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公开(公告)号：US12127757B2
公开(公告)日：2024-10-29
申请号：US17429446
申请日：2019-12-23
Applicant: CARDIOVALVE LTD.
Inventor： Michael Albitov , Meni Iamberger , Ilia Hariton
IPC: A61B17/32
CPC classification number: A61B17/32 , A61B2217/005 , A61B2560/0214 , A61B2560/0425
Abstract: Embodiments of the present disclosure include a method for conditioning ex vivo pericardial tissue that has a parietal side and a fibrous side from which fibers extend. A blade assembly includes a blade head having a blade array and a face that defines gaps therein. The parietal side of the tissue is placed downward against a support plate, and a motor is operated to move the blade array with respect to the face. The face contacts the tissue such that the fibers protrude through the gaps and into the blade head. The blade array shears the fibers that protrude through the gaps into the blade head, yielding sheared fibers. Other embodiments are also described.
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公开(公告)号：US11872124B2
公开(公告)日：2024-01-16
申请号：US18125350
申请日：2023-03-23
Applicant: CARDIOVALVE LTD.
Inventor： Maxim Karalnik , Michael Albitov , Oren Shua , Meni Iamberger , Ilia Hariton
CPC classification number: A61F2/2415 , A61F2/2427 , A61F2/9522 , A61F2/9524 , A61F2/9525 , B21D39/048 , A61F2210/0014 , Y10T29/49865
Abstract: Apparatus for crimping a frame of an implant includes a crimping assembly having a bath having a floor, and one or more side-walls extending upward from the floor to a side-wall height. A crimping mechanism that defines a crimping aperture is attached to the bath such that the crimping aperture is disposed within the bath below the side-wall height. The crimping mechanism further comprises a handle and is actuatable by moving the handle circumferentially around the crimping mechanism. Actuation of the crimping mechanism transitions the crimping aperture from its open state to its narrowed state. Other embodiments are also described.
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公开(公告)号：US20220304804A1
公开(公告)日：2022-09-29
申请号：US17841912
申请日：2022-06-16
Applicant: CARDIOVALVE LTD.
Inventor： Tal HAMMER , Meni Iamberger , Yaron Herman , Yuval Zipory , Eran Hoffer , Michael Albitov , Natalia Kruglova , Tal Reich , Ilia Hariton , Aviram Baum
IPC: A61F2/24
Abstract: A rod (508) is transfemorally advanceable to the heart. An implant (460) comprises (i) a first frame (462), compressed around a first longitudinal site of a distal portion of the rod, (ii) a second frame (464), compressed around a third longitudinal site of the distal portion, (iii) a valve member (50), disposed within the second frame, and (iv) a flexible sheet (466), coupling the first frame to the second frame, and disposed around a second longitudinal site of the distal portion, the second longitudinal site being between the first longitudinal site and the third longitudinal site. An extracorporeal controller (569) is coupled to a proximal portion of the rod, and is operably coupled to the distal portion of the rod. Operating the controller bends the distal portion of the rod causing articulation between the frames. Other embodiments are also described.
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公开(公告)号：US11633277B2
公开(公告)日：2023-04-25
申请号：US16760147
申请日：2018-10-21
Applicant: CARDIOVALVE LTD.
Inventor： Maxim Karalnik , Or Cohen , Michael Albitov , Oren Shua , Meni Iamberger , Ilia Hariton
Abstract: An assembly (10) for crimping a frame (56) of an implant (58) comprises a crimping device (20) with a base (22) and a crimping mechanism (24) that defines a crimping aperture (26). A bath (28) having a floor (30), and one or more side-walls (32) extending upward from the floor to a side-wall height defines a receptacle (18) that is shaped to receive a portion of the crimping device. The apparatus has an assembled state in which the portion of the crimping device has been received by the receptacle, the crimping device is held securely by the bath, and the aperture is below the side-wall height. Other embodiments are also described.
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公开(公告)号：US10426614B2
公开(公告)日：2019-10-01
申请号：US15899858
申请日：2018-02-20
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Boaz Harari , Maxim Karalnik , Michael Albitov , Meni Iamberger
Abstract: A tool is configured for transluminal delivery of an implant. The tool has a proximal part and a distal part, and comprises a shaft, a nosepiece, a sheath, and a balloon. The nosepiece is fixed to the shaft, and is arranged with respect to the implant such that the implant extends proximally away from the nosepiece and over the shaft. The sheath houses the implant. The balloon is disposed at the distal part of the tool, and is in fluid communication with the proximal part of the tool. When maximally inflated, the balloon has (i) a widest part that has an inflated diameter that is less than the diameter of the sheath or at most 10 percent greater than the diameter of the sheath, and (ii) a tapered portion that tapers longitudinally away from the widest part and from the nosepiece.
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Patent Agency Ranking
公开(公告)号：US10154903B2
公开(公告)日：2018-12-18
申请号：US15886517
申请日：2018-02-01
Applicant: CARDIOVALVE LTD.
Inventor： Michael Albitov , Maxim Karalnik , Paul Kaye
Abstract: A tool (410) for use with an implant (20) includes a housing (426) and a controller (440). The housing includes a tubular wall (428) that circumscribes a longitudinal axis; is dimensioned to house at least part of the implant; and defines a track (430) that follows a generally-helical path around the longitudinal axis. The controller includes a rod (442) that extends from a proximal part of the tool to the housing; and an actuator (444). The actuator is fixedly coupled to the rod, includes an engaging element (446) that engages the track, and is rotatable with respect to the housing. The controller and the housing mechanically cooperate such that rotation of the actuator with respect to the housing slides the housing longitudinally with respect to the actuator. Other embodiments are also described.
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公开(公告)号：US20240423796A1
公开(公告)日：2024-12-26
申请号：US18765724
申请日：2024-07-08
Applicant: CARDIOVALVE LTD.
Inventor： Ilia HARITON , Boaz Harari , Maxim Karalnik , Michael Albitov , Meni Iamberger
Abstract: A method includes delivering an implant to a heart of a patient using a delivery tool that includes a nosepiece that is fixed to a shaft and distal to an implant, and an expandable element proximal to the nosepiece. Maximally-expanded, the expandable element (i) has an expanded external diameter at its widest part that is smaller than the expanded internal diameter of a lumen of the frame of the implant and (ii) tapers proximally away from the widest part and from the nosepiece. In a compressed state of the implant a portion of the expandable element is disposed within the lumen of the frame. The method includes, following implantation of the implant, withdrawing the expandable element proximally through the lumen of the implant, between leaflets of the implant, and out of the lumen. Other applications are also described.
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公开(公告)号：US12053379B2
公开(公告)日：2024-08-06
申请号：US17181722
申请日：2021-02-22
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Boaz Harari , Maxim Karalnik , Michael Albitov , Meni Iamberger
CPC classification number: A61F2/2436 , A61F2/2433 , A61F2/966 , A61F2002/9583
Abstract: A delivery tool includes a nosepiece that is fixed to a shaft, and distal to an implant, and an expandable element proximal to the nosepiece. Maximally-expanded, the expandable element (i) has an expanded external diameter at its widest part that is smaller than the expanded internal diameter of a lumen of the frame of the implant, (ii) tapers proximally away from the widest part and from the nosepiece, and (iii) is dimensioned to slide proximally through the lumen of the implant in its expanded state, between leaflets of the implant, and out of the lumen. When non-expanded, the widest part of the expandable element has a non-expanded external diameter that is smaller than the expanded external diameter of the expandable element. In a compressed state of the implant a portion of the expandable element is disposed within the lumen of the frame. Other applications are also described.
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公开(公告)号：US11701225B2
公开(公告)日：2023-07-18
申请号：US16746489
申请日：2020-01-17
Applicant: CARDIOVALVE LTD.
Inventor： Tal Hammer , Meni Iamberger , Yuval Zipory , Michael Albitov , Tal Reich , Ilia Hariton
CPC classification number: A61F2/2436 , A61F2/2418 , A61F2/2439 , A61F2002/828 , A61F2220/0025 , A61F2230/001 , A61F2230/0067 , A61F2250/0039
Abstract: Apparatus includes a delivery tool and a prosthetic valve, the prosthetic valve includes a first frame, and a second frame coupled to the first frame. The delivery tool includes a first catheter, a second catheter, and a rod. A steerable portion of the second catheter extends out of the first catheter, and a steerable distal portion of the rod extends out of the second catheter. An extracorporeal rod-controller is operably coupled to the rod such that operating the extracorporeal rod-controller steers the steerable distal portion of the rod. In a delivery state of the apparatus, the prosthetic valve is compressed onto the rod, distal to the distal end of the second catheter, and the apparatus is transfemorally and transseptally advanceable into a left atrium of a heart of a subject. Other embodiments are also described.
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公开(公告)号：US10952850B2
公开(公告)日：2021-03-23
申请号：US16318025
申请日：2017-08-01
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Boaz Harari , Michael Albitov , Paul Kaye
Abstract: A tool (410) for use with an implant (20) includes a housing (426) and a controller (440). The housing includes a tubular wall (428) that circumscribes a longitudinal axis; is dimensioned to house at least part of the implant; and defines a track (430) that follows a generally-helical path around the longitudinal axis. The controller includes a rod (442) that extends from a proximal part of the tool to the housing; and an actuator (444). The actuator is fixedly coupled to the rod, includes an engaging element (446) that engages the track, and is rotatable with respect to the housing. The controller and the housing mechanically cooperate such that rotation of the actuator with respect to the housing slides the housing longitudinally with respect to the actuator. Other embodiments are also described.
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