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21.发明授权公开(公告)号：US12285331B2
公开(公告)日：2025-04-29
申请号：US16820274
申请日：2020-03-16
Applicant: Foldax, Inc. , California Institute of Technology
Inventor： Garrett Johnson , Jason G. Beith , Marek Lhotak , Praveen De Silva , Peter Millson , Francis P. Maguire , Morteza Gharib
Abstract: Improved prosthetic valves, their methods of manufacture, and systems and devices for manufacturing the valves are described. The prosthetic valves can be configured for transcatheter implantation. The prosthetic valves can have artificial leaflets. The prosthetic valves can be manufactured in numerous ways, such as by polymeric dipping processes and/or electrospinning. Sponge-like polymers for valves and other medical devices are also disclosed.
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22.发明授权公开(公告)号：US12005246B2
公开(公告)日：2024-06-11
申请号：US17143068
申请日：2021-01-06
Applicant: California Institute of Technology
Inventor： Niema M. Pahlevan , Morteza Gharib , Marie Csete
IPC: A61M60/161 , A61L27/36 , A61L27/52 , A61M60/289 , A61M60/465
CPC classification number: A61M60/161 , A61L27/3625 , A61L27/52 , A61M60/289 , A61M60/465
Abstract: A system configured to be at least partially implanted along an aorta includes an inelastic, static member and a pinching member. The pinching member is configured to receive an activation signal at an activation rate and in response to the activation signal, repeatedly compress the aorta at the second location at the activation rate to pump fluid within the aorta in a desired pumping direction. The system is configured to selectively control wave reflections in order to achieve both improved wave dynamics to reduce cardiac load and increased (or at least non-diminished) blood flow to targeted organs within the cardiovascular system.
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公开(公告)号：US11890233B2
公开(公告)日：2024-02-06
申请号：US16839333
申请日：2020-04-03
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Morteza Gharib , Jinglin Huang
CPC classification number: A61F9/04 , A61F9/0017 , A61M31/00 , A61M2205/3368 , A61M2205/3626 , A61M2210/0612
Abstract: Disclosed are example embodiments of methods and systems for inducing drug to thoroughly mix in a patient's vitreous humor. One of the systems includes: a heat transfer pad that transfer heat to or from the eyeball; and a control module electronically coupled to the heat transfer pad for controlling one or more heat transfer elements disposed thereon.
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公开(公告)号：US20230389805A1
公开(公告)日：2023-12-07
申请号：US18452227
申请日：2023-08-18
Applicant: California Institute of Technology
Inventor： Morteza Gharib , Niema M. Pahlevan
CPC classification number: A61B5/02028 , A61B5/0006 , A61B5/021 , A61B5/02233 , A61B5/0285 , A61B7/00 , A61B5/318
Abstract: A non-invasive and convenient method and apparatus for approximation of left ventricular end diastolic pressure (LVEDP) can be used in both hospital/clinic environments and nursing home or home environments. The method and apparatus use non-invasive sensors and a new “cardiac triangle” computational method to obtain an approximation of LVEDP. The computational method uses hemodynamic and electrocardiogram (ECG) waveforms as input, which can be collected by a portable device or devices.
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公开(公告)号：US11730376B2
公开(公告)日：2023-08-22
申请号：US16896976
申请日：2020-06-09
Applicant: California Institute of Technology
Inventor： Morteza Gharib , Niema M. Pahlevan
CPC classification number: A61B5/02028 , A61B5/0006 , A61B5/021 , A61B5/0285 , A61B5/02233 , A61B5/318 , A61B7/00
Abstract: A non-invasive and convenient method and apparatus for approximation of left ventricular end diastolic pressure (LVEDP) can be used in both hospital/clinic environments and nursing home or home environments. The method and apparatus use non-invasive sensors and a new “cardiac triangle” computational method to obtain an approximation of LVEDP. The computational method uses hemodynamic and electrocardiogram (ECG) waveforms as input, which can be collected by a portable device or devices.
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Patent Agency Ranking
公开(公告)号：US20230150660A1
公开(公告)日：2023-05-18
申请号：US18055757
申请日：2022-11-15
Applicant: California Institute of Technology
Inventor： Alireza Ramezani , Morteza Gharib
CPC classification number: B64C37/00 , B64C39/024 , B64C2201/162
Abstract: In some embodiments, a multi-modal robot can be capable of aerial mobility and ground mobility, and can switch between configuration. The multi-modal robot can include a chassis, and a leg attached to the chassis. The leg can include a frontal hip joint. The frontal hip joint can rotate around a frontal hip axis of rotation. The frontal hip axis of rotation can be parallel to a longitudinal axis of the chassis. The leg can further include a sagittal hip joint, wherein the sagittal hip joint is coupled to the first distal end of a first link. The sagittal hip joint can rotate around a sagittal hip axis of rotation. The leg can include a wheel. The wheel can be configured to rotate around a wheel axis of rotation. The leg can further include a propeller. The propeller can be co-axial with the wheel.
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公开(公告)号：US20220063791A1
公开(公告)日：2022-03-03
申请号：US17464499
申请日：2021-09-01
Applicant: California Institute of Technology
Inventor： Morteza Gharib
Abstract: A system and method for improving the flight control and efficiency of an aerial vehicle. Many embodiments are directed to a rotor-shroud assembly system where a plurality of rotor blades are connected to the internal side of a shroud and are set up to pivot through the use of a pitching mechanism. The entire assembly is configured to rotate when attached to a motor.
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公开(公告)号：US11229809B2
公开(公告)日：2022-01-25
申请号：US15912359
申请日：2018-03-05
Applicant: California Institute of Technology
Inventor： David Reza Mittelstein , Morteza Gharib , Stefanie Heyden , Michael Ortiz , Mikhail G. Shapiro
Abstract: Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at a resonance frequency (“oncotripsy”) for the specific cell types are presented. The systems and the methods result in permeabilization, lysis, and/or death of the targeted specific cell types by using ultrasonic harmonic excitations that have a frequency and a pulse duration specifically tuned to disrupt nuclear membranes of the targeted specific cell types by inducing a destructive vibrational response therein while leaving non-targeted cell types intact. Target cells may be neoplastic.
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公开(公告)号：US10742957B2
公开(公告)日：2020-08-11
申请号：US16209089
申请日：2018-12-04
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Morteza Gharib , Alexei Harvard , Scott Hsieh , Jian Lu
IPC: H04N13/207 , H04N13/214 , G06T7/70 , G06T7/593 , H04N13/25 , H04N13/257
Abstract: Hardware and software configurations, optionally, for performing profilometry of an object are disclosed. An advantageous imaging device is described. An advantageous approach to determining imager position is also described. Each aspect described may be used independently of the other. Moreover, the teaching may find use in other fields including velocimetry, etc.
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公开(公告)号：US20190106206A1
公开(公告)日：2019-04-11
申请号：US16150183
申请日：2018-10-02
Applicant: California Institute of Technology
Inventor： Xichen Shi , Marcel Veismann , Christopher J. Dougherty , Stephanie Rider , Soon-Jo Chung , Morteza Gharib , Kyunam Kim , Salar Rahili , Reza Nemovi
Abstract: An automated flying transport vehicle that capitalizes on the strengths and complexities of a fixed and rotary winged aircraft. The air transport vehicle comprises a body aerodynamically designed to generate lift and a plurality of rotors that can generate lift as well as forward thrust from which a fixed wing portion of the air transport vehicle will begin to generate additional lift allowing for a sustained flight.
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