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公开(公告)号：US20200148990A1
公开(公告)日：2020-05-14
申请号：US16569852
申请日：2019-09-13
Applicant: Corning Incorporated
Inventor： Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture apparatus includes one or more plates having a first major surface and an opposing second major surface. The first major surface comprises a structured surface defining a plurality of wells. Each well has an interior surface defining an upper aperture and a nadir, wherein the upper aperture of each well has a diametric dimension in a range from 100 micrometers to 2000 micrometers. The apparatus also includes a plurality of spacers extending from the first major surface along a length of the bottom surface. A plurality of flow channels are defined between adjacent rails.
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公开(公告)号：US20180242573A1
公开(公告)日：2018-08-30
申请号：US15774883
申请日：2016-11-03
Applicant: Corning Incorporated
Inventor： William Joseph Lacey , Gregory Roger Martin , Allison Jean Tanner
CPC classification number: A01N1/0268 , B01L3/5082 , B01L3/50825 , B01L2200/141 , B01L2300/042 , B01L2300/043 , B01L2300/046 , B01L2300/0609 , B01L2300/0832 , B01L2300/0858 , B01L2300/123 , C12M45/22
Abstract: Vial assemblies comprise a tubular body and a cap, the cap including a first portion configured to abut a lip of an open end of the tubular body, a threaded portion configured to couple to threading on an internal surface of the tubular body, and a second portion protruding from the threaded portion and extending into a cavity of the tubular body. Methods for storing and removing frozen samples from such vial assemblies are also described.
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公开(公告)号：US09845451B2
公开(公告)日：2017-12-19
申请号：US14812671
申请日：2015-07-29
Applicant: Corning Incorporated
Inventor： Gregory Roger Martin , Allison Jean Tanner
CPC classification number: C12M23/08 , C12M23/04 , C12M23/24 , C12M23/34 , C12M23/38 , C12M23/58 , C12M25/02 , C12M25/04 , C12M25/06 , C12M29/04 , C12N5/0602
Abstract: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications.
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公开(公告)号：US20170267959A1
公开(公告)日：2017-09-21
申请号：US15528644
申请日：2015-11-20
Applicant: Corning Incorporated
Inventor： Gregory Roger Martin , Allison Jean Tanner , Alexander Meyer Wilks
CPC classification number: C12M23/08 , C12M23/20 , C12N5/0682
Abstract: This disclosure provides a cell culture media extending material capable of releasing nutrients into the cell culture environment slowly over time. In embodiments, this material is a part of a cell culture vessel. In embodiments, the material is a coating or a film on a surface of a cell culture material. In additional embodiments, the material is a surface upon which cells are cultured, such as a cell culture vessel or a microcarrier.
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公开(公告)号：US20170226455A1
公开(公告)日：2017-08-10
申请号：US15499370
申请日：2017-04-27
Applicant: Corning Incorporated
Inventor： Ye Fang , Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , Allison Jean Tanner , Qi Wu
CPC classification number: C12M23/12 , C12M41/36 , C12N5/0062
Abstract: A cell culture apparatus may include a substrate defining a well. The well may define an interior surface, an exterior surface, an upper aperture and a nadir. The substrate may define a thickness between the interior and exterior surfaces that has a thickness proximate the nadir that is greater than or equal to a thickness proximate the upper aperture.
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Patent Agency Ranking
公开(公告)号：US20170218321A1
公开(公告)日：2017-08-03
申请号：US15492730
申请日：2017-04-20
Applicant: Corning Incorporated
Inventor： GREGORY ROGER MARTIN , Allison Jean Tanner
Abstract: A cell culture insert for use in culturing cells to promote the formation of spheroids and methods of using these spheroid-promoting cell culture inserts. The cell culture insert includes a porous membrane and one or more sidewalls that are non-adherent to cells and cause the cells in the insert to associate with each other and form spheroids.
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公开(公告)号：US20150361388A1
公开(公告)日：2015-12-17
申请号：US14768272
申请日：2014-02-26
Applicant: Gregory Roger MARTIN , Allison Jean TANNER , CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner
Abstract: An apparatus (100) for cell release from a cell culture article (101), including: an ultrasonic source (105); a stage comprising a base (112) and a raised portion (114) that defines a cell culture article confinement area; and a mechanism for relative scan motion between the ultrasonic source and the cell culture article confined to the stage. Also disclosed is a method for cell release and harvesting from a cell culture article (101), including: securing a cell culture article in the disclosed cell release apparatus; and accomplishing relative motion scanning between the energized ultrasonic source and the cell culture article for a time, as defined herein.
Abstract translation: 一种用于从细胞培养物品（101）释放细胞的装置（100），包括：超声波源（105）; 包括限定细胞培养物品限制区域的基部（112）和凸起部分（114）的台阶; 以及超声波源和限于该阶段的细胞培养物之间的相对扫描运动的机制。 还公开了从细胞培养物（101）进行细胞释放和收获的方法，包括：确保细胞培养物品在所公开的细胞释放装置中; 并且如本文所定义的那样，在通电的超声波源和细胞培养物品之间完成一段时间的相对运动扫描。
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28.发明申请SPHEROID CELL CULTURE WELL ARTICLE AND METHODS THEREOF 有权SPHEROID CELLURE CULTURE WELL ARTICLE AND METHODS THEREOF公开(公告)号：US20140322806A1
公开(公告)日：2014-10-30
申请号：US14087906
申请日：2013-11-22
Applicant: Corning Incorporated
Inventor： Scott Matthew Bennett , Brian Robb Douglass , Paul Ernest Gagnon, JR. , Gregory Roger Martin , Paul Michael Szlosek , Allison Jean Tanner
IPC: C12N5/071
Abstract: A spheroid cell culture article including: a frame having a chamber including: an opaque side wall surface; a top aperture; a gas-permeable, transparent bottom; and optionally a chamber annex surface and second bottom, and at least a portion of the transparent bottom includes at least one concave arcuate surface, is disclosed. Methods of making and using the article are also disclosed.
Abstract translation: 1.一种球状细胞培养物，其特征在于，具有：具有室的框架，具有：不透明侧壁面; 顶孔; 透气透明的底部; 并且可选地包括室附件表面和第二底部，并且透明底部的至少一部分包括至少一个凹弧形表面。 还公开了制造和使用该制品的方法。
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公开(公告)号：US20140227775A1
公开(公告)日：2014-08-14
申请号：US14254280
申请日：2014-04-16
Applicant: CORNING INCORPORATED
Inventor： GREGORY ROGER MARTIN , Allison Jean Tanner
IPC: C12M1/12
CPC classification number: C12M23/08 , C12M23/04 , C12M23/24 , C12M23/34 , C12M23/38 , C12M23/58 , C12M25/02 , C12M25/04 , C12M25/06 , C12M29/04 , C12N5/0602
Abstract: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications.
Abstract translation: 公开了一种培养细胞的多层细胞培养装置。 细胞培养装置被定义为具有与气管空间组合的多个细胞培养室的整体结构。 该装置的主体在其中赋予气体可渗透的膜与气管空间的组合，其将允许细胞培养室与外部环境之间的气体自由流动。 烧瓶主体还包括孔，其将允许通过针或插管进入细胞生长室。 设备的尺寸和可选的颈部和帽部分的位置允许其通过标准自动化测定设备进行操作，进一步使得该设备对于高通量应用是理想的。
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公开(公告)号：US20140065709A1
公开(公告)日：2014-03-06
申请号：US14075446
申请日：2013-11-08
Applicant: Corning Incorporated
Inventor： GREGORY ROGER MARTIN , Allison Jean Tanner
IPC: C12M1/04
CPC classification number: C12M23/08 , C12M23/04 , C12M23/24 , C12M23/34 , C12M23/38 , C12M23/58 , C12M25/02 , C12M25/04 , C12M25/06 , C12M29/04 , C12N5/0602
Abstract: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications.
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