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44 条记录 (耗时 0.042 秒)

    Potassium channel modulators
    23.
    发明授权
    Potassium channel modulators 失效
    钾通道调节剂

    公开(公告)号：US5965696A

    公开(公告)日：1999-10-12

    申请号：US451371

    申请日：1995-05-26

    申请人： Roger Crossley ,  Albert Opalko ,  David Geraint Owen ,  Brian Robertson

    发明人： Roger Crossley ,  Albert Opalko ,  David Geraint Owen ,  Brian Robertson

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K5/00 ,  C07K7/00

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： This invention concerns peptides (I) having intracellular potassium channel modulating activity comprising the amino acid sequence shown in SEQ ID No: 2:(N terminal function) (I) Met Ile Ser Ser Val Cys Val Ser Ser 1 5} Tyr Arg Gly Arg Lys Ser Gly Asn Lys 10 15 Pro Pro Ser Lys Thr Cys Leu Lys Glu Glu 20 25 (C terminal function) in which the cysteines are optionally linked via a disulphide bridge and wherein______________________________________ Met represents L-methionine Ile represents L-isoleucine Ser represents L-serine Val represents L-valine Cys represents L-cysteine Tyr represents L-tyrosine Arg represents L-arginine Gly represents glycine Lys represents L-lysine Asn represents L-asparagine Pro represents L-proline Thr represents L-threonine Leu represents L-leucine Glu represents L-glutamic acid ______________________________________ or a variant thereof,with the proviso that excluded is the 13-Lys variant (where 13-Arg is replaced by 13-Lys) in which the cysteines are not linked via a disulphide bridge, which are useful in a test method of screening for compounds having potassium channel modulating activity.

    摘要翻译： 本发明涉及具有包含SEQ ID No：2所示氨基酸序列的细胞内钾通道调节活性的肽（I）： - （N末端功能）（I） - - Met Ile Ser Ser Val Cys Val Ser Ser-15} - - Tyr Arg Gly Arg Lys Ser Gly Asn Lys - 10 15 - Pro Pro Ser Lys Thr Cys Leu Lys Glu Glu - 20 25 - - （C末端功能） - 其中半胱氨酸任选通过二硫键连接，其中 - Met表示L-甲硫氨酸 - Ile表示L-异亮氨酸 - Ser表示L-丝氨酸 - Val表示L-缬氨酸 - Cys表示L-半胱氨酸-Tyr表示L-酪氨酸-Arg表示L-精氨酸-Gly表示甘氨酸 - Lys表示L - 赖氨酸 - Asn代表L-天冬酰胺-Pro代表L-脯氨酸 - Thr代表L-苏氨酸-Leu表示L-亮氨酸-Glu表示L-谷氨酸 - 或其变体，条件是排除的是13-Lys变体 （其中13-Arg被13-Lys替代），其中半胱氨酸不通过二硫键连接 桥，其可用于筛选具有钾通道调节活性的化合物的测试方法。

    Concave cover plate
    24.
    发明授权
    Concave cover plate 有权

    公开(公告)号：US10045487B1

    公开(公告)日：2018-08-14

    申请号：US15832142

    申请日：2017-12-05

    申请人： Brian Robertson

    发明人： Brian Robertson

    IPC分类号： A01F12/18 ,  A01F12/28 ,  A01F12/24 ,  A01F12/26

    摘要： The present invention comprises a removable cover plate assembly, which may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The cover plate assembly improves the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. Moreover, the cover plate assembly of the present invention enables a single set of concave grate assemblies to better harvest a wider variety of crop types.

    OPTICAL BEAM ROUTING APPARATUS AND METHODS
    25.
    发明申请
    OPTICAL BEAM ROUTING APPARATUS AND METHODS 审中-公开
    光束路由装置和方法

    公开(公告)号：US20160301994A1

    公开(公告)日：2016-10-13

    申请号：US15174954

    申请日：2016-06-06

    申请人： Daping Chu ,  Neil Collings ,  William Crossland ,  Maura Michelle Redmond ,  Brian Robertson

    发明人： Daping Chu ,  Neil Collings ,  William Crossland ,  Maura Michelle Redmond ,  Brian Robertson

    IPC分类号： H04Q11/00 ,  H04J14/02

    CPC分类号： H04Q11/0005 ,  G02F1/292 ,  G02F2203/12 ,  G02F2203/18 ,  G03H1/0005 ,  G03H1/2294 ,  G03H2225/32 ,  H04J14/0212 ,  H04L45/62 ,  H04Q2011/0016

    摘要： This invention relates to methods and apparatus for routing light beams in telecommunications devices using holographic techniques, in particular by displaying kinoforms on Liquid Crystal on Silicon devices. At least one optical input to receives an input beam. A plurality of optical outputs and a spatial light modulator (SLM) on an optical path between said optical input and said optical outputs are provided, and a driver for said SLM to display a kinoform on said SLM diffracts said input beam into an output beam comprising a plurality of diffraction orders, wherein a routed one of said diffraction orders is directed to at least one selected said optical output; said apparatus is configured to modify a wavefront of said output beam to reduce a coupling of said output beam into said selected optical output; and said kinoform is adapted to compensate for said wavefront modification to compensate for said reduced coupling.

    摘要翻译： 本发明涉及用于使用全息技术在电信设备中布置光束的方法和装置，特别是通过在硅器件上显示液晶的方式和装置。 用于接收输入光束的至少一个光学输入。 提供了在所述光输入和所述光输出之间的光路上的多个光输出和空间光调制器（SLM），并且用于所述SLM的用于在所述SLM上显示kinoform的驱动器将所述输入波束衍射成包括 多个衍射级，其中所述衍射级中的一个所述衍射级指向至少一个所选择的所述光输出; 所述设备被配置为修改所述输出光束的波前以减少所述输出光束到所述选择的光输出中的耦合; 并且所述kinoform适于补偿所述波前修改以补偿所述减小的耦合。

    OPTICAL BEAM STEERING
    27.
    发明申请
    OPTICAL BEAM STEERING 有权
    光束转向

    公开(公告)号：US20110273657A1

    公开(公告)日：2011-11-10

    申请号：US13129029

    申请日：2009-11-13

    申请人： Neil Collings ,  William Crossland ,  Maura Michelle Redmond ,  John Richard Moore ,  David Nugent ,  Brian Robertson

    发明人： Neil Collings ,  William Crossland ,  Maura Michelle Redmond ,  John Richard Moore ,  David Nugent ,  Brian Robertson

    IPC分类号： G02F1/13

    CPC分类号： G02F1/31 ,  G02F1/136277 ,  G02F1/1393 ,  G02F1/292 ,  G02F2001/13355 ,  G02F2203/06 ,  G02F2203/585

    摘要： The invention relates to optical beam steering. There is described an optical beam steering apparatus, comprising: a splitter arranged to split an optical beam into at least a first part having a first polarisation and a second part having a second polarisation, said first and second polarisations being substantially mutually orthogonal; a first liquid crystal device region arranged to receive said first part and to have director orientation substantially aligned to said first polarisation; and a second liquid crystal device region arranged to receive said second part and to have director orientation substantially aligned to said second polarisation.

    摘要翻译： 本发明涉及光束转向。 描述了一种光束转向装置，包括：分离器，被布置成将光束分成至少具有第一偏振的第一部分和具有第二偏振的第二部分，所述第一和第二极化基本上相互正交; 布置成接收所述第一部分并且具有基本上与所述第一极化对准的导向器取向的第一液晶装置区域; 以及布置成接收所述第二部分并且具有基本上对准所述第二偏振的导向器取向的第二液晶装置区域。

    Low-hap and zero-hap polyester resin systems and articles prepared using same
    29.
    发明申请
    Low-hap and zero-hap polyester resin systems and articles prepared using same 有权
    低-hap和zero-hap聚酯树脂体系和使用它们制备的制品

    公开(公告)号：US20050215708A1

    公开(公告)日：2005-09-29

    申请号：US10516238

    申请日：2003-05-27

    申请人： Brian Robertson

    发明人： Brian Robertson

    IPC分类号： C08F283/01 ,  C08L51/08 ,  C09D151/08 ,  C09D167/06 ,  C08G63/48

    CPC分类号： C09D167/06 ,  C08F283/01 ,  C08L51/08 ,  C09D151/08 ,  C08L2666/02

    摘要： A polyester gelcoat composition comprising unsaturated polyester resin; a reactive diluent mixture including para-tertiary-butylstyrene and a minor amount of styrene; and one or more additives. The gelcoat composition does not include appreciable deleterious amounts of hazardous air pollution solvents. A method of making the gelcoat composition is also disclosed.

    摘要翻译： 包含不饱和聚酯树脂的聚酯凝胶涂料组合物; 包括对叔丁基苯乙烯和少量苯乙烯的反应性稀释剂混合物; 和一种或多种添加剂。 凝胶涂层组合物不包括明显有害量的有害空气污染溶剂。 还公开了制备凝胶涂层组合物的方法。