公开(公告)号：US20180230462A1

公开(公告)日：2018-08-16

申请号：US15895504

申请日：2018-02-13

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Xiao-Song Gong ,  Yan Wang

IPC: C12N15/10 ,  C12Q1/686 ,  C12N9/22

CPC classification number: C12N15/1096 ,  C12N9/22 ,  C12N2770/00022 ,  C12Q1/6844 ,  C12Q1/686 ,  C12Q2521/107 ,  C12Q2521/327

Abstract: Hybrid reverse transcriptases formed from portions of FLVRT and MLVRT are provided.

公开(公告)号：US09994887B2

公开(公告)日：2018-06-12

申请号：US14482756

申请日：2014-09-10

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Xiao-Song Gong ,  John Sullivan ,  Rongdian Fu ,  Yan Wang ,  Evan H. Bursey ,  Man Cheng

IPC: C12Q1/68 ,  C12P19/34 ,  C07K16/40 ,  C12N9/12

CPC classification number: C12P19/34 ,  C07K16/40 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2319/80 ,  C12N9/1252 ,  C12Q1/6804 ,  C12Q1/686 ,  C12Q2531/113 ,  C12Q2527/125 ,  C12Q2521/101

Abstract: The present invention provides methods and compositions for improving the efficiency of nucleic acid amplification reactions. The invention encompasses hybrid polymerases that show increased processivity over wild type polymerases as well as decreased exonucleases activity. The invention also encompasses methods, compositions and kits for conducting nucleic acid synthesis and amplification reactions in which non-specific amplification of primers is reduced.

公开(公告)号：US09896682B2

公开(公告)日：2018-02-20

申请号：US15063139

申请日：2016-03-07

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Xiao-Song Gong ,  Cindy Wan

IPC: C12N15/10 ,  C12N9/22

CPC classification number: C12N15/1003 ,  C12N9/22 ,  C12Y301/00

Abstract: Methods and compositions are described herein for protecting RNA from autocatalytic and divalent cation induced degradation in an aqueous solution.

公开(公告)号：US20160369260A1

公开(公告)日：2016-12-22

申请号：US15253648

申请日：2016-08-31

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Jason Ma ,  Xiao-Song Gong

IPC: C12N9/96 ,  C12Q1/68 ,  C12N15/10 ,  C12N9/12

CPC classification number: C12N9/96 ,  C12N9/1276 ,  C12N15/1096 ,  C12P19/34 ,  C12Q1/686 ,  C12Y207/07049 ,  Y02P20/52

Abstract: Reverse transcriptase mixtures with improved storage stability are provided.

Abstract translation: 提供了具有改进的储存稳定性的逆转录酶混合物。

公开(公告)号：US20160032269A1

公开(公告)日：2016-02-04

申请号：US14805348

申请日：2015-07-21

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Xiao-Song Gong

IPC: C12N9/96 ,  C12N9/12 ,  C12P19/34

CPC classification number: C12N9/96 ,  C12N9/1252 ,  C12P19/34 ,  C12Q1/6844 ,  C12Y207/07 ,  C12Y207/07007 ,  C12Q2527/125

Abstract: Amplification reaction mixtures comprising a cationic surfactant and an anionic surfactant are provided.

Abstract translation: 提供包含阳离子表面活性剂和阴离子表面活性剂的扩增反应混合物。