公开(公告)号：US20220235040A1

公开(公告)日：2022-07-28

申请号：US17617324

申请日：2020-06-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter Tai Wah Cheng ,  Hao Zhang ,  Robert F. Kaltenbach, III ,  Jun Li ,  Steven J. Walker ,  Yan Shi

IPC: C07D413/12 ,  C07D261/08 ,  C07D401/04

Abstract: The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20220235026A1

公开(公告)日：2022-07-28

申请号：US17617322

申请日：2020-06-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter Tai Wah Cheng ,  Hao Zhang ,  Robert F. Kaltenbach, III ,  Jun Li ,  Jun Shi ,  Shiwei Tao ,  Yan Shi

IPC: C07D401/04 ,  C07D413/14 ,  C07D405/14 ,  C07D401/14

Abstract: The present invention provides compounds of Formula (I), or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US11267800B2

公开(公告)日：2022-03-08

申请号：US16772825

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Ying Wang ,  Peter Tai Wah Cheng ,  Jun Shi ,  Shiwei Tao ,  James R. Corte ,  Tianan Fang ,  Jun Li ,  Lawrence J. Kennedy ,  Robert F. Kaltenbach, III ,  Sutjano Jusuf

IPC: C07D401/14 ,  C07D401/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D491/052

Abstract: The present invention provides compounds of Formula (I): Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20210163470A1

公开(公告)日：2021-06-03

申请号：US16772842

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Peter Tai Wah Cheng ,  Ying Wang ,  Jun Li ,  Tianan Fang ,  James R. Corte ,  Jun Shi ,  Hao Zhang ,  Lawrence J. Kennedy ,  Shiwei Tao

IPC: C07D417/14 ,  C07D401/14 ,  C07D413/14 ,  C07D403/14

Abstract: The present invention provides compounds of Formula (I): Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20200308148A1

公开(公告)日：2020-10-01

申请号：US16954221

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter Tai Wah Cheng ,  Jun Li ,  Yan Shi ,  Ying Wang ,  Hao Zhang ,  Lawrence J. Kennedy ,  Steven J. Walker ,  Ramesh Babu Reddigunta

IPC: C07D403/04 ,  C07D401/04 ,  C07D231/12 ,  A61P35/00 ,  A61P17/02

Abstract: The present invention provides compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US10576062B2

公开(公告)日：2020-03-03

申请号：US16038739

申请日：2018-07-18

Applicant: Bristol-Myers Squibb Company

Inventor： Peter Tai Wah Cheng ,  Robert F. Kaltenbach, III ,  Jun Li ,  Jun Shi ,  Yan Shi ,  Shiwei Tao ,  Hao Zhang ,  Suresh Dhanusu ,  Kumaravel Selvakumar ,  Ramesh Babu Reddigunta ,  Steven J. Walker ,  Lawrence J. Kennedy ,  James R. Corte ,  Tianan Fang ,  Sutjano Jusuf

IPC: C07D401/14 ,  C07D249/06 ,  A61K31/27 ,  A61K31/4192 ,  A61K31/454 ,  C07D401/04 ,  A61K31/41 ,  C07C62/10

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20230339884A1

公开(公告)日：2023-10-26

申请号：US18321092

申请日：2023-05-22

Applicant: Bristol-Myers Squibb Company

Inventor： Yan Shi ,  Peter Tai Wah Cheng ,  Ying Wang ,  Jun Shi ,  Shiwei Tao ,  Jun Li ,  Lawrence J. Kennedy ,  Robert F. Kaltenbach, III ,  Hao Zhang ,  James R. Corte

IPC: C07D403/04 ,  C07D249/06 ,  A61P35/00 ,  C07C249/06 ,  C07D401/04 ,  C07C403/04

CPC classification number: C07D401/04 ,  A61P35/00 ,  C07C249/06 ,  C07C403/04 ,  C07D249/06 ,  C07D403/04 ,  A61P1/16

Abstract: The present invention provides compounds of Formula (I):





or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20230271946A1

公开(公告)日：2023-08-31

申请号：US18134564

申请日：2023-04-13

Applicant: Bristol-Myers Squibb Company

Inventor： Ke Chen ,  Joerg Deerberg ,  Dong Lin ,  Michael Dummeldinger ,  Bahar Inankur ,  Sergei Kolotuchin ,  Jun Li ,  Amanda J. Rogers ,  Victor W. Rosso ,  Eric M. Simmons ,  Maxime C.D. Soumeillant ,  Daniel S. Treitler ,  Jianji Wang ,  Bin Zheng ,  Michael J. Smith ,  Neil A. Strotman ,  Steven Tymonko ,  Tamas Benkovics

IPC: C07D403/12 ,  C07C211/09 ,  C07D237/24 ,  C07D249/08

CPC classification number: C07D403/12 ,  C07C211/09 ,  C07D237/24 ,  C07D249/08 ,  C07B2200/13

Abstract: The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-5N-(methyl-d3)pyridazine-3-carboxamide of the formula:




Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

公开(公告)号：US11319315B2

公开(公告)日：2022-05-03

申请号：US16772842

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Peter Tai Wah Cheng ,  Ying Wang ,  Jun Li ,  Tianan Fang ,  James R. Corte ,  Jun Shi ,  Hao Zhang ,  Lawrence J. Kennedy ,  Shiwei Tao

IPC: C07D401/14 ,  C07D403/14 ,  C07D417/14 ,  C07D413/14

Abstract: The present invention provides compounds of Formula (I): Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US11312706B2

公开(公告)日：2022-04-26

申请号：US16954325

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Ying Wang ,  Peter Tai Wah Cheng ,  Jun Li ,  Steven J. Walker

IPC: C07D401/14 ,  C07D403/14 ,  C07D401/04

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.