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公开(公告)号：US07238776B2
公开(公告)日：2007-07-03
申请号：US09899422
申请日：2001-07-03
CPC分类号： C07K14/7151 , A61K38/00 , C12Q1/6886 , C12Q2600/158 , G01N33/6863 , Y02A50/473
摘要： The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
摘要翻译： 本发明提供了编码TNF结合蛋白的DNA序列和该蛋白构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。 重组TNF结合蛋白用于治疗TNF具有有害作用的适应症的药物制剂中。 借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质 受体和/或其对TNF的生物活性的影响。
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公开(公告)号：US20060148800A1
公开(公告)日：2006-07-06
申请号：US11206703
申请日：2005-08-17
申请人： Heinz Stadtmueller , Harald Engelhardt , Martin Steegmaier , Anke Baum , Ulrich Guertler , Andreas Schoop , Jen Quant , Flavio Solca , Rudolf Hauptmann , Ulrich Reiser , Stephan Zahn , Lars Herfurth
发明人： Heinz Stadtmueller , Harald Engelhardt , Martin Steegmaier , Anke Baum , Ulrich Guertler , Andreas Schoop , Jen Quant , Flavio Solca , Rudolf Hauptmann , Ulrich Reiser , Stephan Zahn , Lars Herfurth
IPC分类号： A61K31/53
CPC分类号： C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要： The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
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公开(公告)号：US20050261295A1
公开(公告)日：2005-11-24
申请号：US11132091
申请日：2005-05-18
申请人： Heinz Stadtmueller , Harald Engelhardt , Ulrich Reiser , Stephan Zahn , Rudolf Hauptmann , Martin Steegmaier , Ulrich Guertler , Matthias Hoffmann , Matthias Grauert
发明人： Heinz Stadtmueller , Harald Engelhardt , Ulrich Reiser , Stephan Zahn , Rudolf Hauptmann , Martin Steegmaier , Ulrich Guertler , Matthias Hoffmann , Matthias Grauert
IPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D253/08 , A61K31/506 , A61K31/53 , C07D43/02
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12
摘要： The present invention comprises compounds of general formula (1) wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, and the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译： 本发明包括通式（1）的化合物，其中A，X，Y，Z，R a，O，R b，R c， R 1，R 2和R 3定义如权利要求1所述，其适用于治疗以过度或异常细胞为特征的疾病 增殖及其用于制备具有上述性质的药物组合物的用途。
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公开(公告)号：US06271346B1
公开(公告)日：2001-08-07
申请号：US08484312
申请日：1995-06-07
IPC分类号： C07K100
CPC分类号： G01N33/57484 , A61K38/00 , C07K14/7151 , C12Q1/6886 , C12Q2600/136 , G01N33/6863 , Y02A50/473 , Y10S930/12 , Y10S930/144
摘要： DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
摘要翻译： 编码TNF结合蛋白的DNA序列和该蛋白质构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。 重组TNF结合蛋白用于治疗TNF具有有害作用的适应症的药物制剂中。 借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质 受体和/或其对TNF的生物活性的影响。
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公开(公告)号：US5843791A
公开(公告)日：1998-12-01
申请号：US477639
申请日：1995-06-07
IPC分类号： A61K38/00 , C07K14/715 , C12Q1/68 , G01N33/574 , G01N33/68 , G01N33/53
CPC分类号： G01N33/6863 , A61K38/00 , C07K14/7151 , C12Q1/6886 , C12Q2600/136 , G01N33/57484
摘要： DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
摘要翻译： 编码TNF结合蛋白的DNA序列和该蛋白质构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。 借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质 受体和/或其对TNF的生物活性的影响。
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公开(公告)号：US20090306104A1
公开(公告)日：2009-12-10
申请号：US12541961
申请日：2009-08-16
申请人： Gerald Juergen Roth , Armin Heckel , Rainer Walter , Frank Hilberg , Rudolf Hauptmann , Martin Fredrich Stefanic , Florian Colbatzky , Steffan Ernest
发明人： Gerald Juergen Roth , Armin Heckel , Rainer Walter , Frank Hilberg , Rudolf Hauptmann , Martin Fredrich Stefanic , Florian Colbatzky , Steffan Ernest
IPC分类号： A61K31/404 , A61K31/454 , A61K31/517 , A61P37/00 , A61P29/00
CPC分类号： A61K45/06 , A61K31/404 , A61K31/454 , A61K31/517 , A61K2300/00
摘要： The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressives, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said Lck inhibitors together with said other drugs, and the use of the Lck inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.
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公开(公告)号：US07264944B1
公开(公告)日：2007-09-04
申请号：US09525998
申请日：2000-03-15
CPC分类号： C07K14/7151 , A61K38/00 , C12Q1/6886 , C12Q2600/158 , G01N33/6863 , Y02A50/473
摘要： The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
摘要翻译： 本发明提供了编码TNF结合蛋白的DNA序列和该蛋白构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。 重组TNF结合蛋白用于治疗TNF具有有害作用的适应症的药物制剂中。 借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质 受体和/或其对TNF的生物活性的影响。
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公开(公告)号：US06294352B1
公开(公告)日：2001-09-25
申请号：US08383676
申请日：1995-02-01
IPC分类号： C12N1500
CPC分类号： G01N33/57484 , A61K38/00 , C07K14/7151 , C12Q1/6886 , C12Q2600/136 , G01N33/6863 , Y02A50/473 , Y10S930/12 , Y10S930/144
摘要： DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequence can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
摘要翻译： 编码TNF结合蛋白的DNA序列和该蛋白质构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。 重组TNF结合蛋白用于治疗TNF具有有害作用的适应症的药物制剂中。 借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质 受体和/或其对TNF的生物活性的影响。
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公开(公告)号：US06221675B1
公开(公告)日：2001-04-24
申请号：US08477639
申请日：1995-06-07
IPC分类号： G01N33566
CPC分类号： G01N33/6863 , A61K38/00 , C07K14/7151 , C12Q1/6886 , C12Q2600/136 , G01N33/57484
摘要： DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF is receptor and/or for their effect on the biological activity of TNF.
摘要翻译： 编码TNF结合蛋白的DNA序列和该蛋白质构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。 借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质 是受体和/或其对TNF的生物活性的影响。
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公开(公告)号：US4730189A
公开(公告)日：1988-03-08
申请号：US613261
申请日：1984-05-24
申请人： Harald Siegel , Rudolf Hauptmann
发明人： Harald Siegel , Rudolf Hauptmann
IPC分类号： G01S7/292 , G01S13/22 , G01S13/528 , G01S13/53 , G01S13/52
CPC分类号： G01S7/2926 , G01S13/225 , G01S13/528 , G01S13/53
摘要： A pulse Doppler radar system with variable pulse repetition frequency has a coherent integrator to which the reflected pulses are supplied in order to avoid deterioration of the indication of a moving target given over-the-horizon reception. The coherent integrator subjects the reflected pulses to a simplified vectorial addition by the use of a number of filters. A precondition for the modified coherent integration is a staggering of the pulse repetition periods such that their sums formed over successive pulse repetition periods are constant, and a phase reference for the signal amplitudes is obtained such that the phase difference is equal to zero after every second pulse repetition.
摘要翻译： 具有可变脉冲重复频率的脉冲多普勒雷达系统具有相干积分器，反射脉冲向该积分器提供反射脉冲，以避免给定超视距接收的移动目标的指示的恶化。 相干积分器通过使用多个滤波器使反射脉冲受到简化的矢量加法。 改进的相干积分的前提条件是脉冲重复周期的交错，使得它们在连续脉冲重复周期上形成的和是恒定的，并且获得信号幅度的相位基准，使得相位差在每秒之后等于零 脉冲重复。
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