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公开(公告)号：US20090286328A1
公开(公告)日：2009-11-19
申请号：US12264324
申请日：2008-11-04
申请人： Norbert Wild , Herbert Andres , Ursula Garczarek , Andrea Geistanger , Marie-Luise Hagmann , Johan Karl , Freidemann Krause , Michael Pfeffer , Wolfgang Rollinger , Michael Tacke , Michael Thiefolf
发明人： Norbert Wild , Herbert Andres , Ursula Garczarek , Andrea Geistanger , Marie-Luise Hagmann , Johan Karl , Freidemann Krause , Michael Pfeffer , Wolfgang Rollinger , Michael Tacke , Michael Thiefolf
IPC分类号： G01N33/566
CPC分类号： G01N33/57419 , C12Q1/6886 , G01N2333/4727 , G01N2333/805 , G01N2333/8146 , G01N2333/9121
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein S100A12 in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuring S100A12 in said sample. Measurement of S100A12 can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译： 本发明涉及结肠直肠癌的诊断。 它公开了蛋白质S100A12在结肠直肠癌诊断中的应用。 它涉及一种通过测量所述样品中的S100A12从粪便样品中诊断结直肠癌的方法。 S100A12的测定可以例如用于结肠直肠癌的早期检测或诊断。
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公开(公告)号：US07566542B2
公开(公告)日：2009-07-28
申请号：US11404218
申请日：2006-04-14
申请人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
发明人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
IPC分类号： G01N33/53 , G01N33/574 , G01N33/48 , G01N33/536 , G01N33/537 , G01N33/577
CPC分类号： G01N33/57415
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein ASC in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring ASC in the sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of breast cancer.
摘要翻译： 本发明涉及乳腺癌的诊断。 它公开了蛋白质ASC在乳腺癌诊断中的应用。 它涉及一种通过测量样品中的ASC从个体获得的来自液体样品的乳腺癌诊断方法。 ASC的测量可以例如用于乳腺癌的早期检测或诊断。
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公开(公告)号：US20060141543A1
公开(公告)日：2006-06-29
申请号：US11294176
申请日：2005-12-05
申请人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
发明人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N33/57473 , G01N2333/70567
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein cellular retinoic acid binding protein II in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring cellular retinoic acid binding protein II in said sample. Measurement of cellular retinoic acid binding protein II can, e.g., be used in the early detection or diagnosis of breast cancer.
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公开(公告)号：US20110171676A1
公开(公告)日：2011-07-14
申请号：US12968784
申请日：2010-12-15
IPC分类号： C12Q1/37
CPC分类号： G01N33/57423 , G01N2333/4742
摘要： The present invention relates to the assessment of lung cancer. It discloses the use of protein ASC in the assessment of lung cancer. It also relates to a method for assessing lung cancer in vitro using a liquid sample, derived from an individual by measuring ASC in the sample. Measurement of ASC can, e.g., be used in the early detection or in the follow-up of patients with lung cancer.
摘要翻译： 本发明涉及肺癌的评估。 它公开了在评估肺癌中使用蛋白质ASC。 它还涉及一种通过测量样品中的ASC来评估来自个体的液体样品在体外评估肺癌的方法。 ASC的测量可以例如用于早期检测或肺癌患者的随访。
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公开(公告)号：US07897404B2
公开(公告)日：2011-03-01
申请号：US10381941
申请日：2001-08-26
申请人： Eva Hoess , Herbert Andres , Frederic Donie , Rudolf Vogel , Hans-Peter Josel , Rupert Hermann , Herbert Von Der Eltz
发明人： Eva Hoess , Herbert Andres , Frederic Donie , Rudolf Vogel , Hans-Peter Josel , Rupert Hermann , Herbert Von Der Eltz
IPC分类号： G01N30/02
CPC分类号： C07K1/1077 , A61K47/643 , A61K47/6889 , G01N33/5306 , G01N33/531 , G01N33/68 , G01N33/6845 , Y10S435/961 , Y10S435/962
摘要： The invention relates to a process for the production of a biomolecule-linker conjugate of uniform stochiometry. It especially relates to a conjugate consisting of a biomolecule of a molecular weight between 5 kD and 500 kD and a hydrophilic linker molecule said linker having a molecular weight between 1 and 15 kD and between 4 and 60 charged residues, characterized in that said conjugate comprises at least one biomolecule-linker product of uniform stoichiometry in a pre-selected amount.
摘要翻译： 本发明涉及一种制备均匀化学计量学的生物分子 - 接头共轭物的方法。 它特别涉及由分子量在5kD至500kD之间的生物分子和亲水性连接分子之间的共轭物，所述亲水性连接分子的所述连接体具有1至15kD的分子量和4至60个带电荷的残基，其特征在于所述共轭物包含 至少一种具有预选量的均匀化学计量的生物分子 - 接头产物。
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公开(公告)号：US07846653B2
公开(公告)日：2010-12-07
申请号：US11820769
申请日：2007-06-20
IPC分类号： C12Q1/00 , G01N33/574
CPC分类号： G01N33/57419
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein ASC (apoptosis-associated speck-like protein containing a caspase-associated recruitment domain) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring ASC in said sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译： 本发明涉及结肠直肠癌的诊断。 它公开了在结直肠癌诊断中使用蛋白质ASC（含凋亡相关的斑点状蛋白质，含有胱天蛋白酶相关募集域）。 它涉及一种通过测量所述样品中的ASC从个体衍生的来自液体样品的结肠直肠癌的诊断方法。 ASC的测量可以例如用于结肠直肠癌的早期检测或诊断。
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公开(公告)号：US20090264618A1
公开(公告)日：2009-10-22
申请号：US12370886
申请日：2009-02-13
CPC分类号： G01N33/6845 , C07K1/1075 , C07K1/1077 , C07K14/001 , G01N33/5306 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/68
摘要： Disclosed herein are branched linkers of the formula: Zn-Y-Xm Wherein X, Y, Z, m, and n are as defined herein. The branched linkers are useful for producing conjugates that are used in diagnostic or therapeutic methods. Methods of producing the branched linkers are also described.
摘要翻译： 本文公开了下式的支链接头：Zn-Y-Xm，其中X，Y，Z，m和n如本文所定义。 支链接头可用于制备用于诊断或治疗方法的缀合物。 还描述了生产支化接头的方法。
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28.发明授权公开(公告)号：US07579158B2
公开(公告)日：2009-08-25
申请号：US11294176
申请日：2005-12-05
申请人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
发明人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
IPC分类号： G01N33/53 , G01N33/68 , G01N33/96 , G01N33/574
CPC分类号： G01N33/57415 , G01N33/57473 , G01N2333/70567
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein cellular retinoic acid binding protein II in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring cellular retinoic acid binding protein II in said sample. Measurement of cellular retinoic acid binding protein II can, e.g., be used in the early detection or diagnosis of breast cancer.
摘要翻译： 本发明涉及乳腺癌的诊断。 它公开了蛋白质细胞视黄酸结合蛋白II在乳腺癌诊断中的应用。 本发明涉及通过测量所述样品中的细胞视黄酸结合蛋白II从来自个体的液体样品诊断乳腺癌的方法。 细胞视黄酸结合蛋白II的测定可以例如用于乳腺癌的早期检测或诊断。
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公开(公告)号：US20060257952A1
公开(公告)日：2006-11-16
申请号：US11404218
申请日：2006-04-14
申请人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
发明人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57415
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein ASC in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring ASC in the sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of breast cancer.
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