公开(公告)号：US07203551B2

公开(公告)日：2007-04-10

申请号：US10424584

申请日：2003-04-25

申请人： Richard P. M. Houben ,  Mark A. Christopherson ,  Adrianus P. Donders ,  Robert Leinders ,  Curtis D. Deno

发明人： Richard P. M. Houben ,  Mark A. Christopherson ,  Adrianus P. Donders ,  Robert Leinders ,  Curtis D. Deno

IPC分类号： A61N1/00 ,  H01L41/07

CPC分类号： A61N1/08 ,  A61N1/36542

摘要： In general, the invention is directed to an IMD having a piezoelectric transformer to power a lead-based sensor. The IMD powers the piezoelectric transformer with a low amplitude signal. The piezoelectric transformer serves to convert the voltage level of the low amplitude signal to a higher voltage level to drive the sensor produced by a battery in the IMD to voltage levels appropriate for IMD operation. A piezoelectric transformer offers small size and low profile, as well as operational efficiency, and permits the IMD to transmit a low amplitude signal to a remote sensor deployed within an implantable lead. In addition, the piezoelectric transformer provides electrical isolation that reduces electromagnetic interference among different sensors.

摘要翻译： 通常，本发明涉及具有压电变压器以为基于铅的传感器供电的IMD。 IMD用低幅度信号为压电变压器供电。 压电变压器用于将低振幅信号的电压电平转换为更高的电压电平，以将由IMD中的电池产生的传感器驱动到适于IMD操作的电压电平。 压电变压器提供小尺寸和低轮廓以及操作效率，并允许IMD将低振幅信号传输到部署在可植入导线内的远程传感器。 此外，压电变压器提供电隔离，减少不同传感器之间的电磁干扰。

公开(公告)号：US07191008B2

公开(公告)日：2007-03-13

申请号：US10057419

申请日：2002-01-25

申请人： Craig L. Schmidt ,  Paul M. Skarstad ,  Nathan A. Torgerson ,  John J. Grevious ,  Steven L. Jensen ,  John W. Forsberg ,  Robert Leinders ,  Raymond F. McMullen

发明人： Craig L. Schmidt ,  Paul M. Skarstad ,  Nathan A. Torgerson ,  John J. Grevious ,  Steven L. Jensen ,  John W. Forsberg ,  Robert Leinders ,  Raymond F. McMullen

IPC分类号： A61N1/08

CPC分类号： A61N1/08 ,  A61N1/378 ,  A61N1/3787 ,  A61N1/3975

摘要： An implantable medical device includes a control circuit for controlling the operation of the device and for obtaining physiological data from a patient in which the medical device is implanted. The implanted device also includes a communication circuit for transmitting the physiological data to an external device. A first power source is coupled to the control circuit and provides power to the control circuit. A second power source is coupled to the communication circuit and provides power to the communication circuit.

摘要翻译： 可植入医疗装置包括控制电路，用于控制装置的操作并从用于从其中植入医疗装置的患者获得生理数据。 植入装置还包括用于将生理数据发送到外部装置的通信电路。 第一电源耦合到控制电路并向控制电路提供电力。 第二电源耦合到通信电路并向通信电路提供电力。

公开(公告)号：US06505078B1

公开(公告)日：2003-01-07

申请号：US09523072

申请日：2000-03-10

申请人： Gary W. King ,  Robert Leinders ,  Greg Hrdlicka ,  Michael D. Baudino

发明人： Gary W. King ,  Robert Leinders ,  Greg Hrdlicka ,  Michael D. Baudino

IPC分类号： A61N136

CPC分类号： A61N1/36164 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/36017 ,  A61N1/36071 ,  A61N1/36167

摘要： The locus of electrically excitable tissue where action potentials are induced can be controlled using the physiological principle of electrotonus. In one embodiment, first and second pulses are applied to first and second electrodes, respectively, to generate first and second subthreshold potential areas, respectively, within the tissue. The locus within the tissue where action potentials are induced is determined by a superposition of the first and second subthreshold areas according to the physiological principle of electrotonus. In another embodiment, a two-dimensional array of electrodes are formed. The cathode may be positioned near the center of the two-dimensional array or may be left out. The first and second subthreshold areas may thereby be steered. An array of anodal rings may be used to contain the field of excitation.

公开(公告)号：US06482177B1

公开(公告)日：2002-11-19

申请号：US09394318

申请日：1999-09-13

申请人： Robert Leinders

发明人： Robert Leinders

IPC分类号： A61M3700

CPC分类号： A61M5/1684 ,  A61M5/14276 ,  A61M2205/3317 ,  A61M2205/3389

摘要： An implantable pump apparatus and method of operating the implantable pump for infusing a fluid into a body as described. An expandable fluid reservoir member includes a first end, a second end, an inlet for receiving the fluid from an outside source and an outlet for dispensing the fluid into the body. A first conductor is operably attached to the first end of the expandable fluid reservoir member. A second conductor is operably attached to the second end of the expandable fluid reservoir member. The level of fluid within the expandable fluid reservoir member is determined by measuring an inductance value at the first conductor that is proportional to the distance between the first conductor and the second conductor.

摘要翻译： 一种植入式泵装置和操作该植入式泵的方法，用于将流体注入体内，如上所述。 可膨胀流体储存器构件包括第一端，第二端，用于从外部源接收流体的入口和用于将流体分配到主体中的出口。 第一导体可操作地附接到可膨胀流体储存器构件的第一端。 第二导体可操作地附接到可膨胀流体储存器构件的第二端。 通过测量与第一导体和第二导体之间的距离成比例的第一导体处的电感值来确定可膨胀流体储存器件内的流体水平。

公开(公告)号：US5843135A

公开(公告)日：1998-12-01

申请号：US954043

申请日：1997-10-20

申请人： Koen J. Weijand ,  Robert Leinders

发明人： Koen J. Weijand ,  Robert Leinders

IPC分类号： A61N1/05 ,  A61N1/365 ,  A61N1/362

CPC分类号： A61N1/365 ,  A61N1/056 ,  A61N1/36514

摘要： A pacing system is provided having a lead with a pressure transducer or other sensor, the lead being characterized by having only a single conductor connecting the pacemaker with the signals from the sensor and the signals to and from the lead tip electrode. A connecting circuit mounted in the lead near the distal end is powered by a low level alternating constant current square wave to provide multiplexed signals on the conductor. The lead connecting circuit comprises a switching device connected to a sensor, such as a piezoelectric pressure transducer, so that for positive current pulses delivered to the lead, the transducer output is added in series with any cardiac signal sensed by the tip electrode; while for negative currents the pressure transducer is isolated and only the tip electrode signal information is connected back to the pacemaker. The pacemaker contains processing circuitry for decoding the respective cardiac signals and pressure signals from the multiplexed signals.

摘要翻译： 提供具有带有压力传感器或其他传感器的引线的起搏系统，该引线的特征在于仅具有将起搏器与来自传感器的信号和来自引线末端电极的信号连接起来的单个导体。 安装在远端附近的引线中的连接电路由低电平交流恒流方波供电，以在导体上提供复用信号。 引线连接电路包括连接到诸如压电压力传感器的传感器的开关装置，使得对于传递到引线的正电流脉冲，换能器输出与由尖端电极感测的任何心脏信号相加; 而对于负电流，压力传感器是隔离的，只有尖端电极信号信息被连接回起搏器。 起搏器包含用于从复用的信号解码各个心脏信号和压力信号的处理电路。

公开(公告)号：US07657318B2

公开(公告)日：2010-02-02

申请号：US11273310

申请日：2005-11-14

申请人： Gary W. King ,  Robert Leinders ,  Greg Hrdlicka ,  Michael D. Baudino

发明人： Gary W. King ,  Robert Leinders ,  Greg Hrdlicka ,  Michael D. Baudino

IPC分类号： A61N1/36

CPC分类号： A61N1/36164 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/36017 ,  A61N1/36071 ,  A61N1/36167

摘要： The locus of electrically excitable tissue where action potentials are induced can be controlled using the physiological principle of electrotonus. In one embodiment, first and second pulses are applied to first and second electrodes, respectively, to generate first and second subthreshold potential areas, respectively, within the tissue. The locus within the tissue where action potentials are induced is determined by a superposition of the first and second subthreshold areas according to the physiological principle of electrotonus. In another embodiment, a two-dimensional array of electrodes are formed. The cathode may be positioned near the center of the two-dimensional array or may be left out. The first and second subthreshold areas may thereby be steered. An array of anodal rings may be used to contain the field of excitation.

摘要翻译： 诱导动作电位的电可激发组织的位置可以使用电渗的生理原理进行控制。 在一个实施例中，分别将第一和第二脉冲施加到第一和第二电极，以在组织内分别产生第一和第二亚阈值电位区域。 通过根据电生理原理的第一和第二亚阈值区域的叠加来确定在组织内产生动作电位的位点。 在另一个实施例中，形成二维电极阵列。 阴极可以位于二维阵列的中心附近，或者可以被排除。 从而可以控制第一和第二亚阈值区域。 阳极环阵列可用于包含激发场。

公开(公告)号：US07489966B2

公开(公告)日：2009-02-10

申请号：US11170497

申请日：2005-06-29

申请人： Robert Leinders ,  Nathan A. Torgerson ,  Mark T. Stein ,  Todd P. Goblish ,  Todd D. Heathershaw ,  John Delfin Rodriguez

发明人： Robert Leinders ,  Nathan A. Torgerson ,  Mark T. Stein ,  Todd P. Goblish ,  Todd D. Heathershaw ,  John Delfin Rodriguez

IPC分类号： A61N1/00

CPC分类号： A61N1/36071

摘要： Apparatus and method for independently delivering a plurality of therapy programs in an implantable medical device. A therapy controller configures the device to generate independent pulse trains associated with a plurality of therapy programs and dynamically configures the electrodes to deliver the independent pulse trains to the patient. Once configured, the implantable medical device delivers the plurality of therapy programs to the patient wherein the therapy programs may overlap in time.

摘要翻译： 用于在可植入医疗装置中独立地递送多个治疗程序的装置和方法。 治疗控制器配置该装置以产生与多个治疗程序相关联的独立脉冲序列，并且动态地配置电极以将独立的脉冲序列传递给患者。 一旦配置，可植入医疗装置将多个治疗程序递送到患者，其中治疗程序可能在时间上重叠。

公开(公告)号：US07483748B2

公开(公告)日：2009-01-27

申请号：US10133906

申请日：2002-04-26

申请人： Nathan A. Torgerson ,  Robert Leinders ,  Mark Stein ,  Todd P. Goblish ,  Todd D. Heathershaw ,  John Delfin Rodriguez

发明人： Nathan A. Torgerson ,  Robert Leinders ,  Mark Stein ,  Todd P. Goblish ,  Todd D. Heathershaw ,  John Delfin Rodriguez

IPC分类号： A61N1/00

CPC分类号： A61N1/36125

摘要： Apparatus and method provide flexibility in generating a stimulation waveform to an electrode of an Implantable Neuro Stimulator (INS). The stimulation waveform is synthesized for each rate period interval. Each rate period interval is partitioned into time intervals, during which stimulation pulses, recharging, and time duration delays may be induced. With the embodiment of the invention, a second stimulation pulse, having different electrical characteristics than a first stimulation pulse, may be generated during the rate period interval. An embodiment utilizes apparatus comprising a waveform controller and a waveform generator that are controlled by the waveform controller. The waveform controller uses waveform parameters to instruct the waveform generator to form stimulation pulses. Any of the components may be adjusted or deleted in the generation of the stimulation waveform. The embodiment enables any of the associated waveform parameters to be updated at the waveform controller in order to alter the stimulation waveform.

摘要翻译： 装置和方法提供了向植入式神经刺激器（INS）的电极产生刺激波形的灵活性。 针对每个速率周期间隔合成刺激波形。 每个速率周期间隔被划分成时间间隔，在此时间间隔期间可以诱发刺激脉冲，再充电和持续时间延迟。 利用本发明的实施例，可以在速率周期间隔期间产生具有与第一刺激脉冲不同的电特性的第二刺激脉冲。 实施例利用由波形控制器控制的波形控制器和波形发生器的装置。 波形控制器使用波形参数来指示波形发生器形成刺激脉冲。 可以在产生刺激波形时调整或删除任何组件。 该实施例使得能够在波形控制器处更新相关联的波形参数，以便改变刺激波形。

公开(公告)号：US20060079937A1

公开(公告)日：2006-04-13

申请号：US11273310

申请日：2005-11-14

申请人： Gary King ,  Robert Leinders ,  Greg Hrdlicka ,  Michael Baudino

发明人： Gary King ,  Robert Leinders ,  Greg Hrdlicka ,  Michael Baudino

IPC分类号： A61N1/32 ,  A61N1/00

CPC分类号： A61N1/36164 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/36017 ,  A61N1/36071 ,  A61N1/36167

摘要： The locus of electrically excitable tissue where action potentials are induced can be controlled using the physiological principle of electrotonus. In one embodiment, first and second pulses are applied to first and second electrodes, respectively, to generate first and second subthreshold potential areas, respectively, within the tissue. The locus within the tissue where action potentials are induced is determined by a superposition of the first and second subthreshold areas according to the physiological principle of electrotonus. In another embodiment, a two-dimensional array of electrodes are formed. The cathode may be positioned near the center of the two-dimensional array or may be left out. The first and second subthreshold areas may thereby be steered. An array of anodal rings may be used to contain the field of excitation.

公开(公告)号：US6125300A

公开(公告)日：2000-09-26

申请号：US152072

申请日：1998-09-11

申请人： Koen J. Weijand ,  Robert Leinders

发明人： Koen J. Weijand ,  Robert Leinders

IPC分类号： A61N1/36 ,  A61N1/368 ,  A61N1/00

CPC分类号： A61N1/3605 ,  A61N1/368 ,  A61N1/378

摘要： There is provided an implantable device with two or more output stages for delivering concurrent output pulses to two or more sites within a patient's body. Each output circuit has a common architecture, including a switchable generator which has a plurality of storage capacitors and switches for arranging the capacitors either to be charged by the battery, or to discharge a stimulus pulse. A programmable regulator is provided for further regulation of the output voltage; and a multiplexer connects the output to the desired electrodes placed at the patient site. For concurrent dual pulse-dual site stimulation, a pair of active rectifier switches are connected between the negative terminal of each output stage and the battery positive terminal, whereby at the time of concurrent pulse delivery, the output stage having the greatest negative voltage relative to battery plus has its negative terminal connected to the battery plus terminal, while the other output stage is disconnected from the battery so that it floats. This arrangement reduces crosstalk current while ensuring continued positive biasing of the semi-conductor switches in each output stage.

摘要翻译： 提供了一种具有两个或多个输出级的可植入装置，用于将同时的输出脉冲输送到患者体内的两个或多个位置。 每个输出电路具有共同的架构，包括具有多个存储电容器的开关发生器和用于布置要由电池充电的电容器的开关或放电刺激脉冲。 提供可编程调节器，用于进一步调节输出电压; 并且多路复用器将输出连接到放置在患者现场的期望电极。 对于并发双脉冲双站点刺激，一对有源整流开关连接在每个输出级的负极端子和电池正极端子之间，由此在并发脉冲输送时，输出级相对于 电池加上其负极端子连接到电池加端子，而另一个输出级与电池断开，使其浮动。 这样可以降低串扰电流，同时确保在每个输出级中半导体开关的持续正偏置。