公开(公告)号：US12037323B2

公开(公告)日：2024-07-16

申请号：US17052232

申请日：2019-05-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Christine M. Tarby ,  Derek J. Norris ,  Julian C. Lo ,  Vijay T. Ahuja ,  Steven P. Seitz ,  Ashvinikumar V. Gavai ,  John S. Tokarski ,  Mohini Rajasagi ,  Michael Wichroski ,  Matthias Broekema

IPC: C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

Abstract: The invention relates generally to compounds that are Mer-Ax1 inhibitors, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

公开(公告)号：US20230339891A1

公开(公告)日：2023-10-26

申请号：US17052232

申请日：2019-05-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Christine M. Tarby ,  Derek J. Norris ,  Julian C. Lo ,  Vijay T. Ahuja ,  Steven P. Seitz ,  Ashvinikumar V. Gavai ,  John S. Tokarski ,  Mohini Rajasagi ,  Michael Wichroski ,  Matthias Broekema

IPC: C07D401/14 ,  C07D417/14 ,  C07D471/04 ,  C07D405/14

CPC classification number: C07D401/14 ,  C07D417/14 ,  C07D471/04 ,  C07D405/14

Abstract: The invention relates generally to compounds that are Mer-Ax1 inhibitors, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

公开(公告)号：US10959986B2

公开(公告)日：2021-03-30

申请号：US16555634

申请日：2019-08-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James Aaron Balog ,  Steven P. Seitz ,  Susheel Jethanand Nara ,  Saumya Roy ,  Srinivasan Thangathirupathy ,  Soodamani Thangavel ,  Ramesh Kumar Sistla

IPC: A61K31/415 ,  A61K31/5377 ,  C07D231/12 ,  C07D401/12 ,  C07D403/12 ,  C07D261/08 ,  C07D277/22 ,  C07D285/08 ,  C07D211/60 ,  C07D317/50 ,  C07D307/36 ,  C07D333/54 ,  C07D231/56 ,  C07D221/22 ,  C07D471/04 ,  C07D487/04 ,  A61K31/17 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/42 ,  A61K31/426 ,  A61K31/433 ,  A61K31/357 ,  A61K31/341 ,  A61K31/381 ,  C07C275/42

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the disclosure.

公开(公告)号：US20200069695A1

公开(公告)日：2020-03-05

申请号：US16555431

申请日：2019-08-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James Aaron Balog ,  Steven P. Seitz ,  Susheel Jethanand Nara ,  Saumya Roy ,  Srinivasan Thangathirupathy ,  Soodamani Thangavel ,  Srinivas Cheruku

IPC: A61K31/5377 ,  C07C275/42 ,  A61K31/17 ,  C07D277/64 ,  A61K31/428 ,  C07C211/54 ,  A61K31/136 ,  C07D239/47 ,  A61K31/505 ,  A61K31/275 ,  C07D241/18 ,  A61K31/4965 ,  C07D239/42 ,  A61K31/5375 ,  C07D295/03 ,  C07D413/12

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the disclosure.

公开(公告)号：US20160022619A1

公开(公告)日：2016-01-28

申请号：US14776035

申请日：2014-03-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James Aaron Balog ,  Audris Huang ,  Bin Chen ,  Libing Chen ,  Steven P. Seitz ,  Amy C. Hart ,  Jay A. Markwalder

IPC: A61K31/196 ,  A61K31/505 ,  A61K31/44 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/42 ,  A61K31/36 ,  A61K31/27 ,  A61K31/216 ,  A61K31/18 ,  C07D239/42 ,  C07D241/42 ,  C07D213/84 ,  C07D213/75 ,  C07D271/12 ,  C07D261/14 ,  C07D257/04 ,  C07D317/66 ,  C07C271/28 ,  C07C69/743 ,  C07C275/42 ,  C07C311/47 ,  A61K45/06 ,  C07C233/55 ,  A61N5/10 ,  A61K31/498

CPC classification number: A61K31/196 ,  A61K31/18 ,  A61K31/216 ,  A61K31/27 ,  A61K31/36 ,  A61K31/41 ,  A61K31/42 ,  A61K31/4245 ,  A61K31/44 ,  A61K31/498 ,  A61K31/505 ,  A61K45/06 ,  A61N5/10 ,  C07B2200/07 ,  C07C69/743 ,  C07C233/55 ,  C07C235/38 ,  C07C255/44 ,  C07C255/57 ,  C07C271/28 ,  C07C275/42 ,  C07C311/47 ,  C07C311/51 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/02 ,  C07C2602/08 ,  C07C2602/14 ,  C07C2602/42 ,  C07D213/56 ,  C07D213/75 ,  C07D213/84 ,  C07D239/42 ,  C07D241/42 ,  C07D257/04 ,  C07D261/08 ,  C07D261/14 ,  C07D271/12 ,  C07D317/66 ,  Y02A50/411 ,  Y02A50/414

Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或炎症性疾病的方法，其利用 发明。