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    PROGRAMMABLE WAVEFORM PULSES FOR AN IMPLANTABLE MEDICAL DEVICE
    4.
    发明申请
    PROGRAMMABLE WAVEFORM PULSES FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
    可编程医疗器械的可编程波形脉冲

    公开(公告)号：US20090259278A1

    公开(公告)日：2009-10-15

    申请号：US12359958

    申请日：2009-01-26

    申请人： Nathan A. Torgerson ,  Robert Leinders ,  Marc Stein ,  Todd P. Goblish ,  Todd D. Heathershaw ,  John Delfin Rodriguez

    发明人： Nathan A. Torgerson ,  Robert Leinders ,  Marc Stein ,  Todd P. Goblish ,  Todd D. Heathershaw ,  John Delfin Rodriguez

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36125

    摘要： Apparatus and method provide flexibility in generating a stimulation waveform to an electrode of an Implantable Neuro Stimulator (INS). The stimulation waveform is synthesized for each rate period interval. Each rate period interval is partitioned into time intervals, during which stimulation pulses, recharging, and time duration delays may be induced. With the embodiment of the invention, a second stimulation pulse, having different electrical characteristics than a first stimulation pulse, may be generated during the rate period interval. An embodiment utilizes apparatus comprising a waveform controller and a waveform generator that are controlled by the waveform controller. The waveform controller uses waveform parameters to instruct the waveform generator to form stimulation pulses. Any of the components may be adjusted or deleted in the generation of the stimulation waveform. The embodiment enables any of the associated waveform parameters to be updated at the waveform controller in order to alter the stimulation waveform.

    摘要翻译： 装置和方法提供了向植入式神经刺激器（INS）的电极产生刺激波形的灵活性。 针对每个速率周期间隔合成刺激波形。 每个速率周期间隔被划分成时间间隔，在此时间间隔期间可以诱发刺激脉冲，再充电和持续时间延迟。 利用本发明的实施例，可以在速率周期间隔期间产生具有与第一刺激脉冲不同的电特性的第二刺激脉冲。 实施例利用由波形控制器控制的波形控制器和波形发生器的装置。 波形控制器使用波形参数来指示波形发生器形成刺激脉冲。 可以在产生刺激波形时调整或删除任何组件。 该实施例使得能够在波形控制器处更新相关联的波形参数，以便改变刺激波形。

    Voltage/current regulator improvements for an implantable medical device
    5.
    发明授权
    Voltage/current regulator improvements for an implantable medical device 有权
    可植入医疗器械的电压/电流调节器改进

    公开(公告)号：US07805189B2

    公开(公告)日：2010-09-28

    申请号：US11649329

    申请日：2007-01-03

    申请人： Marc T. Stein ,  Nathan A Torgerson ,  Robert Leinders ,  Todd P Goblish ,  Todd D. Heathershaw ,  John Delfin Rodriguez

    发明人： Marc T. Stein ,  Nathan A Torgerson ,  Robert Leinders ,  Todd P Goblish ,  Todd D. Heathershaw ,  John Delfin Rodriguez

    IPC分类号： A61N1/00

    CPC分类号： A61N1/378 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36192 ,  A61N1/37241 ,  A61N1/37252 ,  A61N1/3787

    摘要： Apparatus and method provide flexibility in generating a stimulation waveform to an electrode of an implantable medical device. The stimulation waveform comprises at least one stimulation pulse. The embodiment of the invention supports a generation of a stimulation pulse in which an amplitude and an electrical polarity of the stimulation pulse can be dynamically changed. The embodiment comprises a capacitor arrangement, a regulator and a switching array. The capacitor arrangement can be reconfigured with respect to an electrical reference through the switching array in order for the regulator to deliver the stimulation pulse to a pair of electrodes. In another embodiment, a plurality of stimulation waveforms are generated in which different stimulation waveforms are associated with different electrodes. With the embodiment, a plurality of regulators are connected and reconfigured to the capacitor arrangement in order that the different stimulation waveforms are generated by different regulators.

    摘要翻译： 装置和方法在向可植入医疗装置的电极产生刺激波形方面提供灵活性。 刺激波形包括至少一个刺激脉冲。 本发明的实施例支持产生刺激脉冲，其中可以动态地改变刺激脉冲的振幅和电极性。 该实施例包括电容器布置，调节器和开关阵列。 可以通过开关阵列相对于电参考来重新配置电容器布置，以便调节器将刺激脉冲传送到一对电极。 在另一个实施例中，产生多个刺激波形，其中不同的刺激波形与不同的电极相关联。 利用本实施例，将多个调节器连接并重新配置到电容器装置，以便不同的调节器产生不同的刺激波形。

    Programmable waveform pulses for an implantable medical device
    7.
    发明授权
    Programmable waveform pulses for an implantable medical device 有权
    可植入医疗器械的可编程波形脉冲

    公开(公告)号：US07483748B2

    公开(公告)日：2009-01-27

    申请号：US10133906

    申请日：2002-04-26

    申请人： Nathan A. Torgerson ,  Robert Leinders ,  Mark Stein ,  Todd P. Goblish ,  Todd D. Heathershaw ,  John Delfin Rodriguez

    发明人： Nathan A. Torgerson ,  Robert Leinders ,  Mark Stein ,  Todd P. Goblish ,  Todd D. Heathershaw ,  John Delfin Rodriguez

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36125

    摘要： Apparatus and method provide flexibility in generating a stimulation waveform to an electrode of an Implantable Neuro Stimulator (INS). The stimulation waveform is synthesized for each rate period interval. Each rate period interval is partitioned into time intervals, during which stimulation pulses, recharging, and time duration delays may be induced. With the embodiment of the invention, a second stimulation pulse, having different electrical characteristics than a first stimulation pulse, may be generated during the rate period interval. An embodiment utilizes apparatus comprising a waveform controller and a waveform generator that are controlled by the waveform controller. The waveform controller uses waveform parameters to instruct the waveform generator to form stimulation pulses. Any of the components may be adjusted or deleted in the generation of the stimulation waveform. The embodiment enables any of the associated waveform parameters to be updated at the waveform controller in order to alter the stimulation waveform.

    摘要翻译： 装置和方法提供了向植入式神经刺激器（INS）的电极产生刺激波形的灵活性。 针对每个速率周期间隔合成刺激波形。 每个速率周期间隔被划分成时间间隔，在此时间间隔期间可以诱发刺激脉冲，再充电和持续时间延迟。 利用本发明的实施例，可以在速率周期间隔期间产生具有与第一刺激脉冲不同的电特性的第二刺激脉冲。 实施例利用由波形控制器控制的波形控制器和波形发生器的装置。 波形控制器使用波形参数来指示波形发生器形成刺激脉冲。 可以在产生刺激波形时调整或删除任何组件。 该实施例使得能够在波形控制器处更新相关联的波形参数，以便改变刺激波形。

    Independent therapy programs in an implantable medical device
    8.
    发明申请
    Independent therapy programs in an implantable medical device 有权
    可植入医疗器械中的独立治疗程序

    公开(公告)号：US20050240244A1

    公开(公告)日：2005-10-27

    申请号：US11170497

    申请日：2005-06-29

    申请人： Robert Leinders ,  Nathan Torgerson ,  Marc Stein ,  Todd Goblish ,  Todd Heathershaw ,  John Rodriguez

    发明人： Robert Leinders ,  Nathan Torgerson ,  Marc Stein ,  Todd Goblish ,  Todd Heathershaw ,  John Rodriguez

    IPC分类号： A61N1/05 ,  A61N1/34 ,  A61N1/18

    CPC分类号： A61N1/36071

    摘要： Apparatus and method for independently delivering a plurality of therapy programs in an implantable medical device. A therapy controller configures the device to generate independent pulse trains associated with a plurality of therapy programs and dynamically configures the electrodes to deliver the independent pulse trains to the patient. Once configured, the implantable medical device delivers the plurality of therapy programs to the patient wherein the therapy programs may overlap in time.

    摘要翻译： 用于在可植入医疗装置中独立地递送多个治疗程序的装置和方法。 治疗控制器配置该装置以产生与多个治疗程序相关联的独立脉冲序列，并且动态地配置电极以将独立的脉冲序列传递给患者。 一旦配置，可植入医疗装置将多个治疗程序递送到患者，其中治疗程序可能在时间上重叠。

    Four-chamber pacing system for optimizing cardiac output and determining heart condition
    9.
    发明授权
    Four-chamber pacing system for optimizing cardiac output and determining heart condition 失效
    四心室起搏系统，用于优化心输出量并确定心脏状况

    公开(公告)号：US06238420B1

    公开(公告)日：2001-05-29

    申请号：US09564036

    申请日：2000-05-04

    申请人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

    发明人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

    IPC分类号： A61N1368

    CPC分类号： A61N1/36521 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

    摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment of the invention, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

    摘要翻译： 用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。 系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。 阻抗检测也用于确定心律失常或心力衰竭进展。 在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。 在本发明的优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时间的阻抗测量值，并且调节左心室起搏脉冲的传递时间，以便最佳地同步左心室起搏与右心室 收缩。 心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。

    Four-chamber pacing system for optimizing cardiac output and determining heart condition
    10.
    发明授权
    Four-chamber pacing system for optimizing cardiac output and determining heart condition 失效
    四心室起搏系统，用于优化心输出量并确定心脏状况

    公开(公告)号：US06219579B1

    公开(公告)日：2001-04-17

    申请号：US09493690

    申请日：2000-01-28

    申请人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

    发明人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

    IPC分类号： A61N1365

    CPC分类号： A61N1/36521 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

    摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

    摘要翻译： 用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。 系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。 阻抗检测也用于确定心律失常或心力衰竭进展。 在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。 在优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时机的阻抗测量值，并且调节左心室起搏脉冲的传送时间，以便使左心室起搏与右心室收缩最佳地同步。 心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。