量两种或多种流体并用于供应所得混合物，所述流体供应系统（150）包括多个溶剂供应管线（104至107），每个流体连接有流体 源（100至103）提供相应的流体;泵送单元（110），包括适于吸入在泵送单元（110）的入口处供应的流体的往复运动元件（115），并用于在加压流体的出口 泵送单元（110），其中所述泵送单元（110）适于从选定的溶剂供应管线（104至107）吸入流体并且用于在其出口处供应流体的加压混合物，位于其间的比例阀（108） 溶剂供应管线（104至107）和泵送单元（110）的入口，比例阀（108）适于通过将选定的溶剂供应管线（104至107）中的选定溶剂供应管线（104至107）与入口 泵送单元（110）的纵向混合单元（152）和适于混合流体纵向后续部分的纵向混合单元（152），以便改变它们在流动方向上的连续性。