公开(公告)号：US5332674A

公开(公告)日：1994-07-26

申请号：US16882

申请日：1993-02-12

申请人： Daniele Bianchi ,  Aldo Bosetti ,  Pietro Cesti ,  Paolo Golini ,  Carlo Pina

发明人： Daniele Bianchi ,  Aldo Bosetti ,  Pietro Cesti ,  Paolo Golini ,  Carlo Pina

IPC分类号： C12N11/04 ,  C12P17/04 ,  C12P41/00

CPC分类号： C12P17/04 ,  C12N11/04 ,  C12P41/004

摘要： A process is described for separating the optical isomers of 1,2-isopropylideneglycerol, of formula (I), comprising partially stereoselective enzymatic hydrolysis of 1,2-isopropylideneglycerol benzoyl ester (II) catalyzed by a free or immobilized lipase, the hydrolysis being conducted in the presence of a cosolvent and followed by crystallization enabling crystals of (II) in raceme form and mother liquor containing (II) in the form of the pure enantiomer to be selectively obtained.The compound (I) is widely used industrially as an intermediate in the synthesis of chiral drugs such as (R)-(-)-carnitine, (S)-beta-blockers, (S)-antiviral agents, analgesic drugs etc.

摘要翻译： 描述了用于分离式（I）的1,2-异亚丙基甘油的光学异构体的方法，其包括由游离或固定的脂肪酶催化的1,2-异丙叉基甘油苯甲酰酯（II）的部分立体选择性酶水解，水解进行 在共溶剂的存在下，然后结晶使得可以选择性地获得具有外消旋形式的（II）的结晶和含有纯对映异构体形式的（II）的母液。 化合物（I）在工业上广泛用作合成手性药物如（R） - （ - ） - 肉碱，（S） - β-阻断剂，（S） - 病毒药物，止痛药物等的中间体。

公开(公告)号：US20120172642A1

公开(公告)日：2012-07-05

申请号：US13395028

申请日：2010-09-01

申请人： Aldo Bosetti ,  Daniele Bianchi ,  Giuliana Franzosi ,  Marco Ricci

发明人： Aldo Bosetti ,  Daniele Bianchi ,  Giuliana Franzosi ,  Marco Ricci

IPC分类号： C10L1/04 ,  C12P39/00 ,  C12P5/00

CPC分类号： C10G1/04 ,  C10G1/002 ,  C10G1/02 ,  C10G2300/1003 ,  C10G2300/1011 ,  Y02P30/20 ,  Y02W10/37

摘要： A process for the production of bio-oil from solid urban waste, comprising the following steps: a) subjecting said solid urban waste to liquefaction, obtaining a mixture including an oily phase consisting of bio-oil, a solid phase and an aqueous phase; b) subjecting the aqueous phase obtained in the liquefaction step a) to fermentation, obtaining a fermented biomass; c) feeding the fermented biomass obtained in the fermentation step b) to the liquefaction step a). The bio-oil (or bio-crude) thus obtained can be advantageously used in the production of biofuels which can be used as such or mixed with other motor vehicle fuels. Alternatively, this bio-oil (or bio-crude) can be used as such (biocombustible) or mixed with fossil combustibles (combustible oil, coal, etc.) for the generation of electric energy or heat.

摘要翻译： 一种从固体城市废物生产生物油的方法，包括以下步骤：a）使所述固体城市废物进行液化，得到包括由生物油，固相和水相组成的油相的混合物; b）使在液化步骤a）中获得的水相发酵，获得发酵生物质; c）将发酵步骤b）中获得的发酵生物质送入液化步骤a）。 由此获得的生物油（或生物粗品）可有利地用于生产生物燃料，其可以原样使用或与其它机动车辆燃料混合。 或者，该生物油（或生物粗品）可以原样使用（生物燃烧）或与化石可燃物（可燃油，煤等）混合以产生电能或热量。

公开(公告)号：US06992214B2

公开(公告)日：2006-01-31

申请号：US10220593

申请日：2001-02-01

申请人： Pietro Cesti ,  Aldo Bosetti ,  Franco Mizia ,  Marcella Notari ,  Marco Ricci ,  Franco Rivetti ,  Ugo Romano

发明人： Pietro Cesti ,  Aldo Bosetti ,  Franco Mizia ,  Marcella Notari ,  Marco Ricci ,  Franco Rivetti ,  Ugo Romano

IPC分类号： C07C263/04

CPC分类号： C07C263/04 ,  Y02P20/125 ,  C07C265/12

摘要： Integrated process for the preparation of aromatic isocyanates comprising: the reaction between an aromatic amine and an organiccarbonate in the presence of a catalyst selected from organic and inorganic salts of a metal selected from Zn, Sn, Pb, Cu; the removal of the catalyst; the passivation of the quantity of residual metal in the urethane formed in step a); the removal of the organic solvent and its optional recycling to step a) of the reaction; the evaporation of the aromatic urethane with partial pyrolysis; the complete pyrolysis of the urethane in gas phase; the recovery of the isocyanate.

公开(公告)号：US5801048A

公开(公告)日：1998-09-01

申请号：US712389

申请日：1996-09-11

申请人： Wilhelmus Van Der Goes ,  Antonella Bernardi ,  Aldo Bosetti ,  Giuliana Franzosi ,  Pietro Cesti

发明人： Wilhelmus Van Der Goes ,  Antonella Bernardi ,  Aldo Bosetti ,  Giuliana Franzosi ,  Pietro Cesti

IPC分类号： C12N15/09 ,  C12N1/21 ,  C12N9/80 ,  C12N9/86 ,  C12N15/00 ,  C12N15/31 ,  C12N15/55 ,  C12N15/70 ,  C12P35/02 ,  C12R1/19 ,  C12R1/38

CPC分类号： C12P35/02 ,  C12N15/70 ,  C12N9/80

摘要： The present invention relates to a process for producing large amounts of 7.beta.-(4-carboxybutanamido)-cephalosporanic acid acylase ("GA") enzyme, which process consists in growing, under suitable culture conditions, a recombinant Escherichia coli K12 strain and subsequently extracting the enzyme from the resulting culture. Enzyme production is controlled by a particular expression system which can be induced by corn-steep liquor, an extremely low cost component of the culture medium. The enzyme can be used in the enzymatic preparation of 7-amino-cephalosporanic acid by starting from 7.beta.-(4-carboxybutanamido)-cephalosporanic acid.

摘要翻译： 本发明涉及一种生产大量7β-（4-羧基丁酰氨基） - 头孢烷酸酰基转移酶（“GA”）酶的方法，该方法在合适的培养条件下生长重组大肠杆菌K12菌株，随后 从所得培养物中提取酶。 酶的产生由特定的表达系统控制，该系统可以由培养基成本极低的玉米浆诱导。 该酶可以从7β-（4-羧基丁酰氨基） - 头孢烷酸开始用于7-氨基 - 头孢菌酸的酶制剂。

公开(公告)号：US5688988A

公开(公告)日：1997-11-18

申请号：US671179

申请日：1996-06-27

申请人： Aldo Bosetti ,  Pietro Cesti ,  Emanuele Cauchi ,  Ignazio Prestifilippo

发明人： Aldo Bosetti ,  Pietro Cesti ,  Emanuele Cauchi ,  Ignazio Prestifilippo

IPC分类号： C07B61/00 ,  C07C269/04 ,  C07C271/26 ,  C07C261/00

CPC分类号： C07C269/04

摘要： A process is described for the preparation of aromatic urethanes in which organic carbonate in a stoichiometric quantity or in a quantity higher than the stoichiometric value is reacted with an aromatic amine operating in the presence of a carbamation catalyst, wherein this catalyst is selected from zinc and/or copper carbonate hydroxide. The process gives high yields and selectivity in the useful reaction product.

摘要翻译： 描述了一种用于制备芳族聚氨酯的方法，其中化学计量量或高于化学计量值的有机碳酸酯与在氨基甲酸酯化催化剂存在下操作的芳族胺反应，其中该催化剂选自锌 和/或碳酸氢铜。 该方法在有用的反应产物中产生高产率和选择性。