公开(公告)号：US20230256098A1

公开(公告)日：2023-08-17

申请号：US18304097

申请日：2023-04-20

申请人： ALNYLAM PHARMACEUTICALS, INC.

发明人： Martin MAIER ,  Muthusamy JAYARAMAN ,  Akin AKINC ,  Shigeo MATSUDA ,  Pachamuthu KANDASAMY ,  Kallanthottathil G. RAJEEV ,  Muthiah MANOHARAN

IPC分类号： A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  C07D317/30 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07C235/06 ,  C07C251/38 ,  C07F5/02 ,  C07D233/54 ,  C07D207/32 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07C323/12 ,  C07C323/58 ,  C07C31/125 ,  A61K31/7088 ,  A61K31/7105

CPC分类号： A61K47/18 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/713 ,  C07D317/30 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C217/08 ,  C07C229/12 ,  C07C327/22 ,  C07C327/28 ,  C07C327/32 ,  C07C235/06 ,  C07C251/38 ,  C07F5/022 ,  C07D233/54 ,  C07D207/32 ,  C07D295/08 ,  C07D295/12 ,  C07D295/14 ,  C07C323/12 ,  C07C323/58 ,  C07C31/125 ,  A61K31/7088 ,  A61K31/7105

摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

公开(公告)号：US11664500B2

公开(公告)日：2023-05-30

申请号：US17339926

申请日：2021-06-04

申请人： City University of Hong Kong

发明人： Chunyi Zhi ,  Xinliang Li ,  Zhaodong Huang ,  Ze Chen

IPC分类号： H01M12/08 ,  H01M10/36 ,  H01M4/60 ,  C07C211/09 ,  H01M4/02

CPC分类号： H01M4/60 ,  C07C211/09 ,  H01M10/365 ,  H01M2004/028

摘要： The present invention relates to a range of halide organic salts and their use in a cathode of an electrical cell and in batteries. Elemental halides have attracted intense interest as promising electrodes for energy storage. However, they suffer from a number of inherent physicochemical drawbacks, including the volatility of iodine, the corrosiveness of liquid bromine. The salts of the present invention may serve as a cathode matched with a zinc anode avoiding these issues.

公开(公告)号：US20190218365A1

公开(公告)日：2019-07-18

申请号：US16362957

申请日：2019-03-25

申请人： International Business Machines Corporation

发明人： Scott B. King ,  Brandon M. Kobilka ,  Joseph Kuczynski ,  Jason T. Wertz

IPC分类号： C08K5/00 ,  C07D211/44 ,  C07D211/58 ,  C07F9/22 ,  C07F9/59 ,  C07C211/09 ,  C07F9/6558 ,  C07F9/09

CPC分类号： C08K5/0066 ,  C07C211/09 ,  C07D211/44 ,  C07D211/58 ,  C07F9/095 ,  C07F9/222 ,  C07F9/59 ,  C07F9/65583 ,  C07F9/65586

摘要： A process a process of forming a non-halogenated flame retardant (FR) hindered amine light stabilizer (HALS) cross-linker is disclosed. The process includes forming a mixture that includes a first molecule having a hindered amine group. The first molecule corresponds to a functionalized 2,2,6,6-tetramethylpiperidine (TMP) molecule. The process also includes forming the non-halogenated FR HALS cross-linker via a chemical reaction of the first molecule a second molecule. The second molecule includes a phosphoryl group, a chloride group, and at least one cross-linkable (CL) moiety.

公开(公告)号：US20190062555A1

公开(公告)日：2019-02-28

申请号：US16100119

申请日：2018-08-09

申请人： INVISTA North America S.á r.l.

发明人： Alex Van Eck CONRADIE ,  Adriana Leonora BOTES

IPC分类号： C08L77/12 ,  C12P13/00 ,  C12N15/52 ,  C12N9/88 ,  C12N9/02 ,  C12N9/10 ,  C12P7/42 ,  C12P7/18 ,  C12N9/04 ,  C07C209/68 ,  C07C227/32 ,  C08G69/26 ,  C07C227/18 ,  C07C221/00 ,  C07C213/02 ,  C08G69/08 ,  C07C229/24 ,  C07C229/12 ,  C07C223/02 ,  C07C215/08 ,  C07C211/09

CPC分类号： C08L77/12 ,  C07B2200/07 ,  C07C209/68 ,  C07C213/02 ,  C07C221/00 ,  C07C227/18 ,  C07C227/32 ,  C08G69/08 ,  C08G69/26 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1096 ,  C12N9/88 ,  C12N15/52 ,  C12P7/18 ,  C12P7/42 ,  C12P13/001 ,  C12Y101/01061 ,  C12Y102/99006 ,  C12Y206/01018 ,  C12Y401/01015 ,  C12Y401/01071 ,  C07C229/24 ,  C07C229/12 ,  C07C223/02 ,  C07C215/08 ,  C07C211/09

摘要： This document describes biochemical pathways for producing 4-hydroxybutyrate, 4-aminobutyrate, putrescine or 1,4-butanediol by forming one or two terminal functional groups, comprised of amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate or L-glutamate.

公开(公告)号：US10072150B2

公开(公告)日：2018-09-11

申请号：US14976966

申请日：2015-12-21

申请人： INVISTA North America S.á.r.l.

发明人： Alex Van Eck Conradie ,  Adriana Leonora Botes

IPC分类号： C08L77/12 ,  C12P7/18 ,  C12P7/42 ,  C12P13/00 ,  C12N15/52 ,  C12N9/88 ,  C12N9/00 ,  C12N9/10 ,  C07C209/68 ,  C07C213/02 ,  C07C221/00 ,  C07C227/18 ,  C07C227/32 ,  C08G69/08 ,  C08G69/26 ,  C12N9/02 ,  C12N9/04

CPC分类号： C08L77/12 ,  C07B2200/07 ,  C07C209/68 ,  C07C213/02 ,  C07C221/00 ,  C07C227/18 ,  C07C227/32 ,  C08G69/08 ,  C08G69/26 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1096 ,  C12N9/88 ,  C12N15/52 ,  C12P7/18 ,  C12P7/42 ,  C12P13/001 ,  C12Y101/01061 ,  C12Y102/99006 ,  C12Y206/01018 ,  C12Y401/01015 ,  C12Y401/01071 ,  C07C229/24 ,  C07C229/12 ,  C07C223/02 ,  C07C215/08 ,  C07C211/09

摘要： This document describes biochemical pathways for producing 4-hydroxybutyrate, 4-aminobutyrate, putrescine or 1,4-butanediol by forming one or two terminal functional groups, comprised of amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate or L-glutamate.

公开(公告)号：US20180030206A1

公开(公告)日：2018-02-01

申请号：US15730414

申请日：2017-10-11

申请人： RHODIA OPERATIONS

发明人： Stéphane JEOL

IPC分类号： C08G73/10 ,  C07C211/09 ,  C07C63/313 ,  B29C49/04 ,  C08K3/00 ,  B29C45/00 ,  B29K105/00 ,  B29K79/00

CPC分类号： C08G73/1042 ,  B29C45/0001 ,  B29C49/04 ,  B29K2079/08 ,  B29K2105/0085 ,  C07C63/313 ,  C07C211/09 ,  C08G73/1075 ,  C08G73/1082 ,  C08K3/013 ,  C08L79/08

摘要： The present invention relates to semiaromatic semicrystalline thermoplastic copolyimides obtained by polymerization of at least: (a) an aromatic compound comprising two anhydride functions and/or carboxylic acid and/or ester derivatives thereof; (b) a diamine of formula (I) NH2—R—NH2 in which R is a divalent aliphatic hydrocarbon-based radical optionally comprising heteroatoms, the two amine functions being separated by a number X of carbon atoms, X being between 4 and 12; and (c) a diamine of formula (II) NH2—R′—NH2 in which R′ is a divalent aliphatic hydrocarbon-based radical optionally comprising heteroatoms, the two amine functions being separated by a number Y of carbon atoms, Y being between 10 and 20; it being understood that diamine (b) is different from diamine (c).

公开(公告)号：US20180002619A1

公开(公告)日：2018-01-04

申请号：US15707180

申请日：2017-09-18

申请人： General Electric Company

发明人： Alagarsamy Subbiah ,  Rebika Mayanglambam Devi ,  Nimeshkumar Kantilal Patel ,  Muthukumar Nagu ,  Romit Ghosh ,  Sathees Kesavan ,  Ashok Shankar Shetty ,  Manish Joshi

IPC分类号： C10G75/04 ,  C10G19/00 ,  C10G19/02 ,  C10G19/073 ,  C10G75/00 ,  C10G7/10 ,  C10G21/20 ,  C10G29/20 ,  C10G75/02

CPC分类号： C10G75/04 ,  C07C211/03 ,  C07C211/09 ,  C07C211/10 ,  C07C211/11 ,  C07C211/34 ,  C10G7/10 ,  C10G19/00 ,  C10G19/02 ,  C10G19/073 ,  C10G21/20 ,  C10G29/20 ,  C10G75/00 ,  C10G75/02 ,  C10G2300/4075 ,  C10G2300/44 ,  C10G2300/80

摘要： Treatment compositions for neutralizing acidic species and reducing hydrochloride and amine salts in a fluid hydrocarbon stream are disclosed. The treatment compositions may comprise at least one amine with a salt precipitation potential index of equal to or less than about 1.0. Methods for neutralizing acidic species and reducing deposits of hydrochloride and amine salts in a hydrocarbon refining process are also disclosed. The methods may comprise providing a fluid hydrocarbon stream and adding a treatment composition to the fluid hydrocarbon stream. The treatment compositions used may have a salt precipitation potential index of equal to or less than about 1.0 and comprise either water-soluble or oil-soluble amines.

公开(公告)号：US20170309407A1

公开(公告)日：2017-10-26

申请号：US15493220

申请日：2017-04-21

申请人： Panasonic Intellectual Property Management Co., Ltd.

发明人： MICHIO SUZUKA ,  RYUUSUKE UCHIDA ,  TOMOYASU YOKOYAMA

IPC分类号： H01G9/20 ,  C07C211/09

CPC分类号： H01G9/2059 ,  C07C211/09 ,  C09K11/664 ,  H01G9/2027 ,  H01L31/00 ,  H01L51/4253

摘要： A light absorption material comprising: a compound having a perovskite crystal structure represented by ABX3 where the A site contains (NH2)2CH+, the B site contains Pb2+, and the X site contains I−. A ratio of the number of atoms of I to the number of atoms of Pb measured by an X-ray photoelectron spectroscopy is 2.7 or less, or a ratio of the number of atoms of I to the number of atoms of Pb measured by a Rutherford backscattering spectroscopy is 2.9 or less.

公开(公告)号：US20170281501A1

公开(公告)日：2017-10-05

申请号：US15479136

申请日：2017-04-04

申请人： Henkel AG & Co. KGaA

发明人： Antje Gebert-Schwarzwalder ,  Helmut Giesa ,  Jan-Michael Schonebeck

IPC分类号： A61K8/49 ,  C07C211/09 ,  C09B57/00 ,  C07D233/24 ,  C07C211/18

CPC分类号： A61K8/4946 ,  A61Q5/10 ,  C07C211/09 ,  C07C211/18 ,  C07D233/24 ,  C09B57/00

摘要： An agent for oxidative changing of the color of keratin fibers, in particular human hair, includes, in a cosmetic support, as a developer-type oxidation dye precursor, at least one compound of formula (I) as further defined herein.

公开(公告)号：US09663446B2

公开(公告)日：2017-05-30

申请号：US15027727

申请日：2013-10-15

申请人： RHODIA OPERATIONS ,  Centre National De La Recherche Scientifique

发明人： Zhen Yan ,  Mohamad Ousmane ,  Marc Pera-Titus ,  Floryan DeCampo

IPC分类号： C07C209/18 ,  C07C209/16 ,  C07D215/06 ,  C07D307/14 ,  C07D307/52 ,  B01J23/63 ,  B01J35/10 ,  B01J37/02

CPC分类号： C07C209/18 ,  B01J23/63 ,  B01J35/1019 ,  B01J37/0201 ,  C07C209/16 ,  C07C2601/16 ,  C07D215/06 ,  C07D307/14 ,  C07D307/52 ,  C07C211/48 ,  C07C211/12 ,  C07C211/11 ,  C07C211/09 ,  C07C211/10 ,  C07C211/27 ,  C07C211/45

摘要： Disclosed is a process for preparing a primary, a secondary or a tertiary amine via the direct amination of an alcohol in the presence of a catalyst. The catalyst is composed of palladium or a palladium compound and a cerium oxide supporter.