摘要:
Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
摘要:
The present invention provides compounds of formula I: where R1 is H, CONH2, T(n)—R, or T(n)—Ar2, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要:
Provided are products for animal use including humans having a certificate verifying at least one of efficacy and methods of providing such certificates.
摘要:
Provided are products for animal use including humans having a certificate verifying at least one of efficacy or safety and methods of providing such certificates.
摘要:
A binocular vision analyzer apparatus is used for determining a prescription of visual aids for the eyes of an individual. The apparatus includes first and second targets respectively corresponding to the first and second eyes of the individual and at least one illuminator unit for illuminating the targets. An optical system is configured to present respective virtual images of the first and second targets so as to be viewable by the respective first and second eyes. At least one beam splitter disposed in front of the first and second eyes directs the virtual images toward the respective eyes. The apparatus also includes first and second spherical correction devices and first and second cylindrical correction devices that respectively correspond to the first and second eyes.
摘要:
Provided are products for animal use including humans having a certificate verifying at least one of efficacy or safety and methods of providing such certificates.
摘要:
The present invention provides compounds of formula I: where R1 is H, CONH2, T(n)-R, or T(n)-Ar2, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要:
Robotic systems for modeling, mapping and exploring subterranean void spaces such as mines, caves, tunnels, bunkers, and conduits. Robotic modeling of subterranean voids is generally enabled by a procedural system consisting of preprocessing, ingress, void modeling, mapping and navigation, exploration, conveying payloads other than void modeling sensors, egress, and post processing. The robots can either be imposed mobility or can be self mobile with either autonomous, remote, teleoperated, or manual modes of operation. The robot may optionally transform from a compact size into a more conventional operating size if the operating size exceeds the void entry opening size. Void geometries with flat floors are amenable to robot locomotion such as rolling, crawling, walking or swimming. Alternatively, irregular floor geometries that preclude self mobilization may be accessible by imposed mobilization such as dropping or pushing a movable robotic sensor into such voids. The robotic device is preferably adaptable to voids filled with a gas or liquid. To maximize mapping applicability, the robot optionally includes sensing, locomotion and environmental tolerance to submersion and safeguarding, according to use criteria.
摘要:
A method for processing mail pieces having information thereon includes scanning the mail piece information and storing scanned mail piece information. Stored information is accessed when a scanned mail piece information is incomplete to obtain previously stored complete mail piece information. The previously stored complete mail piece information is employed in processing the mail piece with the incomplete information. The information may be a code or text that is scanned and stored during the processing of the mail. Fragmentary information from various sources on the scanned mail piece may be combined to access a previously stored mail piece record. The accessed information may be displayed.