公开(公告)号：US11304805B2

公开(公告)日：2022-04-19

申请号：US16135979

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: A prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body, a plurality of atrial anchoring arms configured to extend radially outward from the valve body, and a plurality of ventricular anchoring legs configured to extend radially outward from the valve body. The prosthetic valve may also include a blood-inflatable cuff situated between the arms and legs. The cuff may be configured to substantially fill a volume between the arms and the legs when the cuff is fully inflated with blood.

公开(公告)号：US10973636B2

公开(公告)日：2021-04-13

申请号：US16678355

申请日：2019-11-08

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari

IPC: A61F2/24 ,  A61F2/95 ,  A61F2/915

Abstract: Prosthetic valves and methods of use of prosthetic valves may be provided. In one implementation, a prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an annular valve body having atrial anchoring arms and ventricular anchoring legs extending therefrom. The atrial anchoring arms and the ventricular anchoring legs may be configured for independent outward radial deflection. In some embodiments, at least one atrial anchoring arm may include first and third arm segments configured to extend in upstream directions and a second arm segment configured to extend in a downstream direction, the second arm segment situated between the first and third arm segments. The terminal end of the at least one atrial anchoring arm may be configured to be situated upstream from the rest of the arm when the prosthetic valve is radially-expanded.

公开(公告)号：US20210085457A1

公开(公告)日：2021-03-25

申请号：US17114771

申请日：2020-12-08

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: An expandable prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an expandable annular valve body. The valve body may include an atrial inlet opening and a ventricular outlet opening. The valve body may additionally include a plurality of tissue anchors extending from the valve body. The prosthetic valve may additionally include a flexible annular protective sleeve positioned about the rim of the valve body outlet opening and affixed to the outlet opening.

公开(公告)号：US10881511B2

公开(公告)日：2021-01-05

申请号：US16136150

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: A prosthetic valve configured for implantation within a native valve may be provided. The prosthetic valve may include an expandable valve body having an inner lumen extending along a longitudinal axis of the valve body. The prosthetic valve may additionally include a plurality of ventricular tissue anchors configured to extend from the valve body to ventricular anchor distal ends, as well as a plurality of atrial tissue anchors configured to extend from the valve body to atrial anchor distal ends. Each atrial tissue anchor may include a rigid portion, and a flexible portion situated between a distal end of the rigid portion and the atrial anchor distal end. The ventricular anchor distal end of a ventricular tissue anchor and the distal end of the rigid portion of an atrial tissue anchor may be configured to be equidistant from the longitudinal axis of the valve body.

公开(公告)号：US10799345B2

公开(公告)日：2020-10-13

申请号：US16135843

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: A prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body. The prosthetic valve may also include a plurality of tissue anchors arranged about the valve body and configured to extend from connection points on the valve body. The prosthetic valve may also include at least one protective fabric covering extending over each of the connection points between each tissue anchor and the valve body.

公开(公告)号：US10722360B2

公开(公告)日：2020-07-28

申请号：US16559365

申请日：2019-09-03

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari

IPC: A61F2/24 ,  A61F2/915 ,  A61F2/95

Abstract: Prosthetic valves and methods of using prosthetic valves may be provided. In one implementation, an expandable annular valve body may include a plurality of atrial anchoring arms and ventricular anchoring legs extending therefrom. The anchoring arms and anchoring legs may be configured to assume a delivery configuration in which they are radially constrained, such as within a delivery device, such that at least one atrial anchoring arm extends in a first upstream direction from the annular valve body, and a deployed configuration, in which they may deflect radially outward. In the deployed configuration, a first arm portion may be configured to deflect radially outward to extend in a downstream direction, and a second arm portion may be configured to deflect radially outward to extend in a second upstream direction, the first upstream direction being angled relative to the second upstream direction.

公开(公告)号：US10682227B2

公开(公告)日：2020-06-16

申请号：US15995725

申请日：2018-06-01

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari

IPC: A61B17/24 ,  A61F2/24 ,  A61F2/915 ,  A61F2/95

Abstract: Embodiments of the present disclosure are directed to prosthetic valves and methods of use thereof. In one implementation, an annular valve body may include a plurality of atrial anchoring arms and ventricular anchoring legs configured to extend therefrom. The anchoring arms and anchoring legs may be configured to assume a delivery configuration in which they are substantially parallel to a longitudinal axis of the valve body, and a deployed configuration, in which they may deflect radially outward. The anchoring arms may include a pivoting portion configured to extend in a non-ventricular direction when the arm is in the delivery configuration and in a ventricular direction when the arm is in the deployed configuration. The entire length of each leg may be configured to extend in a non-ventricular direction when the legs are in both the delivery and deployed configurations.

公开(公告)号：USD841813S1

公开(公告)日：2019-02-26

申请号：US29635661

申请日：2018-02-01

Applicant: CARDIOVALVE LTD.

Designer： Ilia Hariton ,  Boaz Harari ,  Meni Iamberger ,  Aviram Baum

公开(公告)号：US20190038405A1

公开(公告)日：2019-02-07

申请号：US15956956

申请日：2018-04-19

Applicant: CARDIOVALVE LTD.

Inventor： Meni Iamberger ,  Aviram Baum ,  Ilia Hariton ,  Yelena Kasimov

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2/2415 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2220/0025 ,  A61F2230/0065 ,  A61F2240/001 ,  A61F2250/0003 ,  B29C39/003 ,  B29C39/10 ,  B29K2083/00 ,  B29L2031/40

Abstract: A frame assembly includes a valve body, a plurality of arms that each extend radially outward from the valve body to a respective arm-tip, and a plurality of ventricular legs that are coupled to the valve body and that extend radially outward from the valve body and toward the plurality of arms. A liner lines the lumen. Prosthetic leaflets are attached to the liner within the lumen. A first sheet of flexible material is attached to the plurality of arms. A second sheet of flexible material is attached to the first sheet and extends radially inwards and downstream, and is attached to the valve body. The first sheet, the second sheet, and the liner define an inflatable pouch therebetween. The apparatus defines a plurality of windows from the lumen into the pouch.

公开(公告)号：US12053379B2

公开(公告)日：2024-08-06

申请号：US17181722

申请日：2021-02-22

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari ,  Maxim Karalnik ,  Michael Albitov ,  Meni Iamberger

IPC: A61F2/24 ,  A61F2/966 ,  A61F2/958

CPC classification number: A61F2/2436 ,  A61F2/2433 ,  A61F2/966 ,  A61F2002/9583

Abstract: A delivery tool includes a nosepiece that is fixed to a shaft, and distal to an implant, and an expandable element proximal to the nosepiece. Maximally-expanded, the expandable element (i) has an expanded external diameter at its widest part that is smaller than the expanded internal diameter of a lumen of the frame of the implant, (ii) tapers proximally away from the widest part and from the nosepiece, and (iii) is dimensioned to slide proximally through the lumen of the implant in its expanded state, between leaflets of the implant, and out of the lumen. When non-expanded, the widest part of the expandable element has a non-expanded external diameter that is smaller than the expanded external diameter of the expandable element. In a compressed state of the implant a portion of the expandable element is disposed within the lumen of the frame. Other applications are also described.