公开(公告)号：US10479838B2

公开(公告)日：2019-11-19

申请号：US15195098

申请日：2016-06-28

Applicant: The Rockefeller University ,  BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jeffrey V. Ravetch ,  Rony Dahan ,  Bryan C. Barnhart ,  Brigitte Devaux ,  Aaron P. Yamniuk ,  Shannon L. Okada ,  Brenda L. Stevens

IPC: A61K39/395 ,  C07K16/28 ,  A61K39/00

Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

公开(公告)号：US10167343B2

公开(公告)日：2019-01-01

申请号：US15432180

申请日：2017-02-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Nils Lonberg ,  Alan J. Korman ,  Bryan C. Barnhart ,  Aaron P. Yamniuk ,  Mohan Srinivasan ,  Karla A. Henning ,  Ming Lei ,  Emanuela Sega ,  Angela Goodenough ,  Maria N. Jure-Kunkel ,  Guodong Chen ,  John S. Sack ,  Richard Y. Huang ,  Martin J. Corbett ,  Joseph E. Myers, Jr. ,  Liang Schweizer ,  Sandra V. Hatcher ,  Haichun Huang ,  Pingping Zhang

IPC: C07K16/30 ,  C07K16/40 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  G01N33/573 ,  C07K16/28

Abstract: The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.

公开(公告)号：US09605080B2

公开(公告)日：2017-03-28

申请号：US14994828

申请日：2016-01-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Nils Lonberg ,  Alan J. Korman ,  Bryan C. Barnhart ,  Aaron P. Yamniuk ,  Mohan Srinivasan ,  Karla A. Henning ,  Ming Lei ,  Emanuela Sega ,  Angela Goodenough ,  Maria N. Jure-Kunkel ,  Guodong Chen ,  John S. Sack ,  Richard Huang ,  Martin J. Corbett ,  Joseph E. Myers, Jr. ,  Liang Schweizer ,  Sandra V. Hatcher ,  Haichun Huang ,  Pingping Zhang

IPC: C07K16/30 ,  C07K16/40 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  G01N33/573

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3061 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/573 ,  G01N2333/916

Abstract: The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.

公开(公告)号：US08853154B2

公开(公告)日：2014-10-07

申请号：US14025307

申请日：2013-09-12

Applicant: Bristol-Myers Squibb Company

Inventor： Sharon Cload ,  Linda Engle ,  Dasa Lipovsek ,  Malavi Madireddi ,  Ginger Chao Rakestraw ,  Joanna Swain ,  Wenjun Zhao ,  Hui Wei ,  Aaron P. Yamniuk ,  Vidhyashankar Ramamurthy ,  Alexander T. Kozhich ,  Martin J. Corbett ,  Stanley Richard Krystek, Jr.

IPC: A61K38/00 ,  A61P3/04 ,  A61K38/28 ,  A61P5/50 ,  A61P3/10 ,  A61P7/12 ,  A61P35/00 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C07H21/04 ,  G01N33/00 ,  C12N1/20 ,  C12N1/00 ,  C12P21/06 ,  C12N15/00 ,  C12N5/07 ,  C12N5/10 ,  C12N5/071 ,  G01N33/566 ,  A61K45/06 ,  C07K14/435 ,  A61K38/39 ,  C07K16/46 ,  G01N33/74 ,  A61K47/48 ,  C07K14/78

CPC classification number: A61K38/39 ,  A61K38/00 ,  A61K38/17 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/60 ,  A61K47/642 ,  C07K14/435 ,  C07K14/765 ,  C07K14/78 ,  C07K14/79 ,  C07K16/18 ,  C07K16/46 ,  C07K2319/30 ,  C07K2319/31 ,  G01N33/74

Abstract: The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

Abstract translation: 本发明涉及结合肌生成抑制素的基于纤连蛋白的支架结构域蛋白。 本发明还涉及这些蛋白质用于治疗肌营养不良症，恶病质，肌肉减少症，骨关节炎，骨质疏松症，糖尿病，肥胖症，COPD，慢性肾脏疾病，心力衰竭，心肌梗死和纤维化的治疗应用中的用途。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码蛋白质的多核苷酸的载体。