公开(公告)号：US20170240631A1

公开(公告)日：2017-08-24

申请号：US15502766

申请日：2015-08-08

Applicant: ALECTOR LLC

Inventor： Kate MONROE ,  Tina SCHWABE ,  Francesca AVOGADRI-CONNORS ,  IIaria TASSI ,  Helen LAM ,  Arnon ROSENTHAL

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/283 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention is generally directed to methods and compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 and/or human TREM2. The methods provided herein find use in preventing, reducing risk, or treating an individual having dementia, frontotemporal dementia, Alzheimer's disease, Nasu-Hakola disease, or multiple sclerosis.

公开(公告)号：US20250145709A1

公开(公告)日：2025-05-08

申请号：US19015556

申请日：2025-01-09

Applicant: Alector LLC

Inventor： Patricia CULP ,  Seung-Joo LEE ,  Helen LAM ,  Wei-Hsien HO ,  Arnon ROSENTHAL

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20240076362A1

公开(公告)日：2024-03-07

申请号：US18310207

申请日：2023-05-01

Applicant: Alector LLC

Inventor： Jeonghoon SUN ,  Wei-Hsien HO ,  Muhammad A. ALHAWAGRI ,  Philip Ling KONG ,  Herve RHINN ,  Hua LONG ,  Karpagam SRINIVASAN ,  Ananya MITRA ,  Daniel P. BERMINGHAM ,  Klaus-Dieter HEGER ,  Santiago Viveros SALAZAR ,  Francesca CIGNARELLA ,  Ilaria TASSI ,  Tina SCHWABE ,  Angie Grace YEE ,  Arnon ROSENTHAL

IPC: C07K16/18

CPC classification number: C07K16/18 ,  A61K2039/505

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, humanized antibodies and antibody fragments, that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20230159637A1

公开(公告)日：2023-05-25

申请号：US17801776

申请日：2021-02-23

Applicant: Alector LLC ,  Washington University

Inventor： Francesca CIGNARELLA ,  Fabia FILIPELLO ,  Bryan BOLLMAN ,  Arnon ROSENTHAL ,  Tina SCHWABE ,  Ilaria TASSI ,  Laura PICCIO

IPC: C07K16/28 ,  A61P25/28

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61K2039/505

Abstract: The present disclosure is generally directed to the use of anti-TREM2 antibodies in preventing, reducing risk, or treating disease in an individual in need thereof.

公开(公告)号：US20220380455A1

公开(公告)日：2022-12-01

申请号：US17722624

申请日：2022-04-18

Applicant: Alector LLC

Inventor： Philip KONG ,  Herve RHINN ,  Tina SCHWABE ,  Angie YEE ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61P25/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, anti-body fragments, etc., that specifically bind a MS4A6A polypeptide, e g., a mammalian MS4A6A or human MS4A6A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20210017275A1

公开(公告)日：2021-01-21

申请号：US16614302

申请日：2018-05-15

Applicant: Alector LLC

Inventor： Kate MONROE ,  Helen LAM ,  Patricia CULP ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61P37/00 ,  A61P25/00 ,  A61P25/28 ,  A61P25/08 ,  A61P31/04 ,  A61P29/00 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-5 protein, e.g., human Siglec-5 or a mammalian Siglec-5, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20200317776A1

公开(公告)日：2020-10-08

申请号：US16835140

申请日：2020-03-30

Applicant: Alector LLC

Inventor： Tina SCHWABE ,  Eric BROWN ,  Philip KONG ,  Ilaria TASSI ,  Seung-Joo LEE ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Nels P. NIELSON

IPC: C07K16/28 ,  A61P25/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20200223928A1

公开(公告)日：2020-07-16

申请号：US16741658

申请日：2020-01-13

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190330335A1

公开(公告)日：2019-10-31

申请号：US15766363

申请日：2016-10-06

Applicant: ALECTOR LLC

Inventor： Tina SCHWABE ,  Francesca AVOGADRI-CONNORS ,  Helen LAM ,  Ilaria TASSI ,  Seung-Joo LEE ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61P25/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20180186878A1

公开(公告)日：2018-07-05

申请号：US15498004

申请日：2017-04-26

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL

IPC: C07K16/28 ,  A61K39/395 ,  C07K14/705 ,  C07K14/725 ,  C07K16/24

CPC classification number: C07K16/2803 ,  A61K39/0011 ,  A61K39/3955 ,  A61K2039/507 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K14/7051 ,  C07K14/70517 ,  C07K16/244 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/033 ,  C07K2319/30 ,  A61K2300/00

Abstract: The present disclosure is related to compositions that include polynucleotides encoding chimeric receptors, methods of delivering polynucleotides encoding chimeric receptors to immune cells, and methods of using immune cells encoding chimeric receptors to treat or prevent cancer.