公开(公告)号：US20050208059A1

公开(公告)日：2005-09-22

申请号：US11125805

申请日：2005-05-09

申请人： Pia Challita-Eid ,  Rene Hubert ,  Steve Mitchell ,  Arthur Raitano ,  Mary Faris ,  Daniel Afar ,  Aya Jakobovits

发明人： Pia Challita-Eid ,  Rene Hubert ,  Steve Mitchell ,  Arthur Raitano ,  Mary Faris ,  Daniel Afar ,  Aya Jakobovits

IPC分类号： A61K38/00 ,  C07K14/47 ,  G01N33/574 ,  C12Q1/68 ,  A61K39/395 ,  C07K14/82 ,  C07K16/30

CPC分类号： G01N33/574 ,  A61K38/00 ,  C07K14/47 ,  Y02A50/465 ,  Y02A50/473

摘要： A novel gene (designated 121P1F1) and its encoded protein are described. While 121P1F1 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including prostate, bladder, kidney, brain, bone, cervical, uterine, ovarian, breast, pancreatic, stomach, colon, rectal, leukocytic, liver and lung cancers. Consequently, 121P1F1 provides a diagnostic and/or therapeutic target for cancers, and the 121P1F1 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.

公开(公告)号：US20080181885A1

公开(公告)日：2008-07-31

申请号：US11548626

申请日：2006-10-11

申请人： Arthur Raitano ,  Mary Faris ,  Pia Challita-Eid ,  Aya Jakobovits ,  Wangmao Ge

发明人： Arthur Raitano ,  Mary Faris ,  Pia Challita-Eid ,  Aya Jakobovits ,  Wangmao Ge

IPC分类号： A61K39/395 ,  A01K67/00 ,  A61K31/70 ,  C07H21/04 ,  C12N5/06 ,  G01N33/574 ,  C12Q1/68 ,  C07K14/00 ,  A61P43/00 ,  A61K38/00

CPC分类号： C12N5/0693 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K47/6851 ,  A61K2039/505 ,  C07K14/435 ,  C07K14/47 ,  C07K2319/00 ,  G01N33/57484 ,  Y02A50/466

摘要： A novel gene 202P5A5 and its encoded protein, and variants thereof, are described wherein 202P5A5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 202P5A5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 202P5A5 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 202P5A5 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因202P5A5及其编码的蛋白质及其变体，其中202P5A5在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，202P5A5提供诊断，预后，预防和/ 或癌症的治疗靶标。 202P5A5基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与202P5A5反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US20070031335A1

公开(公告)日：2007-02-08

申请号：US10121024

申请日：2002-04-10

申请人： Aya Jakobovits ,  Pia Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene Hubert ,  Karen Jane Morrison ,  Robert Morrison ,  Arthur Raitano ,  Daniel Afar

发明人： Aya Jakobovits ,  Pia Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene Hubert ,  Karen Jane Morrison ,  Robert Morrison ,  Arthur Raitano ,  Daniel Afar

IPC分类号： A61K49/00 ,  A61K39/395 ,  C07K16/46 ,  C12N5/06

CPC分类号： C07K14/47 ,  A61K47/646 ,  A61K47/6851 ,  A61K47/6901 ,  A61K51/1045

摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.

摘要翻译： 图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此， 基因 2提供癌症的诊断，预后，预防和/或治疗靶点。 图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。

公开(公告)号：US20070037745A1

公开(公告)日：2007-02-15

申请号：US11090545

申请日：2005-03-25

申请人： Pia Challita-Eid ,  Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

发明人： Pia Challita-Eid ,  Arthur Raitano ,  Mary Faris ,  Rene Hubert ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

IPC分类号： A01K67/00 ,  A61K39/395 ,  C12N5/06 ,  C07K14/82 ,  C07K16/18

CPC分类号： C07K14/82 ,  A01K2217/05 ,  A01K2267/0331

摘要： A novel gene (designated 213P1F11) and its encoded protein, and variants thereof, are described wherein 213P1F11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 213P1F11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 213P1F11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 213P1F11 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因（称为213P1F11）及其编码的蛋白及其变体，其中213P1F11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，213P1F11提供诊断，预后， 癌症的预防和/或治疗靶标。 213P1F11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与213P1F11反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US20070015704A1

公开(公告)日：2007-01-18

申请号：US11483302

申请日：2006-07-06

申请人： Arthur Raitano ,  Pia Challita-Eid ,  Mary Faris ,  Rene Hubert ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

发明人： Arthur Raitano ,  Pia Challita-Eid ,  Mary Faris ,  Rene Hubert ,  Robert Morrison ,  Wangmao Ge ,  Aya Jakobovits

IPC分类号： A61K38/17

CPC分类号： C07K16/30 ,  A61K39/395 ,  A61K2039/505 ,  C07K14/47 ,  C07K2317/34 ,  A61K2300/00

摘要： A novel gene (designated 238P1B2) and its encoded protein, and variants thereof, are described wherein 238P1B2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 238P1B2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 238P1B2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 238P1B2 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因（命名为238P1B2）及其编码的蛋白及其变体，其中238P1B2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，238P1B2提供诊断，预后， 癌症的预防和/或治疗靶标。 238P1B2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与238P1B2反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US20050227253A1

公开(公告)日：2005-10-13

申请号：US10990137

申请日：2004-11-15

申请人： Mary Faris ,  Rene Hubert ,  Arthur Raitano ,  Daniel Afar ,  Elana Levin ,  Pia Challita-Eid ,  Aya Jakobovits

发明人： Mary Faris ,  Rene Hubert ,  Arthur Raitano ,  Daniel Afar ,  Elana Levin ,  Pia Challita-Eid ,  Aya Jakobovits

IPC分类号： A61K38/17 ,  A61K39/00 ,  A61K39/38 ,  A61K39/395 ,  A61K48/00 ,  C07K14/47 ,  C12M1/34 ,  C12N15/12 ,  C12Q1/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/574

CPC分类号： C07K14/47

摘要： A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1D7 provides a diagnostic and/or therapeutic target for cancers,. The 158P1D7 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.

摘要翻译： 描述了一种新型基因（称为158P1D7）及其编码的蛋白质。 虽然158P1D7在正常成人组织中表现出组织特异性表达，但是在多种癌症中异常表达，如表1所示。因此，158P1D7为癌症提供诊断和/或治疗靶标。 158P1D7基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。

公开(公告)号：US20060073150A1

公开(公告)日：2006-04-06

申请号：US10236878

申请日：2002-09-06

申请人： Mary Faris ,  Wangmao Ge ,  Arthur Raitano ,  Pia Challita-Eid ,  Aya Jakobovits

发明人： Mary Faris ,  Wangmao Ge ,  Arthur Raitano ,  Pia Challita-Eid ,  Aya Jakobovits

IPC分类号： A61K39/395

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K51/1045 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/723 ,  C07K16/30 ,  C07K2319/00 ,  G01N33/57484

摘要： A novel gene 08P1D4 (also designated STEAP-1) and its encoded protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.

公开(公告)号：US20060052321A1

公开(公告)日：2006-03-09

申请号：US11068859

申请日：2005-02-28

申请人： Arthur Raitano ,  Wangmao Ge ,  Aya Jakobovits ,  Pia Challita-Eid ,  Mary Faris

发明人： Arthur Raitano ,  Wangmao Ge ,  Aya Jakobovits ,  Pia Challita-Eid ,  Mary Faris

IPC分类号： C07K14/82 ,  A61K48/00 ,  C12P21/06 ,  C07H21/02

CPC分类号： C07K14/47

摘要： A novel gene 098P4B6 (also designated STEAP-2) and its encoded protein, and variants thereof, are described wherein 98P4B6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 98P4B6 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 98P4B6 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 98P4B6 can be used in active or passive immunization.

公开(公告)号：US20070298424A1

公开(公告)日：2007-12-27

申请号：US11708975

申请日：2007-02-20

申请人： Pia Challita-Eid ,  Mary Faris ,  Arthur Raitano ,  Aya Jakobovits ,  Wangmao Ge

发明人： Pia Challita-Eid ,  Mary Faris ,  Arthur Raitano ,  Aya Jakobovits ,  Wangmao Ge

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/566 ,  G01N33/567

CPC分类号： C12N5/0693 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K47/6851 ,  A61K2039/505 ,  C07K14/435 ,  C07K14/47 ,  C07K2319/00 ,  G01N33/57484 ,  Y02A50/466

摘要： A novel gene 273P4B7 and its encoded protein, and variants thereof, are described wherein 273P4B7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table 1. Consequently, 273P4B7 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 273P4B7 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 273P4B7 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因273P4B7及其编码的蛋白质及其变体，其中273P4B7在正常成人组织中表现出组织特异性表达，并且在表1中列出的癌症中异常表达。因此，273P4B7提供诊断，预后，预防和/ 或癌症的治疗靶标。 273P4B7基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与273P4B7反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US20070059729A1

公开(公告)日：2007-03-15

申请号：US11438944

申请日：2006-05-23

申请人： Mary Faris ,  Pia Challita-Eid ,  Aya Jakobovits ,  Arthur Raitano ,  Wangmao Ge

发明人： Mary Faris ,  Pia Challita-Eid ,  Aya Jakobovits ,  Arthur Raitano ,  Wangmao Ge

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C07K14/82 ,  A61K48/00 ,  C07K16/30

CPC分类号： C12N5/0693 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K47/6851 ,  A61K2039/505 ,  C07K14/435 ,  C07K14/47 ,  C07K2319/00 ,  G01N33/57484 ,  Y02A50/466

摘要： A novel gene 282P1G3 and its encoded protein, and variants thereof, are described wherein 282P1G3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 282P1G3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 282P1G3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 282P1G3 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因282P1G3及其编码的蛋白及其变体，其中282P1G3在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，282P1G3提供诊断，预后，预防和/ 或癌症的治疗靶标。 282P1G3基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与282P1G3反应的抗体或T细胞可用于主动或被动免疫。