公开(公告)号：US20080275731A1

公开(公告)日：2008-11-06

申请号：US11435657

申请日：2006-05-17

申请人： R. Bharat Rao ,  Sriram Krishnan ,  William A. Landi

发明人： R. Bharat Rao ,  Sriram Krishnan ,  William A. Landi

IPC分类号： G06F19/00 ,  G06F17/30

CPC分类号： G06Q50/24 ,  G06F19/321 ,  G16H50/70

摘要： Improvements in mining information from patient records and/or use of such mined information are provided. The identity of the patient is used to link to patient records at different institutions for mining. The user controls one or more thresholds for mining and/or inferring. By providing a user interface that allows selection of a portion of the statistical summary, data supporting the statistics may be output. To assist in understanding the knowledge base used for mining or inferring, a visual representation is output. The mining may be used for diagnosis related groupings.

摘要翻译： 提供了从患者记录中挖掘信息和/或使用这种开采信息的改进。 患者的身份用于链接到不同机构的患者记录进行采矿。 用户控制用于挖掘和/或推断的一个或多个阈值。 通过提供允许选择统计摘要的一部分的用户界面，可以输出支持统计的数据。 为了帮助理解用于挖掘或推断的知识库，输出视觉表示。 采矿可用于诊断相关分组。

公开(公告)号：US20070036414A1

公开(公告)日：2007-02-15

申请号：US11502709

申请日：2006-08-10

申请人： Bogdan Georgescu ,  Xiang Zhou ,  Wei Hong ,  Dorin Comaniciu ,  Sriram Krishnan

发明人： Bogdan Georgescu ,  Xiang Zhou ,  Wei Hong ,  Dorin Comaniciu ,  Sriram Krishnan

IPC分类号： G06K9/00 ,  G06K9/62

CPC分类号： G06T7/149 ,  G06T7/12 ,  G06T2207/10136 ,  G06T2207/20081 ,  G06T2207/30048

摘要： The present invention is directed to a method for automatic detection and segmentation of a target anatomical structure in received three dimensional (3D) volumetric medical images using a database of a set of volumetric images with expertly delineated anatomical structures. A 3D anatomical structure detection and segmentation module is trained offline by learning anatomical structure appearance using the set of expertly delineated anatomical structures. A received volumetric image for the anatomical structure of interest is searched online using the offline learned 3D anatomical structure detection and segmentation module.

摘要翻译： 本发明涉及一种使用具有专门描绘的解剖结构的一组体积图像的数据库来自动检测和分割接收的三维（3D）体积医学图像中的目标解剖结构的方法。 3D解剖结构检测和分割模块通过使用专门描绘的解剖结构集合学习解剖结构外观来进行离线训练。 使用离线学习的3D解剖结构检测和分割模块在线搜索用于感兴趣解剖结构的接收体积图像。

公开(公告)号：US20060100518A1

公开(公告)日：2006-05-11

申请号：US11179422

申请日：2005-07-12

申请人： Sriram Krishnan

发明人： Sriram Krishnan

IPC分类号： A61B8/02

CPC分类号： A61B8/483 ,  A61B6/503 ,  A61B8/08 ,  A61B8/0858 ,  A61B8/0883

摘要： Automated analysis of heart function is provided with ultrasound images. A clip of ultrasound images of the heart is used to detect two or three dimensional motion, such as determining a two-dimensional motion vector by tracking wall segments with B-mode data. The amplitude of motion during the e-wave and/or a-wave phase of diastole is extracted for diagnosis assistance.

摘要翻译： 超声图像提供心脏功能的自动分析。 使用心脏的超声图像的剪辑来检测两维或三维运动，例如通过使用B模式数据跟踪壁段来确定二维运动矢量。 提取舒张期的e波和/或a波期间的运动幅度用于诊断辅助。

公开(公告)号：US20060034508A1

公开(公告)日：2006-02-16

申请号：US11143257

申请日：2005-06-02

申请人： Xiang Zhou ,  Lu-yong Wang ,  Dorin Comaniciu ,  David Gustafson ,  Bill Stewart ,  Sriram Krishnan

发明人： Xiang Zhou ,  Lu-yong Wang ,  Dorin Comaniciu ,  David Gustafson ,  Bill Stewart ,  Sriram Krishnan

IPC分类号： G06K9/62

CPC分类号： G16H50/70 ,  G16B25/00

摘要： By inputting genetic and imaging information into a trained classification system, a second opinion diagnosis, a prognosis, clinical trial qualification or similar case information are output to assist a user. Consistent analysis may be provided using image based measurements in combination with pharmacogenomics studies. Fusing imaging, genetics and other information, such as clinical data, may more likely reduce the number of uncertainties in medical analysis, possibly improving patient safety, identifying new capabilities and supporting research.

摘要翻译： 通过将遗传和成像信息输入到经过训练的分类系统中，输出第二意见诊断，预后，临床试验资格或类似情况信息以帮助用户。 可以使用基于图像的测量结合药物基因组学研究来提供一致的分析。 融合成像，遗传学和其他信息（如临床数据）可能更有可能减少医疗分析中的不确定性数量，可能改善患者安全性，识别新功能和支持研究。

公开(公告)号：US20050234740A1

公开(公告)日：2005-10-20

申请号：US10877127

申请日：2004-06-25

申请人： Sriram Krishnan ,  R. Rao ,  William Landi ,  Sathyakama Sandilya

发明人： Sriram Krishnan ,  R. Rao ,  William Landi ,  Sathyakama Sandilya

IPC分类号： G06Q10/00 ,  G06Q30/00 ,  G06F17/60

CPC分类号： G06Q10/10 ,  G06Q10/06398 ,  G06Q30/02 ,  G06Q50/22 ,  G16H50/70

摘要： Business methods and systems that are provided use knowledge-based expert systems for mining (extracting) highly structured clinical information from various structured and unstructured sources of healthcare provider data. In one business method for on-line healthcare management and decision support, a service provider maintaining a collection of structured clinical data, the structured clinical data comprising information automatically mined from various structured and unstructured sources of healthcare provider data from one or more different healthcare providers. The service provider provides a customer on-line access to structured clinical data in the collection, or providing an on-line service to the customer using structured clinical data in the collection, based on a service agreement between the customer and the service provider.

摘要翻译： 提供的业务方法和系统使用基于知识的专家系统，从各种结构化和非结构化的医疗保健提供者数据来源挖掘（提取）高度结构化的临床信息。 在一种用于在线医疗保健管理和决策支持的业务方法中，服务提供商维护结构化临床数据的集合，结构化临床数据包括从来自一个或多个不同医疗保健提供者的医疗保健提供者数据的各种结构化和非结构化来源自动开采的信息 。 服务提供商可以根据客户和服务提供商之间的服务协议，在收集中提供客户在线访问收集中的结构化临床数据，或在收集中使用结构化临床数据向客户提供在线服务。

公开(公告)号：US06413218B1

公开(公告)日：2002-07-02

申请号：US09501443

申请日：2000-02-10

申请人： John W. Allison ,  Lewis J. Thomas ,  Sriram Krishnan ,  Gregory L. Holley

发明人： John W. Allison ,  Lewis J. Thomas ,  Sriram Krishnan ,  Gregory L. Holley

IPC分类号： A61B800

CPC分类号： A61B8/4281 ,  A61B8/461 ,  A61B8/469 ,  A61B8/56 ,  G01S7/52036 ,  G01S7/5205 ,  G01S7/52074 ,  G01S7/52076 ,  G01S7/52084

摘要： The preferred embodiments described herein provide a medical diagnostic ultrasound imaging system and method for determining an acoustic output parameter of a transmitted ultrasonic beam. In one preferred embodiment, the ultrasound system determines an acoustic output parameter of a transmitted ultrasonic beam in a user-selected region. In another preferred embodiment, the ultrasound system achieves a specified acoustic output parameter of a transmitted ultrasonic beam in a selected region by automatically adjusting an operating parameter of the ultrasound imaging system. In yet another preferred embodiment, a region is selected in the ultrasound image that does not contain a peak acoustic output parameter of a transmitted ultrasonic beam. The system then determines an acoustic output parameter of the transmitted ultrasonic beam in that region and provides an indication of the determined acoustic output parameter.

摘要翻译： 本文描述的优选实施例提供了用于确定发射超声波束的声输出参数的医学诊断超声成像系统和方法。 在一个优选实施例中，超声系统在用户选择的区域中确定发射的超声波束的声输出参数。 在另一个优选实施例中，超声系统通过自动调节超声成像系统的操作参数来实现选定区域中的发射超声波束的指定声输出参数。 在另一优选实施例中，在超声波图像中选择不包含发射超声波束的峰值声输出参数的区域。 然后，该系统确定该区域中发射的超声波束的声输出参数，并提供所确定的声输出参数的指示。

公开(公告)号：US06340348B1

公开(公告)日：2002-01-22

申请号：US09348246

申请日：1999-07-02

申请人： Sriram Krishnan ,  Gregory L. Holley ,  Edward A. Gardner ,  Samuel H. Maslak

发明人： Sriram Krishnan ,  Gregory L. Holley ,  Edward A. Gardner ,  Samuel H. Maslak

IPC分类号： A61B800

CPC分类号： A61B8/481 ,  A61B8/543 ,  A61B17/22004 ,  A61B2017/22008

摘要： The invention is directed to improvements in diagnostic medical ultrasound contrast agent imaging. In a preferred embodiment, high pulse repetition frequency (HPRF) destruction pulses are fired at a rate higher than necessary for receiving returning echoes. Pulse parameters can also be changed between the plurality of contrast agent-destroying pulses. Other preferred embodiments of the invention are directed to simultaneous transmission of multiple beams of destruction pulses. Destruction frames that consist of a plurality of destruction pulses can be triggered and swept over the entire region of tissue being imaged and at a variety of focal depths from the transmitter. The destruction frames are fired at some time triggered from a timer or some fixed part of a physiological signal, such as an ECG signal. Other preferred embodiments of the invention are directed to continuous low power imaging pulses alternating with destruction pulses triggered at a fixed point of a physiological signal, and a comparison of the received signals from imaging pulses fired before and after the destruction pulses. Alternatively, destruction pulses are triggered at a fixed point on a physiological signal different from the fixed point of a physiological signal used to trigger imaging pulses. In another embodiment, triggered destruction frames are used to enable a comparison of imaging frames in order to determine physiological functions, such as perfusion of blood in cardiac tissue. Finally, in another embodiment, destruction pulses are combined with subharmonic imaging.

摘要翻译： 本发明涉及诊断医学超声造影剂成像的改进。 在优选实施例中，高脉冲重复频率（HPRF）破坏脉冲以高于接收返回回波所需的速率被发射。 也可以在多个造影剂破坏脉冲之间改变脉冲参数。 本发明的其它优选实施例涉及同时传输多束破坏脉冲。 由多个破坏脉冲组成的破坏帧可以被触发并扫过被成像的组织的整个区域并且在来自发射器的各种焦深处扫过。 在由定时器或生理信号的某些固定部分（例如ECG信号）触发的某个时间触发破坏帧。 本发明的其它优选实施例涉及与生理信号的固定点触发的破坏脉冲交替的连续低功率成像脉冲，以及在破坏脉冲之前和之后激发的成像脉冲的接收信号的比较。 或者，在与用于触发成像脉冲的生理信号的固定点不同的生理信号上的固定点触发销毁脉冲。 在另一个实施例中，触发的破坏帧用于使成像帧的比较能够确定生理功能，例如心脏组织中血液的灌注。 最后，在另一个实施例中，销毁脉冲与次谐波成像组合。

公开(公告)号：US06210333B1

公开(公告)日：2001-04-03

申请号：US09416041

申请日：1999-10-12

申请人： Edward A. Gardner ,  Sriram Krishnan ,  Nils Sponheim

发明人： Edward A. Gardner ,  Sriram Krishnan ,  Nils Sponheim

IPC分类号： A61B802

CPC分类号： A61B8/481 ,  A61B8/543

摘要： A region of interest in the body is imaged using at least two different trigger intervals between images. Imaging automatically switches from one trigger interval to another in response to a user command, such as depressing a button. This automation avoids cumbersome manual changes of the trigger intervals. Perfusion is measured in a shorter time in this way, reducing the effects of breathing and transducer movement. Variation of the trigger intervals allows for a convenient determination of perfusion. For example, the trigger intervals are varied from one heart cycle to two heart cycles and then to other integer numbers of heart cycles.

摘要翻译： 使用图像之间的至少两个不同的触发间隔对体内感兴趣的区域成像。 响应于诸如按下按钮的用户命令，成像自动从一个触发间隔切换到另一触发间隔。 这种自动化避免了手动更改触发间隔的麻烦。 以这种方式在更短的时间内测量灌注，减少呼吸和换能器运动的影响。 触发间隔的变化允许方便地确定灌注。 例如，触发间隔从一个心脏周期变化到两个心脏周期，然后变化到其他整数个心脏周期。

公开(公告)号：US08977825B1

公开(公告)日：2015-03-10

申请号：US13435907

申请日：2012-03-30

申请人： Eric Scott Lewine ,  Neil Schutzman ,  Scott D. Von Rhee ,  Sriram Krishnan ,  Mario Wurzl

发明人： Eric Scott Lewine ,  Neil Schutzman ,  Scott D. Von Rhee ,  Sriram Krishnan ,  Mario Wurzl

IPC分类号： G06F12/00 ,  G06F13/00 ,  G06F13/28

CPC分类号： G06F13/28 ,  G06F3/0605 ,  G06F3/0631 ,  G06F3/0665 ,  G06F3/067 ,  G06F13/00 ,  G06F17/30

摘要： A method performed by a storage management computer includes (a) receiving a set of storage profile definitions (SPDs) from an administrator of a data storage system over a user interface, each SPD of the set of SPDs including (1) a storage profile name and (2) a set of storage policies assigned to that SPD, (b) providing the storage profile names from the set of SPDs to an environment management application, the environment management application being configured to manage environments that use storage from the data storage system, (c) in response to providing, receiving a selection of a particular SPD from the environment management application to be used in connection with a particular environment, and (d) provisioning a unit of storage from the data storage system to the particular environment in accordance with the set of storage policies assigned to the particular SPD.

摘要翻译： 由存储管理计算机执行的方法包括（a）通过用户接口从数据存储系统的管理员接收一组存储简档定义（SPD），所述SPD组的每个SPD包括（1）存储简档名称 以及（2）分配给该SPD的一组存储策略，（b）将该SPD的存储简档名称提供给环境管理应用，所述环境管理应用被配置为管理使用来自数据存储系统的存储的环境 （c）响应于提供，从环境管理应用中接收特定SPD的选择以与特定环境结合使用，以及（d）将数据存储系统中的存储单元提供给特定环境中的特定环境 根据分配给特定SPD的一组存储策略。

公开(公告)号：US08579784B2

公开(公告)日：2013-11-12

申请号：US12944288

申请日：2010-11-11

申请人： Sriram Krishnan ,  R. Bharat Rao ,  Christopher Jude Amies

发明人： Sriram Krishnan ,  R. Bharat Rao ,  Christopher Jude Amies

IPC分类号： A61N5/00

CPC分类号： A61N5/103 ,  A61N2005/1041 ,  G06F19/00 ,  G06F19/3481 ,  G16H50/30 ,  G16H50/50

摘要： Automated treatment planning is provided with individual specific consideration. One or more prognosis models indicate survivability as a function of patient specific information for a given dose. By determining survivability for a plurality of doses, the biological model represented by survivability as a function of dose is determined from the specific patient. Similarly, the chances of complications or side effects are determined. The chance of survivability and chance of complication are used as or instead of the tumor control probability and normal tissue complications probability, respectively. The desired tumor dosage and tolerance dosage are selected as a function of the patient specific dose distributions. The selected dosages are input to an inverse treatment planning system for establishing radiation treatment parameters.

摘要翻译： 提供自动化治疗计划，具体考虑。 一个或多个预后模型表明作为给定剂量的患者特异性信息的函数的存活率。 通过确定多个剂量的存活率，从特定患者确定作为剂量的函数的存活率所表示的生物学模型。 类似地，确定并发症或副作用的机会。 生存能力和并发症的机会分别被用作肿瘤控制概率和正常组织并发症概率。 选择所需的肿瘤剂量和耐受剂量作为患者具体剂量分布的函数。 选择的剂量被输入到用于建立放射治疗参数的反向治疗计划系统。