公开(公告)号：US12076175B2

公开(公告)日：2024-09-03

申请号：US17647310

申请日：2022-01-06

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC: A61B6/50 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/46 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/74 ,  G06V10/764 ,  G06V10/82

CPC classification number: A61B6/504 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/463 ,  A61B6/467 ,  A61B6/481 ,  A61B6/5205 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/0012 ,  G06V10/20 ,  G06V10/245 ,  G06V10/761 ,  G06V10/764 ,  G06V10/82 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/247

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US20240266066A1

公开(公告)日：2024-08-08

申请号：US18614595

申请日：2024-03-22

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Shant Malkasian ,  Hugo Miguel Rodrigues Marques ,  Chung Chan ,  Shai Ronen

IPC: G16H50/30 ,  A61B5/00 ,  A61B5/02 ,  G06T7/00 ,  G06T7/10 ,  G06T7/60 ,  G06V20/50 ,  G16H30/40

CPC classification number: G16H50/30 ,  A61B5/02028 ,  A61B5/4848 ,  G06T7/0016 ,  G06T7/10 ,  G06T7/60 ,  G06V20/50 ,  G16H30/40 ,  G06T2207/10048 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/10116 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V2201/031

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

公开(公告)号：US20240266063A1

公开(公告)日：2024-08-08

申请号：US18614580

申请日：2024-03-22

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Shant Malkasian ,  Hugo Miguel Rodrigues Marques ,  Chung Chan ,  Shai Ronen

IPC: G16H50/30 ,  A61B5/00 ,  A61B5/02 ,  G06T7/00 ,  G06T7/10 ,  G06T7/60 ,  G06V20/50 ,  G16H30/40

CPC classification number: G16H50/30 ,  A61B5/02028 ,  A61B5/4848 ,  G06T7/0016 ,  G06T7/10 ,  G06T7/60 ,  G06V20/50 ,  G16H30/40 ,  G06T2207/10048 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/10116 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V2201/031

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

公开(公告)号：US20240260921A1

公开(公告)日：2024-08-08

申请号：US18592081

申请日：2024-02-29

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls

IPC: A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  G06T7/00 ,  G06T7/62 ,  G06V10/22 ,  G06V10/26 ,  G16H30/40 ,  G16H50/20

CPC classification number: A61B6/5217 ,  A61B6/032 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5229 ,  G06T7/0012 ,  G06T7/62 ,  G06V10/22 ,  G06V10/26 ,  G16H30/40 ,  G16H50/20 ,  G06T2207/10081 ,  G06T2207/20076 ,  G06T2207/30048 ,  G06T2207/30104 ,  G06V2201/031

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

公开(公告)号：US20240252132A1

公开(公告)日：2024-08-01

申请号：US18444339

申请日：2024-02-16

Applicant: Cleerly, Inc.

Inventor： James K. Min

IPC: A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  G06T7/00 ,  G06T7/62 ,  G06V10/22 ,  G06V10/26 ,  G16H30/40 ,  G16H50/20

CPC classification number: A61B6/5217 ,  A61B6/032 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5229 ,  G06T7/0012 ,  G06T7/62 ,  G06V10/22 ,  G06V10/26 ,  G16H30/40 ,  G16H50/20 ,  G06T2207/10081 ,  G06T2207/20076 ,  G06T2207/30048 ,  G06T2207/30104 ,  G06V2201/031

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

公开(公告)号：US20240215936A1

公开(公告)日：2024-07-04

申请号：US18457197

申请日：2023-08-28

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Ben Hootnick

IPC: A61B6/00 ,  A61B5/00 ,  A61B5/02 ,  A61B5/055 ,  A61B6/03 ,  A61B6/50 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/74 ,  G06V10/764 ,  G06V40/14

CPC classification number: A61B6/481 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/02007 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/504 ,  A61B6/5205 ,  A61B6/5217 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/0012 ,  G06V10/20 ,  G06V10/245 ,  G06V10/761 ,  G06V10/764 ,  G06V40/14 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/247

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US12023190B2

公开(公告)日：2024-07-02

申请号：US18458498

申请日：2023-08-30

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques

IPC: A61B6/50 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/46 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/00 ,  G06V10/20 ,  G06V10/24 ,  G06V10/74 ,  G06V10/764 ,  G06V10/82

CPC classification number: A61B6/504 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/055 ,  A61B5/7267 ,  A61B5/742 ,  A61B5/7475 ,  A61B6/032 ,  A61B6/037 ,  A61B6/463 ,  A61B6/467 ,  A61B6/481 ,  A61B6/5205 ,  A61B8/12 ,  A61B8/14 ,  A61K49/04 ,  G06F18/10 ,  G06T7/0012 ,  G06V10/20 ,  G06V10/245 ,  G06V10/761 ,  G06V10/764 ,  G06V10/82 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/20081 ,  G06T2207/30048 ,  G06T2207/30101 ,  G06V10/247

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

公开(公告)号：US20240197276A1

公开(公告)日：2024-06-20

申请号：US18592038

申请日：2024-02-29

Applicant: Cleerly, Inc.

Inventor： James K. Min

IPC: A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  G06T7/00 ,  G06T7/62 ,  G06V10/22 ,  G06V10/26 ,  G16H30/40 ,  G16H50/20

CPC classification number: A61B6/5217 ,  A61B6/032 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5229 ,  G06T7/0012 ,  G06T7/62 ,  G06V10/22 ,  G06V10/26 ,  G16H30/40 ,  G16H50/20 ,  G06T2207/10081 ,  G06T2207/20076 ,  G06T2207/30048 ,  G06T2207/30104 ,  G06V2201/031

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

公开(公告)号：US20240188917A1

公开(公告)日：2024-06-13

申请号：US18444367

申请日：2024-02-16

Applicant: Cleerly, Inc.

Inventor： James K. Min

IPC: A61B6/00 ,  A61B6/03 ,  A61B6/50 ,  G06T7/00 ,  G06T7/62 ,  G06V10/22 ,  G06V10/26 ,  G16H30/40 ,  G16H50/20

CPC classification number: A61B6/5217 ,  A61B6/032 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5229 ,  G06T7/0012 ,  G06T7/62 ,  G06V10/22 ,  G06V10/26 ,  G16H30/40 ,  G16H50/20 ,  G06T2207/10081 ,  G06T2207/20076 ,  G06T2207/30048 ,  G06T2207/30104 ,  G06V2201/031

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

公开(公告)号：US20230394663A1

公开(公告)日：2023-12-07

申请号：US18454462

申请日：2023-08-23

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Shant Malkasian ,  Hugo Miguel Rodrigues Marques ,  Chung Chan ,  Shai Ronen

IPC: G06T7/00 ,  A61B5/00 ,  G06T7/62

CPC classification number: G06T7/0012 ,  A61B5/7275 ,  G06T7/62 ,  G06T2207/10108 ,  G06T2207/10101 ,  G06T2207/10132 ,  G06T2207/30101 ,  G06T2207/20081 ,  G06T2207/10104 ,  G06T2207/10116 ,  G06T2207/10048 ,  G06T2207/10081

Abstract: Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.